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Items: 19


Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans.

Mustoe AM, Corley M, Laederach A, Weeks KM.

Biochemistry. 2018 Jul 3;57(26):3537-3539. doi: 10.1021/acs.biochem.8b00395. Epub 2018 Jun 12. No abstract available.


Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing.

Mustoe AM, Busan S, Rice GM, Hajdin CE, Peterson BK, Ruda VM, Kubica N, Nutiu R, Baryza JL, Weeks KM.

Cell. 2018 Mar 22;173(1):181-195.e18. doi: 10.1016/j.cell.2018.02.034. Epub 2018 Mar 15.


An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression.

Corley M, Solem A, Phillips G, Lackey L, Ziehr B, Vincent HA, Mustoe AM, Ramos SBV, Weeks KM, Moorman NJ, Laederach A.

Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):E10244-E10253. doi: 10.1073/pnas.1706539114. Epub 2017 Nov 6.


Tuning RNA folding and function through rational design of junction topology.

Daher M, Mustoe AM, Morriss-Andrews A, Brooks CL III, Walter NG.

Nucleic Acids Res. 2017 Sep 19;45(16):9706-9715. doi: 10.1093/nar/gkx614.


Direct identification of base-paired RNA nucleotides by correlated chemical probing.

Krokhotin A, Mustoe AM, Weeks KM, Dokholyan NV.

RNA. 2017 Jan;23(1):6-13. Epub 2016 Nov 1.


Direct Duplex Detection: An Emerging Tool in the RNA Structure Analysis Toolbox.

Weidmann CA, Mustoe AM, Weeks KM.

Trends Biochem Sci. 2016 Sep;41(9):734-736. doi: 10.1016/j.tibs.2016.07.001. Epub 2016 Jul 14.


Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme.

Mustoe AM, Al-Hashimi HM, Brooks CL 3rd.

Nucleic Acids Res. 2016 Jan 8;44(1):402-12. doi: 10.1093/nar/gkv1055. Epub 2015 Oct 19.


Noncanonical secondary structure stabilizes mitochondrial tRNA(Ser(UCN)) by reducing the entropic cost of tertiary folding.

Mustoe AM, Liu X, Lin PJ, Al-Hashimi HM, Fierke CA, Brooks CL 3rd.

J Am Chem Soc. 2015 Mar 18;137(10):3592-9. doi: 10.1021/ja5130308. Epub 2015 Mar 9.


An RNA tertiary switch by modifying how helices are tethered.

Ganser LR, Mustoe AM, Al-Hashimi HM.

Genome Biol. 2014 Jul 30;15(7):425. doi: 10.1186/s13059-014-0425-z.


Efficient in silico exploration of RNA interhelical conformations using Euler angles and WExplore.

Dickson A, Mustoe AM, Salmon L, Brooks CL 3rd.

Nucleic Acids Res. 2014 Oct 29;42(19):12126-37. doi: 10.1093/nar/gku799. Epub 2014 Oct 7.


Topological constraints are major determinants of tRNA tertiary structure and dynamics and provide basis for tertiary folding cooperativity.

Mustoe AM, Brooks CL 3rd, Al-Hashimi HM.

Nucleic Acids Res. 2014 Oct;42(18):11792-804. doi: 10.1093/nar/gku807. Epub 2014 Sep 12.


Hierarchy of RNA functional dynamics.

Mustoe AM, Brooks CL, Al-Hashimi HM.

Annu Rev Biochem. 2014;83:441-66. doi: 10.1146/annurev-biochem-060713-035524. Epub 2014 Mar 5. Review.


Coarse grained models reveal essential contributions of topological constraints to the conformational free energy of RNA bulges.

Mustoe AM, Al-Hashimi HM, Brooks CL 3rd.

J Phys Chem B. 2014 Mar 13;118(10):2615-27. doi: 10.1021/jp411478x. Epub 2014 Mar 3.


Single transcriptional and translational preQ1 riboswitches adopt similar pre-folded ensembles that follow distinct folding pathways into the same ligand-bound structure.

Suddala KC, Rinaldi AJ, Feng J, Mustoe AM, Eichhorn CD, Liberman JA, Wedekind JE, Al-Hashimi HM, Brooks CL 3rd, Walter NG.

Nucleic Acids Res. 2013 Dec;41(22):10462-75. doi: 10.1093/nar/gkt798. Epub 2013 Sep 3.


Use of a global metabolic network to curate organismal metabolic networks.

Pah AR, Guimerà R, Mustoe AM, Amaral LA.

Sci Rep. 2013;3:1695. doi: 10.1038/srep01695.


Functional complexity and regulation through RNA dynamics.

Dethoff EA, Chugh J, Mustoe AM, Al-Hashimi HM.

Nature. 2012 Feb 15;482(7385):322-30. doi: 10.1038/nature10885. Review.


3D maps of RNA interhelical junctions.

Bailor MH, Mustoe AM, Brooks CL 3rd, Al-Hashimi HM.

Nat Protoc. 2011 Sep 15;6(10):1536-45. doi: 10.1038/nprot.2011.385.


New insights into the fundamental role of topological constraints as a determinant of two-way junction conformation.

Mustoe AM, Bailor MH, Teixeira RM, Brooks CL 3rd, Al-Hashimi HM.

Nucleic Acids Res. 2012 Jan;40(2):892-904. doi: 10.1093/nar/gkr751. Epub 2011 Sep 21.


Topological constraints: using RNA secondary structure to model 3D conformation, folding pathways, and dynamic adaptation.

Bailor MH, Mustoe AM, Brooks CL 3rd, Al-Hashimi HM.

Curr Opin Struct Biol. 2011 Jun;21(3):296-305. doi: 10.1016/ Epub 2011 Apr 14. Review.

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