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Items: 19

1.

Mutational analysis and modeling of negative allosteric modulator binding sites in AMPA receptors.

Stenum-Berg C, Musgaard M, Chavez-Abiega S, Thisted CL, Barrella L, Biggin PC, Kristensen AS.

Mol Pharmacol. 2019 Oct 3. pii: mol.119.116871. doi: 10.1124/mol.119.116871. [Epub ahead of print]

2.

A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6.

Busch JMC, Erat MC, Blank ID, Musgaard M, Biggin PC, Vakonakis I.

Sci Rep. 2019 Mar 5;9(1):3526. doi: 10.1038/s41598-019-40294-2.

3.

Promiscuous attraction of ligands within the ATP binding site of RyR2 promotes diverse gating behaviour.

Lindsay C, Sitsapesan M, Chan WM, Venturi E, Welch W, Musgaard M, Sitsapesan R.

Sci Rep. 2018 Oct 9;8(1):15011. doi: 10.1038/s41598-018-33328-8.

4.

Functional Validation of Heteromeric Kainate Receptor Models.

Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC.

Biophys J. 2017 Nov 21;113(10):2173-2177. doi: 10.1016/j.bpj.2017.08.047. Epub 2017 Sep 19.

5.

Insights into channel dysfunction from modelling and molecular dynamics simulations.

Musgaard M, Paramo T, Domicevica L, Andersen OJ, Biggin PC.

Neuropharmacology. 2018 Apr;132:20-30. doi: 10.1016/j.neuropharm.2017.06.030. Epub 2017 Jun 29. Review.

6.

Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.

Alcaino C, Musgaard M, Minguez T, Mazzaferro S, Faundez M, Iturriaga-Vasquez P, Biggin PC, Bermudez I.

J Biol Chem. 2017 Jan 13;292(2):551-562. doi: 10.1074/jbc.M116.751206. Epub 2016 Nov 18.

7.

Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors.

Musgaard M, Biggin PC.

J Chem Inf Model. 2016 Sep 26;56(9):1787-97. doi: 10.1021/acs.jcim.6b00297. Epub 2016 Aug 12.

PMID:
27482759
8.

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.

Dawe GB, Musgaard M, Aurousseau MRP, Nayeem N, Green T, Biggin PC, Bowie D.

Neuron. 2016 Mar 16;89(6):1264-1276. doi: 10.1016/j.neuron.2016.01.038. Epub 2016 Feb 25.

9.

MD Simulations of P-Type ATPases in a Lipid Bilayer System.

Autzen HE, Musgaard M.

Methods Mol Biol. 2016;1377:459-92. doi: 10.1007/978-1-4939-3179-8_40.

PMID:
26695055
10.

Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D.

J Physiol. 2016 Apr 1;594(7):1821-40. doi: 10.1113/JP271690. Epub 2016 Feb 2.

11.

Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes.

Lees K, Musgaard M, Suwanmanee S, Buckingham SD, Biggin P, Sattelle D.

PLoS One. 2014 May 13;9(5):e97468. doi: 10.1371/journal.pone.0097468. eCollection 2014.

12.

Defining the structural relationship between kainate-receptor deactivation and desensitization.

Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D.

Nat Struct Mol Biol. 2013 Sep;20(9):1054-61. doi: 10.1038/nsmb.2654. Epub 2013 Aug 18.

13.

The dynamics of camphor in the cytochrome P450 CYP101D2.

Vohra S, Musgaard M, Bell SG, Wong LL, Zhou W, Biggin PC.

Protein Sci. 2013 Sep;22(9):1218-29. doi: 10.1002/pro.2309. Epub 2013 Aug 12.

14.

Ion pathways in the sarcoplasmic reticulum Ca2+-ATPase.

Bublitz M, Musgaard M, Poulsen H, Thøgersen L, Olesen C, Schiøtt B, Morth JP, Møller JV, Nissen P.

J Biol Chem. 2013 Apr 12;288(15):10759-65. doi: 10.1074/jbc.R112.436550. Epub 2013 Feb 11. Review.

15.

Tracing cytoplasmic Ca(2+) ion and water access points in the Ca(2+)-ATPase.

Musgaard M, Thøgersen L, Schiøtt B, Tajkhorshid E.

Biophys J. 2012 Jan 18;102(2):268-77. doi: 10.1016/j.bpj.2011.12.009.

16.

Protonation states of important acidic residues in the central Ca²⁺ ion binding sites of the Ca²⁺-ATPase: a molecular modeling study.

Musgaard M, Thøgersen L, Schiøtt B.

Biochemistry. 2011 Dec 27;50(51):11109-20. doi: 10.1021/bi201164b. Epub 2011 Nov 30.

PMID:
22082179
17.

Mutual adaptation of a membrane protein and its lipid bilayer during conformational changes.

Sonntag Y, Musgaard M, Olesen C, Schiøtt B, Møller JV, Nissen P, Thøgersen L.

Nat Commun. 2011;2:304. doi: 10.1038/ncomms1307.

PMID:
21556058
18.

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

Sinning S, Musgaard M, Jensen M, Severinsen K, Celik L, Koldsø H, Meyer T, Bols M, Jensen HH, Schiøtt B, Wiborg O.

J Biol Chem. 2010 Mar 12;285(11):8363-74. doi: 10.1074/jbc.M109.045401. Epub 2009 Nov 30.

19.

P-type ATPases as drug targets: tools for medicine and science.

Yatime L, Buch-Pedersen MJ, Musgaard M, Morth JP, Lund Winther AM, Pedersen BP, Olesen C, Andersen JP, Vilsen B, Schiøtt B, Palmgren MG, Møller JV, Nissen P, Fedosova N.

Biochim Biophys Acta. 2009 Apr;1787(4):207-20. Review.

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