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Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

Weith M, Seiler J, van den Boom J, Kracht M, Hülsmann J, Primorac I, Del Pino Garcia J, Kaschani F, Kaiser M, Musacchio A, Bollen M, Meyer H.

Mol Cell. 2018 Nov 15;72(4):766-777.e6. doi: 10.1016/j.molcel.2018.09.020. Epub 2018 Oct 18.


Reconstitution of a 26-Subunit Human Kinetochore Reveals Cooperative Microtubule Binding by CENP-OPQUR and NDC80.

Pesenti ME, Prumbaum D, Auckland P, Smith CM, Faesen AC, Petrovic A, Erent M, Maffini S, Pentakota S, Weir JR, Lin YC, Raunser S, McAinsh AD, Musacchio A.

Mol Cell. 2018 Sep 20;71(6):923-939.e10. doi: 10.1016/j.molcel.2018.07.038. Epub 2018 Aug 30.


Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification.

Pan D, Brockmeyer A, Mueller F, Musacchio A, Bange T.

Anal Chem. 2018 Sep 18;90(18):10990-10999. doi: 10.1021/acs.analchem.8b02593. Epub 2018 Aug 29.


Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ.

Nat Cell Biol. 2018 Jul;20(7):800-810. doi: 10.1038/s41556-018-0130-3. Epub 2018 Jun 18.


The kinetochore proteins CENP-E and CENP-F directly and specifically interact with distinct BUB mitotic checkpoint Ser/Thr kinases.

Ciossani G, Overlack K, Petrovic A, Huis In 't Veld PJ, Koerner C, Wohlgemuth S, Maffini S, Musacchio A.

J Biol Chem. 2018 Jun 29;293(26):10084-10101. doi: 10.1074/jbc.RA118.003154. Epub 2018 May 10.


Multivalency of NDC80 in the outer kinetochore is essential to track shortening microtubules and generate forces.

Volkov VA, Huis In 't Veld PJ, Dogterom M, Musacchio A.

Elife. 2018 Apr 9;7. pii: e36764. doi: 10.7554/eLife.36764.


Decoding the centromeric nucleosome through CENP-N.

Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K.

Elife. 2017 Dec 27;6. pii: e33442. doi: 10.7554/eLife.33442.


Fructooligosaccharides production by Schedonorus arundinaceus sucrose:sucrose 1-fructosyltransferase constitutively expressed to high levels in Pichia pastoris.

Hernández L, Menéndez C, Pérez ER, Martínez D, Alfonso D, Trujillo LE, Ramírez R, Sobrino A, Mazola Y, Musacchio A, Pimentel E.

J Biotechnol. 2018 Jan 20;266:59-71. doi: 10.1016/j.jbiotec.2017.12.008. Epub 2017 Dec 12.


BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling.

Overlack K, Bange T, Weissmann F, Faesen AC, Maffini S, Primorac I, Müller F, Peters JM, Musacchio A.

Curr Biol. 2017 Oct 9;27(19):2915-2927.e7. doi: 10.1016/j.cub.2017.08.033. Epub 2017 Sep 21.


The greatest kinetochore show on earth.

Vader G, Musacchio A.

EMBO Rep. 2017 Sep;18(9):1473-1475. doi: 10.15252/embr.201744541. Epub 2017 Jul 18. No abstract available.


Structure of the RZZ complex and molecular basis of its interaction with Spindly.

Mosalaganti S, Keller J, Altenfeld A, Winzker M, Rombaut P, Saur M, Petrovic A, Wehenkel A, Wohlgemuth S, Müller F, Maffini S, Bange T, Herzog F, Waldmann H, Raunser S, Musacchio A.

J Cell Biol. 2017 Apr 3;216(4):961-981. doi: 10.1083/jcb.201611060. Epub 2017 Mar 20.


Catalytic intermolecular hydroaminations of unactivated olefins with secondary alkyl amines.

Musacchio AJ, Lainhart BC, Zhang X, Naguib SG, Sherwood TC, Knowles RR.

Science. 2017 Feb 17;355(6326):727-730. doi: 10.1126/science.aal3010.


A Molecular View of Kinetochore Assembly and Function.

Musacchio A, Desai A.

Biology (Basel). 2017 Jan 24;6(1). pii: E5. doi: 10.3390/biology6010005. Review.


Basis of catalytic assembly of the mitotic checkpoint complex.

Faesen AC, Thanasoula M, Maffini S, Breit C, Müller F, van Gerwen S, Bange T, Musacchio A.

Nature. 2017 Feb 23;542(7642):498-502. doi: 10.1038/nature21384. Epub 2017 Jan 19.


CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading.

Pan D, Klare K, Petrovic A, Take A, Walstein K, Singh P, Rondelet A, Bird AW, Musacchio A.

Elife. 2017 Jan 6;6. pii: e23352. doi: 10.7554/eLife.23352.


Molecular basis of outer kinetochore assembly on CENP-T.

Huis In 't Veld PJ, Jeganathan S, Petrovic A, Singh P, John J, Krenn V, Weissmann F, Bange T, Musacchio A.

Elife. 2016 Dec 24;5. pii: e21007. doi: 10.7554/eLife.21007.


Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.

Petrovic A, Keller J, Liu Y, Overlack K, John J, Dimitrova YN, Jenni S, van Gerwen S, Stege P, Wohlgemuth S, Rombaut P, Herzog F, Harrison SC, Vetter IR, Musacchio A.

Cell. 2016 Nov 3;167(4):1028-1040.e15. doi: 10.1016/j.cell.2016.10.005. Epub 2016 Oct 27.


Insights from biochemical reconstitution into the architecture of human kinetochores.

Weir JR, Faesen AC, Klare K, Petrovic A, Basilico F, Fischböck J, Pentakota S, Keller J, Pesenti ME, Pan D, Vogt D, Wohlgemuth S, Herzog F, Musacchio A.

Nature. 2016 Sep 8;537(7619):249-253. doi: 10.1038/nature19333. Epub 2016 Aug 31.


Microtubules: 50 years on from the discovery of tubulin.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E.

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45. Review.


Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin.

Friese A, Faesen AC, Huis in 't Veld PJ, Fischböck J, Prumbaum D, Petrovic A, Raunser S, Herzog F, Musacchio A.

Nat Commun. 2016 Apr 20;7:11407. doi: 10.1038/ncomms11407.


Progress in the structural and functional characterization of kinetochores.

Pesenti ME, Weir JR, Musacchio A.

Curr Opin Struct Biol. 2016 Apr;37:152-63. doi: 10.1016/ Epub 2016 Apr 1. Review.


Insights from the reconstitution of the divergent outer kinetochore of Drosophila melanogaster.

Liu Y, Petrovic A, Rombaut P, Mosalaganti S, Keller J, Raunser S, Herzog F, Musacchio A.

Open Biol. 2016 Feb;6(2):150236. doi: 10.1098/rsob.150236.


Adaptation of the STARR test for adult Italian population: A speech test for a realistic estimate in real-life listening conditions.

Dincer D'Alessandro H, Ballantyne D, De Seta E, Musacchio A, Mancini P.

Int J Audiol. 2016;55(4):262-7. doi: 10.3109/14992027.2015.1124296. Epub 2016 Jan 21.


Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint.

O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C.

Biol Open. 2015 Dec 18;5(1):11-9. doi: 10.1242/bio.014969.


Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1.

Breit C, Bange T, Petrovic A, Weir JR, Müller F, Vogt D, Musacchio A.

PLoS One. 2015 Dec 10;10(12):e0144673. doi: 10.1371/journal.pone.0144673. eCollection 2015.


The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.

Krenn V, Musacchio A.

Front Oncol. 2015 Oct 16;5:225. doi: 10.3389/fonc.2015.00225. eCollection 2015. Review.


The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics.

Musacchio A.

Curr Biol. 2015 Oct 19;25(20):R1002-18. doi: 10.1016/j.cub.2015.08.051. Review. Erratum in: Curr Biol. 2015 Nov 16;25(22):3017.


A comparative molecular dynamics study of thermophilic and mesophilic β-fructosidase enzymes.

Mazola Y, Guirola O, Palomares S, Chinea G, Menéndez C, Hernández L, Musacchio A.

J Mol Model. 2015 Sep;21(9):228. doi: 10.1007/s00894-015-2772-4. Epub 2015 Aug 13.


CENP-C is a blueprint for constitutive centromere-associated network assembly within human kinetochores.

Klare K, Weir JR, Basilico F, Zimniak T, Massimiliano L, Ludwigs N, Herzog F, Musacchio A.

J Cell Biol. 2015 Jul 6;210(1):11-22. doi: 10.1083/jcb.201412028. Epub 2015 Jun 29.


Closing the Mad2 cycle.

Musacchio A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.08283.


Complex assembly, crystallization and preliminary X-ray crystallographic analysis of the human Rod-Zwilch-ZW10 (RZZ) complex.

Altenfeld A, Wohlgemuth S, Wehenkel A, Vetter IR, Musacchio A.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):438-42. doi: 10.1107/S2053230X15004343. Epub 2015 Mar 20.


HJURP involvement in de novo CenH3(CENP-A) and CENP-C recruitment.

Tachiwana H, Müller S, Blümer J, Klare K, Musacchio A, Almouzni G.

Cell Rep. 2015 Apr 7;11(1):22-32. doi: 10.1016/j.celrep.2015.03.013. Epub 2015 Apr 2.


The (phospho) needle in the (MELT) Haystack.

Faesen AC, Musacchio A.

Mol Cell. 2015 Mar 5;57(5):765-766. doi: 10.1016/j.molcel.2015.02.026.


Adequate formal language performance in unilateral cochlear implanted children: is it indicative of complete recovery in all linguistic domains? Insights from referential communication.

Mancini P, Dincer D'Alessandro H, Guerzoni L, Cuda D, Ruoppolo G, Musacchio A, Di Mario A, De Seta E, Bosco E, Nicastri M.

Int J Pediatr Otorhinolaryngol. 2015 Apr;79(4):598-604. doi: 10.1016/j.ijporl.2015.02.003. Epub 2015 Feb 11.


DNA-Directed Assembly of Capture Tools for Constitutional Studies of Large Protein Complexes.

Meyer R, Faesen A, Vogel K, Jeganathan S, Musacchio A, Niemeyer CM.

Small. 2015 Jun 10;11(22):2669-74. doi: 10.1002/smll.201403544. Epub 2015 Feb 3.


A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint.

Overlack K, Primorac I, Vleugel M, Krenn V, Maffini S, Hoffmann I, Kops GJ, Musacchio A.

Elife. 2015 Jan 22;4:e05269. doi: 10.7554/eLife.05269.


HORMA domains at the heart of meiotic chromosome dynamics.

Vader G, Musacchio A.

Dev Cell. 2014 Nov 24;31(4):389-91. doi: 10.1016/j.devcel.2014.11.009. Epub 2014 Nov 24.


Inhibitor-3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore-bound protein phosphatase-1.

Eiteneuer A, Seiler J, Weith M, Beullens M, Lesage B, Krenn V, Musacchio A, Bollen M, Meyer H.

EMBO J. 2014 Nov 18;33(22):2704-20. doi: 10.15252/embj.201489054. Epub 2014 Oct 8.


Catalytic olefin hydroamination with aminium radical cations: a photoredox method for direct C-N bond formation.

Musacchio AJ, Nguyen LQ, Beard GH, Knowles RR.

J Am Chem Soc. 2014 Sep 3;136(35):12217-20. doi: 10.1021/ja5056774. Epub 2014 Aug 19.


The pseudo GTPase CENP-M drives human kinetochore assembly.

Basilico F, Maffini S, Weir JR, Prumbaum D, Rojas AM, Zimniak T, De Antoni A, Jeganathan S, Voss B, van Gerwen S, Krenn V, Massimiliano L, Valencia A, Vetter IR, Herzog F, Raunser S, Pasqualato S, Musacchio A.

Elife. 2014 Jul 8;3:e02978. doi: 10.7554/eLife.02978.


Oral versus short-term intratympanic prednisolone therapy for idiopathic sudden hearing loss.

Filipo R, Attanasio G, Russo FY, Cartocci G, Musacchio A, De Carlo A, Roukos R, De Seta E, Di Tillo G, Viccaro M, Sarnacchiaro P, Covelli E.

Audiol Neurootol. 2014;19(4):225-33. doi: 10.1159/000360069. Epub 2014 Jul 1.


When Mad met Bub.

Overlack K, Krenn V, Musacchio A.

EMBO Rep. 2014 Apr;15(4):326-8. doi: 10.1002/embr.201438574. Epub 2014 Feb 21.


Modular assembly of RWD domains on the Mis12 complex underlies outer kinetochore organization.

Petrovic A, Mosalaganti S, Keller J, Mattiuzzo M, Overlack K, Krenn V, De Antoni A, Wohlgemuth S, Cecatiello V, Pasqualato S, Raunser S, Musacchio A.

Mol Cell. 2014 Feb 20;53(4):591-605. doi: 10.1016/j.molcel.2014.01.019. Epub 2014 Feb 13.


Neutralizing antibodies and broad, functional T cell immune response following immunization with hepatitis C virus proteins-based vaccine formulation.

Martinez-Donato G, Amador-Cañizares Y, Alvarez-Lajonchere L, Guerra I, Pérez A, Dubuisson J, Wychowsk C, Musacchio A, Aguilar D, Dueñas-Carrera S.

Vaccine. 2014 Mar 26;32(15):1720-6. doi: 10.1016/j.vaccine.2014.01.046. Epub 2014 Jan 30.


KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats.

Krenn V, Overlack K, Primorac I, van Gerwen S, Musacchio A.

Curr Biol. 2014 Jan 6;24(1):29-39. doi: 10.1016/j.cub.2013.11.046. Epub 2013 Dec 19.


Cell cycle, differentiation and disease.

Musacchio A, Helin K.

Curr Opin Cell Biol. 2013 Dec;25(6):673-5. doi: 10.1016/ Epub 2013 Oct 16. No abstract available.


Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling.

Primorac I, Weir JR, Chiroli E, Gross F, Hoffmann I, van Gerwen S, Ciliberto A, Musacchio A.

Elife. 2013 Sep 24;2:e01030. doi: 10.7554/eLife.01030.


Affinity maturation and fine functional mapping of an antibody fragment against a novel neutralizing epitope on human vascular endothelial growth factor.

Lamdan H, Gavilondo JV, Muñoz Y, Pupo A, Huerta V, Musacchio A, Pérez L, Ayala M, Rojas G, Balint RF, Larrick JW.

Mol Biosyst. 2013 Aug;9(8):2097-106. doi: 10.1039/c3mb70136k. Epub 2013 May 24.


Panta rhei: the APC/C at steady state.

Primorac I, Musacchio A.

J Cell Biol. 2013 Apr 15;201(2):177-89. doi: 10.1083/jcb.201301130. Review.


Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant.

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O'Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW.

Chromosome Res. 2013 Apr;21(2):101-6. doi: 10.1007/s10577-013-9347-y. Epub 2013 Apr 12.

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