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The Alternative Splicing Regulator Nova2 Constrains Vascular Erk Signaling to Limit Specification of the Lymphatic Lineage.

Baek S, Oh TG, Secker G, Sutton DL, Okuda KS, Paterson S, Bower NI, Toubia J, Koltowska K, Capon SJ, Baillie GJ, Simons C, Muscat GEO, Lagendijk AK, Smith KA, Harvey NL, Hogan BM.

Dev Cell. 2019 Apr 22;49(2):279-292.e5. doi: 10.1016/j.devcel.2019.03.017.


Epigenetic arginine methylation in breast cancer: emerging therapeutic strategies.

Wang SM, Dowhan DH, Muscat GEO.

J Mol Endocrinol. 2019 Apr 1;62(3):R223-R237. doi: 10.1530/JME-18-0224. Review.


The Nuclear Receptor Nor-1 Is a Pleiotropic Regulator of Exercise-Induced Adaptations.

Pearen MA, Muscat GEO.

Exerc Sport Sci Rev. 2018 Apr;46(2):97-104. doi: 10.1249/JES.0000000000000143. Review.


NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.

Fane ME, Chhabra Y, Hollingsworth DEJ, Simmons JL, Spoerri L, Oh TG, Chauhan J, Chin T, Harris L, Harvey TJ, Muscat GEO, Goding CR, Sturm RA, Haass NK, Boyle GM, Piper M, Smith AG.

EBioMedicine. 2017 Feb;16:63-75. doi: 10.1016/j.ebiom.2017.01.013. Epub 2017 Jan 16.


Therapeutic Implications of Epigenetic Signaling in Breast Cancer.

Oh TG, Wang SM, Muscat GE.

Endocrinology. 2017 Mar 1;158(3):431-447. doi: 10.1210/en.2016-1716. Review.


Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

Tuong ZK, Fitzsimmons R, Wang SM, Oh TG, Lau P, Steyn F, Thomas G, Muscat GEO.

EBioMedicine. 2016 Sep;11:101-117. doi: 10.1016/j.ebiom.2016.08.027. Epub 2016 Aug 20.


The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis.

Oh TG, Wang SM, Acharya BR, Goode JM, Graham JD, Clarke CL, Yap AS, Muscat GEO.

EBioMedicine. 2016 Apr;6:59-72. doi: 10.1016/j.ebiom.2016.02.028. Epub 2016 Feb 18.


The Nuclear Receptor, Nor-1, Induces the Physiological Responses Associated With Exercise.

Goode JM, Pearen MA, Tuong ZK, Wang SC, Oh TG, Shao EX, Muscat GE.

Mol Endocrinol. 2016 Jun;30(6):660-76. doi: 10.1210/me.2015-1300. Epub 2016 May 4.


RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

Tuong ZK, Lau P, Du X, Condon ND, Goode JM, Oh TG, Yeo JC, Muscat GE, Stow JL.

PLoS One. 2016 Jan 26;11(1):e0147179. doi: 10.1371/journal.pone.0147179. eCollection 2016.


Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.

Lau P, Tuong ZK, Wang SC, Fitzsimmons RL, Goode JM, Thomas GP, Cowin GJ, Pearen MA, Mardon K, Stow JL, Muscat GE.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E159-71. doi: 10.1152/ajpendo.00056.2014. Epub 2014 Nov 25.


Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease.

Hilton HN, Doan TB, Graham JD, Oakes SR, Silvestri A, Santucci N, Kantimm S, Huschtscha LI, Ormandy CJ, Funder JW, Simpson ER, Kuczek ES, Leedman PJ, Tilley WD, Fuller PJ, Muscat GE, Clarke CL.

Oncotarget. 2014 Sep 30;5(18):8651-64.


PRMT2 and RORγ expression are associated with breast cancer survival outcomes.

Oh TG, Bailey P, Dray E, Smith AG, Goode J, Eriksson N, Funder JW, Fuller PJ, Simpson ER, Tilley WD, Leedman PJ, Clarke CL, Grimmond S, Dowhan DH, Muscat GE.

Mol Endocrinol. 2014 Jul;28(7):1166-85. doi: 10.1210/me.2013-1403. Epub 2014 Jun 9.


Breast cancer prognosis predicted by nuclear receptor-coregulator networks.

Doan TB, Eriksson NA, Graham D, Funder JW, Simpson ER, Kuczek ES, Clyne C, Leedman PJ, Tilley WD, Fuller PJ, Muscat GE, Clarke CL.

Mol Oncol. 2014 Jul;8(5):998-1013. doi: 10.1016/j.molonc.2014.03.017. Epub 2014 Apr 4.


Nuclear receptor expression in human differentiated thyroid tumors.

Mond M, Alexiadis M, Eriksson N, Davis MJ, Muscat GE, Fuller PJ, Gilfillan C.

Thyroid. 2014 Jun;24(6):1000-11. doi: 10.1089/thy.2013.0509. Epub 2014 May 19.


The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair.

Jagirdar K, Yin K, Harrison M, Lim W, Muscat GE, Sturm RA, Smith AG.

PLoS One. 2013 Nov 6;8(11):e78075. doi: 10.1371/journal.pone.0078075. eCollection 2013.


Distinct nuclear receptor expression in stroma adjacent to breast tumors.

Knower KC, Chand AL, Eriksson N, Takagi K, Miki Y, Sasano H, Visvader JE, Lindeman GJ, Funder JW, Fuller PJ, Simpson ER, Tilley WD, Leedman PJ, Graham J, Muscat GE, Clarke CL, Clyne CD.

Breast Cancer Res Treat. 2013 Nov;142(1):211-23.


Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance.

Pearen MA, Goode JM, Fitzsimmons RL, Eriksson NA, Thomas GP, Cowin GJ, Wang SC, Tuong ZK, Muscat GE.

Mol Endocrinol. 2013 Nov;27(11):1897-917. doi: 10.1210/me.2013-1205. Epub 2013 Sep 24.


Caveolin-1 is necessary for hepatic oxidative lipid metabolism: evidence for crosstalk between caveolin-1 and bile acid signaling.

Fernández-Rojo MA, Gongora M, Fitzsimmons RL, Martel N, Martin SD, Nixon SJ, Brooks AJ, Ikonomopoulou MP, Martin S, Lo HP, Myers SA, Restall C, Ferguson C, Pilch PF, McGee SL, Anderson RL, Waters MJ, Hancock JF, Grimmond SM, Muscat GE, Parton RG.

Cell Rep. 2013 Jul 25;4(2):238-47. doi: 10.1016/j.celrep.2013.06.017. Epub 2013 Jul 11.


Nuclear receptors and epigenetic signaling: novel regulators of glycogen metabolism in skeletal muscle.

Wang SC, Muscat GE.

IUBMB Life. 2013 Aug;65(8):657-64. doi: 10.1002/iub.1181. Epub 2013 Jul 11. Review.


Research resource: nuclear receptors as transcriptome: discriminant and prognostic value in breast cancer.

Muscat GE, Eriksson NA, Byth K, Loi S, Graham D, Jindal S, Davis MJ, Clyne C, Funder JW, Simpson ER, Ragan MA, Kuczek E, Fuller PJ, Tilley WD, Leedman PJ, Clarke CL.

Mol Endocrinol. 2013 Feb;27(2):350-65. doi: 10.1210/me.2012-1265. Epub 2013 Jan 4.


Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.

Tuong ZK, Lau P, Yeo JC, Pearen MA, Wall AA, Stanley AC, Stow JL, Muscat GE.

Endocrinology. 2013 Jan;154(1):140-9. doi: 10.1210/en.2012-1889. Epub 2012 Dec 13.


Orphan nuclear receptors and the regulation of nutrient metabolism: understanding obesity.

Pearen MA, Muscat GE.

Physiology (Bethesda). 2012 Jun;27(3):156-66. doi: 10.1152/physiol.00007.2012. Review.


Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes.

Dowhan DH, Harrison MJ, Eriksson NA, Bailey P, Pearen MA, Fuller PJ, Funder JW, Simpson ER, Leedman PJ, Tilley WD, Brown MA, Clarke CL, Muscat GE.

Endocr Relat Cancer. 2012 Jul 22;19(4):509-26. doi: 10.1530/ERC-12-0100. Print 2012 Aug.


Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling.

Diaz M, Martel N, Fitzsimmons RL, Eriksson NA, Cowin GJ, Thomas GP, Cao KA, Muscat GE, Leong GM.

Obesity (Silver Spring). 2012 Nov;20(11):2157-67. doi: 10.1038/oby.2012.101. Epub 2012 Apr 19.


CARM1/PRMT4 is necessary for the glycogen gene expression programme in skeletal muscle cells.

Wang SC, Dowhan DH, Eriksson NA, Muscat GE.

Biochem J. 2012 Jun 1;444(2):323-31. doi: 10.1042/BJ20112033.


The nuclear receptor, Nor-1, markedly increases type II oxidative muscle fibers and resistance to fatigue.

Pearen MA, Eriksson NA, Fitzsimmons RL, Goode JM, Martel N, Andrikopoulos S, Muscat GE.

Mol Endocrinol. 2012 Mar;26(3):372-84. doi: 10.1210/me.2011-1274. Epub 2012 Jan 26.


Caveolin-1 orchestrates the balance between glucose and lipid-dependent energy metabolism: implications for liver regeneration.

Fernández-Rojo MA, Restall C, Ferguson C, Martel N, Martin S, Bosch M, Kassan A, Leong GM, Martin SD, McGee SL, Muscat GE, Anderson RL, Enrich C, Pol A, Parton RG.

Hepatology. 2012 May;55(5):1574-84. doi: 10.1002/hep.24810. Epub 2012 Apr 4.


Nuclear receptor profiling of ovarian granulosa cell tumors.

Alexiadis M, Eriksson N, Jamieson S, Davis M, Drummond AE, Chu S, Clyne CD, Muscat GE, Fuller PJ.

Horm Cancer. 2011 Jun;2(3):157-69. doi: 10.1007/s12672-011-0069-3.


Retinoid-related orphan receptor alpha and the regulation of lipid homeostasis.

Fitzsimmons RL, Lau P, Muscat GE.

J Steroid Biochem Mol Biol. 2012 Jul;130(3-5):159-68. doi: 10.1016/j.jsbmb.2011.06.009. Epub 2011 Jun 23. Review.


Regulation of NR4A nuclear receptor expression by oncogenic BRAF in melanoma cells.

Smith AG, Lim W, Pearen M, Muscat GE, Sturm RA.

Pigment Cell Melanoma Res. 2011 Jun;24(3):551-63. doi: 10.1111/j.1755-148X.2011.00843.x. Epub 2011 Mar 31.


Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle.

Lau P, Fitzsimmons RL, Pearen MA, Watt MJ, Muscat GE.

Diabetologia. 2011 May;54(5):1169-80. doi: 10.1007/s00125-011-2046-3. Epub 2011 Jan 29.


Nr4a1 siRNA expression attenuates α-MSH regulated gene expression in 3T3-L1 adipocytes.

Wang SC, Myers SA, Eriksson NA, Fitzsimmons RL, Muscat GE.

Mol Endocrinol. 2011 Feb;25(2):291-306. doi: 10.1210/me.2010-0231. Epub 2011 Jan 14.


Chicken ovalbumin upstream promoter-transcription factor II regulates nuclear receptor, myogenic, and metabolic gene expression in skeletal muscle cells.

Crowther LM, Wang SC, Eriksson NA, Myers SA, Murray LA, Muscat GE.

Physiol Genomics. 2011 Feb 24;43(4):213-27. doi: 10.1152/physiolgenomics.00195.2010. Epub 2010 Nov 30.


Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.

Pearen MA, Muscat GE.

Mol Endocrinol. 2010 Oct;24(10):1891-903. doi: 10.1210/me.2010-0015. Epub 2010 Apr 14. Review.


Identification and validation of the pathways and functions regulated by the orphan nuclear receptor, ROR alpha1, in skeletal muscle.

Raichur S, Fitzsimmons RL, Myers SA, Pearen MA, Lau P, Eriksson N, Wang SM, Muscat GE.

Nucleic Acids Res. 2010 Jul;38(13):4296-312. doi: 10.1093/nar/gkq180. Epub 2010 Mar 24.


The Ski proto-oncogene regulates body composition and suppresses lipogenesis.

Leong GM, Kee AJ, Millard SM, Martel N, Eriksson N, Turner N, Cooney GJ, Hardeman EC, Muscat GE.

Int J Obes (Lond). 2010 Mar;34(3):524-36. doi: 10.1038/ijo.2009.265. Epub 2009 Dec 22.


Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells.

Ramakrishnan SN, Lau P, Crowther LM, Cleasby ME, Millard S, Leong GM, Cooney GJ, Muscat GE.

Biochem Biophys Res Commun. 2009 Oct 30;388(4):654-9. doi: 10.1016/j.bbrc.2009.08.045. Epub 2009 Aug 12.


An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells.

Wang SC, Myers S, Dooms C, Capon R, Muscat GE.

Mol Cell Endocrinol. 2010 Feb 5;315(1-2):146-52. doi: 10.1016/j.mce.2009.07.012. Epub 2009 Jul 23.


Beta-adrenergic signaling regulates NR4A nuclear receptor and metabolic gene expression in multiple tissues.

Myers SA, Eriksson N, Burow R, Wang SC, Muscat GE.

Mol Cell Endocrinol. 2009 Oct 15;309(1-2):101-8. doi: 10.1016/j.mce.2009.05.006. Epub 2009 May 22.


Sox18 induces development of the lymphatic vasculature in mice.

François M, Caprini A, Hosking B, Orsenigo F, Wilhelm D, Browne C, Paavonen K, Karnezis T, Shayan R, Downes M, Davidson T, Tutt D, Cheah KS, Stacker SA, Muscat GE, Achen MG, Dejana E, Koopman P.

Nature. 2008 Dec 4;456(7222):643-7. doi: 10.1038/nature07391. Epub 2008 Oct 19.


PPARgamma agonists attenuate proliferation and modulate Wnt/beta-catenin signalling in melanoma cells.

Smith AG, Beaumont KA, Smit DJ, Thurber AE, Cook AL, Boyle GM, Parsons PG, Sturm RA, Muscat GE.

Int J Biochem Cell Biol. 2009 Apr;41(4):844-52. doi: 10.1016/j.biocel.2008.08.037. Epub 2008 Sep 6.


The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.

Lau P, Fitzsimmons RL, Raichur S, Wang SC, Lechtken A, Muscat GE.

J Biol Chem. 2008 Jun 27;283(26):18411-21. doi: 10.1074/jbc.M710526200. Epub 2008 Apr 25.


The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle.

Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE.

Endocrinology. 2008 Jun;149(6):2853-65. doi: 10.1210/en.2007-1202. Epub 2008 Mar 6.


Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.

Smith AG, Luk N, Newton RA, Roberts DW, Sturm RA, Muscat GE.

J Biol Chem. 2008 May 2;283(18):12564-70. doi: 10.1074/jbc.M800480200. Epub 2008 Feb 21.


International Union of Pharmacology. LXVI. Orphan nuclear receptors.

Benoit G, Cooney A, Giguere V, Ingraham H, Lazar M, Muscat G, Perlmann T, Renaud JP, Schwabe J, Sladek F, Tsai MJ, Laudet V.

Pharmacol Rev. 2006 Dec;58(4):798-836. Review.


Halofenate is a selective peroxisome proliferator-activated receptor gamma modulator with antidiabetic activity.

Allen T, Zhang F, Moodie SA, Clemens LE, Smith A, Gregoire F, Bell A, Muscat GE, Gustafson TA.

Diabetes. 2006 Sep;55(9):2523-33.


The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle.

Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE.

Endocrinology. 2006 Nov;147(11):5217-27. Epub 2006 Aug 10.


Effect of disrupted SOX18 transcription factor function on tumor growth, vascularization, and endothelial development.

Young N, Hahn CN, Poh A, Dong C, Wilhelm D, Olsson J, Muscat GE, Parsons P, Gamble JR, Koopman P.

J Natl Cancer Inst. 2006 Aug 2;98(15):1060-7.


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