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Africa should set its own health-research agenda.

Mutapi F.

Nature. 2019 Nov;575(7784):567. doi: 10.1038/d41586-019-03627-9. No abstract available.


Strengthening national health research systems in the WHO African Region - progress towards universal health coverage.

Rusakaniko S, Makanga M, Ota MO, Bockarie M, Banda G, Okeibunor J, Mutapi F, Tumusiime P, Nyirenda T, Kirigia JM, Nabyonga-Orem J.

Global Health. 2019 Jul 26;15(1):50. doi: 10.1186/s12992-019-0492-8.


In-depth proteomic characterization of Schistosoma haematobium: Towards the development of new tools for elimination.

Sotillo J, Pearson MS, Becker L, Mekonnen GG, Amoah AS, van Dam G, Corstjens PLAM, Murray J, Mduluza T, Mutapi F, Loukas A.

PLoS Negl Trop Dis. 2019 May 15;13(5):e0007362. doi: 10.1371/journal.pntd.0007362. eCollection 2019 May.


Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity.

Chisango TJ, Ndlovu B, Vengesai A, Nhidza AF, Sibanda EP, Zhou D, Mutapi F, Mduluza T.

BMC Infect Dis. 2019 Mar 4;19(1):219. doi: 10.1186/s12879-019-3811-z.


The anthelmintic drug praziquantel promotes human Tr1 differentiation.

Eyoh E, McCallum P, Killick J, Amanfo S, Mutapi F, Astier AL.

Immunol Cell Biol. 2019 May;97(5):512-518. doi: 10.1111/imcb.12229. Epub 2019 Jan 30.


Population level changes in schistosome-specific antibody levels following chemotherapy.

Fukushige M, Mutapi F, Woolhouse MEJ.

Parasite Immunol. 2019 Jan;41(1):e12604. doi: 10.1111/pim.12604.


Evidence of a distinct group of Black African patients with systemic lupus erythematosus.

Sibanda EN, Chase-Topping M, Pfavayi LT, Woolhouse MEJ, Mutapi F.

BMJ Glob Health. 2018 Sep 16;3(5):e000697. doi: 10.1136/bmjgh-2017-000697. eCollection 2018.


Coinfections and comorbidities in African health systems: At the interface of infectious and noninfectious diseases.

Osakunor DNM, Sengeh DM, Mutapi F.

PLoS Negl Trop Dis. 2018 Sep 20;12(9):e0006711. doi: 10.1371/journal.pntd.0006711. eCollection 2018 Sep. Review.


Universal Health Coverage in Africa: Coinfections and Comorbidities.

Osakunor DNM, Sengeh DM, Mutapi F.

Trends Parasitol. 2018 Oct;34(10):813-817. doi: 10.1016/ Epub 2018 Jul 26.


Dynamics of paediatric urogenital schistosome infection, morbidity and treatment: a longitudinal study among preschool children in Zimbabwe.

Osakunor DNM, Mduluza T, Midzi N, Chase-Topping M, Mutsaka-Makuvaza MJ, Chimponda T, Eyoh E, Mduluza T, Pfavayi LT, Wami WM, Amanfo SA, Murray J, Tshuma C, Woolhouse MEJ, Mutapi F.

BMJ Glob Health. 2018 Mar 27;3(2):e000661. doi: 10.1136/bmjgh-2017-000661. eCollection 2018.


Paediatric schistosomiasis: What we know and what we need to know.

Osakunor DNM, Woolhouse MEJ, Mutapi F.

PLoS Negl Trop Dis. 2018 Feb 8;12(2):e0006144. doi: 10.1371/journal.pntd.0006144. eCollection 2018 Feb. Review.


Group 2 ILCs: A way of enhancing immune protection against human helminths?

Nausch N, Mutapi F.

Parasite Immunol. 2018 Feb;40(2). doi: 10.1111/pim.12450. Epub 2017 Jul 12. Review.


Putting the treatment of paediatric schistosomiasis into context.

Mduluza T, Mutapi F.

Infect Dis Poverty. 2017 Apr 7;6(1):85. doi: 10.1186/s40249-017-0300-8. Review.


Human schistosomiasis in the post mass drug administration era.

Mutapi F, Maizels R, Fenwick A, Woolhouse M.

Lancet Infect Dis. 2017 Feb;17(2):e42-e48. doi: 10.1016/S1473-3099(16)30475-3. Epub 2016 Dec 15. Review.


Getting a GRiPP on everyday schistosomiasis: experience from Zimbabwe.

Mutapi F.

Parasitology. 2017 Oct;144(12):1624-1632. doi: 10.1017/S0031182016001724. Epub 2016 Oct 12. Review.


Comparative Assessment of Health Benefits of Praziquantel Treatment of Urogenital Schistosomiasis in Preschool and Primary School-Aged Children.

Wami WM, Nausch N, Midzi N, Gwisai R, Mduluza T, Woolhouse ME, Mutapi F.

Biomed Res Int. 2016;2016:9162631. doi: 10.1155/2016/9162631. Epub 2016 Aug 18.


Seroepidemiology of Plasmodium species infections in Zimbabwean population.

Amanfo SA, Mduluza T, Midzi N, Cavanagh DR, Mutapi F.

Malar J. 2016 May 10;15(1):267. doi: 10.1186/s12936-016-1325-3.


Schistosomiasis therapeutics: whats in the pipeline?

Trainor-Moss S, Mutapi F.

Expert Rev Clin Pharmacol. 2016;9(2):157-60. doi: 10.1586/17512433.2015.1102051. Epub 2015 Oct 27.


The gut microbiome in the helminth infected host.

Mutapi F.

Trends Parasitol. 2015 Sep;31(9):405-6. doi: 10.1016/ Epub 2015 Jul 1.


The helminth parasite proteome at the host-parasite interface - Informing diagnosis and control.

van der Ree AM, Mutapi F.

Exp Parasitol. 2015 Oct;157:48-58. doi: 10.1016/j.exppara.2015.06.007. Epub 2015 Jun 24. Review.


Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children.

Kay GL, Millard A, Sergeant MJ, Midzi N, Gwisai R, Mduluza T, Ivens A, Nausch N, Mutapi F, Pallen M.

PLoS Negl Trop Dis. 2015 Jun 26;9(6):e0003861. doi: 10.1371/journal.pntd.0003861. eCollection 2015. Erratum in: PLoS Negl Trop Dis. 2015 Jul;9(7):e0003969.


Of monkeys and men: immunomic profiling of sera from humans and non-human primates resistant to schistosomiasis reveals novel potential vaccine candidates.

Pearson MS, Becker L, Driguez P, Young ND, Gaze S, Mendes T, Li XH, Doolan DL, Midzi N, Mduluza T, McManus DP, Wilson RA, Bethony JM, Nausch N, Mutapi F, Felgner PL, Loukas A.

Front Immunol. 2015 May 5;6:213. doi: 10.3389/fimmu.2015.00213. eCollection 2015.


Group 2 innate lymphoid cell proportions are diminished in young helminth infected children and restored by curative anti-helminthic treatment.

Nausch N, Appleby LJ, Sparks AM, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2015 Mar 23;9(3):e0003627. doi: 10.1371/journal.pntd.0003627. eCollection 2015 Mar.


Identifying and evaluating field indicators of urogenital schistosomiasis-related morbidity in preschool-aged children.

Wami WM, Nausch N, Midzi N, Gwisai R, Mduluza T, Woolhouse M, Mutapi F.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003649. doi: 10.1371/journal.pntd.0003649. eCollection 2015 Mar.


A Meta-Analysis of Experimental Studies of Attenuated Schistosoma mansoni Vaccines in the Mouse Model.

Fukushige M, Mitchell KM, Bourke CD, Woolhouse ME, Mutapi F.

Front Immunol. 2015 Feb 27;6:85. doi: 10.3389/fimmu.2015.00085. eCollection 2015.


Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation.

Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE, Mutapi F.

Front Immunol. 2015 Feb 18;6:51. doi: 10.3389/fimmu.2015.00051. eCollection 2015.


Changing policy and practice in the control of pediatric schistosomiasis.

Mutapi F.

Pediatrics. 2015 Mar;135(3):536-44. doi: 10.1542/peds.2014-3189. Review.


Distribution of schistosomiasis and soil transmitted helminthiasis in Zimbabwe: towards a national plan of action for control and elimination.

Midzi N, Mduluza T, Chimbari MJ, Tshuma C, Charimari L, Mhlanga G, Manangazira P, Munyati SM, Phiri I, Mutambu SL, Midzi SS, Ncube A, Muranzi LP, Rusakaniko S, Mutapi F.

PLoS Negl Trop Dis. 2014 Aug 14;8(8):e3014. doi: 10.1371/journal.pntd.0003014. eCollection 2014 Aug.


CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1.

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 Aug 7;8(8):e3049. doi: 10.1371/journal.pntd.0003049. eCollection 2014 Aug.


Predicted impact of mass drug administration on the development of protective immunity against Schistosoma haematobium.

Mitchell KM, Mutapi F, Mduluza T, Midzi N, Savill NJ, Woolhouse ME.

PLoS Negl Trop Dis. 2014 Jul 31;8(7):e3059. doi: 10.1371/journal.pntd.0003059. eCollection 2014.


The microbiota and helminths: sharing the same niche in the human host.

Glendinning L, Nausch N, Free A, Taylor DW, Mutapi F.

Parasitology. 2014 Sep;141(10):1255-71. doi: 10.1017/S0031182014000699. Epub 2014 Jun 5. Review.


Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2014 May 8;8(5):e2846. doi: 10.1371/journal.pntd.0002846. eCollection 2014 May.


Comparing parasitological vs serological determination of Schistosoma haematobium infection prevalence in preschool and primary school-aged children: implications for control programmes.

Wami WM, Nausch N, Bauer K, Midzi N, Gwisai R, Simmonds P, Mduluza T, Woolhouse M, Mutapi F.

Parasitology. 2014 Dec;141(14):1962-70. doi: 10.1017/S0031182014000213. Epub 2014 Mar 28.


Field evaluation of a new antibody-based diagnostic for Schistosoma haematobium and S. mansoni at the point-of-care in northeast Zimbabwe.

Nausch N, Dawson EM, Midzi N, Mduluza T, Mutapi F, Doenhoff MJ.

BMC Infect Dis. 2014 Mar 26;14:165. doi: 10.1186/1471-2334-14-165.


Parasite-derived microRNAs in host serum as novel biomarkers of helminth infection.

Hoy AM, Lundie RJ, Ivens A, Quintana JF, Nausch N, Forster T, Jones F, Kabatereine NB, Dunne DW, Mutapi F, Macdonald AS, Buck AH.

PLoS Negl Trop Dis. 2014 Feb 20;8(2):e2701. doi: 10.1371/journal.pntd.0002701. eCollection 2014 Feb.


Immunological consequences of antihelminthic treatment in preschool children exposed to urogenital schistosome infection.

Rujeni N, Nausch N, Midzi N, Cowan GJ, Burchmore R, Cavanagh DR, Taylor DW, Mduluza T, Mutapi F.

J Trop Med. 2013;2013:283619. doi: 10.1155/2013/283619. Epub 2013 Jun 5.


Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection.

Rujeni N, Nausch N, Midzi N, Gwisai R, Mduluza T, Taylor DW, Mutapi F.

Int Arch Allergy Immunol. 2013;161(4):333-41. doi: 10.1159/000346545. Epub 2013 May 14.


Sources of heterogeneity in human monocyte subsets.

Appleby LJ, Nausch N, Midzi N, Mduluza T, Allen JE, Mutapi F.

Immunol Lett. 2013 Apr;152(1):32-41. doi: 10.1016/j.imlet.2013.03.004. Epub 2013 Apr 1.


Infection and treatment immunizations for successful parasite vaccines.

Mutapi F, Billingsley PF, Secor WE.

Trends Parasitol. 2013 Mar;29(3):135-41. doi: 10.1016/ Epub 2013 Feb 15.


Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children.

Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE, Mutapi F.

PLoS Negl Trop Dis. 2012;6(11):e1898. doi: 10.1371/journal.pntd.0001898. Epub 2012 Nov 8.


Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response.

Bourke CD, Mutapi F, Nausch N, Photiou DM, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M, Bager P.

Clin Exp Allergy. 2012 Nov;42(11):1582-95. doi: 10.1111/j.1365-2222.2012.04063.x.


Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis.

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T, Mutapi F.

J Infect Dis. 2013 Jul;208(1):159-69. doi: 10.1093/infdis/jis524. Epub 2012 Oct 8.


Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection.

Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IY, Appleby LJ, Bourke CD, Midzi N, Mduluza T, Mutapi F.

PLoS Negl Trop Dis. 2012;6(9):e1824. doi: 10.1371/journal.pntd.0001824. Epub 2012 Sep 27.


Human schistosome infection and allergic sensitisation.

Rujeni N, Taylor DW, Mutapi F.

J Parasitol Res. 2012;2012:154743. doi: 10.1155/2012/154743. Epub 2012 Aug 27.


Advances in parasite control in Africa: from basic science to translation.

Mutapi F.

J Parasitol Res. 2012;2012:158039. doi: 10.1155/2012/158039. Epub 2012 Jul 19. No abstract available.


Protective immunity to Schistosoma haematobium infection is primarily an anti-fecundity response stimulated by the death of adult worms.

Mitchell KM, Mutapi F, Savill NJ, Woolhouse ME.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13347-52. doi: 10.1073/pnas.1121051109. Epub 2012 Jul 30.


Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium.

Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T, Mutapi F.

Sci Rep. 2012;2:472. doi: 10.1038/srep00472. Epub 2012 Jun 26.


Association between Micronutrients (Vitamin A, D, Iron) and Schistosome-Specific Cytokine Responses in Zimbabweans Exposed to Schistosoma haematobium.

Reilly L, Nausch N, Midzi N, Mduluza T, Mutapi F.

J Parasitol Res. 2012;2012:128628. doi: 10.1155/2012/128628. Epub 2012 Feb 20.


Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells.

Caserta S, Nausch N, Sawtell A, Drummond R, Barr T, Macdonald AS, Mutapi F, Zamoyska R.

PLoS One. 2012;7(4):e35466. doi: 10.1371/journal.pone.0035466. Epub 2012 Apr 9.


Helminth parasite proteomics: from experimental models to human infections.

Mutapi F.

Parasitology. 2012 Aug;139(9):1195-204. doi: 10.1017/S0031182011002423. Epub 2012 Mar 28. Review.

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