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Items: 18


The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration.

Song Y, Li D, Farrelly O, Miles L, Li F, Kim SE, Lo TY, Wang F, Li T, Thompson-Peer KL, Gong J, Murthy SE, Coste B, Yakubovich N, Patapoutian A, Xiang Y, Rompolas P, Jan LY, Jan YN.

Neuron. 2019 Feb 15. pii: S0896-6273(19)30077-7. doi: 10.1016/j.neuron.2019.01.050. [Epub ahead of print]


Cryo-EM structure of the mechanically activated ion channel OSCA1.2.

Jojoa-Cruz S, Saotome K, Murthy SE, Tsui CCA, Sansom MS, Patapoutian A, Ward AB.

Elife. 2018 Nov 1;7. pii: e41845. doi: 10.7554/eLife.41845.


OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels.

Murthy SE, Dubin AE, Whitwam T, Jojoa-Cruz S, Cahalan SM, Mousavi SAR, Ward AB, Patapoutian A.

Elife. 2018 Nov 1;7. pii: e41844. doi: 10.7554/eLife.41844.


The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat9897. doi: 10.1126/scitranslmed.aat9897.


Toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

Tweed CD, Crook AM, Amukoye EI, Dawson R, Diacon AH, Hanekom M, McHugh TD, Mendel CM, Meredith SK, Murphy ME, Murthy SE, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Wills GH, Gillespie SH.

BMC Infect Dis. 2018 Jul 11;18(1):317. doi: 10.1186/s12879-018-3230-6.


Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

Murthy SE, Chatterjee F, Crook A, Dawson R, Mendel C, Murphy ME, Murray SR, Nunn AJ, Phillips PPJ, Singh KP, McHugh TD, Gillespie SH; REMoxTB Consortium.

BMC Med. 2018 May 21;16(1):73. doi: 10.1186/s12916-018-1053-3.


Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A.

Cell. 2018 Apr 5;173(2):443-455.e12. doi: 10.1016/j.cell.2018.02.047. Epub 2018 Mar 22.


Structure of the mechanically activated ion channel Piezo1.

Saotome K, Murthy SE, Kefauver JM, Whitwam T, Patapoutian A, Ward AB.

Nature. 2018 Feb 22;554(7693):481-486. doi: 10.1038/nature25453. Epub 2017 Dec 20.


Piezos thrive under pressure: mechanically activated ion channels in health and disease.

Murthy SE, Dubin AE, Patapoutian A.

Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. doi: 10.1038/nrm.2017.92. Epub 2017 Oct 4. Review.


LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A.

Cell. 2016 Jan 28;164(3):499-511. doi: 10.1016/j.cell.2015.12.031.


Piezo1 ion channel pore properties are dictated by C-terminal region.

Coste B, Murthy SE, Mathur J, Schmidt M, Mechioukhi Y, Delmas P, Patapoutian A.

Nat Commun. 2015 May 26;6:7223. doi: 10.1038/ncomms8223.


One-channel cell-attached patch-clamp recording.

Maki BA, Cummings KA, Paganelli MA, Murthy SE, Popescu GK.

J Vis Exp. 2014 Jun 9;(88). doi: 10.3791/51629.


Piezo1, a mechanically activated ion channel, is required for vascular development in mice.

Ranade SS, Qiu Z, Woo SH, Hur SS, Murthy SE, Cahalan SM, Xu J, Mathur J, Bandell M, Coste B, Li YS, Chien S, Patapoutian A.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10347-52. doi: 10.1073/pnas.1409233111. Epub 2014 Jun 23.


Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels.

Albuisson J, Murthy SE, Bandell M, Coste B, Louis-Dit-Picard H, Mathur J, Fénéant-Thibault M, Tertian G, de Jaureguiberry JP, Syfuss PY, Cahalan S, Garçon L, Toutain F, Simon Rohrlich P, Delaunay J, Picard V, Jeunemaitre X, Patapoutian A.

Nat Commun. 2013;4:1884. doi: 10.1038/ncomms2899. Erratum in: Nat Commun. 2013;4:2440.


Probing the activation sequence of NMDA receptors with lurcher mutations.

Murthy SE, Shogan T, Page JC, Kasperek EM, Popescu GK.

J Gen Physiol. 2012 Sep;140(3):267-77. doi: 10.1085/jgp.201210786. Epub 2012 Aug 13.


The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.

Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM.

Biochemistry. 2012 May 15;51(19):4015-27. doi: 10.1021/bi3001837. Epub 2012 May 2.


NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers.

Borschel WF, Murthy SE, Kasperek EM, Popescu GK.

Nat Commun. 2011 Oct 11;2:498. doi: 10.1038/ncomms1512.


Zinc effects on NMDA receptor gating kinetics.

Amico-Ruvio SA, Murthy SE, Smith TP, Popescu GK.

Biophys J. 2011 Apr 20;100(8):1910-8. doi: 10.1016/j.bpj.2011.02.042.

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