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Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver.

Choudhury SR, Babes L, Rahn JJ, Ahn BY, Goring KR, King JC, Lau A, Petri B, Hao X, Chojnacki AK, Thanabalasuriar A, McAvoy EF, Tabariès S, Schraeder C, Patel KD, Siegel PM, Kopciuk KA, Schriemer DC, Muruve DA, Kelly MM, Yipp BG, Kubes P, Robbins SM, Senger DL.

Cell. 2019 Aug 22;178(5):1205-1221.e17. doi: 10.1016/j.cell.2019.07.017.


The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Perissinotti L, Guo J, Kudaibergenova M, Lees-Miller J, Ol'khovich M, Sharapova A, Perlovich GL, Muruve DA, Gerull B, Noskov SY, Duff HJ.

Mol Pharmacol. 2019 Aug;96(2):259-271. doi: 10.1124/mol.118.115642. Epub 2019 Jun 10.


The role of inflammasomes in kidney disease.

Komada T, Muruve DA.

Nat Rev Nephrol. 2019 Aug;15(8):501-520. doi: 10.1038/s41581-019-0158-z. Review.


The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. a ΔmucA mutant in anaerobic acidified nitrite sensitivity of planktonic and biofilm bacteria in vitro and during chronic murine lung infection.

Panmanee W, Su S, Schurr MJ, Lau GW, Zhu X, Ren Z, McDaniel CT, Lu LJ, Ohman DE, Muruve DA, Panos RJ, Yu HD, Thompson TB, Tseng BS, Hassett DJ.

PLoS One. 2019 Jun 3;14(6):e0216401. doi: 10.1371/journal.pone.0216401. eCollection 2019.


Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19.


NOD-like receptors and inflammasomes: A review of their canonical and non-canonical signaling pathways.

Platnich JM, Muruve DA.

Arch Biochem Biophys. 2019 Jul 30;670:4-14. doi: 10.1016/ Epub 2019 Feb 14. Review.


A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

Sporinova B, McRae SA, Muruve DA, Fritzler MJ, Nasr SH, Chin AC, Benediktsson H.

BMC Nephrol. 2019 Jan 31;20(1):29. doi: 10.1186/s12882-019-1227-z.


Application of immobilized ATP to the study of NLRP inflammasomes.

Liao KC, Sandall CF, Carlson DA, Ulke-Lemée A, Platnich JM, Hughes PF, Muruve DA, Haystead TAJ, MacDonald JA.

Arch Biochem Biophys. 2019 Jul 30;670:104-115. doi: 10.1016/ Epub 2019 Jan 11.


Anticoagulant Related Nephropathy Induced by Dabigatran.

Sharfuddin N, Nourbakhsh M, Box A, Benediktsson H, Muruve DA.

Case Rep Nephrol. 2018 Dec 9;2018:7381505. doi: 10.1155/2018/7381505. eCollection 2018.


Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome.

Platnich JM, Chung H, Lau A, Sandall CF, Bondzi-Simpson A, Chen HM, Komada T, Trotman-Grant AC, Brandelli JR, Chun J, Beck PL, Philpott DJ, Girardin SE, Ho M, Johnson RP, MacDonald JA, Armstrong GD, Muruve DA.

Cell Rep. 2018 Nov 6;25(6):1525-1536.e7. doi: 10.1016/j.celrep.2018.09.071.


Trends in Biopsy-Based Diagnosis of Kidney Disease: A Population Study.

Cunningham A, Benediktsson H, Muruve DA, Hildebrand AM, Ravani P.

Can J Kidney Health Dis. 2018 Sep 20;5:2054358118799690. doi: 10.1177/2054358118799690. eCollection 2018.


Correction for Kumar et al., "Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis".

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.

J Virol. 2018 Jul 17;92(15). pii: e02176-17. doi: 10.1128/JVI.02176-17. Print 2018 Aug 1. No abstract available.


Quantification of Inflammasome Adaptor Protein ASC in Biological Samples by Multiple-Reaction Monitoring Mass Spectrometry.

Ulke-Lemée A, Lau A, Nelson MC, James MT, Muruve DA, MacDonald JA.

Inflammation. 2018 Aug;41(4):1396-1408. doi: 10.1007/s10753-018-0787-6.


Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.

Lau A, Chung H, Komada T, Platnich JM, Sandall CF, Choudhury SR, Chun J, Naumenko V, Surewaard BG, Nelson MC, Ulke-Lemée A, Beck PL, Benediktsson H, Jevnikar AM, Snelgrove SL, Hickey MJ, Senger DL, James MT, Macdonald JA, Kubes P, Jenne CN, Muruve DA.

J Clin Invest. 2018 Jul 2;128(7):2894-2913. doi: 10.1172/JCI96640. Epub 2018 Jun 4.


Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD.

Komada T, Chung H, Lau A, Platnich JM, Beck PL, Benediktsson H, Duff HJ, Jenne CN, Muruve DA.

J Am Soc Nephrol. 2018 Apr;29(4):1165-1181. doi: 10.1681/ASN.2017080863. Epub 2018 Feb 9.


The NLR Protein NLRP6 Does Not Impact Gut Microbiota Composition.

Lemire P, Robertson SJ, Maughan H, Tattoli I, Streutker CJ, Platnich JM, Muruve DA, Philpott DJ, Girardin SE.

Cell Rep. 2017 Dec 26;21(13):3653-3661. doi: 10.1016/j.celrep.2017.12.026.


The biobank for the molecular classification of kidney disease: research translation and precision medicine in nephrology.

Muruve DA, Mann MC, Chapman K, Wong JF, Ravani P, Page SA, Benediktsson H.

BMC Nephrol. 2017 Jul 26;18(1):252. doi: 10.1186/s12882-017-0669-4.


New Answers to Old Conundrums: What Antibodies, Exosomes and Inflammasomes Bring to the Conversation. Canadian National Transplant Research Program International Summit Report.

Dieudé M, West LJ, Muruve DA, Gunaratnam L, Mohanakumar T, Zorn E, Cairo CW, Freed DH, Schultz KR, Fairchild RL, Hébert MJ.

Transplantation. 2018 Feb;102(2):209-214. doi: 10.1097/TP.0000000000001872. Review. Erratum in: Transplantation. 2018 Jul;102(7):e360. Gunaratman, Lakshman [corrected to Gunaratnam, Lakshman].


Cyclooxygenase-2 Inhibition Limits Angiotensin II-Induced DNA Oxidation and Protein Nitration in Humans.

Pialoux V, Poulin MJ, Hemmelgarn BR, Muruve DA, Chirico EN, Faes C, Sola DY, Ahmed SB.

Front Physiol. 2017 Mar 10;8:138. doi: 10.3389/fphys.2017.00138. eCollection 2017.


Exaggerated IL-15 and Altered Expression of foxp3+ Cell-Derived Cytokines Contribute to Enhanced Colitis in Nlrp3-/- Mice.

Hirota SA, Ueno A, Tulk SE, Becker HM, Schenck LP, Potentier MS, Li Y, Ghosh S, Muruve DA, MacDonald JA, Beck PL.

Mediators Inflamm. 2016;2016:5637685. doi: 10.1155/2016/5637685. Epub 2016 Aug 17.


A survey of patient perspectives on the research use of health information and biospecimens.

Page SA, Manhas KP, Muruve DA.

BMC Med Ethics. 2016 Aug 15;17(1):48. doi: 10.1186/s12910-016-0130-4.


Peptide-based biocoatings for corrosion protection of stainless steel biomaterial in a chloride solution.

Muruve NGG, Cheng YF, Feng Y, Liu T, Muruve DA, Hassett DJ, Irvin RT.

Mater Sci Eng C Mater Biol Appl. 2016 Nov 1;68:695-700. doi: 10.1016/j.msec.2016.06.053. Epub 2016 Jun 16.


NLRP3 Localizes to the Tubular Epithelium in Human Kidney and Correlates With Outcome in IgA Nephropathy.

Chun J, Chung H, Wang X, Barry R, Taheri ZM, Platnich JM, Ahmed SB, Trpkov K, Hemmelgarn B, Benediktsson H, James MT, Muruve DA.

Sci Rep. 2016 Apr 20;6:24667. doi: 10.1038/srep24667.


A Putative ABC Transporter Permease Is Necessary for Resistance to Acidified Nitrite and EDTA in Pseudomonas aeruginosa under Aerobic and Anaerobic Planktonic and Biofilm Conditions.

McDaniel C, Su S, Panmanee W, Lau GW, Browne T, Cox K, Paul AT, Ko SH, Mortensen JE, Lam JS, Muruve DA, Hassett DJ.

Front Microbiol. 2016 Apr 1;7:291. doi: 10.3389/fmicb.2016.00291. eCollection 2016.


NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis.

Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi-Simpson A, Platnich JM, Bracey NA, French MC, Beck PL, Chun J, Vallance BA, Muruve DA.

Cell Death Differ. 2016 Aug;23(8):1331-46. doi: 10.1038/cdd.2016.14. Epub 2016 Feb 19.


Peptide-Mediated PEGylation of Polysulfone Reduces Protein Adsorption and Leukocyte Activation.

Davis EM, Platnich JM, Irvin RT, Muruve DA.

ASAIO J. 2015 Nov-Dec;61(6):710-7. doi: 10.1097/MAT.0000000000000265.


Vitamin D₃ metabolites enhance the NLRP3-dependent secretion of IL-1β from human THP-1 monocytic cells.

Tulk SE, Liao KC, Muruve DA, Li Y, Beck PL, MacDonald JA.

J Cell Biochem. 2015 May;116(5):711-20. doi: 10.1002/jcb.24985.


Hierarchical regulation of wound healing by NOD-like receptors in cardiovascular disease.

Bracey NA, Duff HJ, Muruve DA.

Antioxid Redox Signal. 2015 May 1;22(13):1176-87. doi: 10.1089/ars.2014.6125. Epub 2014 Nov 10. Review.


Mitochondrial NLRP3 protein induces reactive oxygen species to promote Smad protein signaling and fibrosis independent from the inflammasome.

Bracey NA, Gershkovich B, Chun J, Vilaysane A, Meijndert HC, Wright JR Jr, Fedak PW, Beck PL, Muruve DA, Duff HJ.

J Biol Chem. 2014 Jul 11;289(28):19571-84. doi: 10.1074/jbc.M114.550624. Epub 2014 May 19.


Inflammasomes in the CNS.

Walsh JG, Muruve DA, Power C.

Nat Rev Neurosci. 2014 Feb;15(2):84-97. doi: 10.1038/nrn3638. Epub 2014 Jan 8. Review.


Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.

Chung H, Ramachandran R, Hollenberg MD, Muruve DA.

J Biol Chem. 2013 Dec 27;288(52):37319-31. doi: 10.1074/jbc.M113.492793. Epub 2013 Nov 19.


Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins.

MacDonald JA, Wijekoon CP, Liao KC, Muruve DA.

IUBMB Life. 2013 Oct;65(10):851-62. doi: 10.1002/iub.1210. Review.


Reduced T-dependent humoral immunity in CD20-deficient mice.

Morsy DE, Sanyal R, Zaiss AK, Deo R, Muruve DA, Deans JP.

J Immunol. 2013 Sep 15;191(6):3112-8. doi: 10.4049/jimmunol.1202098. Epub 2013 Aug 21.


Glucose regulates secretion of exogenously expressed insulin from HepG2 cells in vitro and in a mouse model of diabetes mellitus in vivo.

Liu YY, Jia W, Wanke IE, Muruve DA, Xiao HP, Wong NC.

J Mol Endocrinol. 2013 Apr 12;50(3):337-46. doi: 10.1530/JME-12-0239. Print 2013 Jun.


Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis.

Kumar M, Roe K, Orillo B, Muruve DA, Nerurkar VR, Gale M Jr, Verma S.

J Virol. 2013 Apr;87(7):3655-67. doi: 10.1128/JVI.02667-12. Epub 2013 Jan 9. Erratum in: J Virol. 2018 Jul 17;92(15):.


Inflammasome-independent NLRP3 augments TGF-β signaling in kidney epithelium.

Wang W, Wang X, Chun J, Vilaysane A, Clark S, French G, Bracey NA, Trpkov K, Bonni S, Duff HJ, Beck PL, Muruve DA.

J Immunol. 2013 Feb 1;190(3):1239-49. doi: 10.4049/jimmunol.1201959. Epub 2012 Dec 21.


Intrarectal instillation of Clostridium difficile toxin A triggers colonic inflammation and tissue damage: development of a novel and efficient mouse model of Clostridium difficile toxin exposure.

Hirota SA, Iablokov V, Tulk SE, Schenck LP, Becker H, Nguyen J, Al Bashir S, Dingle TC, Laing A, Liu J, Li Y, Bolstad J, Mulvey GL, Armstrong GD, MacNaughton WK, Muruve DA, MacDonald JA, Beck PL.

Infect Immun. 2012 Dec;80(12):4474-84. doi: 10.1128/IAI.00933-12. Epub 2012 Oct 8.


The Nlrp3 inflammasome promotes myocardial dysfunction in structural cardiomyopathy through interleukin-1β.

Bracey NA, Beck PL, Muruve DA, Hirota SA, Guo J, Jabagi H, Wright JR Jr, Macdonald JA, Lees-Miller JP, Roach D, Semeniuk LM, Duff HJ.

Exp Physiol. 2013 Feb;98(2):462-72. doi: 10.1113/expphysiol.2012.068338. Epub 2012 Jul 30.


Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis.

Gulbransen BD, Bashashati M, Hirota SA, Gui X, Roberts JA, MacDonald JA, Muruve DA, McKay DM, Beck PL, Mawe GM, Thompson RJ, Sharkey KA.

Nat Med. 2012 Mar 18;18(4):600-4. doi: 10.1038/nm.2679.


Plasmodium falciparum-induced CD36 clustering rapidly strengthens cytoadherence via p130CAS-mediated actin cytoskeletal rearrangement.

Davis SP, Amrein M, Gillrie MR, Lee K, Muruve DA, Ho M.

FASEB J. 2012 Mar;26(3):1119-30. doi: 10.1096/fj.11-196923. Epub 2011 Nov 21.


Increased urinary protein excretion in the "normal" range is associated with increased renin-angiotensin system activity.

Nicholl DD, Hemmelgarn BR, Turin TC, MacRae JM, Muruve DA, Sola DY, Ahmed SB.

Am J Physiol Renal Physiol. 2012 Mar 1;302(5):F526-32. doi: 10.1152/ajprenal.00458.2011. Epub 2011 Nov 16.


Nucleotide-binding oligomerization domain-like receptors and inflammasomes in the pathogenesis of non-microbial inflammation and diseases.

Mason DR, Beck PL, Muruve DA.

J Innate Immun. 2012;4(1):16-30. doi: 10.1159/000334247. Epub 2011 Nov 4. Review.


Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2).

Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MD.

J Biol Chem. 2011 Jul 15;286(28):24638-48. doi: 10.1074/jbc.M110.201988. Epub 2011 May 16.


The inflammasomes in kidney disease.

Anders HJ, Muruve DA.

J Am Soc Nephrol. 2011 Jun;22(6):1007-18. doi: 10.1681/ASN.2010080798. Epub 2011 May 12. Review.


The genome of self-complementary adeno-associated viral vectors increases Toll-like receptor 9-dependent innate immune responses in the liver.

Martino AT, Suzuki M, Markusic DM, Zolotukhin I, Ryals RC, Moghimi B, Ertl HC, Muruve DA, Lee B, Herzog RW.

Blood. 2011 Jun 16;117(24):6459-68. doi: 10.1182/blood-2010-10-314518. Epub 2011 Apr 7.


Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity.

Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, Ward SM, Seamone ME, Vilaysane A, Mucsi AD, Fong Y, Prenner E, Ling CC, Tschopp J, Muruve DA, Amrein MW, Shi Y.

Nat Med. 2011 Apr;17(4):479-87. doi: 10.1038/nm.2306. Epub 2011 Mar 13.


Anti-BK virus mechanisms of sirolimus and leflunomide alone and in combination: toward a new therapy for BK virus infection.

Liacini A, Seamone ME, Muruve DA, Tibbles LA.

Transplantation. 2010 Dec 27;90(12):1450-7. doi: 10.1097/TP.0b013e3182007be2.


Intravascular danger signals guide neutrophils to sites of sterile inflammation.

McDonald B, Pittman K, Menezes GB, Hirota SA, Slaba I, Waterhouse CC, Beck PL, Muruve DA, Kubes P.

Science. 2010 Oct 15;330(6002):362-6. doi: 10.1126/science.1195491. Erratum in: Science. 2011 Mar 25;331(6024):1517.


MAP kinase activation increases BK polyomavirus replication and facilitates viral propagation in vitro.

Seamone ME, Wang W, Acott P, Beck PL, Tibbles LA, Muruve DA.

J Virol Methods. 2010 Dec;170(1-2):21-9. doi: 10.1016/j.jviromet.2010.08.014. Epub 2010 Sep 8.


The NLRP3 inflammasome promotes renal inflammation and contributes to CKD.

Vilaysane A, Chun J, Seamone ME, Wang W, Chin R, Hirota S, Li Y, Clark SA, Tschopp J, Trpkov K, Hemmelgarn BR, Beck PL, Muruve DA.

J Am Soc Nephrol. 2010 Oct;21(10):1732-44. doi: 10.1681/ASN.2010020143. Epub 2010 Aug 5.

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