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Items: 37

1.

Novel PIKK inhibitor antibody-drug conjugates: Synthesis and anti-tumor activity.

Zhou D, Casavant J, Graziani EI, He H, Janso J, Loganzo F, Musto S, Tumey N, O'Donnell CJ, Dushin R.

Bioorg Med Chem Lett. 2019 Apr 1;29(7):943-947. doi: 10.1016/j.bmcl.2019.01.009. Epub 2019 Jan 11.

PMID:
30655215
2.

Natural Product Bis-Intercalator Depsipeptides as a New Class of Payloads for Antibody-Drug Conjugates.

Ratnayake AS, Chang LP, Tumey LN, Loganzo F, Chemler JA, Wagenaar M, Musto S, Li F, Janso JE, Ballard TE, Rago B, Steele GL, Ding W, Feng X, Hosselet C, Buklan V, Lucas J, Koehn FE, O'Donnell CJ, Graziani EI.

Bioconjug Chem. 2019 Jan 16;30(1):200-209. doi: 10.1021/acs.bioconjchem.8b00843. Epub 2018 Dec 13.

PMID:
30543418
3.

"Selfie" harm: Effects on mood and body image in young women.

Mills JS, Musto S, Williams L, Tiggemann M.

Body Image. 2018 Dec;27:86-92. doi: 10.1016/j.bodyim.2018.08.007. Epub 2018 Aug 24.

4.

Establishing in vitro-in vivo correlation for antibody drug conjugate efficacy: a PK/PD modeling approach.

Shah DK, Loganzo F, Haddish-Berhane N, Musto S, Wald HS, Barletta F, Lucas J, Clark T, Hansel S, Betts A.

J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):339-349. doi: 10.1007/s10928-018-9577-x. Epub 2018 Feb 8.

PMID:
29423862
5.

Multivalent peptidic linker enables identification of preferred sites of conjugation for a potent thialanstatin antibody drug conjugate.

Puthenveetil S, He H, Loganzo F, Musto S, Teske J, Green M, Tan X, Hosselet C, Lucas J, Tumey LN, Sapra P, Subramanyam C, O'Donnell CJ, Graziani EI.

PLoS One. 2017 May 30;12(5):e0178452. doi: 10.1371/journal.pone.0178452. eCollection 2017.

6.

Site Selection: a Case Study in the Identification of Optimal Cysteine Engineered Antibody Drug Conjugates.

Tumey LN, Li F, Rago B, Han X, Loganzo F, Musto S, Graziani EI, Puthenveetil S, Casavant J, Marquette K, Clark T, Bikker J, Bennett EM, Barletta F, Piche-Nicholas N, Tam A, O'Donnell CJ, Gerber HP, Tchistiakova L.

AAPS J. 2017 Jul;19(4):1123-1135. doi: 10.1208/s12248-017-0083-7. Epub 2017 Apr 24.

PMID:
28439809
7.

Development of Fluorophore-Labeled Thailanstatin Antibody-Drug Conjugates for Cellular Trafficking Studies.

Kulkarni C, Finley JE, Bessire AJ, Zhong X, Musto S, Graziani EI.

Bioconjug Chem. 2017 Apr 19;28(4):1041-1047. doi: 10.1021/acs.bioconjchem.6b00718. Epub 2017 Mar 1.

PMID:
28191936
8.

Design, Synthesis, and Cytotoxic Evaluation of Novel Tubulysin Analogues as ADC Payloads.

Leverett CA, Sukuru SC, Vetelino BC, Musto S, Parris K, Pandit J, Loganzo F, Varghese AH, Bai G, Liu B, Liu D, Hudson S, Doppalapudi VR, Stock J, O'Donnell CJ, Subramanyam C.

ACS Med Chem Lett. 2016 Aug 26;7(11):999-1004. eCollection 2016 Nov 10.

9.

Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.

Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C.

ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. eCollection 2016 Nov 10.

10.

Natural Product Splicing Inhibitors: A New Class of Antibody-Drug Conjugate (ADC) Payloads.

Puthenveetil S, Loganzo F, He H, Dirico K, Green M, Teske J, Musto S, Clark T, Rago B, Koehn F, Veneziale R, Falahaptisheh H, Han X, Barletta F, Lucas J, Subramanyam C, O'Donnell CJ, Tumey LN, Sapra P, Gerber HP, Ma D, Graziani EI.

Bioconjug Chem. 2016 Aug 17;27(8):1880-8. doi: 10.1021/acs.bioconjchem.6b00291. Epub 2016 Jul 28.

PMID:
27412791
11.

Development of Solid-Phase Site-Specific Conjugation and Its Application toward Generation of Dual Labeled Antibody and Fab Drug Conjugates.

Puthenveetil S, Musto S, Loganzo F, Tumey LN, O'Donnell CJ, Graziani E.

Bioconjug Chem. 2016 Apr 20;27(4):1030-9. doi: 10.1021/acs.bioconjchem.6b00054. Epub 2016 Mar 22.

PMID:
26942771
12.

Tumor cells chronically treated with a trastuzumab-maytansinoid antibody-drug conjugate develop varied resistance mechanisms but respond to alternate treatments.

Loganzo F, Tan X, Sung M, Jin G, Myers JS, Melamud E, Wang F, Diesl V, Follettie MT, Musto S, Lam MH, Hu W, Charati MB, Khandke K, Kim KS, Cinque M, Lucas J, Graziani E, Maderna A, O'Donnell CJ, Arndt KT, Gerber HP.

Mol Cancer Ther. 2015 Apr;14(4):952-63. doi: 10.1158/1535-7163.MCT-14-0862. Epub 2015 Feb 2.

13.

Correlates of Heroin and Methamphetamine Use among Homeless Male Ex-Jail and Prison Offenders.

Nyamathi A, Salem BE, Farabee D, Hall E, Zhang S, Marfisee M, Khalilifard F, Musto S, Leake B.

Addict Res Theory. 2014 Dec;22(6):463-473.

14.

Discovery of cytotoxic dolastatin 10 analogues with N-terminal modifications.

Maderna A, Doroski M, Subramanyam C, Porte A, Leverett CA, Vetelino BC, Chen Z, Risley H, Parris K, Pandit J, Varghese AH, Shanker S, Song C, Sukuru SC, Farley KA, Wagenaar MM, Shapiro MJ, Musto S, Lam MH, Loganzo F, O'Donnell CJ.

J Med Chem. 2014 Dec 26;57(24):10527-43. doi: 10.1021/jm501649k. Epub 2014 Dec 9.

PMID:
25431858
15.

Synthesis, molecular editing, and biological assessment of the potent cytotoxin leiodermatolide.

Mailhol D, Willwacher J, Kausch-Busies N, Rubitski EE, Sobol Z, Schuler M, Lam MH, Musto S, Loganzo F, Maderna A, F├╝rstner A.

J Am Chem Soc. 2014 Nov 5;136(44):15719-29. doi: 10.1021/ja508846g. Epub 2014 Oct 27.

PMID:
25347620
16.

New cytotoxic benzosuberene analogs. Synthesis, molecular modeling and biological evaluation.

Chen Z, Maderna A, Sukuru SC, Wagenaar M, O'Donnell CJ, Lam MH, Musto S, Loganzo F.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6688-94. doi: 10.1016/j.bmcl.2013.10.039. Epub 2013 Oct 29.

PMID:
24210503
17.

Nursing's role in cancer pain management.

Vallerand AH, Musto S, Polomano RC.

Curr Pain Headache Rep. 2011 Aug;15(4):250-62. doi: 10.1007/s11916-011-0203-5. Review.

PMID:
21538044
18.

Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.

Hari M, Loganzo F, Annable T, Tan X, Musto S, Morilla DB, Nettles JH, Snyder JP, Greenberger LM.

Mol Cancer Ther. 2006 Feb;5(2):270-8.

19.

Hybrids of the hemiasterlin analogue taltobulin and the dolastatins are potent antimicrotubule agents.

Zask A, Kaplan J, Musto S, Loganzo F.

J Am Chem Soc. 2005 Dec 21;127(50):17667-71.

PMID:
16351096
20.

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as covalent-binding, irreversible inhibitors of the kinase domain of vascular endothelial growth factor receptor-2.

Wissner A, Floyd MB, Johnson BD, Fraser H, Ingalls C, Nittoli T, Dushin RG, Discafani C, Nilakantan R, Marini J, Ravi M, Cheung K, Tan X, Musto S, Annable T, Siegel MM, Loganzo F.

J Med Chem. 2005 Dec 1;48(24):7560-81.

PMID:
16302797
21.

Two photoaffinity analogues of the tripeptide, hemiasterlin, exclusively label alpha-tubulin.

Nunes M, Kaplan J, Wooters J, Hari M, Minnick AA Jr, May MK, Shi C, Musto S, Beyer C, Krishnamurthy G, Qiu Y, Loganzo F, Ayral-Kaloustian S, Zask A, Greenberger LM.

Biochemistry. 2005 May 10;44(18):6844-57.

PMID:
15865430
22.

Cells resistant to HTI-286 do not overexpress P-glycoprotein but have reduced drug accumulation and a point mutation in alpha-tubulin.

Loganzo F, Hari M, Annable T, Tan X, Morilla DB, Musto S, Zask A, Kaplan J, Minnick AA Jr, May MK, Ayral-Kaloustian S, Poruchynsky MS, Fojo T, Greenberger LM.

Mol Cancer Ther. 2004 Oct;3(10):1319-27.

23.

Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment.

Yamashita A, Norton EB, Kaplan JA, Niu C, Loganzo F, Hernandez R, Beyer CF, Annable T, Musto S, Discafani C, Zask A, Ayral-Kaloustian S.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5317-22.

PMID:
15454219
24.

Synthesis and biological activity of analogues of the antimicrotubule agent N,beta,beta-trimethyl-L-phenylalanyl-N(1)-[(1S,2E)-3-carboxy-1-isopropylbut-2-enyl]- N(1),3-dimethyl-L-valinamide (HTI-286).

Zask A, Birnberg G, Cheung K, Kaplan J, Niu C, Norton E, Suayan R, Yamashita A, Cole D, Tang Z, Krishnamurthy G, Williamson R, Khafizova G, Musto S, Hernandez R, Annable T, Yang X, Discafani C, Beyer C, Greenberger LM, Loganzo F, Ayral-Kaloustian S.

J Med Chem. 2004 Sep 9;47(19):4774-86.

PMID:
15341492
25.

MAC-321, a novel taxane with greater efficacy than paclitaxel and docetaxel in vitro and in vivo.

Sampath D, Discafani CM, Loganzo F, Beyer C, Liu H, Tan X, Musto S, Annable T, Gallagher P, Rios C, Greenberger LM.

Mol Cancer Ther. 2003 Sep;2(9):873-84.

26.

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

Loganzo F, Discafani CM, Annable T, Beyer C, Musto S, Hari M, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM.

Cancer Res. 2003 Apr 15;63(8):1838-45.

27.

Wants vs. needs. A case study in polypharmacy and drug advertising.

Dragunas KM, Long KJ, Musto SM, Rettew EA, Roberto S, Savrin C.

Adv Nurse Pract. 2002 May;10(5):83-4. No abstract available.

PMID:
12420537
28.
29.

Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells.

Pellegrino CM, Rybicki AC, Musto S, Nagel RL, Schwartz RS.

Blood Cells Mol Dis. 1998 Mar;24(1):31-40.

PMID:
9516379
31.

Identification of a band-3 binding site near the N-terminus of erythrocyte membrane protein 4.2.

Rybicki AC, Musto S, Schwartz RS.

Biochem J. 1995 Jul 15;309 ( Pt 2):677-81.

32.

Trauma junkie: taking charge of my survival.

Musto SM.

J Psychosoc Nurs Ment Health Serv. 1995 Jul;33(7):11-3.

PMID:
7562681
33.

BW-755C diminishes smoke-induced pulmonary edema.

Hales CA, Musto S, Hutchison WG, Mahoney E.

J Appl Physiol (1985). 1995 Jan;78(1):64-9.

PMID:
7713845
34.

Cyclooxygenase and lipoxygenase inhibition by BW-755C reduces acrolein smoke-induced acute lung injury.

Janssens SP, Musto SW, Hutchison WG, Spence C, Witten M, Jung W, Hales CA.

J Appl Physiol (1985). 1994 Aug;77(2):888-95.

PMID:
8002544
36.

Smoke aldehyde component influences pulmonary edema.

Hales CA, Musto SW, Janssens S, Jung W, Quinn DA, Witten M.

J Appl Physiol (1985). 1992 Feb;72(2):555-61.

PMID:
1559932
37.

Altered therapy of suspected pulmonary embolism using leg venography.

Akers S, Musto S, Marino PL.

Chest. 1987 Dec;92(6):1105-6.

PMID:
3677821

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