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Items: 32


Losartan and Vitamin D Inhibit Colonic Tumor Development in a Conditional Apc-Deleted Mouse Model of Sporadic Colon Cancer.

Dougherty U, Mustafi R, Haider HI, Khalil A, Souris JS, Joseph L, Hart J, Konda VJ, Zhang W, Pekow J, Li YC, Bissonnette M.

Cancer Prev Res (Phila). 2019 Jul;12(7):433-448. doi: 10.1158/1940-6207.CAPR-18-0380. Epub 2019 May 14.


miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.

Pekow J, Meckel K, Dougherty U, Huang Y, Chen X, Almoghrabi A, Mustafi R, Ayaloglu-Butun F, Deng Z, Haider HI, Hart J, Rubin DT, Kwon JH, Bissonnette M.

Clin Cancer Res. 2017 Sep 1;23(17):5281-5291. doi: 10.1158/1078-0432.CCR-17-0171. Epub 2017 Jun 9.


ADAM17 is a Tumor Promoter and Therapeutic Target in Western Diet-associated Colon Cancer.

Mustafi R, Dougherty U, Mustafi D, Ayaloglu-Butun F, Fletcher M, Adhikari S, Sadiq F, Meckel K, Haider HI, Khalil A, Pekow J, Konda V, Joseph L, Hart J, Fichera A, Li YC, Bissonnette M.

Clin Cancer Res. 2017 Jan 15;23(2):549-561. doi: 10.1158/1078-0432.CCR-15-3140. Epub 2016 Aug 3.


Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.

Pekow J, Meckel K, Dougherty U, Butun F, Mustafi R, Lim J, Crofton C, Chen X, Joseph L, Bissonnette M.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G179-87. doi: 10.1152/ajpgi.00208.2014. Epub 2014 Dec 4.


The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.

Dougherty U, Mustafi R, Sadiq F, Almoghrabi A, Mustafi D, Kreisheh M, Sundaramurthy S, Liu W, Konda VJ, Pekow J, Khare S, Hart J, Joseph L, Wyrwicz A, Karczmar GS, Li YC, Bissonnette M.

Clin Cancer Res. 2014 Nov 15;20(22):5848-5859. doi: 10.1158/1078-0432.CCR-14-0209. Epub 2014 Sep 11.


Both stromal cell and colonocyte epidermal growth factor receptors control HCT116 colon cancer cell growth in tumor xenografts.

Mustafi R, Dougherty U, Shah H, Dehghan H, Gliksberg A, Wu J, Zhu H, Joseph L, Hart J, Dive C, Fichera A, Threadgill D, Bissonnette M.

Carcinogenesis. 2012 Oct;33(10):1930-9. doi: 10.1093/carcin/bgs231. Epub 2012 Jul 12.


American ginseng suppresses Western diet-promoted tumorigenesis in model of inflammation-associated colon cancer: role of EGFR.

Dougherty U, Mustafi R, Wang Y, Musch MW, Wang CZ, Konda VJ, Kulkarni A, Hart J, Dawson G, Kim KE, Yuan CS, Chang EB, Bissonnette M.

BMC Complement Altern Med. 2011 Nov 9;11:111. doi: 10.1186/1472-6882-11-111.


EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western diet-promoted murine colon cancer: role of G1 regulators.

Zhu H, Dougherty U, Robinson V, Mustafi R, Pekow J, Kupfer S, Li YC, Hart J, Goss K, Fichera A, Joseph L, Bissonnette M.

Mol Cancer Res. 2011 Jul;9(7):960-75. doi: 10.1158/1541-7786.MCR-10-0531. Epub 2011 Jun 8.


Upregulation of glycogen synthase kinase 3β in human colorectal adenocarcinomas correlates with accumulation of CTNNB1.

Wang HL, Hart J, Fan L, Mustafi R, Bissonnette M.

Clin Colorectal Cancer. 2011 Mar 1;10(1):30-6. doi: 10.3816/CCC.2011.n.004.


miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.

Pekow JR, Dougherty U, Mustafi R, Zhu H, Kocherginsky M, Rubin DT, Hanauer SB, Hart J, Chang EB, Fichera A, Joseph LJ, Bissonnette M.

Inflamm Bowel Dis. 2012 Jan;18(1):94-100. doi: 10.1002/ibd.21742. Epub 2011 May 6.


Inactivation of the vitamin D receptor in APC(min/+) mice reveals a critical role for the vitamin D receptor in intestinal tumor growth.

Zheng W, Wong KE, Zhang Z, Dougherty U, Mustafi R, Kong J, Deb DK, Zheng H, Bissonnette M, Li YC.

Int J Cancer. 2012 Jan 1;130(1):10-9. doi: 10.1002/ijc.25992. Epub 2011 Apr 20.


Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2.

Dougherty U, Cerasi D, Taylor I, Kocherginsky M, Tekin U, Badal S, Aluri L, Sehdev A, Cerda S, Mustafi R, Delgado J, Joseph L, Zhu H, Hart J, Threadgill D, Fichera A, Bissonnette M.

Clin Cancer Res. 2009 Nov 15;15(22):6780-9. doi: 10.1158/1078-0432.CCR-09-1678. Epub 2009 Nov 10.


Sorafenib inhibits MAPK-mediated proliferation in a Barrett's esophageal adenocarcinoma cell line.

Keswani RN, Chumsangsri A, Mustafi R, Delgado J, Cohen EE, Bissonnette M.

Dis Esophagus. 2008;21(6):514-21. doi: 10.1111/j.1442-2050.2007.00799.x.


Lithocholic acid down-regulation of NF-kappaB activity through vitamin D receptor in colonic cancer cells.

Sun J, Mustafi R, Cerda S, Chumsangsri A, Xia YR, Li YC, Bissonnette M.

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):37-40. doi: 10.1016/j.jsbmb.2008.01.003. Epub 2008 Apr 25.


Sorafenib triggers antiproliferative and pro-apoptotic signals in human esophageal adenocarcinoma cells.

Delgado JS, Mustafi R, Yee J, Cerda S, Chumsangsri A, Dougherty U, Lichtenstein L, Fichera A, Bissonnette M.

Dig Dis Sci. 2008 Dec;53(12):3055-64. doi: 10.1007/s10620-008-0294-y. Epub 2008 May 30.


Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein.

Khare S, Mustafi R, Cerda S, Yuan W, Jagadeeswaran S, Dougherty U, Tretiakova M, Samarel A, Cohen G, Wang J, Moore C, Wali R, Holgren C, Joseph L, Fichera A, Li YC, Bissonnette M.

Nutr Cancer. 2008;60(3):389-400. doi: 10.1080/01635580701883003.


Epidermal growth factor receptor controls flat dysplastic aberrant crypt foci development and colon cancer progression in the rat azoxymethane model.

Dougherty U, Sehdev A, Cerda S, Mustafi R, Little N, Yuan W, Jagadeeswaran S, Chumsangsri A, Delgado J, Tretiakova M, Joseph L, Hart J, Cohen EE, Aluri L, Fichera A, Bissonnette M.

Clin Cancer Res. 2008 Apr 15;14(8):2253-62. doi: 10.1158/1078-0432.CCR-07-4926.


A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model.

Fichera A, Little N, Dougherty U, Mustafi R, Cerda S, Li YC, Delgado J, Arora A, Campbell LK, Joseph L, Hart J, Noffsinger A, Bissonnette M.

J Surg Res. 2007 Oct;142(2):239-45. Epub 2007 Jun 15.


Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis.

Fichera A, Little N, Jagadeeswaran S, Dougherty U, Sehdev A, Mustafi R, Cerda S, Yuan W, Khare S, Tretiakova M, Gong C, Tallerico M, Cohen G, Joseph L, Hart J, Turner JR, Bissonnette M.

Cancer Res. 2007 Jan 15;67(2):827-35.


Protein Kinase-zeta inhibits collagen I-dependent and anchorage-independent growth and enhances apoptosis of human Caco-2 cells.

Mustafi R, Cerda S, Chumsangsri A, Fichera A, Bissonnette M.

Mol Cancer Res. 2006 Sep;4(9):683-94. Epub 2006 Aug 28.


Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci.

Cohen G, Mustafi R, Chumsangsri A, Little N, Nathanson J, Cerda S, Jagadeeswaran S, Dougherty U, Joseph L, Hart J, Yerian L, Tretiakova M, Yuan W, Obara P, Khare S, Sinicrope FA, Fichera A, Boss GR, Carroll R, Bissonnette M.

Cancer Res. 2006 Jun 1;66(11):5656-64.


Protein kinase C delta inhibits Caco-2 cell proliferation by selective changes in cell cycle and cell death regulators.

Cerda SR, Mustafi R, Little H, Cohen G, Khare S, Moore C, Majumder P, Bissonnette M.

Oncogene. 2006 May 25;25(22):3123-38.


PKC-delta inhibits anchorage-dependent and -independent growth, enhances differentiation, and increases apoptosis in CaCo-2 cells.

Cerda SR, Bissonnette M, Scaglione-Sewell B, Lyons MR, Khare S, Mustafi R, Brasitus TA.

Gastroenterology. 2001 Jun;120(7):1700-12.


Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.

Wali RK, Skarosi S, Hart J, Zhang Y, Dolan ME, Moschel RC, Nguyen L, Mustafi R, Brasitus TA, Bissonnette M.

Carcinogenesis. 1999 Dec;20(12):2355-60.


DNA and chromosome breaks induced by iodine-123-labeled estrogen in Chinese hamster ovary cells.

Schwartz JL, Mustafi R, Hughes A, DeSombre ER.

Radiat Res. 1996 Aug;146(2):151-8.


DNA double-strand break rejoining rates, inherent radiation sensitivity and human tumour response to radiotherapy.

Schwartz JL, Mustafi R, Beckett MA, Weichselbaum RR.

Br J Cancer. 1996 Jul;74(1):37-42.


The genetic and functional basis of purine nucleotide feedback-resistant phosphoribosylpyrophosphate synthetase superactivity.

Becker MA, Smith PR, Taylor W, Mustafi R, Switzer RL.

J Clin Invest. 1995 Nov;96(5):2133-41.


Enhancement of X-ray toxicity in squamous cell carcinoma cell lines by DNA polymerase inhibitors.

Mustafi R, Heaton D, Brinkman W, Schwartz JL.

Int J Radiat Biol. 1994 Jun;65(6):675-81.


Faster rates of DNA unwinding under alkaline conditions in xrs-5 cells may reflect chromatin structure alterations.

Schwartz JL, Moan E, Mustafi R, Fink L, Yasui LS.

Mutat Res. 1992 May;282(1):13-7.


Inhibition of protein kinases sensitizes human tumor cells to ionizing radiation.

Hallahan DE, Virudachalam S, Schwartz JL, Panje N, Mustafi R, Weichselbaum RR.

Radiat Res. 1992 Mar;129(3):345-50.


Radiation-induced DNA double-strand break frequencies in human squamous cell carcinoma cell lines of different radiation sensitivities.

Schwartz JL, Mustafi R, Beckett MA, Czyzewski EA, Farhangi E, Grdina DJ, Rotmensch J, Weichselbaum RR.

Int J Radiat Biol. 1991 Jun;59(6):1341-52.


Prediction of the radiation sensitivity of human squamous cell carcinoma cells using DNA filter elution.

Schwartz JL, Mustafi R, Beckett MA, Weichselbaum RR.

Radiat Res. 1990 Jul;123(1):1-6.


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