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Items: 8


Widespread transcriptional pausing and elongation control at enhancers.

Henriques T, Scruggs BS, Inouye MO, Muse GW, Williams LH, Burkholder AB, Lavender CA, Fargo DC, Adelman K.

Genes Dev. 2018 Jan 1;32(1):26-41. doi: 10.1101/gad.309351.117. Epub 2018 Jan 29.


Bidirectional Transcription Arises from Two Distinct Hubs of Transcription Factor Binding and Active Chromatin.

Scruggs BS, Gilchrist DA, Nechaev S, Muse GW, Burkholder A, Fargo DC, Adelman K.

Mol Cell. 2015 Jun 18;58(6):1101-12. doi: 10.1016/j.molcel.2015.04.006. Epub 2015 May 28.


Pausing of RNA polymerase II regulates mammalian developmental potential through control of signaling networks.

Williams LH, Fromm G, Gokey NG, Henriques T, Muse GW, Burkholder A, Fargo DC, Hu G, Adelman K.

Mol Cell. 2015 Apr 16;58(2):311-322. doi: 10.1016/j.molcel.2015.02.003. Epub 2015 Mar 12.


Stable pausing by RNA polymerase II provides an opportunity to target and integrate regulatory signals.

Henriques T, Gilchrist DA, Nechaev S, Bern M, Muse GW, Burkholder A, Fargo DC, Adelman K.

Mol Cell. 2013 Nov 21;52(4):517-28. doi: 10.1016/j.molcel.2013.10.001. Epub 2013 Oct 31.


Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle.

Gupte R, Muse GW, Chinenov Y, Adelman K, Rogatsky I.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14616-21. doi: 10.1073/pnas.1309898110. Epub 2013 Aug 15.


Immediate mediators of the inflammatory response are poised for gene activation through RNA polymerase II stalling.

Adelman K, Kennedy MA, Nechaev S, Gilchrist DA, Muse GW, Chinenov Y, Rogatsky I.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18207-12. doi: 10.1073/pnas.0910177106. Epub 2009 Oct 9.


RNA polymerase is poised for activation across the genome.

Muse GW, Gilchrist DA, Nechaev S, Shah R, Parker JS, Grissom SF, Zeitlinger J, Adelman K.

Nat Genet. 2007 Dec;39(12):1507-11. Epub 2007 Nov 11.

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