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Items: 20


Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.

Millan AJ, Elizaldi SR, Lee EM, Aceves JO, Murugesh D, Loots GG, Manilay JO.

J Immunol. 2019 Apr 15;202(8):2296-2306. doi: 10.4049/jimmunol.1801157. Epub 2019 Feb 27.


Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression.

Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

Int J Mol Sci. 2018 Sep 7;19(9). pii: E2657. doi: 10.3390/ijms19092657.


Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects.

Loots GG, Robling AG, Chang JC, Murugesh DK, Bajwa J, Carlisle C, Manilay JO, Wong A, Yellowley CE, Genetos DC.

Bone. 2018 Nov;116:307-314. doi: 10.1016/j.bone.2018.08.022. Epub 2018 Aug 30.


Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation.

Sebastian A, Hum NR, Morfin C, Murugesh DK, Loots GG.

Gene. 2018 Oct 30;675:312-321. doi: 10.1016/j.gene.2018.06.079. Epub 2018 Jul 5.


Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.

Yee CS, Manilay JO, Chang JC, Hum NR, Murugesh DK, Bajwa J, Mendez ME, Economides AE, Horan DJ, Robling AG, Loots GG.

J Bone Miner Res. 2018 Oct;33(10):1748-1759. doi: 10.1002/jbmr.3467. Epub 2018 Jun 29.


SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.

Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG.

J Bone Miner Res. 2018 Jun;33(6):1105-1113. doi: 10.1002/jbmr.3397. Epub 2018 Apr 2.


Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG.

PLoS One. 2017 Nov 27;12(11):e0188264. doi: 10.1371/journal.pone.0188264. eCollection 2017.


Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation.

Robling AG, Kang KS, Bullock WA, Foster WH, Murugesh D, Loots GG, Genetos DC.

Bone. 2016 Nov;92:180-188. doi: 10.1016/j.bone.2016.09.001. Epub 2016 Sep 4.


Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.

Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG.

Bone. 2016 Jul;88:20-30. doi: 10.1016/j.bone.2016.04.005. Epub 2016 Apr 19.


Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.

Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

J Orthop Res. 2017 Mar;35(3):474-485. doi: 10.1002/jor.23263. Epub 2016 May 10.


Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.

Yee CS, Xie L, Hatsell S, Hum N, Murugesh D, Economides AN, Loots GG, Collette NM.

Bone. 2016 Jan;82:122-34. doi: 10.1016/j.bone.2015.04.048. Epub 2015 May 5.


Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.


Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair.

Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE.

J Orthop Res. 2012 Nov;30(11):1853-9. doi: 10.1002/jor.22145. Epub 2012 May 16.


Global gene expression analysis of murine limb development.

Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG.

PLoS One. 2011;6(12):e28358. doi: 10.1371/journal.pone.0028358. Epub 2011 Dec 9.


TGF-β regulates sclerostin expression via the ECR5 enhancer.

Loots GG, Keller H, Leupin O, Murugesh D, Collette NM, Genetos DC.

Bone. 2012 Mar;50(3):663-9. doi: 10.1016/j.bone.2011.11.016. Epub 2011 Dec 2.


Genetic evidence that SOST inhibits WNT signaling in the limb.

Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG.

Dev Biol. 2010 Jun 15;342(2):169-79. doi: 10.1016/j.ydbio.2010.03.021. Epub 2010 Mar 30.


Contrasting in vivo effects of murine and human apolipoprotein A-II. Role of monomer versus dimer.

Gong EL, Stoltfus LJ, Brion CM, Murugesh D, Rubin EM.

J Biol Chem. 1996 Mar 15;271(11):5984-7.


Gene modification of primary tumor cells for active immunotherapy of human breast and ovarian cancer.

Philip R, Clary B, Brunette E, Kilinski L, Murugesh D, Sorich M, Yau J, Lebkowski J, Lyerly HK, Philip M.

Clin Cancer Res. 1996 Jan;2(1):59-68.


Efficient and sustained gene expression in primary T lymphocytes and primary and cultured tumor cells mediated by adeno-associated virus plasmid DNA complexed to cationic liposomes.

Philip R, Brunette E, Kilinski L, Murugesh D, McNally MA, Ucar K, Rosenblatt J, Okarma TB, Lebkowski JS.

Mol Cell Biol. 1994 Apr;14(4):2411-8.


Selective erythroid replacement in murine beta-thalassemia using fetal hematopoietic stem cells.

Bethel CA, Murugesh D, Harrison MR, Mohandas N, Rubin EM.

Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10120-4. Erratum in: Proc Natl Acad Sci U S A 1994 Sep 27;91(20):9664.

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