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Items: 1 to 50 of 181

1.

Structural and functional studies on Salmonella typhimurium pyridoxal kinase: the first structural evidence for the formation of Schiff base with the substrate.

Deka G, Kalyani JN, Jahangir FB, Sabharwal P, Savithri HS, Murthy MRN.

FEBS J. 2019 May 22. doi: 10.1111/febs.14933. [Epub ahead of print]

PMID:
31116912
2.

Structural and functional insights into phosphomannose isomerase: the role of zinc and catalytic residues.

Bangera M, Gowda K G, Sagurthi SR, Murthy MRN.

Acta Crystallogr D Struct Biol. 2019 May 1;75(Pt 5):475-487. doi: 10.1107/S2059798319004169. Epub 2019 Apr 29.

PMID:
31063150
3.

Development of sesbania mosaic virus nanoparticles for imaging.

Vishnu Vardhan GP, Hema M, Sushmitha C, Savithri HS, Natraj U, Murthy MRN.

Arch Virol. 2019 Feb;164(2):497-507. doi: 10.1007/s00705-018-4097-y. Epub 2018 Nov 14.

PMID:
30430265
4.

Structural and biochemical studies on the role of active site Thr166 and Asp236 in the catalytic function of D-Serine deaminase from Salmonella typhimurium.

Deka G, Bharath SR, Savithri HS, Murthy MRN.

Biochem Biophys Res Commun. 2018 Sep 26;504(1):40-45. doi: 10.1016/j.bbrc.2018.08.116. Epub 2018 Aug 30.

PMID:
30173889
5.

Comparative structural and enzymatic studies on Salmonella typhimurium diaminopropionate ammonia lyase reveal its unique features.

Deka G, Bisht S, Savithri HS, Murthy MRN.

J Struct Biol. 2018 May;202(2):118-128. doi: 10.1016/j.jsb.2017.12.012. Epub 2017 Dec 30.

PMID:
29294403
6.

Structural and biophysical characterization of Rv3716c, a hypothetical protein from Mycobacterium tuberculosis.

Gopalan A, Deka G, Prabhavathi M, Savithri HS, Murthy MRN, Raja A.

Biochem Biophys Res Commun. 2018 Jan 1;495(1):982-987. doi: 10.1016/j.bbrc.2017.11.093. Epub 2017 Nov 15.

PMID:
29154992
7.

Molecular dynamics studies on the domain swapped Salmonella typhimurium survival protein SurE: insights on the possible reasons for catalytic cooperativity.

Mathiharan YK, Murthy MRN.

J Biomol Struct Dyn. 2018 Jul;36(9):2303-2311. doi: 10.1080/07391102.2017.1351400. Epub 2017 Aug 10.

PMID:
28714824
8.

Seeing but not believing: the structure of glycerol dehydrogenase initially assumed to be the structure of a survival protein from Salmonella typhimurium.

Hatti K, Mathiharan YK, Srinivasan N, Murthy MRN.

Acta Crystallogr D Struct Biol. 2017 Jul 1;73(Pt 7):609-617. doi: 10.1107/S2059798317007677. Epub 2017 Jun 28.

PMID:
28695861
9.

Structural studies on the decameric S. typhimurium arginine decarboxylase (ADC): Pyridoxal 5'-phosphate binding induces conformational changes.

Deka G, Bharath SR, Savithri HS, Murthy MRN.

Biochem Biophys Res Commun. 2017 Sep 2;490(4):1362-1368. doi: 10.1016/j.bbrc.2017.07.032. Epub 2017 Jul 8.

PMID:
28694189
10.

Structure determination of contaminant proteins using the MarathonMR procedure.

Hatti K, Biswas A, Chaudhary S, Dadireddy V, Sekar K, Srinivasan N, Murthy MRN.

J Struct Biol. 2017 Mar;197(3):372-378. doi: 10.1016/j.jsb.2017.01.005. Epub 2017 Feb 3.

PMID:
28167161
11.

Determination of crystal structures of proteins of unknown identity using a marathon molecular replacement procedure: structure of Stenotrophomonas maltophilia phosphate-binding protein.

Hatti K, Gulati A, Srinivasan N, Murthy MR.

Acta Crystallogr D Struct Biol. 2016 Oct 1;72(Pt 10):1081-1089. Epub 2016 Sep 15.

PMID:
27710929
12.

Biodistribution and toxicity evaluation of sesbania mosaic virus nanoparticles in mice.

Vishnu Vardhan GP, Savithri HS, Murthy MR, Hema M.

Arch Virol. 2016 Oct;161(10):2673-81. doi: 10.1007/s00705-016-2958-9. Epub 2016 Jul 9.

PMID:
27395369
13.

Crystal structure of a thiolase from Escherichia coli at 1.8 Å resolution.

Ithayaraja M, Janardan N, Wierenga RK, Savithri HS, Murthy MR.

Acta Crystallogr F Struct Biol Commun. 2016 Jul;72(Pt 7):534-44. doi: 10.1107/S2053230X16008451. Epub 2016 Jun 22.

14.

Intracellular delivery of antibodies by chimeric Sesbania mosaic virus (SeMV) virus like particles.

Abraham A, Natraj U, Karande AA, Gulati A, Murthy MR, Murugesan S, Mukunda P, Savithri HS.

Sci Rep. 2016 Feb 24;6:21803. doi: 10.1038/srep21803.

15.

Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme.

Pareek V, Samanta M, Joshi NV, Balaram H, Murthy MR, Balaram P.

Chembiochem. 2016 Apr 1;17(7):620-9. doi: 10.1002/cbic.201500532. Epub 2016 Feb 29.

PMID:
26762569
16.

Structural studies on tobacco streak virus coat protein: Insights into the pleomorphic nature of ilarviruses.

Gulati A, Alapati K, Murthy A, Savithri HS, Murthy MR.

J Struct Biol. 2016 Feb;193(2):95-105. doi: 10.1016/j.jsb.2015.12.007. Epub 2015 Dec 17.

PMID:
26706030
17.

Structural studies on chimeric Sesbania mosaic virus coat protein: Revisiting SeMV assembly.

Gulati A, Murthy A, Abraham A, Mohan K, Natraj U, Savithri HS, Murthy MR.

Virology. 2016 Feb;489:34-43. doi: 10.1016/j.virol.2015.11.029. Epub 2015 Dec 17.

18.

Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis.

Janardan N, Harijan RK, Kiema TR, Wierenga RK, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2479-93. doi: 10.1107/S1399004715019331. Epub 2015 Nov 27.

PMID:
26627655
19.

Insights into stabilizing interactions in the distorted domain-swapped dimer of Salmonella typhimurium survival protein.

Mathiharan YK, Savithri HS, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1812-23. doi: 10.1107/S1399004715011992. Epub 2015 Aug 25.

PMID:
26327371
20.

Structures of substrate- and nucleotide-bound propionate kinase from Salmonella typhimurium: substrate specificity and phosphate-transfer mechanism.

Murthy AM, Mathivanan S, Chittori S, Savithri HS, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1640-8. doi: 10.1107/S1399004715009992. Epub 2015 Jul 28.

PMID:
26249345
21.

Probing the role of highly conserved residues in triosephosphate isomerase--analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzyme.

Bandyopadhyay D, Murthy MR, Balaram H, Balaram P.

FEBS J. 2015 Oct;282(20):3863-82. doi: 10.1111/febs.13384. Epub 2015 Aug 11.

22.

Structural and functional analysis of two universal stress proteins YdaA and YnaF from Salmonella typhimurium: possible roles in microbial stress tolerance.

Bangera M, Panigrahi R, Sagurthi SR, Savithri HS, Murthy MR.

J Struct Biol. 2015 Mar;189(3):238-50. doi: 10.1016/j.jsb.2015.01.003. Epub 2015 Jan 16.

PMID:
25600413
23.

Viruses and viral proteins.

Verdaguer N, Ferrero D, Murthy MR.

IUCrJ. 2014 Oct 14;1(Pt 6):492-504. doi: 10.1107/S205225251402003X. eCollection 2014 Nov 1. Review.

24.

Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis.

Anbazhagan P, Harijan RK, Kiema TR, Janardan N, Murthy MR, Michels PA, Juffer AH, Wierenga RK.

Tuberculosis (Edinb). 2014 Jul;94(4):405-12. doi: 10.1016/j.tube.2014.03.003. Epub 2014 Apr 4.

PMID:
24825023
25.

Successful data recovery from oscillation photographs containing strong polycrystalline diffraction rings from an unknown small-molecule contaminant: preliminary structure solution of Salmonella typhimurium pyridoxal kinase (PdxK).

Deka G, Kalyani JN, Benazir JF, Savithri HS, Murthy MR.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):526-9. doi: 10.1107/S2053230X14005342. Epub 2014 Mar 25.

26.

Structural and kinetic studies on adenylosuccinate lyase from Mycobacterium smegmatis and Mycobacterium tuberculosis provide new insights on the catalytic residues of the enzyme.

Banerjee S, Agrawal MJ, Mishra D, Sharan S, Balaram H, Savithri HS, Murthy MR.

FEBS J. 2014 Mar;281(6):1642-58. doi: 10.1111/febs.12730. Epub 2014 Feb 20.

27.

Identification of key amino acid residues in the catalytic mechanism of diaminopropionate ammonialyase from Salmonella typhimurium.

Kalyani JN, Bisht S, Lakshmikanth M, Murthy MR, Savithri HS.

FEBS J. 2013 Oct;280(20):5039-51. doi: 10.1111/febs.12474. Epub 2013 Sep 2.

28.

Crystal structures of SCP2-thiolases of Trypanosomatidae, human pathogens causing widespread tropical diseases: the importance for catalysis of the cysteine of the unique HDCF loop.

Harijan RK, Kiema TR, Karjalainen MP, Janardan N, Murthy MR, Weiss MS, Michels PA, Wierenga RK.

Biochem J. 2013 Oct 1;455(1):119-30. doi: 10.1042/BJ20130669.

PMID:
23909465
29.

Mechanistic features of Salmonella typhimurium propionate kinase (TdcD): insights from kinetic and crystallographic studies.

Chittori S, Simanshu DK, Banerjee S, Murthy AM, Mathivanan S, Savithri HS, Murthy MR.

Biochim Biophys Acta. 2013 Oct;1834(10):2036-44. doi: 10.1016/j.bbapap.2013.05.020. Epub 2013 Jun 5.

PMID:
23747922
30.
31.
32.

Crystal structure of a monomeric thiolase-like protein type 1 (TLP1) from Mycobacterium smegmatis.

Janardan N, Harijan RK, Wierenga RK, Murthy MR.

PLoS One. 2012;7(7):e41894. doi: 10.1371/journal.pone.0041894. Epub 2012 Jul 26.

33.

Structural and mutational studies on substrate specificity and catalysis of Salmonella typhimurium D-cysteine desulfhydrase.

Bharath SR, Bisht S, Harijan RK, Savithri HS, Murthy MR.

PLoS One. 2012;7(5):e36267. doi: 10.1371/journal.pone.0036267. Epub 2012 May 4.

34.

Crystal structure of Escherichia coli diaminopropionate ammonia-lyase reveals mechanism of enzyme activation and catalysis.

Bisht S, Rajaram V, Bharath SR, Kalyani JN, Khan F, Rao AN, Savithri HS, Murthy MR.

J Biol Chem. 2012 Jun 8;287(24):20369-81. doi: 10.1074/jbc.M112.351809. Epub 2012 Apr 13.

35.

Preliminary X-ray crystallographic studies on acetate kinase (AckA) from Salmonella typhimurium in two crystal forms.

Chittori S, Savithri HS, Murthy MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Dec 1;67(Pt 12):1658-61. doi: 10.1107/S1744309111043740. Epub 2011 Nov 30.

36.

Cloning, expression, purification and preliminary X-ray diffraction studies of a putative Mycobacterium smegmatis thiolase.

Janardan N, Paul A, Harijan RK, Wierenga RK, Murthy MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jul 1;67(Pt 7):817-20. doi: 10.1107/S1744309111019324. Epub 2011 Jun 30.

37.

Revisiting the mechanism of the triosephosphate isomerase reaction: the role of the fully conserved glutamic acid 97 residue.

Samanta M, Murthy MR, Balaram H, Balaram P.

Chembiochem. 2011 Aug 16;12(12):1886-96. doi: 10.1002/cbic.201100116. Epub 2011 Jun 10.

PMID:
21671330
38.

Crystal structures of open and closed forms of d-serine deaminase from Salmonella typhimurium - implications on substrate specificity and catalysis.

Bharath SR, Bisht S, Savithri HS, Murthy MR.

FEBS J. 2011 Aug;278(16):2879-91. doi: 10.1111/j.1742-4658.2011.08210.x. Epub 2011 Jul 12.

39.

Probing the role of the fully conserved Cys126 in triosephosphate isomerase by site-specific mutagenesis--distal effects on dimer stability.

Samanta M, Banerjee M, Murthy MR, Balaram H, Balaram P.

FEBS J. 2011 Jun;278(11):1932-43. doi: 10.1111/j.1742-4658.2011.08110.x. Epub 2011 Apr 28.

40.

Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity.

Chittori S, Savithri HS, Murthy MR.

J Struct Biol. 2011 Apr;174(1):58-68. doi: 10.1016/j.jsb.2010.10.008. Epub 2010 Oct 21.

PMID:
20970504
41.

Preliminary X-ray crystallographic analysis of 2-methylcitrate synthase from Salmonella typhimurium.

Chittori S, Simanshu DK, Savithri HS, Murthy MR.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Apr 1;66(Pt 4):467-70. doi: 10.1107/S1744309110007256. Epub 2010 Mar 31.

42.

NSs encoded by groundnut bud necrosis virus is a bifunctional enzyme.

Lokesh B, Rashmi PR, Amruta BS, Srisathiyanarayanan D, Murthy MR, Savithri HS.

PLoS One. 2010 Mar 18;5(3):e9757. doi: 10.1371/journal.pone.0009757. Erratum in: PLoS One. 2010;5(4). doi: 10.1371/annotation/82e3c2dd-e7e5-4267-88e5-19d77d5e58e7.

43.

A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimer.

Pappachan A, Chinnathambi S, Satheshkumar PS, Savithri HS, Murthy MR.

Virology. 2009 Sep 30;392(2):215-21. doi: 10.1016/j.virol.2009.06.047. Epub 2009 Jul 30.

44.

Biochemical and structural characterization of residue 96 mutants of Plasmodium falciparum triosephosphate isomerase: active-site loop conformation, hydration and identification of a dimer-interface ligand-binding site.

Gayathri P, Banerjee M, Vijayalakshmi A, Balaram H, Balaram P, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2009 Aug;65(Pt 8):847-57. doi: 10.1107/S0907444909018666. Epub 2009 Jul 17.

PMID:
19622869
45.

Structures of mannose-6-phosphate isomerase from Salmonella typhimurium bound to metal atoms and substrate: implications for catalytic mechanism.

Sagurthi SR, Gowda G, Savithri HS, Murthy MR.

Acta Crystallogr D Biol Crystallogr. 2009 Jul;65(Pt 7):724-32. doi: 10.1107/S0907444909013328. Epub 2009 Jun 20.

PMID:
19564693
46.

Detection of the protein dimers, multiple monomeric states and hydrated forms of Plasmodium falciparum triosephosphate isomerase in the gas phase.

Thakur SS, Deepalakshmi PD, Gayathri P, Banerjee M, Murthy MR, Balaram P.

Protein Eng Des Sel. 2009 May;22(5):289-304. doi: 10.1093/protein/gzp005. Epub 2009 Mar 4.

PMID:
19261703
47.

Structural and functional studies of Bacillus stearothermophilus serine hydroxymethyltransferase: the role of Asn(341), Tyr(60) and Phe(351) in tetrahydrofolate binding.

Pai VR, Rajaram V, Bisht S, Bhavani BS, Rao NA, Murthy MR, Savithri HS.

Biochem J. 2009 Mar 15;418(3):635-42. doi: 10.1042/BJ20081739.

PMID:
19046138
48.

Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium.

Pappachan A, Savithri HS, Murthy MR.

FEBS J. 2008 Dec;275(23):5855-64. doi: 10.1111/j.1742-4658.2008.06715.x.

49.

Systematic study on crystal-contact engineering of diphthine synthase: influence of mutations at crystal-packing regions on X-ray diffraction quality.

Mizutani H, Saraboji K, Malathy Sony SM, Ponnuswamy MN, Kumarevel T, Krishna Swamy BS, Simanshu DK, Murthy MR, Kunishima N.

Acta Crystallogr D Biol Crystallogr. 2008 Oct;64(Pt 10):1020-33. doi: 10.1107/S0907444908023019. Epub 2008 Sep 19.

PMID:
18931409
50.

Stacking interactions of W271 and H275 of SeMV serine protease with W43 of natively unfolded VPg confer catalytic activity to protease.

Nair S, Gayathri P, Murthy MR, Savithri HS.

Virology. 2008 Dec 5;382(1):83-90. doi: 10.1016/j.virol.2008.08.034. Epub 2008 Oct 7.

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