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Modulation of Nitric Oxide Synthases by Oxidized LDLs: Role in Vascular Inflammation and Atherosclerosis Development.

Gliozzi M, Scicchitano M, Bosco F, Musolino V, Carresi C, Scarano F, Maiuolo J, Nucera S, Maretta A, Paone S, Mollace R, Ruga S, Zito MC, Macrì R, Oppedisano F, Palma E, Salvemini D, Muscoli C, Mollace V.

Int J Mol Sci. 2019 Jul 4;20(13). pii: E3294. doi: 10.3390/ijms20133294. Review.


The Role of Endothelial Dysfunction in Peripheral Blood Nerve Barrier: Molecular Mechanisms and Pathophysiological Implications.

Maiuolo J, Gliozzi M, Musolino V, Carresi C, Nucera S, Macrì R, Scicchitano M, Bosco F, Scarano F, Ruga S, Zito MC, Oppedisano F, Mollace R, Paone S, Palma E, Muscoli C, Mollace V.

Int J Mol Sci. 2019 Jun 20;20(12). pii: E3022. doi: 10.3390/ijms20123022. Review.


Key Role of Cytochrome C for Apoptosis Detection Using Raman Microimaging in an Animal Model of Brain Ischemia with Insulin Treatment.

Russo V, Candeloro P, Malara N, Perozziello G, Iannone M, Scicchitano M, Mollace R, Musolino V, Gliozzi M, Carresi C, Morittu VM, Gratteri S, Palma E, Muscoli C, Di Fabrizio E, Mollace V.

Appl Spectrosc. 2019 Jul 12:3702819858671. doi: 10.1177/0003702819858671. [Epub ahead of print]


The effect of bergamot polyphenolic fraction on lipid transfer protein system and vascular oxidative stress in a rat model of hyperlipemia.

Musolino V, Gliozzi M, Nucera S, Carresi C, Maiuolo J, Mollace R, Paone S, Bosco F, Scarano F, Scicchitano M, Ruga S, Zito MC, Colica C, Macrì R, Palma E, Ragusa S, Muscoli C, Mollace V.

Lipids Health Dis. 2019 May 17;18(1):115. doi: 10.1186/s12944-019-1061-0.


Second edition of SIMPAR's "Feed Your Destiny" workshop: the role of lifestyle in improving pain management.

De Gregori M, Belfer I, De Giorgio R, Marchesini M, Muscoli C, Rondanelli M, Martini D, Mena P, Arranz LI, Lorente-Cebrián S, Perna S, Villarini A, Salamone M, Allegri M, Schatman ME.

J Pain Res. 2018 Aug 27;11:1627-1636. doi: 10.2147/JPR.S160660. eCollection 2018. Review.


The "Frail" Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections.

Maiuolo J, Gliozzi M, Musolino V, Scicchitano M, Carresi C, Scarano F, Bosco F, Nucera S, Ruga S, Zito MC, Mollace R, Palma E, Fini M, Muscoli C, Mollace V.

Int J Mol Sci. 2018 Sep 10;19(9). pii: E2693. doi: 10.3390/ijms19092693. Review.


Ethanol-induced cardiomyocyte toxicity implicit autophagy and NFkB transcription factor.

Maiuolo J, Maretta A, Gliozzi M, Musolino V, Carresi C, Bosco F, Mollace R, Scarano F, Palma E, Scicchitano M, Nucera S, Sergi D, Muscoli S, Gratteri S, Muscoli C, Mollace V.

Pharmacol Res. 2018 Jul;133:141-150. doi: 10.1016/j.phrs.2018.04.004. Epub 2018 Apr 19.


Anti-oxidant effect of bergamot polyphenolic fraction counteracts doxorubicin-induced cardiomyopathy: Role of autophagy and c-kitposCD45negCD31neg cardiac stem cell activation.

Carresi C, Musolino V, Gliozzi M, Maiuolo J, Mollace R, Nucera S, Maretta A, Sergi D, Muscoli S, Gratteri S, Palma E, Bosco F, Giancotta C, Muscoli C, Marino F, Aquila I, Torella D, Romeo F, Mollace V.

J Mol Cell Cardiol. 2018 Jun;119:10-18. doi: 10.1016/j.yjmcc.2018.04.007. Epub 2018 Apr 12.


Cost-efficacy analysis of 3% diclofenac sodium, ingenol mebutate, and 3.75% imiquimod in the treatment of actinic keratosis.

Nisticò S, Del Duca E, Torchia V, Gliozzi M, Bottoni U, Muscoli C.

Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:2058738418757925. doi: 10.1177/2058738418757925.


Lipid-lowering effect of bergamot polyphenolic fraction: role of pancreatic cholesterol ester hydrolase.

Musolino V, Gliozzi M, Carresi C, Maiuolo J, Mollace R, Bosco F, Scarano F, Scicchitano M, Maretta A, Palma E, Iannone M, Morittu VM, Gratteri S, Muscoli C, Fini M, Mollace V.

J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):1087-1093.


Antioxidant activity of oleuropein and semisynthetic acetyl-derivatives determined by measuring malondialdehyde in rat brain.

Rizzo M, Ventrice D, Giannetto F, Cirinnà S, Santagati NA, Procopio A, Mollace V, Muscoli C.

J Pharm Pharmacol. 2017 Nov;69(11):1502-1512. doi: 10.1111/jphp.12807. Epub 2017 Sep 6.


Aspirin wears smart.

Mollace V, Rosano G, Malara N, Di Fabrizio E, Vitale C, Coluccio M, Maiuolo J, Ali Wasti A, Muscoli C, Gliozzi M, Mollace R, Musolino V, Carresi C, Fini M, Silvestrini B.

Eur Heart J Cardiovasc Pharmacother. 2017 Oct 1;3(4):185-188. doi: 10.1093/ehjcvp/pvx017. No abstract available.


Combining pain therapy with lifestyle: the role of personalized nutrition and nutritional supplements according to the SIMPAR Feed Your Destiny approach.

De Gregori M, Muscoli C, Schatman ME, Stallone T, Intelligente F, Rondanelli M, Franceschi F, Arranz LI, Lorente-Cebrián S, Salamone M, Ilari S, Belfer I, Allegri M.

J Pain Res. 2016 Dec 8;9:1179-1189. eCollection 2016. Review.


Pharmacological effect of a new idebenone formulation in a model of carrageenan-induced inflammatory pain.

Lauro F, Ilari S, Giancotti LA, Ventura CA, Morabito C, Gliozzi M, Malafoglia V, Palma E, Paolino D, Mollace V, Muscoli C.

Pharmacol Res. 2016 Sep;111:767-773. doi: 10.1016/j.phrs.2016.07.043. Epub 2016 Jul 29.


Megestrol acetate improves cardiac function in a model of cancer cachexia-induced cardiomyopathy by autophagic modulation.

Musolino V, Palus S, Tschirner A, Drescher C, Gliozzi M, Carresi C, Vitale C, Muscoli C, Doehner W, von Haehling S, Anker SD, Mollace V, Springer J.

J Cachexia Sarcopenia Muscle. 2016 Dec;7(5):555-566. Epub 2016 Apr 7.


Inhibition of Spinal Oxidative Stress by Bergamot Polyphenolic Fraction Attenuates the Development of Morphine Induced Tolerance and Hyperalgesia in Mice.

Lauro F, Giancotti LA, Ilari S, Dagostino C, Gliozzi M, Morabito C, Malafoglia V, Raffaeli W, Muraca M, Goffredo BM, Mollace V, Muscoli C.

PLoS One. 2016 May 26;11(5):e0156039. doi: 10.1371/journal.pone.0156039. eCollection 2016.


Pharmacoeconomy of drugs used in the treatment of actinic keratoses.

Nisticò S, Torchia V, Gliozzi M, Bottoni U, Del Duca E, Muscoli C.

Int J Immunopathol Pharmacol. 2016 Dec;29(4):796-804. Epub 2016 May 11.


Transient Receptor Potential Melastatin-3 (TRPM3) Mediates Nociceptive-Like Responses in Hydra vulgaris.

Malafoglia V, Traversetti L, Del Grosso F, Scalici M, Lauro F, Russo V, Persichini T, Salvemini D, Mollace V, Fini M, Raffaeli W, Muscoli C, Colasanti M.

PLoS One. 2016 Mar 14;11(3):e0151386. doi: 10.1371/journal.pone.0151386. eCollection 2016.



Nisticò S, Ehrlich J, Gliozzi M, Maiuolo J, Del Duca E, Muscoli C, Mollace V.

J Biol Regul Homeost Agents. 2015 Jul-Sep;29(3):723-8.


Regulation of uric acid metabolism and excretion.

Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V.

Int J Cardiol. 2016 Jun 15;213:8-14. doi: 10.1016/j.ijcard.2015.08.109. Epub 2015 Aug 14. Review.


Continuous wound infusion of local anesthetic and steroid after major abdominal surgery: study protocol for a randomized controlled trial.

Bugada D, De Gregori M, Compagnone C, Muscoli C, Raimondi F, Bettinelli S, Avanzini MA, Cobianchi L, Peloso A, Baciarello M, Dagostino C, Giancotti LA, Ilari S, Lauro F, Grimaldi S, Tasciotti E, Fini M, Saccani Jotti GM, Meschi T, Fanelli G, Allegri M.

Trials. 2015 Aug 14;16:357. doi: 10.1186/s13063-015-0874-z.


Amyloid β peptide-induced inhibition of endothelial nitric oxide production involves oxidative stress-mediated constitutive eNOS/HSP90 interaction and disruption of agonist-mediated Akt activation.

Lamoke F, Mazzone V, Persichini T, Maraschi A, Harris MB, Venema RC, Colasanti M, Gliozzi M, Muscoli C, Bartoli M, Mollace V.

J Neuroinflammation. 2015 May 3;12:84. doi: 10.1186/s12974-015-0304-x.


Oxidized LDL attenuates protective autophagy and induces apoptotic cell death of endothelial cells: Role of oxidative stress and LOX-1 receptor expression.

Mollace V, Gliozzi M, Musolino V, Carresi C, Muscoli S, Mollace R, Tavernese A, Gratteri S, Palma E, Morabito C, Vitale C, Muscoli C, Fini M, Romeo F.

Int J Cardiol. 2015 Apr 1;184:152-8. doi: 10.1016/j.ijcard.2015.02.007. Epub 2015 Feb 11.


The effect of peroxynitrite decomposition catalyst MnTBAP on aldehyde dehydrogenase-2 nitration by organic nitrates: role in nitrate tolerance.

Mollace V, Muscoli C, Dagostino C, Giancotti LA, Gliozzi M, Sacco I, Visalli V, Gratteri S, Palma E, Malara N, Musolino V, Carresi C, Muscoli S, Vitale C, Salvemini D, Romeo F.

Pharmacol Res. 2014 Nov;89:29-35. doi: 10.1016/j.phrs.2014.07.007. Epub 2014 Aug 28.


Pain assessment in animal models: do we need further studies?

Gigliuto C, De Gregori M, Malafoglia V, Raffaeli W, Compagnone C, Visai L, Petrini P, Avanzini MA, Muscoli C, Viganò J, Calabrese F, Dominioni T, Allegri M, Cobianchi L.

J Pain Res. 2014 May 8;7:227-36. doi: 10.2147/JPR.S59161. eCollection 2014. Review.


Olea Europea-derived phenolic products attenuate antinociceptive morphine tolerance: an innovative strategic approach to treat cancer pain.

Muscoli C, Lauro F, Dagostino C, Ilari S, Giancotti LA, Gliozzi M, Costa N, Carresi C, Musolino V, Casale F, Ventrice D, Oliverio M, Palma E, Nisticò S, Procopio A, Rizzo M, Mollace V.

J Biol Regul Homeost Agents. 2014 Jan-Mar;28(1):105-16. Erratum in: J Biol Regul Homeost Agents. 2014 Oct-Dec;28(4):809. D'Agostino, C [corrected to Dagostino, C]; Oliverio, E [corrected to Oliverio, M]; Nistico', S [corrected to Nisticò, S]; Rizzo, M [added].


S-nitrosoglutathione reductase deficiency-induced S-nitrosylation results in neuromuscular dysfunction.

Montagna C, Di Giacomo G, Rizza S, Cardaci S, Ferraro E, Grumati P, De Zio D, Maiani E, Muscoli C, Lauro F, Ilari S, Bernardini S, Cannata S, Gargioli C, Ciriolo MR, Cecconi F, Bonaldo P, Filomeni G.

Antioxid Redox Signal. 2014 Aug 1;21(4):570-87. doi: 10.1089/ars.2013.5696. Epub 2014 May 13.


Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.

Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E, Ragusa S, Aloe A, Palma E, Muscoli C, Romeo F, Mollace V.

Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8.


Posttranslational nitration of tyrosine residues modulates glutamate transmission and contributes to N-methyl-D-aspartate-mediated thermal hyperalgesia.

Muscoli C, Dagostino C, Ilari S, Lauro F, Gliozzi M, Bardhi E, Palma E, Mollace V, Salvemini D.

Mediators Inflamm. 2013;2013:950947. doi: 10.1155/2013/950947. Epub 2013 Jun 20.


Testosterone-induced effects on lipids and inflammation.

Vodo S, Bechi N, Petroni A, Muscoli C, Aloisi AM.

Mediators Inflamm. 2013;2013:183041. doi: 10.1155/2013/183041. Epub 2013 Mar 31. Review.


Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain.

Doyle T, Chen Z, Muscoli C, Bryant L, Esposito E, Cuzzocrea S, Dagostino C, Ryerse J, Rausaria S, Kamadulski A, Neumann WL, Salvemini D.

J Neurosci. 2012 May 2;32(18):6149-60. doi: 10.1523/JNEUROSCI.6343-11.2012.


Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.

Doyle T, Chen Z, Muscoli C, Obeid LM, Salvemini D.

FASEB J. 2011 Aug;25(8):2782-91. doi: 10.1096/fj.10-178095. Epub 2011 May 6.


The protective effect of tianeptine on Gp120-induced apoptosis in astroglial cells: role of GS and NOS, and NF-κB suppression.

Janda E, Visalli V, Colica C, Aprigliano S, Musolino V, Vadalà N, Muscoli C, Sacco I, Iannone M, Rotiroti D, Spedding M, Mollace V.

Br J Pharmacol. 2011 Nov;164(6):1590-9. doi: 10.1111/j.1476-5381.2010.01172.x.


Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids.

Muscoli C, Doyle T, Dagostino C, Bryant L, Chen Z, Watkins LR, Ryerse J, Bieberich E, Neumman W, Salvemini D.

J Neurosci. 2010 Nov 17;30(46):15400-8. doi: 10.1523/JNEUROSCI.2391-10.2010.


Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S, Muscoli C, Rotiroti D, Romeo F.

Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4.


Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance.

Doyle T, Bryant L, Muscoli C, Cuzzocrea S, Esposito E, Chen Z, Salvemini D.

Neurosci Lett. 2010 Oct 11;483(2):85-9. doi: 10.1016/j.neulet.2010.07.013. Epub 2010 Jul 14.


NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing.

Chen Z, Muscoli C, Doyle T, Bryant L, Cuzzocrea S, Mollace V, Mastroianni R, Masini E, Salvemini D.

Pain. 2010 Apr;149(1):100-6. doi: 10.1016/j.pain.2010.01.015. Epub 2010 Feb 18.


The novel radical scavenger IAC is effective in preventing and protecting against post-ischemic brain damage in Mongolian gerbils.

Canistro D, Affatato AA, Soleti A, Mollace V, Muscoli C, Sculco F, Sacco I, Visalli V, Bonamassa B, Martano M, Iannone M, Sapone A, Paolini M.

J Neurol Sci. 2010 Mar 15;290(1-2):90-5. doi: 10.1016/j.jns.2009.10.023. Epub 2009 Nov 28.


Apoptosis and telomeres shortening related to HIV-1 induced oxidative stress in an astrocytoma cell line.

Pollicita M, Muscoli C, Sgura A, Biasin A, Granato T, Masuelli L, Mollace V, Tanzarella C, Del Duca C, Rodinò P, Perno CF, Aquaro S.

BMC Neurosci. 2009 May 22;10:51. doi: 10.1186/1471-2202-10-51.


Spinal ceramide modulates the development of morphine antinociceptive tolerance via peroxynitrite-mediated nitroxidative stress and neuroimmune activation.

Ndengele MM, Cuzzocrea S, Masini E, Vinci MC, Esposito E, Muscoli C, Petrusca DN, Mollace V, Mazzon E, Li D, Petrache I, Matuschak GM, Salvemini D.

J Pharmacol Exp Ther. 2009 Apr;329(1):64-75. doi: 10.1124/jpet.108.146290. Epub 2008 Nov 25.


The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation.

Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L, Dugo P, Rotiroti D, Romeo F.

J Cardiovasc Pharmacol Ther. 2008 Jun;13(2):120-9. doi: 10.1177/1074248407313821. Epub 2008 Apr 15.


N-acetylcysteine prevents HIV gp 120-related damage of human cultured astrocytes: correlation with glutamine synthase dysfunction.

Visalli V, Muscoli C, Sacco I, Sculco F, Palma E, Costa N, Colica C, Rotiroti D, Mollace V.

BMC Neurosci. 2007 Dec 6;8:106.


Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.

Muscoli C, Cuzzocrea S, Ndengele MM, Mollace V, Porreca F, Fabrizi F, Esposito E, Masini E, Matuschak GM, Salvemini D.

J Clin Invest. 2007 Nov;117(11):3530-9.


The contribution of peroxynitrite generation in HIV replication in human primary macrophages.

Aquaro S, Muscoli C, Ranazzi A, Pollicita M, Granato T, Masuelli L, Modesti A, Perno CF, Mollace V.

Retrovirology. 2007 Oct 21;4:76.


Reduction of antigen-induced respiratory abnormalities and airway inflammation in sensitized guinea pigs by a superoxide dismutase mimetic.

Masini E, Bani D, Vannacci A, Pierpaoli S, Mannaioni PF, Comhair SA, Xu W, Muscoli C, Erzurum SC, Salvemini D.

Free Radic Biol Med. 2005 Aug 15;39(4):520-31.


Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors.

Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D.

Pharmacol Rev. 2005 Jun;57(2):217-52. Review.


Superoxide potentiates NF-kappaB activation and modulates endotoxin-induced cytokine production in alveolar macrophages.

Ndengele MM, Muscoli C, Wang ZQ, Doyle TM, Matuschak GM, Salvemini D.

Shock. 2005 Feb;23(2):186-93.


The effect of inflammatory stimuli on NMDA-related activation of glutamine synthase in human cultured astroglial cells.

Muscoli C, Visalli V, Colica C, Nisticò R, Palma E, Costa N, Rotiroti D, Nisticò G, Mollace V.

Neurosci Lett. 2005 Jan 20;373(3):184-8. Epub 2004 Nov 25.


The role of nitrinergic connections in central cardiovascular responses mediated by physostigmine infused into posterior hypothalamus.

Palma E, Muscoli C, Mancuso E, Sculco F, Sacco I, Alecce W, Costa N, Colica C, Cristiano D, Rotiroti D, Mollace V.

Neurosci Lett. 2004 Sep 16;368(1):112-5.


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