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Prediction modelling of 1-year outcomes to a personalized lifestyle intervention for Canadians with Metabolic Syndrome.

Lowry DE, Feng Z, Jeejeebhoy K, Dhaliwal R, Brauer P, Royall D, Tremblay A, Klein D, Mutch DM.

Appl Physiol Nutr Metab. 2019 Nov 18. doi: 10.1139/apnm-2019-0375. [Epub ahead of print]


Exercise and Dairy Protein have Distinct Effects on Indices of Liver and Systemic Lipid Metabolism.

Townsend LK, Gandhi S, Shamshoum H, Trottier SK, Mutch DM, Reimer RA, Shearer J, LeBlanc PJ, Wright DC.

Obesity (Silver Spring). 2020 Jan;28(1):97-105. doi: 10.1002/oby.22621. Epub 2019 Nov 15.


DHA supplementation decreases resting metabolic rate in healthy young females.

Jannas-Vela S, Klingel SL, Mutch DM, Spriet LL.

Appl Physiol Nutr Metab. 2019 Oct 3:1-5. doi: 10.1139/apnm-2019-0581. [Epub ahead of print]


EPA and DHA have divergent effects on serum triglycerides and lipogenesis, but similar effects on lipoprotein lipase activity: a randomized controlled trial.

Klingel SL, Metherel AH, Irfan M, Rajna A, Chabowski A, Bazinet RP, Mutch DM.

Am J Clin Nutr. 2019 Dec 1;110(6):1502-1509. doi: 10.1093/ajcn/nqz234.


Compound-specific isotope analysis reveals no retroconversion of DHA to EPA but substantial conversion of EPA to DHA following supplementation: a randomized control trial.

Metherel AH, Irfan M, Klingel SL, Mutch DM, Bazinet RP.

Am J Clin Nutr. 2019 Oct 1;110(4):823-831. doi: 10.1093/ajcn/nqz097.


Nutrient intake and dietary quality changes within a personalized lifestyle intervention program for metabolic syndrome in primary care.

Brauer P, Royall D, Li A, Rodrigues A, Green J, Macklin S, Craig A, Pasanen J, Brunelle L, Maitland S, Dhaliwal R, Klein D, Tremblay A, Rheaume C, Mutch DM, Jeejeebhoy K.

Appl Physiol Nutr Metab. 2019 Dec;44(12):1297-1304. doi: 10.1139/apnm-2019-0070. Epub 2019 Apr 30.


Reduced delta-6 desaturase activity partially protects against high-fat diet-induced impairment in whole-body glucose tolerance.

Hucik B, Sarr O, Nakamura MT, Dyck DJ, Mutch DM.

J Nutr Biochem. 2019 May;67:173-181. doi: 10.1016/j.jnutbio.2019.02.005. Epub 2019 Mar 2.


The Association between Plasma Omega-6/Omega-3 Ratio and Anthropometric Traits Differs by Racial/Ethnic Groups and NFKB1 Genotypes in Healthy Young Adults.

Bauman-Fortin J, Ma DWL, Mutch DM, Abdelmagid SA, Badawi A, El-Sohemy A, Fontaine-Bisson B.

J Pers Med. 2019 Feb 16;9(1). pii: E13. doi: 10.3390/jpm9010013.


Docosahexaenoic acid reduces resting blood pressure but increases muscle sympathetic outflow compared with eicosapentaenoic acid in healthy men and women.

Lee JB, Notay K, Klingel SL, Chabowski A, Mutch DM, Millar PJ.

Am J Physiol Heart Circ Physiol. 2019 Apr 1;316(4):H873-H881. doi: 10.1152/ajpheart.00677.2018. Epub 2019 Feb 8.


Variants in APOA5 and ADIPOQ Moderate Improvements in Metabolic Syndrome during a One-Year Lifestyle Intervention.

Lowry DE, Fenwick PH, Roke K, Jeejeebhoy K, Dhaliwal R, Brauer P, Royall D, Tremblay A, Klein D, Mutch DM.

Lifestyle Genom. 2018;11(2):80-89. doi: 10.1159/000494331. Epub 2018 Nov 23.


Dietary EPA and DHA prevent changes in white adipose tissue omega-3 PUFA and oxylipin content associated with a Fads2 deficiency.

Sarr O, Payne GW, Hucik B, Abdelmagid S, Nakamura MT, Ma DWL, Mutch DM.

J Nutr Biochem. 2019 Jan;63:140-149. doi: 10.1016/j.jnutbio.2018.09.017. Epub 2018 Sep 26.


TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex.

Notay K, Klingel SL, Lee JB, Doherty CJ, Seed JD, Swiatczak M, Mutch DM, Millar PJ.

J Physiol. 2018 Nov;596(21):5135-5148. doi: 10.1113/JP276526. Epub 2018 Sep 19.


Conditioned gaping produced by high dose Δ9-tetrahydracannabinol: Dysregulation of the hypothalamic endocannabinoid system.

DeVuono MV, Hrelja KM, Sabaziotis L, Rajna A, Rock EM, Limebeer CL, Mutch DM, Parker LA.

Neuropharmacology. 2018 Oct;141:272-282. doi: 10.1016/j.neuropharm.2018.08.039. Epub 2018 Sep 7.


Patient experiences of a lifestyle program for metabolic syndrome offered in family medicine clinics: a mixed methods study.

Klein J, Brauer P, Royall D, Israeloff-Smith M, Klein D, Tremblay A, Dhaliwal R, Rheaume C, Mutch DM, Jeejeebhoy K.

BMC Fam Pract. 2018 Aug 31;19(1):148. doi: 10.1186/s12875-018-0837-z.


FADS1 genotype is distinguished by human subcutaneous adipose tissue fatty acids, but not inflammatory gene expression.

Klingel SL, Valsesia A, Astrup A, Kunesova M, Saris WHM, Langin D, Viguerie N, Mutch DM.

Int J Obes (Lond). 2019 Aug;43(8):1539-1548. doi: 10.1038/s41366-018-0169-z. Epub 2018 Aug 6.


Lifestyle Genomics: Addressing the Multifactorial Nature of Personalized Health.

Mutch DM, Zulyniak MA, Rudkowska I, Tejero ME.

Lifestyle Genom. 2018;11(1):1-8. doi: 10.1159/000492297. Epub 2018 Jul 26. No abstract available.


Guelph Family Health Study: pilot study of a home-based obesity prevention intervention.

Haines J, Douglas S, Mirotta JA, O'Kane C, Breau R, Walton K, Krystia O, Chamoun E, Annis A, Darlington GA, Buchholz AC, Duncan AM, Vallis LA, Spriet LL, Mutch DM, Brauer P, Allen-Vercoe E, Taveras EM, Ma DWL; Guelph Family Health Study.

Can J Public Health. 2018 Aug;109(4):549-560. doi: 10.17269/s41997-018-0072-3. Epub 2018 Apr 25.


Alpha-linolenic acid and linoleic acid differentially regulate the skeletal muscle secretome of obese Zucker rats.

Rajna A, Gibling H, Sarr O, Matravadia S, Holloway GP, Mutch DM.

Physiol Genomics. 2018 Aug 1;50(8):580-589. doi: 10.1152/physiolgenomics.00038.2018. Epub 2018 May 4.


Awareness of Omega-3 Fatty Acids and Possible Health Effects among Young Adults.

Roke K, Rattner J, Brauer P, Mutch DM.

Can J Diet Pract Res. 2018 Sep 1;79(3):106-112. doi: 10.3148/cjdpr-2018-005. Epub 2018 Mar 16.


Safflower (n-6) and flaxseed (n-3) high-fat diets differentially regulate hypothalamic fatty acid profiles, gene expression, and insulin signalling.

Fernandes MF, Tache MC, Klingel SL, Leri F, Mutch DM.

Prostaglandins Leukot Essent Fatty Acids. 2018 Jan;128:67-73. doi: 10.1016/j.plefa.2017.12.002. Epub 2017 Dec 8.


Lifestyle genomics and the metabolic syndrome: A review of genetic variants that influence response to diet and exercise interventions.

Fenwick PH, Jeejeebhoy K, Dhaliwal R, Royall D, Brauer P, Tremblay A, Klein D, Mutch DM.

Crit Rev Food Sci Nutr. 2019;59(13):2028-2039. doi: 10.1080/10408398.2018.1437022. Epub 2018 Mar 1. Review.


Single Nucleotide Polymorphisms in Taste Receptor Genes Are Associated with Snacking Patterns of Preschool-Aged Children in the Guelph Family Health Study: A Pilot Study.

Chamoun E, Hutchinson JM, Krystia O, Mirotta JA, Mutch DM, Buchholz AC, Duncan AM, Darlington G, Haines J, Ma DWL; Guelph Family Health Study.

Nutrients. 2018 Jan 30;10(2). pii: E153. doi: 10.3390/nu10020153.


PEMT, Δ6 desaturase, and palmitoyldocosahexaenoyl phosphatidylcholine are increased in rats during pregnancy.

Chalil A, Kitson AP, Aristizabal Henao JJ, Marks KA, Elzinga JL, Lamontagne-Kam DME, Chalil D, Badoud F, Mutch DM, Stark KD.

J Lipid Res. 2018 Jan;59(1):123-136. doi: 10.1194/jlr.M080309. Epub 2017 Nov 22.


Rosiglitazone is superior to resveratrol in inducing the expression of glyceroneogenic genes in adipose tissue from obese participants.

Beaudoin MS, Gaudio N, Reed JK, Foute-Nelong J, Mutch DM, Wright DC.

Appl Physiol Nutr Metab. 2018 Mar;43(3):307-311. doi: 10.1139/apnm-2017-0606. Epub 2017 Nov 16.


Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes.

Klingel SL, Roke K, Hidalgo B, Aslibekyan S, Straka RJ, An P, Province MA, Hopkins PN, Arnett DK, Ordovas JM, Lai CQ, Mutch DM.

Lipids. 2017 Dec;52(12):969-980. doi: 10.1007/s11745-017-4307-5. Epub 2017 Oct 27.


Neither linoleic acid nor arachidonic acid promote white adipose tissue inflammation in Fads2-/- mice fed low fat diets.

Suitor K, Payne GW, Sarr O, Abdelmagid S, Nakamura MT, Ma DW, Mutch DM.

Prostaglandins Leukot Essent Fatty Acids. 2017 Nov;126:84-91. doi: 10.1016/j.plefa.2017.09.008. Epub 2017 Sep 15.


The CHANGE program: Exercise intervention in primary care.

Klein D, Jeejeebhoy K, Tremblay A, Kallio M, Rheaume C, Humphries S, Royall D, Brauer P, Heyland D, Dhaliwal R, Mutch DM.

Can Fam Physician. 2017 Jul;63(7):546-552.


Reduced SCD1 activity alters markers of fatty acid reesterification, glyceroneogenesis, and lipolysis in murine white adipose tissue and 3T3-L1 adipocytes.

Dragos SM, Bergeron KF, Desmarais F, Suitor K, Wright DC, Mounier C, Mutch DM.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C295-C304. doi: 10.1152/ajpcell.00097.2017. Epub 2017 Jun 28.


Multi-omics Integrative Investigation of Fatty Acid Metabolism in Obese and Lean Subcutaneous Tissue.

Badoud F, Brewer D, Charchoglyan A, Cuthbertson DJ, Mutch DM.

OMICS. 2017 Jul;21(7):371-379. doi: 10.1089/omi.2017.0049. Epub 2017 Jun 15.


Subcutaneous and Visceral Adipose Tissue Secretions from Extremely Obese Men and Women both Acutely Suppress Muscle Insulin Signaling.

Sarr O, Strohm RJ, MacDonald TL, Gaudio N, Reed JK, Foute-Nelong J, Dyck DJ, Mutch DM.

Int J Mol Sci. 2017 May 2;18(5). pii: E959. doi: 10.3390/ijms18050959.


Family physician-led, team-based, lifestyle intervention in patients with metabolic syndrome: results of a multicentre feasibility project.

Jeejeebhoy K, Dhaliwal R, Heyland DK, Leung R, Day AG, Brauer P, Royall D, Tremblay A, Mutch DM, Pliamm L, Rhéaume C, Klein D.

CMAJ Open. 2017 Mar 14;5(1):E229-E236. doi: 10.9778/cmajo.20160101. eCollection 2017 Jan-Mar. Erratum in: CMAJ Open. 2017 May 1;5(2):E337.


Circulating concentrations and relative percent composition of trans fatty acids in healthy Canadian young adults between 2004 and 2010: a cross-sectional study.

Abdelmagid SA, Nielsen DE, Badawi A, El-Sohemy A, Mutch DM, Ma DW.

CMAJ Open. 2017 Feb 14;5(1):E130-E136. doi: 10.9778/cmajo.20160048. eCollection 2017 Jan-Mar.


Evaluating Changes in Omega-3 Fatty Acid Intake after Receiving Personal FADS1 Genetic Information: A Randomized Nutrigenetic Intervention.

Roke K, Walton K, Klingel SL, Harnett A, Subedi S, Haines J, Mutch DM.

Nutrients. 2017 Mar 6;9(3). pii: E240. doi: 10.3390/nu9030240.


Two-way learning with one-way supervision for gene expression data.

Wong MH, Mutch DM, McNicholas PD.

BMC Bioinformatics. 2017 Mar 4;18(1):150. doi: 10.1186/s12859-017-1564-5.


Lack of effects of fish oil supplementation for 12 weeks on resting metabolic rate and substrate oxidation in healthy young men: A randomized controlled trial.

Jannas-Vela S, Roke K, Boville S, Mutch DM, Spriet LL.

PLoS One. 2017 Feb 17;12(2):e0172576. doi: 10.1371/journal.pone.0172576. eCollection 2017.


Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity.

Lounis MA, Lalonde S, Rial SA, Bergeron KF, Ralston JC, Mutch DM, Mounier C.

Lipids. 2017 Feb;52(2):129-150. doi: 10.1007/s11745-016-4210-5. Epub 2016 Nov 12.


Reduced ATGL-mediated lipolysis attenuates β-adrenergic-induced AMPK signaling, but not the induction of PKA-targeted genes, in adipocytes and adipose tissue.

MacPherson RE, Dragos SM, Ramos S, Sutton C, Frendo-Cumbo S, Castellani L, Watt MJ, Perry CG, Mutch DM, Wright DC.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C269-76. doi: 10.1152/ajpcell.00126.2016. Epub 2016 Jun 29.


A review of the associations between single nucleotide polymorphisms in taste receptors, eating behaviors, and health.

Chamoun E, Mutch DM, Allen-Vercoe E, Buchholz AC, Duncan AM, Spriet LL, Haines J, Ma DWL; Guelph Family Health Study.

Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):194-207. doi: 10.1080/10408398.2016.1152229. Epub 2017 Jul 21. Review.


North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression.

Garbett J, Wilson SA, Ralston JC, De Boer AA, Lui EM, Wright DC, Mutch DM.

J Ginseng Res. 2016 Apr;40(2):141-50. doi: 10.1016/j.jgr.2015.07.001. Epub 2015 Jul 18.


FADS2 genotype influences whole-body resting fat oxidation in young adult men.

Roke K, Jannas-Vela S, Spriet LL, Mutch DM.

Appl Physiol Nutr Metab. 2016 Jul;41(7):791-4. doi: 10.1139/apnm-2016-0043. Epub 2016 Mar 16.


LA and ALA prevent glucose intolerance in obese male rats without reducing reactive lipid content, but cause tissue-specific changes in fatty acid composition.

Matravadia S, Zabielski P, Chabowski A, Mutch DM, Holloway GP.

Am J Physiol Regul Integr Comp Physiol. 2016 Apr 1;310(7):R619-30. doi: 10.1152/ajpregu.00297.2015. Epub 2016 Jan 13.


Fish oil regulates blood fatty acid composition and oxylipin levels in healthy humans: A comparison of young and older men.

Zulyniak MA, Roke K, Gerling C, Logan SL, Spriet LL, Mutch DM.

Mol Nutr Food Res. 2016 Mar;60(3):631-41. doi: 10.1002/mnfr.201500830. Epub 2016 Jan 25.


SCD1 mediates the influence of exogenous saturated and monounsaturated fatty acids in adipocytes: Effects on cellular stress, inflammatory markers and fatty acid elongation.

Ralston JC, Metherel AH, Stark KD, Mutch DM.

J Nutr Biochem. 2016 Jan;27:241-8. doi: 10.1016/j.jnutbio.2015.09.011. Epub 2015 Sep 25.


Metabolomics Reveals Metabolically Healthy and Unhealthy Obese Individuals Differ in their Response to a Caloric Challenge.

Badoud F, Lam KP, Perreault M, Zulyniak MA, Britz-McKibbin P, Mutch DM.

PLoS One. 2015 Aug 14;10(8):e0134613. doi: 10.1371/journal.pone.0134613. eCollection 2015.


Development of a Dietary Management Care Map for Metabolic Syndrome.

Royall D, Brauer P, Bjorklund L, O'Young O, Tremblay A, Jeejeebhoy K, Heyland D, Dhaliwal R, Klein D, Mutch DM.

Can J Diet Pract Res. 2014 Sep;75(3):132-9. doi: 10.3148/cjdpr-2014-005. Review.


Fructose:glucose ratios--a study of sugar self-administration and associated neural and physiological responses in the rat.

Levy A, Marshall P, Zhou Y, Kreek MJ, Kent K, Daniels S, Shore A, Downs T, Fernandes MF, Mutch DM, Leri F.

Nutrients. 2015 May 22;7(5):3869-90. doi: 10.3390/nu7053869.


SCD1 inhibition during 3T3-L1 adipocyte differentiation remodels triacylglycerol, diacylglycerol and phospholipid fatty acid composition.

Ralston JC, Mutch DM.

Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:29-37. doi: 10.1016/j.plefa.2015.04.008. Epub 2015 Apr 28.


Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study.

Abdelmagid SA, Clarke SE, Roke K, Nielsen DE, Badawi A, El-Sohemy A, Mutch DM, Ma DW.

Nutr Metab (Lond). 2015 Apr 21;12:14. doi: 10.1186/s12986-015-0010-9. eCollection 2015.

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