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Genetic heterogeneity of the Spy1336/R28-Spy1337 virulence axis in Streptococcus pyogenes and effect on gene transcript levels and pathogenesis.

Eraso JM, Kachroo P, Olsen RJ, Beres SB, Zhu L, Badu T, Shannon S, Cantu CC, Saavedra MO, Kubiak SL, Porter AR, DeLeo FR, Musser JM.

PLoS One. 2020 Mar 26;15(3):e0229064. doi: 10.1371/journal.pone.0229064. eCollection 2020.


Genome-Wide Screens Identify Group A Streptococcus Surface Proteins Promoting Female Genital Tract Colonization and Virulence.

Zhu L, Olsen RJ, Beres SB, Ojeda Saavedra M, Kubiak SL, Cantu CC, Jenkins L, Yerramilli P, Pruitt L, Charbonneau ARL, Waller AS, Musser JM.

Am J Pathol. 2020 Apr;190(4):862-873. doi: 10.1016/j.ajpath.2019.12.003. Epub 2020 Mar 19.


New Pathogenesis Mechanisms and Translational Leads Identified by Multidimensional Analysis of Necrotizing Myositis in Primates.

Kachroo P, Eraso JM, Olsen RJ, Zhu L, Kubiak SL, Pruitt L, Yerramilli P, Cantu CC, Ojeda Saavedra M, Pensar J, Corander J, Jenkins L, Kao L, Granillo A, Porter AR, DeLeo FR, Musser JM.

mBio. 2020 Feb 18;11(1). pii: e03363-19. doi: 10.1128/mBio.03363-19.


Reduced In Vitro Susceptibility of Streptococcus pyogenes to β-Lactam Antibiotics Associated with Mutations in the pbp2x Gene Is Geographically Widespread.

Musser JM, Beres SB, Zhu L, Olsen RJ, Vuopio J, Hyyryläinen HL, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Darenberg J, Henriques-Normark B, Hoffmann S, Caugant DA, Smith AJ, Lindsay DSJ, Boragine DM, Palzkill T.

J Clin Microbiol. 2020 Mar 25;58(4). pii: e01993-19. doi: 10.1128/JCM.01993-19. Print 2020 Mar 25.


Development and Evaluation of a Novel Protein-Based Assay for Specific Detection of KPC β-Lactamases from Klebsiella pneumoniae Clinical Isolates.

Lu S, Soeung V, Nguyen HAT, Long SW, Musser JM, Palzkill T.

mSphere. 2020 Jan 8;5(1). pii: e00918-19. doi: 10.1128/mSphere.00918-19.


The Use of Alfaxalone in Quaker Parrots (Myiopsitta monachus).

Whitehead MC, Hoppes SM, Musser JMB, Perkins JL, Lepiz ML.

J Avian Med Surg. 2019 Dec 9;33(4):340-348. doi: 10.1647/2018-393.


Treatment With Nonsteroidal Anti-Inflammatory Drugs Fails To Ameliorate Pathology In Cockatiels Experimentally Infected With Parrot Bornavirus-2.

Escandon P, Heatley JJ, Tizard I, Guo J, Shivaprasad HL, Musser JM.

Vet Med (Auckl). 2019 Nov 22;10:185-195. doi: 10.2147/VMRR.S229936. eCollection 2019.


Comparison Of Four Anti-Avian IgY Secondary Antibodies Used In Western Blot And Dot-Blot ELISA To Detect Avian Bornavirus Antibodies In Four Different Bird Species.

Escandon P, Heatley JJ, Berghman LR, Tizard I, Musser JM.

Vet Med (Auckl). 2019 Nov 12;10:141-150. doi: 10.2147/VMRR.S227616. eCollection 2019.


Polymorphisms in Regulator of Cov Contribute to the Molecular Pathogenesis of Serotype M28 Group A Streptococcus.

Bernard PE, Kachroo P, Eraso JM, Zhu L, Madry JE, Linson SE, Ojeda Saavedra M, Cantu C, Musser JM, Olsen RJ.

Am J Pathol. 2019 Oct;189(10):2002-2018. doi: 10.1016/j.ajpath.2019.06.009. Epub 2019 Jul 29.


Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.

Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M.

Nucleic Acids Res. 2019 Sep 5;47(15):8333-8334. doi: 10.1093/nar/gkz641. No abstract available.


Draft Genome Sequence of Candida auris Strain LOM, a Human Clinical Isolate from Greater Metropolitan Houston, Texas.

Long SW, Olsen RJ, Nguyen HAT, Ojeda Saavedra M, Musser JM.

Microbiol Resour Announc. 2019 Jun 20;8(25). pii: e00532-19. doi: 10.1128/MRA.00532-19.


Environmental pH and peptide signaling control virulence of Streptococcus pyogenes via a quorum-sensing pathway.

Do H, Makthal N, VanderWal AR, Saavedra MO, Olsen RJ, Musser JM, Kumaraswami M.

Nat Commun. 2019 Jun 13;10(1):2586. doi: 10.1038/s41467-019-10556-8.


Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.

Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M.

Nucleic Acids Res. 2019 Aug 22;47(14):7476-7493. doi: 10.1093/nar/gkz524. Erratum in: Nucleic Acids Res. 2019 Sep 5;47(15):8333-8334.


Evolution of neuronal types and families.

Arendt D, Bertucci PY, Achim K, Musser JM.

Curr Opin Neurobiol. 2019 Jun;56:144-152. doi: 10.1016/j.conb.2019.01.022. Epub 2019 Mar 1. Review.


Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis.

Kachroo P, Eraso JM, Beres SB, Olsen RJ, Zhu L, Nasser W, Bernard PE, Cantu CC, Saavedra MO, Arredondo MJ, Strope B, Do H, Kumaraswami M, Vuopio J, Gröndahl-Yli-Hannuksela K, Kristinsson KG, Gottfredsson M, Pesonen M, Pensar J, Davenport ER, Clark AG, Corander J, Caugant DA, Gaini S, Magnussen MD, Kubiak SL, Nguyen HAT, Long SW, Porter AR, DeLeo FR, Musser JM.

Nat Genet. 2019 Mar;51(3):548-559. doi: 10.1038/s41588-018-0343-1. Epub 2019 Feb 18.


Gene fitness landscape of group A streptococcus during necrotizing myositis.

Zhu L, Olsen RJ, Beres SB, Eraso JM, Saavedra MO, Kubiak SL, Cantu CC, Jenkins L, Charbonneau ARL, Waller AS, Musser JM.

J Clin Invest. 2019 Feb 1;129(2):887-901. doi: 10.1172/JCI124994. Epub 2019 Jan 22.


Phenotypic Variation in the Group A Streptococcus Due to Natural Mutation of the Accessory Protein-Encoding Gene rocA.

Sarkar P, Danger JL, Jain I, Meadows LA, Beam C, Medicielo J, Burgess C, Musser JM, Sumby P.

mSphere. 2018 Oct 17;3(5). pii: e00519-18. doi: 10.1128/mSphere.00519-18.


RocA Has Serotype-Specific Gene Regulatory and Pathogenesis Activities in Serotype M28 Group A Streptococcus.

Bernard PE, Kachroo P, Zhu L, Beres SB, Eraso JM, Kajani Z, Long SW, Musser JM, Olsen RJ.

Infect Immun. 2018 Oct 25;86(11). pii: e00467-18. doi: 10.1128/IAI.00467-18. Print 2018 Nov.


Postpartum Group A Streptococcus Case Series: Reach Out to Infection Prevention!

Alexander AJ, Myers C, Beres SB, Olsen RJ, Musser JM, Mangino JE.

Open Forum Infect Dis. 2018 Jul 2;5(7):ofy159. doi: 10.1093/ofid/ofy159. eCollection 2018 Jul.


Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth Ex Vivo and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus.

Makthal N, Do H, VanderWal AR, Olsen RJ, Musser JM, Kumaraswami M.

Infect Immun. 2018 Apr 23;86(5). pii: e00169-18. doi: 10.1128/IAI.00169-18. Print 2018 May.


Pervasive Correlated Evolution in Gene Expression Shapes Cell and Tissue Type Transcriptomes.

Liang C, Musser JM, Cloutier A, Prum RO, Wagner GP.

Genome Biol Evol. 2018 Feb 1;10(2):538-552. doi: 10.1093/gbe/evy016.


Deletion of from Streptococcus pyogenes. Results in Hypervirulence in a Mouse Model of Sepsis and is LuxS Independent.

Sitkiewicz I, Musser JM.

Pol J Microbiol. 2017 Mar 30;66(1):17-24. doi: 10.5604/17331331.1234989.


Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae.

Nguyen M, Brettin T, Long SW, Musser JM, Olsen RJ, Olson R, Shukla M, Stevens RL, Xia F, Yoo H, Davis JJ.

Sci Rep. 2018 Jan 11;8(1):421. doi: 10.1038/s41598-017-18972-w.


Whole-Genome Sequencing of a Human Clinical Isolate of emm28 Streptococcus pyogenes Causing Necrotizing Fasciitis Acquired Contemporaneously with Hurricane Harvey.

Long SW, Kachroo P, Musser JM, Olsen RJ.

Genome Announc. 2017 Nov 9;5(45). pii: e01269-17. doi: 10.1128/genomeA.01269-17.


Novel Genes Required for the Fitness of Streptococcus pyogenes in Human Saliva.

Zhu L, Charbonneau ARL, Waller AS, Olsen RJ, Beres SB, Musser JM.

mSphere. 2017 Nov 1;2(6). pii: e00460-17. doi: 10.1128/mSphereDirect.00460-17. eCollection 2017 Nov-Dec.


Genome sequence analysis of emm89 Streptococcus pyogenes strains causing infections in Scotland, 2010-2016.

Beres SB, Olsen RJ, Ojeda Saavedra M, Ure R, Reynolds A, Lindsay DSJ, Smith AJ, Musser JM.

J Med Microbiol. 2017 Dec;66(12):1765-1773. doi: 10.1099/jmm.0.000622. Epub 2017 Nov 3.


Leaderless secreted peptide signaling molecule alters global gene expression and increases virulence of a human bacterial pathogen.

Do H, Makthal N, VanderWal AR, Rettel M, Savitski MM, Peschek N, Papenfort K, Olsen RJ, Musser JM, Kumaraswami M.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8498-E8507. doi: 10.1073/pnas.1705972114. Epub 2017 Sep 18.


Loss and gain of cone types in vertebrate ciliary photoreceptor evolution.

Musser JM, Arendt D.

Dev Biol. 2017 Nov 1;431(1):26-35. doi: 10.1016/j.ydbio.2017.08.038. Epub 2017 Sep 4. Review.


Population Genomic Analysis of 1,777 Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates, Houston, Texas: Unexpected Abundance of Clonal Group 307.

Long SW, Olsen RJ, Eagar TN, Beres SB, Zhao P, Davis JJ, Brettin T, Xia F, Musser JM.

mBio. 2017 May 16;8(3). pii: e00489-17. doi: 10.1128/mBio.00489-17.


Rapid Emergence of a New Clone Impacts the Population at Risk and Increases the Incidence of Type emm89 Group A Streptococcus Invasive Disease.

Teatero S, Coleman BL, Beres SB, Olsen RJ, Kandel C, Reynolds O, Athey TBT, Musser JM, McGeer A, Fittipaldi N.

Open Forum Infect Dis. 2017 Mar 4;4(2):ofx042. doi: 10.1093/ofid/ofx042. eCollection 2017 Spring.


Opacification Domain of Serum Opacity Factor Inhibits Beta-Hemolysis and Contributes to Virulence of Streptococcus pyogenes.

Zhu L, Olsen RJ, Musser JM.

mSphere. 2017 Apr 19;2(2). pii: e00147-17. doi: 10.1128/mSphereDirect.00147-17. eCollection 2017 Mar-Apr.


Increased Pilus Production Conferred by a Naturally Occurring Mutation Alters Host-Pathogen Interaction in Favor of Carriage in Streptococcus pyogenes.

Flores AR, Olsen RJ, Cantu C, Pallister KB, Guerra FE, Voyich JM, Musser JM.

Infect Immun. 2017 Apr 21;85(5). pii: e00949-16. doi: 10.1128/IAI.00949-16. Print 2017 May.


Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis.

Skwark MJ, Croucher NJ, Puranen S, Chewapreecha C, Pesonen M, Xu YY, Turner P, Harris SR, Beres SB, Musser JM, Parkhill J, Bentley SD, Aurell E, Corander J.

PLoS Genet. 2017 Feb 16;13(2):e1006508. doi: 10.1371/journal.pgen.1006508. eCollection 2017 Feb.


Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections.

Zhu L, Olsen RJ, Lee JD, Porter AR, DeLeo FR, Musser JM.

Am J Pathol. 2017 Mar;187(3):605-613. doi: 10.1016/j.ajpath.2016.11.003. Epub 2016 Dec 27.


The origin and evolution of cell types.

Arendt D, Musser JM, Baker CVH, Bergman A, Cepko C, Erwin DH, Pavlicev M, Schlosser G, Widder S, Laubichler MD, Wagner GP.

Nat Rev Genet. 2016 Dec;17(12):744-757. doi: 10.1038/nrg.2016.127. Epub 2016 Nov 7. Review.


Venous Blood Gas, Electrolyte, and Hematologic Analytes of the Mottled Duck, Anas fulvigula.

Ratliff C, Gentry J, Kusmierczyk J, Hartke KM, Acierno MJ, Musser JM, Russell KE, Heatley JJ.

J Wildl Dis. 2017 Jan;53(1):159-164. doi: 10.7589/2015-10-288. Epub 2016 Oct 17.


Genomic Characteristics Behind the Spread of Bacteremic Group A Streptococcus Type emm89 in Finland, 2004-2014.

Latronico F, Nasser W, Puhakainen K, Ollgren J, Hyyryläinen HL, Beres SB, Lyytikäinen O, Jalava J, Musser JM, Vuopio J.

J Infect Dis. 2016 Dec 15;214(12):1987-1995. Epub 2016 Oct 5.


Unique Footprint in the scl1.3 Locus Affects Adhesion and Biofilm Formation of the Invasive M3-Type Group A Streptococcus.

Bachert BA, Choi SJ, LaSala PR, Harper TI, McNitt DH, Boehm DT, Caswell CC, Ciborowski P, Keene DR, Flores AR, Musser JM, Squeglia F, Marasco D, Berisio R, Lukomski S.

Front Cell Infect Microbiol. 2016 Aug 31;6:90. doi: 10.3389/fcimb.2016.00090. eCollection 2016.


Genomic Landscape of Intrahost Variation in Group A Streptococcus: Repeated and Abundant Mutational Inactivation of the fabT Gene Encoding a Regulator of Fatty Acid Synthesis.

Eraso JM, Olsen RJ, Beres SB, Kachroo P, Porter AR, Nasser W, Bernard PE, DeLeo FR, Musser JM.

Infect Immun. 2016 Nov 18;84(12):3268-3281. Print 2016 Dec.


Transcriptome Remodeling Contributes to Epidemic Disease Caused by the Human Pathogen Streptococcus pyogenes.

Beres SB, Kachroo P, Nasser W, Olsen RJ, Zhu L, Flores AR, de la Riva I, Paez-Mayorga J, Jimenez FE, Cantu C, Vuopio J, Jalava J, Kristinsson KG, Gottfredsson M, Corander J, Fittipaldi N, Di Luca MC, Petrelli D, Vitali LA, Raiford A, Jenkins L, Musser JM.

mBio. 2016 May 31;7(3). pii: e00403-16. doi: 10.1128/mBio.00403-16.


Intergenic Variable-Number Tandem-Repeat Polymorphism Upstream of rocA Alters Toxin Production and Enhances Virulence in Streptococcus pyogenes.

Zhu L, Olsen RJ, Horstmann N, Shelburne SA, Fan J, Hu Y, Musser JM.

Infect Immun. 2016 Jun 23;84(7):2086-2093. doi: 10.1128/IAI.00258-16. Print 2016 Jul.


Integrating Rapid Diagnostics and Antimicrobial Stewardship in Two Community Hospitals Improved Process Measures and Antibiotic Adjustment Time.

Lockwood AM, Perez KK, Musick WL, Ikwuagwu JO, Attia E, Fasoranti OO, Cernoch PL, Olsen RJ, Musser JM.

Infect Control Hosp Epidemiol. 2016 Apr;37(4):425-32. doi: 10.1017/ice.2015.313. Epub 2016 Jan 7.


Structural and functional analysis of RopB: a major virulence regulator in Streptococcus pyogenes.

Makthal N, Gavagan M, Do H, Olsen RJ, Musser JM, Kumaraswami M.

Mol Microbiol. 2016 Mar;99(6):1119-33. doi: 10.1111/mmi.13294. Epub 2016 Feb 19.


Musser et al. Reply to "Emergence of the Same Successful Clade among Distinct Populations of emm89 Streptococcus pyogenes in Multiple Geographic Regions".

Musser JM, Zhu L, Olsen RJ, Nasser W.

mBio. 2015 Dec 1;6(6):e01838-15. doi: 10.1128/mBio.01838-15. No abstract available.


Trading Capsule for Increased Cytotoxin Production: Contribution to Virulence of a Newly Emerged Clade of emm89 Streptococcus pyogenes.

Zhu L, Olsen RJ, Nasser W, de la Riva Morales I, Musser JM.

mBio. 2015 Oct 6;6(5):e01378-15. doi: 10.1128/mBio.01378-15.


The majority of 9,729 group A streptococcus strains causing disease secrete SpeB cysteine protease: pathogenesis implications.

Olsen RJ, Raghuram A, Cantu C, Hartman MH, Jimenez FE, Lee S, Ngo A, Rice KA, Saddington D, Spillman H, Valson C, Flores AR, Beres SB, Long SW, Nasser W, Musser JM.

Infect Immun. 2015 Dec;83(12):4750-8. doi: 10.1128/IAI.00989-15. Epub 2015 Sep 28.


A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus.

Flores AR, Jewell BE, Yelamanchili D, Olsen RJ, Musser JM.

Infect Immun. 2015 Nov;83(11):4237-46. doi: 10.1128/IAI.00656-15. Epub 2015 Aug 17.


A molecular trigger for intercontinental epidemics of group A Streptococcus.

Zhu L, Olsen RJ, Nasser W, Beres SB, Vuopio J, Kristinsson KG, Gottfredsson M, Porter AR, DeLeo FR, Musser JM.

J Clin Invest. 2015 Sep;125(9):3545-59. doi: 10.1172/JCI82478. Epub 2015 Aug 10.


Ribavirin Inhibits Parrot Bornavirus 4 Replication in Cell Culture.

Musser JM, Heatley JJ, Koinis AV, Suchodolski PF, Guo J, Escandon P, Tizard IR.

PLoS One. 2015 Jul 29;10(7):e0134080. doi: 10.1371/journal.pone.0134080. eCollection 2015.


Character trees from transcriptome data: Origin and individuation of morphological characters and the so-called "species signal".

Musser JM, Wagner GP.

J Exp Zool B Mol Dev Evol. 2015 Nov;324(7):588-604. doi: 10.1002/jez.b.22636. Epub 2015 Jul 14. Review.


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