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Sp140 is a multi-SUMO-1 target and its PHD finger promotes SUMOylation of the adjacent Bromodomain.

Zucchelli C, Tamburri S, Filosa G, Ghitti M, Quilici G, Bachi A, Musco G.

Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):456-465. doi: 10.1016/j.bbagen.2018.11.011. Epub 2018 Nov 19.


Probing the interaction of a quercetin bioconjugate with Bcl-2 in living human cancer cells with in-cell NMR spectroscopy.

Primikyri A, Sayyad N, Quilici G, Vrettos EI, Lim K, Chi SW, Musco G, Gerothanassis IP, Tzakos AG.

FEBS Lett. 2018 Oct;592(20):3367-3379. doi: 10.1002/1873-3468.13250. Epub 2018 Sep 29.


mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma.

Drusian L, Nigro EA, Mannella V, Pagliarini R, Pema M, Costa ASH, Benigni F, Larcher A, Chiaravalli M, Gaude E, Montorsi F, Capitanio U, Musco G, Frezza C, Boletta A.

Cell Rep. 2018 Jul 31;24(5):1093-1104.e6. doi: 10.1016/j.celrep.2018.06.106.


Succinimide-Based Conjugates Improve IsoDGR Cyclopeptide Affinity to αvβ3 without Promoting Integrin Allosteric Activation.

Nardelli F, Paissoni C, Quilici G, Gori A, Traversari C, Valentinis B, Sacchi A, Corti A, Curnis F, Ghitti M, Musco G.

J Med Chem. 2018 Sep 13;61(17):7474-7485. doi: 10.1021/acs.jmedchem.8b00745. Epub 2018 Jun 26.


A critical assessment of force field accuracy against NMR data for cyclic peptides containing β-amino acids.

Paissoni C, Nardelli F, Zanella S, Curnis F, Belvisi L, Musco G, Ghitti M.

Phys Chem Chem Phys. 2018 Jun 13;20(23):15807-15816. doi: 10.1039/c8cp00234g.


A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent.

Gioelli N, Maione F, Camillo C, Ghitti M, Valdembri D, Morello N, Darche M, Zentilin L, Cagnoni G, Qiu Y, Giacca M, Giustetto M, Paques M, Cascone I, Musco G, Tamagnone L, Giraudo E, Serini G.

Sci Transl Med. 2018 May 23;10(442). pii: eaah4807. doi: 10.1126/scitranslmed.aah4807. Erratum in: Sci Transl Med. 2018 Jul 25;10(451):.


A persulfidation-based mechanism controls aquaporin-8 conductance.

Bestetti S, Medraño-Fernandez I, Galli M, Ghitti M, Bienert GP, Musco G, Orsi A, Rubartelli A, Sitia R.

Sci Adv. 2018 May 2;4(5):eaar5770. doi: 10.1126/sciadv.aar5770. eCollection 2018 May.


Glycine N-methylation in NGR-Tagged Nanocarriers Prevents Isoaspartate formation and Integrin Binding without Impairing CD13 Recognition and Tumor Homing.

Corti A, Gasparri AM, Ghitti M, Sacchi A, Sudati F, Fiocchi M, Buttiglione V, Perani L, Gori A, Valtorta S, Moresco RM, Pastorino F, Ponzoni M, Musco G, Curnis F.

Adv Funct Mater. 2017 Sep 26;27(36). pii: 1701245. doi: 10.1002/adfm.201701245.


Dissecting intrinsic and ligand-induced structural communication in the β3 headpiece of integrins.

Felline A, Ghitti M, Musco G, Fanelli F.

Biochim Biophys Acta Gen Subj. 2017 Sep;1861(9):2367-2381. doi: 10.1016/j.bbagen.2017.05.018. Epub 2017 May 23.


New Insights into Cooperative Binding of Homeodomain Transcription Factors PREP1 and PBX1 to DNA.

Zucchelli C, Ferrari E, Blasi F, Musco G, Bruckmann C.

Sci Rep. 2017 Jan 17;7:40665. doi: 10.1038/srep40665.


Assessing Heterogeneity of Osteolytic Lesions in Multiple Myeloma by ¹H HR-MAS NMR Metabolomics.

Tavel L, Fontana F, Garcia Manteiga JM, Mari S, Mariani E, Caneva E, Sitia R, Camnasio F, Marcatti M, Cenci S, Musco G.

Int J Mol Sci. 2016 Oct 31;17(11). pii: E1814.


Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia.

Carrabba MG, Tavel L, Oliveira G, Forcina A, Quilici G, Nardelli F, Tresoldi C, Ambrosi A, Ciceri F, Bernardi M, Vago L, Musco G.

J Hematol Oncol. 2016 Oct 28;9(1):115.


dMM-PBSA: A New HADDOCK Scoring Function for Protein-Peptide Docking.

Spiliotopoulos D, Kastritis PL, Melquiond AS, Bonvin AM, Musco G, Rocchia W, Spitaleri A.

Front Mol Biosci. 2016 Aug 31;3:46. doi: 10.3389/fmolb.2016.00046. eCollection 2016.


Flexible vs Rigid Epitope Conformations for Diagnostic- and Vaccine-Oriented Applications: Novel Insights from the Burkholderia pseudomallei BPSL2765 Pal3 Epitope.

Gori A, Peri C, Quilici G, Nithichanon A, Gaudesi D, Longhi R, Gourlay L, Bolognesi M, Lertmemongkolchai G, Musco G, Colombo G.

ACS Infect Dis. 2016 Mar 11;2(3):221-30. doi: 10.1021/acsinfecdis.5b00118. Epub 2016 Jan 11.


Metabolic determinants of the immune modulatory function of neural stem cells.

Drago D, Basso V, Gaude E, Volpe G, Peruzzotti-Jametti L, Bachi A, Musco G, Andolfo A, Frezza C, Mondino A, Pluchino S.

J Neuroinflammation. 2016 Sep 2;13(1):232. doi: 10.1186/s12974-016-0667-7.


HMGB1 as biomarker and drug target.

Venereau E, De Leo F, Mezzapelle R, Careccia G, Musco G, Bianchi ME.

Pharmacol Res. 2016 Sep;111:534-544. doi: 10.1016/j.phrs.2016.06.031. Epub 2016 Jul 1. Review.


Structural basis for PHDVC5HCHNSD1-C2HRNizp1 interaction: implications for Sotos syndrome.

Berardi A, Quilici G, Spiliotopoulos D, Corral-Rodriguez MA, Martin-Garcia F, Degano M, Tonon G, Ghitti M, Musco G.

Nucleic Acids Res. 2016 Apr 20;44(7):3448-63. doi: 10.1093/nar/gkw103. Epub 2016 Feb 20.


Structural and biochemical characterization of an RNA/DNA binding motif in the N-terminal domain of RecQ4 helicases.

Marino F, Mojumdar A, Zucchelli C, Bhardwaj A, Buratti E, Vindigni A, Musco G, Onesti S.

Sci Rep. 2016 Feb 18;6:21501. doi: 10.1038/srep21501.


2-Deoxy-d-Glucose Ameliorates PKD Progression.

Chiaravalli M, Rowe I, Mannella V, Quilici G, Canu T, Bianchi V, Gurgone A, Antunes S, D'Adamo P, Esposito A, Musco G, Boletta A.

J Am Soc Nephrol. 2016 Jul;27(7):1958-69. doi: 10.1681/ASN.2015030231. Epub 2015 Nov 3.


SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.

Saare M, Hämarik U, Venta R, Panarina M, Zucchelli C, Pihlap M, Remm A, Kisand K, Toots U, Möll K, Salupere R, Musco G, Uibo R, Peterson P.

J Immunol Res. 2015;2015:526518. doi: 10.1155/2015/526518. Epub 2015 Aug 11.


Metadynamics Simulations Rationalise the Conformational Effects Induced by N-Methylation of RGD Cyclic Hexapeptides.

Paissoni C, Ghitti M, Belvisi L, Spitaleri A, Musco G.

Chemistry. 2015 Sep 28;21(40):14165-70. doi: 10.1002/chem.201501196. Epub 2015 Aug 6.


The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.

Segalla S, Pivetti S, Todoerti K, Chudzik MA, Giuliani EC, Lazzaro F, Volta V, Lazarevic D, Musco G, Muzi-Falconi M, Neri A, Biffo S, Tonon G.

Nucleic Acids Res. 2015 May 26;43(10):5182-93. doi: 10.1093/nar/gkv387. Epub 2015 Apr 29.


Backbone and side-chain (1)H, (15)N, (13)C assignment and secondary structure of BPSL1445 from Burkholderia pseudomallei.

Quilici G, Berardi A, Gaudesi D, Gourlay LJ, Bolognesi M, Musco G.

Biomol NMR Assign. 2015 Oct;9(2):347-50. doi: 10.1007/s12104-015-9607-1. Epub 2015 Apr 19.


Identification of TMPRSS6 cleavage sites of hemojuvelin.

Rausa M, Ghitti M, Pagani A, Nai A, Campanella A, Musco G, Camaschella C, Silvestri L.

J Cell Mol Med. 2015 Apr;19(4):879-88. doi: 10.1111/jcmm.12462. Epub 2015 Feb 22.


Structure-based design of a B cell antigen from B. pseudomallei.

Gaudesi D, Peri C, Quilici G, Gori A, Ferrer-Navarro M, Conchillo-Solé O, Thomas R, Nithichanon A, Lertmemongkolchai G, Titball R, Daura X, Colombo G, Musco G.

ACS Chem Biol. 2015 Mar 20;10(3):803-12. doi: 10.1021/cb500831y. Epub 2014 Dec 22.


Identification of a novel de novo deletion in RAF1 associated with biventricular hypertrophy in Noonan syndrome.

Sana ME, Spitaleri A, Spiliotopoulos D, Pezzoli L, Preda L, Musco G, Ferrazzi P, Iascone M.

Am J Med Genet A. 2014 Aug;164A(8):2069-73. doi: 10.1002/ajmg.a.36588. Epub 2014 Apr 29.


NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions.

Ghitti M, Musco G, Spitaleri A.

Adv Exp Med Biol. 2014;805:271-304. doi: 10.1007/978-3-319-02970-2_12. Review.


Oxidation-induced structural changes of ceruloplasmin foster NGR motif deamidation that promotes integrin binding and signaling.

Barbariga M, Curnis F, Spitaleri A, Andolfo A, Zucchelli C, Lazzaro M, Magnani G, Musco G, Corti A, Alessio M.

J Biol Chem. 2014 Feb 7;289(6):3736-48. doi: 10.1074/jbc.M113.520981. Epub 2013 Dec 23.


The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein.

Perniola R, Musco G.

Biochim Biophys Acta. 2014 Feb;1842(2):326-37. doi: 10.1016/j.bbadis.2013.11.020. Epub 2013 Nov 22. Review.


Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.

Zucchelli C, Tamburri S, Quilici G, Palagano E, Berardi A, Saare M, Peterson P, Bachi A, Musco G.

FEBS J. 2014 Jan;281(1):216-31. doi: 10.1111/febs.12588. Epub 2013 Nov 25.


Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke.

Peruzzotti-Jametti L, Cambiaghi M, Bacigaluppi M, Gallizioli M, Gaude E, Mari S, Sandrone S, Cursi M, Teneud L, Comi G, Musco G, Martino G, Leocani L.

Stroke. 2013 Nov;44(11):3166-74. doi: 10.1161/STROKEAHA.113.001687. Epub 2013 Aug 27.


The stem cell secretome and its role in brain repair.

Drago D, Cossetti C, Iraci N, Gaude E, Musco G, Bachi A, Pluchino S.

Biochimie. 2013 Dec;95(12):2271-85. doi: 10.1016/j.biochi.2013.06.020. Epub 2013 Jul 1. Review.


¹H, ¹³C, ¹⁵N backbone and side chain NMR resonance assignments of BPSL1050 from Burkholderia pseudomallei.

Gaudesi D, Quilici G, Musco G.

Biomol NMR Assign. 2014 Apr;8(1):181-4. doi: 10.1007/s12104-013-9479-1. Epub 2013 Apr 25.


Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Rowe I, Chiaravalli M, Mannella V, Ulisse V, Quilici G, Pema M, Song XW, Xu H, Mari S, Qian F, Pei Y, Musco G, Boletta A.

Nat Med. 2013 Apr;19(4):488-93. doi: 10.1038/nm.3092. Epub 2013 Mar 24.


Exploring PHD fingers and H3K4me0 interactions with molecular dynamics simulations and binding free energy calculations: AIRE-PHD1, a comparative study.

Spiliotopoulos D, Spitaleri A, Musco G.

PLoS One. 2012;7(10):e46902. doi: 10.1371/journal.pone.0046902. Epub 2012 Oct 15.


AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.

Gaetani M, Matafora V, Saare M, Spiliotopoulos D, Mollica L, Quilici G, Chignola F, Mannella V, Zucchelli C, Peterson P, Bachi A, Musco G.

Nucleic Acids Res. 2012 Dec;40(22):11756-68. doi: 10.1093/nar/gks933. Epub 2012 Oct 15.


Molecular dynamics reveal that isoDGR-containing cyclopeptides are true αvβ3 antagonists unable to promote integrin allostery and activation.

Ghitti M, Spitaleri A, Valentinis B, Mari S, Asperti C, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2012 Jul 27;51(31):7702-5. doi: 10.1002/anie.201202032. Epub 2012 Jun 20.


Metabolomics of B to plasma cell differentiation.

Garcia-Manteiga JM, Mari S, Godejohann M, Spraul M, Napoli C, Cenci S, Musco G, Sitia R.

J Proteome Res. 2011 Sep 2;10(9):4165-76. doi: 10.1021/pr200328f. Epub 2011 Jul 29.


Use of metadynamics in the design of isoDGR-based αvβ3 antagonists to fine-tune the conformational ensemble.

Spitaleri A, Ghitti M, Mari S, Alberici L, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1832-6. doi: 10.1002/anie.201007091. Epub 2011 Jan 18. No abstract available.


HMGB1-carbenoxolone interactions: dynamics insights from combined nuclear magnetic resonance and molecular dynamics.

Mollica L, Morra G, Colombo G, Musco G.

Chem Asian J. 2011 May 2;6(5):1171-80. doi: 10.1002/asia.201000726. Epub 2011 Feb 3.


The CCPN Metabolomics Project: a fast protocol for metabolite identification by 2D-NMR.

Chignola F, Mari S, Stevens TJ, Fogh RH, Mannella V, Boucher W, Musco G.

Bioinformatics. 2011 Mar 15;27(6):885-6. doi: 10.1093/bioinformatics/btr013. Epub 2011 Jan 6.


Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.

Wodarczyk C, Distefano G, Rowe I, Gaetani M, Bricoli B, Muorah M, Spitaleri A, Mannella V, Ricchiuto P, Pema M, Castelli M, Casanova AE, Mollica L, Banzi M, Boca M, Antignac C, Saunier S, Musco G, Boletta A.

PLoS One. 2010 Sep 14;5(9):e12719. doi: 10.1371/journal.pone.0012719.


2D TR-NOESY experiments interrogate and rank ligand-receptor interactions in living human cancer cells.

Mari S, Invernizzi C, Spitaleri A, Alberici L, Ghitti M, Bordignon C, Traversari C, Rizzardi GP, Musco G.

Angew Chem Int Ed Engl. 2010 Feb 1;49(6):1071-4. doi: 10.1002/anie.200905941. No abstract available.


The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation.

Chignola F, Gaetani M, Rebane A, Org T, Mollica L, Zucchelli C, Spitaleri A, Mannella V, Peterson P, Musco G.

Nucleic Acids Res. 2009 May;37(9):2951-61. doi: 10.1093/nar/gkp166. Epub 2009 Mar 17.


Structural basis for the interaction of isoDGR with the RGD-binding site of alphavbeta3 integrin.

Spitaleri A, Mari S, Curnis F, Traversari C, Longhi R, Bordignon C, Corti A, Rizzardi GP, Musco G.

J Biol Chem. 2008 Jul 11;283(28):19757-68. doi: 10.1074/jbc.M710273200. Epub 2008 May 13.


The autoimmune regulator PHD finger binds to non-methylated histone H3K4 to activate gene expression.

Org T, Chignola F, Hetényi C, Gaetani M, Rebane A, Liiv I, Maran U, Mollica L, Bottomley MJ, Musco G, Peterson P.

EMBO Rep. 2008 Apr;9(4):370-6. doi: 10.1038/sj.embor.2008.11. Epub 2008 Feb 22.


A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA.

Ivanov S, Dragoi AM, Wang X, Dallacosta C, Louten J, Musco G, Sitia G, Yap GS, Wan Y, Biron CA, Bianchi ME, Wang H, Chu WM.

Blood. 2007 Sep 15;110(6):1970-81. Epub 2007 Jun 4.


Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities.

Mollica L, De Marchis F, Spitaleri A, Dallacosta C, Pennacchini D, Zamai M, Agresti A, Trisciuoglio L, Musco G, Bianchi ME.

Chem Biol. 2007 Apr;14(4):431-41.


Interactions of the C2 domain of human factor V with a model membrane.

Mollica L, Fraternali F, Musco G.

Proteins. 2006 Aug 1;64(2):363-75.


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