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Proteomics analysis of the matrisome from MC38 experimental mouse liver metastases.

Yuzhalin AE, Lim SY, Gordon-Weeks AN, Fischer R, Kessler BM, Yu D, Muschel RJ.

Am J Physiol Gastrointest Liver Physiol. 2019 Nov 1;317(5):G625-G639. doi: 10.1152/ajpgi.00014.2019. Epub 2019 Sep 23.


Type I IFN protects cancer cells from CD8+ T cell-mediated cytotoxicity after radiation.

Chen J, Cao Y, Markelc B, Kaeppler J, Vermeer JA, Muschel RJ.

J Clin Invest. 2019 Oct 1;129(10):4224-4238. doi: 10.1172/JCI127458.


Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition.

Gordon-Weeks A, Lim SY, Yuzhalin A, Lucotti S, Vermeer JAF, Jones K, Chen J, Muschel RJ.

Cancers (Basel). 2019 May 6;11(5). pii: E630. doi: 10.3390/cancers11050630.


Image-Based Artefact Removal in Laser Scanning Microscopy.

Papiez BW, Markelc B, Brown G, Muschel RJ, Brady SM, Schnabel JA.

IEEE Trans Biomed Eng. 2020 Jan;67(1):79-87. doi: 10.1109/TBME.2019.2908345. Epub 2019 Apr 29.


Buparlisib with thoracic radiotherapy and its effect on tumour hypoxia: A phase I study in patients with advanced non-small cell lung carcinoma.

McGowan DR, Skwarski M, Bradley KM, Campo L, Fenwick JD, Gleeson FV, Green M, Horne A, Maughan TS, McCole MG, Mohammed S, Muschel RJ, Ng SM, Panakis N, Prevo R, Strauss VY, Stuart R, Tacconi EMC, Vallis KA, McKenna WG, Macpherson RE, Higgins GS.

Eur J Cancer. 2019 May;113:87-95. doi: 10.1016/j.ejca.2019.03.015. Epub 2019 Apr 13.


Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2.

Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ.

J Clin Invest. 2019 Mar 25;129(5):1845-1862. doi: 10.1172/JCI121985. eCollection 2019 Mar 25.


Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade.

Jones KI, Tiersma J, Yuzhalin AE, Gordon-Weeks AN, Buzzelli J, Im JH, Muschel RJ.

EMBO Mol Med. 2018 Dec;10(12). pii: e9342. doi: 10.15252/emmm.201809342.


Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.

Yuzhalin AE, Gordon-Weeks AN, Tognoli ML, Jones K, Markelc B, Konietzny R, Fischer R, Muth A, O'Neill E, Thompson PR, Venables PJ, Kessler BM, Lim SY, Muschel RJ.

Nat Commun. 2018 Nov 14;9(1):4783. doi: 10.1038/s41467-018-07306-7.


Prospective gating control for highly efficient cardio-respiratory synchronised short and constant TR MRI in the mouse.

Kinchesh P, Gilchrist S, Beech JS, Gomes AL, Kersemans V, Newman RG, Vojnovic B, Allen PD, Brady M, Muschel RJ, Smart SC.

Magn Reson Imaging. 2018 Nov;53:20-27. doi: 10.1016/j.mri.2018.06.017. Epub 2018 Jun 30.


Functional Parameters Derived from Magnetic Resonance Imaging Reflect Vascular Morphology in Preclinical Tumors and in Human Liver Metastases.

Kannan P, Kretzschmar WW, Winter H, Warren D, Bates R, Allen PD, Syed N, Irving B, Papiez BW, Kaeppler J, Markelc B, Kinchesh P, Gilchrist S, Smart S, Schnabel JA, Maughan T, Harris AL, Muschel RJ, Partridge M, Sharma RA, Kersemans V.

Clin Cancer Res. 2018 Oct 1;24(19):4694-4704. doi: 10.1158/1078-0432.CCR-18-0033. Epub 2018 Jun 29.


STING-Dependent Interferon-λ1 Induction in HT29 Cells, a Human Colorectal Cancer Cell Line, After Gamma-Radiation.

Chen J, Markelc B, Kaeppler J, Ogundipe VML, Cao Y, McKenna WG, Muschel RJ.

Int J Radiat Oncol Biol Phys. 2018 May 1;101(1):97-106. doi: 10.1016/j.ijrobp.2018.01.091. Epub 2018 Feb 3.


Protease nexin-1 prevents growth of human B cell lymphoma via inhibition of sonic hedgehog signaling.

Xin X, Ding Y, Yang Y, Fu X, Zhou J, McKee CM, Muschel RJ, Gale RP, Apperley JF, Xu D.

Blood Cancer J. 2018 Feb 26;8(2):24. doi: 10.1038/s41408-018-0063-x. No abstract available.


Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance.

Buzzelli JN, Ouaret D, Brown G, Allen PD, Muschel RJ.

Stem Cell Res. 2018 Mar;27:109-120. doi: 10.1016/j.scr.2018.01.016. Epub 2018 Jan 28.


A core matrisome gene signature predicts cancer outcome.

Yuzhalin AE, Urbonas T, Silva MA, Muschel RJ, Gordon-Weeks AN.

Br J Cancer. 2018 Feb 6;118(3):435-440. doi: 10.1038/bjc.2017.458. Epub 2018 Jan 23.


Patched 1 Expression Correlates with Biochemical Relapse in High-Risk Prostate Cancer Patients.

Gonnissen A, Isebaert S, Perneel C, McKee CM, Van Utterbeeck F, Lerut E, Verrill C, Bryant RJ, Joniau S, Muschel RJ, Haustermans K.

Am J Pathol. 2018 Mar;188(3):795-804. doi: 10.1016/j.ajpath.2017.11.019. Epub 2018 Jan 12.


Tissue microarray analysis indicates hedgehog signaling as a potential prognostic factor in intermediate-risk prostate cancer.

Gonnissen A, Isebaert S, Perneel C, McKee CM, Verrill C, Bryant RJ, Van Utterbeeck F, Lerut E, Haustermans K, Muschel RJ.

BMC Cancer. 2017 Sep 6;17(1):634. doi: 10.1186/s12885-017-3619-4.


Segmentation of Vasculature From Fluorescently Labeled Endothelial Cells in Multi-Photon Microscopy Images.

Bates R, Irving B, Markelc B, Kaeppler J, Brown G, Muschel RJ, Brady SM, Grau V, Schnabel JA.

IEEE Trans Med Imaging. 2019 Jan;38(1):1-10. doi: 10.1109/TMI.2017.2725639. Epub 2017 Aug 9.


Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer.

D'Costa Z, Jones K, Azad A, van Stiphout R, Lim SY, Gomes AL, Kinchesh P, Smart SC, Gillies McKenna W, Buffa FM, Sansom OJ, Muschel RJ, O'Neill E, Fokas E.

Cancer Res. 2017 Nov 1;77(21):5952-5962. doi: 10.1158/0008-5472.CAN-16-2833. Epub 2017 Aug 1.


Microvessel Chaste: An Open Library for Spatial Modeling of Vascularized Tissues.

Grogan JA, Connor AJ, Markelc B, Muschel RJ, Maini PK, Byrne HM, Pitt-Francis JM.

Biophys J. 2017 May 9;112(9):1767-1772. doi: 10.1016/j.bpj.2017.03.036.


An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse.

Kersemans V, Beech JS, Gilchrist S, Kinchesh P, Allen PD, Thompson J, Gomes AL, D'Costa Z, Bird L, Tullis IDC, Newman RG, Corroyer-Dulmont A, Falzone N, Azad A, Vallis KA, Sansom OJ, Muschel RJ, Vojnovic B, Hill MA, Fokas E, Smart SC.

PLoS One. 2017 Apr 28;12(4):e0176693. doi: 10.1371/journal.pone.0176693. eCollection 2017.


The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells.

Gonnissen A, Isebaert S, McKee CM, Muschel RJ, Haustermans K.

Int J Mol Sci. 2017 Feb 13;18(2). pii: E399. doi: 10.3390/ijms18020399.


PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy.

Azad A, Yin Lim S, D'Costa Z, Jones K, Diana A, Sansom OJ, Kruger P, Liu S, McKenna WG, Dushek O, Muschel RJ, Fokas E.

EMBO Mol Med. 2017 Feb;9(2):167-180. doi: 10.15252/emmm.201606674.


Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.

Lim SY, Yuzhalin AE, Gordon-Weeks AN, Muschel RJ.

Oncogene. 2016 Nov 3;35(44):5735-5745. doi: 10.1038/onc.2016.107. Epub 2016 Apr 18.


Low dose angiostatic treatment counteracts radiotherapy-induced tumor perfusion and enhances the anti-tumor effect.

Kleibeuker EA, Fokas E, Allen PD, Kersemans V, Griffioen AW, Beech J, Im JH, Smart SC, Castricum KC, van den Berg J, Schulkens IA, Hill SA, Harris AL, Slotman BJ, Verheul HM, Muschel RJ, Thijssen VL.

Oncotarget. 2016 Nov 22;7(47):76613-76627. doi: 10.18632/oncotarget.12814.


The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo.

Gonnissen A, Isebaert S, McKee CM, Dok R, Haustermans K, Muschel RJ.

Oncotarget. 2016 Dec 20;7(51):84286-84298. doi: 10.18632/oncotarget.12483.


Prognostic role and correlation of CA9, CD31, CD68 and CD20 with the desmoplastic stroma in pancreatic ductal adenocarcinoma.

Diana A, Wang LM, D'Costa Z, Azad A, Silva MA, Soonawalla Z, Allen P, Liu S, McKenna WG, Muschel RJ, Fokas E.

Oncotarget. 2016 Nov 8;7(45):72819-72832. doi: 10.18632/oncotarget.12022.


Predicting the Influence of Microvascular Structure On Tumor Response to Radiotherapy.

Grogan JA, Markelc B, Connor AJ, Muschel RJ, Pitt-Francis JM, Maini PK, Byrne HM.

IEEE Trans Biomed Eng. 2017 Mar;64(3):504-511. doi: 10.1109/TBME.2016.2606563. Epub 2016 Sep 8.


The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia.

Ashton TM, Fokas E, Kunz-Schughart LA, Folkes LK, Anbalagan S, Huether M, Kelly CJ, Pirovano G, Buffa FM, Hammond EM, Stratford M, Muschel RJ, Higgins GS, McKenna WG.

Nat Commun. 2016 Jul 25;7:12308. doi: 10.1038/ncomms12308.


Prognostic value, localization and correlation of PD-1/PD-L1, CD8 and FOXP3 with the desmoplastic stroma in pancreatic ductal adenocarcinoma.

Diana A, Wang LM, D'Costa Z, Allen P, Azad A, Silva MA, Soonawalla Z, Liu S, McKenna WG, Muschel RJ, Fokas E.

Oncotarget. 2016 Jul 5;7(27):40992-41004. doi: 10.18632/oncotarget.10038.


Targeting the CCL2-CCR2 signaling axis in cancer metastasis.

Lim SY, Yuzhalin AE, Gordon-Weeks AN, Muschel RJ.

Oncotarget. 2016 May 10;7(19):28697-710. doi: 10.18632/oncotarget.7376. Review.


IP-10/CXCL10 attracts regulatory T cells: Implication for pancreatic cancer.

Lunardi S, Lim SY, Muschel RJ, Brunner TB.

Oncoimmunology. 2015 Apr 2;4(9):e1027473. eCollection 2015 Sep.


The pH low insertion peptide pHLIP Variant 3 as a novel marker of acidic malignant lesions.

Tapmeier TT, Moshnikova A, Beech J, Allen D, Kinchesh P, Smart S, Harris A, McIntyre A, Engelman DM, Andreev OA, Reshetnyak YK, Muschel RJ.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9710-5. doi: 10.1073/pnas.1509488112. Epub 2015 Jul 20.


Improving In Vivo High-Resolution CT Imaging of the Tumour Vasculature in Xenograft Mouse Models through Reduction of Motion and Bone-Streak Artefacts.

Kersemans V, Kannan P, Beech JS, Bates R, Irving B, Gilchrist S, Allen PD, Thompson J, Kinchesh P, Casteleyn C, Schnabel J, Partridge M, Muschel RJ, Smart SC.

PLoS One. 2015 Jun 5;10(6):e0128537. doi: 10.1371/journal.pone.0128537. eCollection 2015.


Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.

Lim SY, Gordon-Weeks A, Allen D, Kersemans V, Beech J, Smart S, Muschel RJ.

Hepatology. 2015 Aug;62(2):521-33. doi: 10.1002/hep.27838. Epub 2015 May 6.


Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen.

Tiwana GS, Prevo R, Buffa FM, Yu S, Ebner DV, Howarth A, Folkes LK, Budwal B, Chu KY, Durrant L, Muschel RJ, McKenna WG, Higgins GS.

Oncotarget. 2015 Mar 20;6(8):5978-89.


A dual radiolabelling approach for tracking metal complexes: investigating the speciation of copper bis(thiosemicarbazonates) in vitro and in vivo.

Hueting R, Kersemans V, Tredwell M, Cornelissen B, Christlieb M, Gee AD, Passchier J, Smart SC, Gouverneur V, Muschel RJ, Dilworth JR.

Metallomics. 2015 May;7(5):795-804. doi: 10.1039/c4mt00330f. Epub 2015 Mar 13.


Molecular magnetic resonance imaging of angiogenesis in vivo using polyvalent cyclic RGD-iron oxide microparticle conjugates.

Melemenidis S, Jefferson A, Ruparelia N, Akhtar AM, Xie J, Allen D, Hamilton A, Larkin JR, Perez-Balderas F, Smart SC, Muschel RJ, Chen X, Sibson NR, Choudhury RP.

Theranostics. 2015 Feb 15;5(5):515-29. doi: 10.7150/thno.10319. eCollection 2015.


Protease nexin 1 induces apoptosis of prostate tumor cells through inhibition of X-chromosome-linked inhibitor of apoptosis protein.

McKee CM, Ding Y, Zhou J, Li C, Huang L, Xin X, He J, Allen JE, El-Deiry WS, Cao Y, Muschel RJ, Xu D.

Oncotarget. 2015 Feb 28;6(6):3784-96.


RhoC and ROCKs regulate cancer cell interactions with endothelial cells.

Reymond N, Im JH, Garg R, Cox S, Soyer M, Riou P, Colomba A, Muschel RJ, Ridley AJ.

Mol Oncol. 2015 Jun;9(6):1043-55. doi: 10.1016/j.molonc.2015.01.004. Epub 2015 Jan 22.


Drug radiotherapy combinations: review of previous failures and reasons for future optimism.

Higgins GS, O'Cathail SM, Muschel RJ, McKenna WG.

Cancer Treat Rev. 2015 Feb;41(2):105-13. doi: 10.1016/j.ctrv.2014.12.012. Epub 2015 Jan 3. Review.


Pancreatic ductal adenocarcinoma: From genetics to biology to radiobiology to oncoimmunology and all the way back to the clinic.

Fokas E, O'Neill E, Gordon-Weeks A, Mukherjee S, McKenna WG, Muschel RJ.

Biochim Biophys Acta. 2015 Jan;1855(1):61-82. doi: 10.1016/j.bbcan.2014.12.001. Epub 2014 Dec 7. Review.


IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival.

Lunardi S, Jamieson NB, Lim SY, Griffiths KL, Carvalho-Gaspar M, Al-Assar O, Yameen S, Carter RC, McKay CJ, Spoletini G, D'Ugo S, Silva MA, Sansom OJ, Janssen KP, Muschel RJ, Brunner TB.

Oncotarget. 2014 Nov 30;5(22):11064-80.


Radiation and ATM inhibition: the heart of the matter.

Hammond EM, Muschel RJ.

J Clin Invest. 2014 Aug;124(8):3289-91. doi: 10.1172/JCI77195. Epub 2014 Jul 18.


Regulation of O2 consumption by the PI3K and mTOR pathways contributes to tumor hypoxia.

Kelly CJ, Hussien K, Fokas E, Kannan P, Shipley RJ, Ashton TM, Stratford M, Pearson N, Muschel RJ.

Radiother Oncol. 2014 Apr;111(1):72-80. doi: 10.1016/j.radonc.2014.02.007. Epub 2014 Mar 13.


A comparison of the behavior of (64)Cu-acetate and (64)Cu-ATSM in vitro and in vivo.

Hueting R, Kersemans V, Cornelissen B, Tredwell M, Hussien K, Christlieb M, Gee AD, Passchier J, Smart SC, Dilworth JR, Gouverneur V, Muschel RJ.

J Nucl Med. 2014 Jan;55(1):128-34. doi: 10.2967/jnumed.113.119917. Epub 2013 Dec 12.


The stromal compartments in pancreatic cancer: are there any therapeutic targets?

Lunardi S, Muschel RJ, Brunner TB.

Cancer Lett. 2014 Feb 28;343(2):147-55. doi: 10.1016/j.canlet.2013.09.039. Epub 2013 Oct 16. Review.


Recruitment of myeloid cells to the tumor microenvironment supports liver metastasis.

Lim SY, Gordon-Weeks AN, Zhao L, Tapmeier TT, Im JH, Cao Y, Beech J, Allen D, Smart S, Muschel RJ.

Oncoimmunology. 2013 Mar 1;2(3):e23187.


Proteomic analysis reveals a proteolytic feedback loop in murine seminal fluid.

McKee CM, Xu D, Kessler BM, Muschel RJ.

Prostate. 2013 Sep;73(13):1427-40. doi: 10.1002/pros.22690. Epub 2013 Jun 14.


Coagulation and metastasis: what does the experimental literature tell us?

Gil-Bernabé AM, Lucotti S, Muschel RJ.

Br J Haematol. 2013 Aug;162(4):433-41. doi: 10.1111/bjh.12381. Epub 2013 May 21. Review.


Ultrasonography-guided intracardiac injection: an improvement for quantitative brain colonization assays.

Balathasan L, Beech JS, Muschel RJ.

Am J Pathol. 2013 Jul;183(1):26-34. doi: 10.1016/j.ajpath.2013.03.003. Epub 2013 May 8.


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