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Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking.

Li Y, Yu HB, Zhang Y, Leao T, Glukhov E, Pierce ML, Zhang C, Kim H, Mao HH, Fang F, Cottrell GW, Murray TF, Gerwick L, Guan H, Gerwick WH.

J Nat Prod. 2020 Jan 9. doi: 10.1021/acs.jnatprod.9b01019. [Epub ahead of print]


Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry.

Arttamangkul S, Plazek A, Platt EJ, Jin H, Murray TF, Birdsong WT, Rice KC, Farrens DL, Williams JT.

Elife. 2019 Oct 7;8. pii: e49319. doi: 10.7554/eLife.49319.


A Comparison of the Ability of Leu8- and Pro8-Oxytocin to Regulate Intracellular Ca2+ and Ca2+-Activated K+ Channels at Human and Marmoset Oxytocin Receptors.

Pierce ML, Mehrotra S, Mustoe AC, French JA, Murray TF.

Mol Pharmacol. 2019 Apr;95(4):376-385. doi: 10.1124/mol.118.114744. Epub 2019 Feb 9.


Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH.

J Org Chem. 2018 Mar 16;83(6):3034-3046. doi: 10.1021/acs.joc.8b00028. Epub 2018 Mar 8.


Design, synthesis, and opioid activity of arodyn analogs cyclized by ring-closing metathesis involving Tyr(allyl).

Fang WJ, Murray TF, Aldrich JV.

Bioorg Med Chem. 2018 Mar 15;26(6):1157-1161. doi: 10.1016/j.bmc.2017.11.029. Epub 2017 Nov 21.


Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species.

Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH.

J Nat Prod. 2017 Aug 25;80(8):2328-2334. doi: 10.1021/acs.jnatprod.7b00367. Epub 2017 Aug 7.


Alanine scan of the opioid peptide dynorphin B amide.

Joshi AA, Murray TF, Aldrich JV.

Biopolymers. 2017 Sep;108(5). doi: 10.1002/bip.23026.


A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.

Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH.

J Nat Prod. 2017 May 26;80(5):1514-1521. doi: 10.1021/acs.jnatprod.7b00019. Epub 2017 Apr 27.


Synthesis and biological evaluation of palmyrolide A macrocycles as sodium channel blockers towards neuroprotection.

Philkhana SC, Mehrotra S, Murray TF, Reddy DS.

Org Biomol Chem. 2016 Sep 28;14(36):8457-73. doi: 10.1039/c6ob01372d. Epub 2016 Aug 18.


Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin.

Joshi AA, Murray TF, Aldrich JV.

J Med Chem. 2015 Nov 25;58(22):8783-95. doi: 10.1021/jm501827k. Epub 2015 Nov 16.


Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products Workflows.

Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH.

PLoS One. 2015 Jul 29;10(7):e0133297. doi: 10.1371/journal.pone.0133297. eCollection 2015.


Involvement of JNK and caspase activation in hoiamide A-induced neurotoxicity in neocortical neurons.

Cao Z, Li X, Zou X, Greenwood M, Gerwick WH, Murray TF.

Mar Drugs. 2015 Feb 10;13(2):903-19. doi: 10.3390/md13020903.


Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists.

Mehrotra S, Duggan BM, Tello-Aburto R, Newar TD, Gerwick WH, Murray TF, Maio WA.

J Nat Prod. 2014 Nov 26;77(11):2553-60. doi: 10.1021/np500644k. Epub 2014 Oct 24.


Gambierol inhibition of voltage-gated potassium channels augments spontaneous Ca2+ oscillations in cerebrocortical neurons.

Cao Z, Cui Y, Busse E, Mehrotra S, Rainier JD, Murray TF.

J Pharmacol Exp Ther. 2014 Sep;350(3):615-23. doi: 10.1124/jpet.114.215319. Epub 2014 Jun 23.


Structural and biological exploration of phe(3)-phe(4)-modified endomorphin-2 peptidomimetics.

Lesma G, Salvadori S, Airaghi F, Murray TF, Recca T, Sacchetti A, Balboni G, Silvani A.

ACS Med Chem Lett. 2013 Jul 11;4(8):795-9. doi: 10.1021/ml400189r. eCollection 2013 Aug 8.


Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour.

Aldrich JV, Senadheera SN, Ross NC, Reilley KA, Ganno ML, Eans SE, Murray TF, McLaughlin JP.

Br J Pharmacol. 2014 Jul;171(13):3212-22. doi: 10.1111/bph.12664.


Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx.

Li H, Bowling JJ, Fronczek FR, Hong J, Jabba SV, Murray TF, Ha NC, Hamann MT, Jung JH.

Biochim Biophys Acta. 2013 Mar;1830(3):2591-9.


Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity.

George J, Baden DG, Gerwick WH, Murray TF.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19840-5. doi: 10.1073/pnas.1212584109. Epub 2012 Nov 12.


Novel C-1 substituted cocaine analogs unlike cocaine or benztropine.

Reith ME, Ali S, Hashim A, Sheikh IS, Theddu N, Gaddiraju NV, Mehrotra S, Schmitt KC, Murray TF, Sershen H, Unterwald EM, Davis FA.

J Pharmacol Exp Ther. 2012 Nov;343(2):413-25. doi: 10.1124/jpet.112.193771. Epub 2012 Aug 15.


Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH.

J Org Chem. 2012 May 4;77(9):4198-208. doi: 10.1021/jo300160e. Epub 2012 Apr 19.


Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH.

J Nat Prod. 2012 Jan 27;75(1):60-6. doi: 10.1021/np200611f. Epub 2011 Dec 12.


Unexpected opioid activity profiles of analogues of the novel peptide kappa opioid receptor ligand CJ-15,208.

Aldrich JV, Kulkarni SS, Senadheera SN, Ross NC, Reilley KJ, Eans SO, Ganno ML, Murray TF, McLaughlin JP.

ChemMedChem. 2011 Sep 5;6(9):1739-45. doi: 10.1002/cmdc.201100113. Epub 2011 Jul 14.


Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera.

Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH.

J Nat Prod. 2011 Aug 26;74(8):1737-43. doi: 10.1021/np200236c. Epub 2011 Jul 13.


Novel opioid cyclic tetrapeptides: Trp isomers of CJ-15,208 exhibit distinct opioid receptor agonism and short-acting κ opioid receptor antagonism.

Ross NC, Reilley KJ, Murray TF, Aldrich JV, McLaughlin JP.

Br J Pharmacol. 2012 Feb;165(4b):1097-108. doi: 10.1111/j.1476-5381.2011.01544.x.


Additivity of pyrethroid actions on sodium influx in cerebrocortical neurons in primary culture.

Cao Z, Shafer TJ, Crofton KM, Gennings C, Murray TF.

Environ Health Perspect. 2011 Sep;119(9):1239-46. doi: 10.1289/ehp.1003394. Epub 2011 Jun 10.


κ-Opioid receptor inhibition of calcium oscillations in spinal cord neurons.

Kelamangalath L, Dravid SM, George J, Aldrich JV, Murray TF.

Mol Pharmacol. 2011 Jun;79(6):1061-71. doi: 10.1124/mol.111.071456. Epub 2011 Mar 21.


Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons.

Cao Z, Shafer TJ, Murray TF.

J Pharmacol Exp Ther. 2011 Jan;336(1):197-205. doi: 10.1124/jpet.110.171850. Epub 2010 Sep 29.


Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria.

Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH.

Org Lett. 2010 Oct 15;12(20):4490-3. doi: 10.1021/ol101752n.


The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria.

Choi H, Pereira AR, Cao Z, Shuman CF, Engene N, Byrum T, Matainaho T, Murray TF, Mangoni A, Gerwick WH.

J Nat Prod. 2010 Aug 27;73(8):1411-21. doi: 10.1021/np100468n.


Deletion of Ac-NMePhe(1) from [NMePhe(1) ]arodyn under acidic conditions, part 2: effects of substitutions on pharmacological activity.

Fang WJ, Bennett MA, Murray TF, Aldrich JV.

Biopolymers. 2011;96(1):103-10. doi: 10.1002/bip.21495.


Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons.

Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF.

Toxicol Sci. 2010 Apr;114(2):323-34. doi: 10.1093/toxsci/kfp312. Epub 2010 Jan 4.


Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels.

Jabba SV, Prakash A, Dravid SM, Gerwick WH, Murray TF.

J Pharmacol Exp Ther. 2010 Mar;332(3):698-709. doi: 10.1124/jpet.109.161802. Epub 2009 Dec 21.


Solid Phase Synthesis and Application of Labeled Peptide Derivatives: Probes of Receptor-Opioid Peptide Interactions.

Aldrich JV, Kumar V, Dattachowdhury B, Peck AM, Wang X, Murray TF.

Int J Pept Res Ther. 2008 Dec 1;14(4):315-321.


The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues.

Patkar KA, Murray TF, Aldrich JV.

J Med Chem. 2009 Nov 12;52(21):6814-21. doi: 10.1021/jm900715m.


Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii.

Soria-Mercado IE, Pereira A, Cao Z, Murray TF, Gerwick WH.

Org Lett. 2009 Oct 15;11(20):4704-7. doi: 10.1021/ol901438b.


Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria.

Pereira A, Cao Z, Murray TF, Gerwick WH.

Chem Biol. 2009 Aug 28;16(8):893-906. doi: 10.1016/j.chembiol.2009.06.012. Erratum in: Chem Biol. 2009 Nov 25;16(11):1208.


Design, synthesis, and pharmacological activities of dynorphin A analogues cyclized by ring-closing metathesis.

Fang WJ, Cui Y, Murray TF, Aldrich JV.

J Med Chem. 2009 Sep 24;52(18):5619-25. doi: 10.1021/jm900577k.


Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties.

Suyama TL, Cao Z, Murray TF, Gerwick WH.

Toxicon. 2010 Feb-Mar;55(2-3):204-10. doi: 10.1016/j.toxicon.2009.07.020. Epub 2009 Jul 26.


Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.

Sinha B, Cao Z, Murray TF, Aldrich JV.

J Med Chem. 2009 Dec 10;52(23):7372-5. doi: 10.1021/jm9007592.


Design and synthesis of cyclic arodyn analogues by ring-closing metathesis (RCM) for kappa opioid receptor (KOP) antagonists.

Fang WJ, Kulkarni SS, Murray TF, Aldrich JV.

Adv Exp Med Biol. 2009;611:279-80. No abstract available.


The synthesis of DAMGO-based potential affinity labels with high mu opioid receptor affinity and the formation of cyclic O-alkyl thiocarbamates.

Dattachowdhury B, Murray TF, Aldrich JV.

Adv Exp Med Biol. 2009;611:265-6. No abstract available.


Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons.

George J, Dravid SM, Prakash A, Xie J, Peterson J, Jabba SV, Baden DG, Murray TF.

J Neurosci. 2009 Mar 11;29(10):3288-301. doi: 10.1523/JNEUROSCI.6104-08.2009.


Effects of the second-generation synthetic lipid A analogue E5564 on responses to endotoxin in [corrected] equine whole blood and monocytes.

Figueiredo MD, Moore JN, Vandenplas ML, Sun WC, Murray TF.

Am J Vet Res. 2008 Jun;69(6):796-803. doi: 10.2460/ajvr.69.6.796. Erratum in: Am J Vet Res. 2008 Aug;69(8):1021.


Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons.

Cao Z, George J, Gerwick WH, Baden DG, Rainier JD, Murray TF.

J Pharmacol Exp Ther. 2008 Aug;326(2):604-13. doi: 10.1124/jpet.108.138230. Epub 2008 Apr 30.


Brevetoxin-induced phosphorylation of Pyk2 and Src in murine neocortical neurons involves distinct signaling pathways.

Cao Z, George J, Baden DG, Murray TF.

Brain Res. 2007 Dec 12;1184:17-27. Epub 2007 Oct 4.


Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes.

Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden J, Cao Z, Murray TF.

Vet Immunol Immunopathol. 2008 Jan 15;121(1-2):91-100. Epub 2007 Aug 25.


Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.

Sun WC, Moore JN, Hurley DJ, Vandenplas ML, Linden JM, Murray TF.

Am J Vet Res. 2007 Sep;68(9):981-7.


Gambierol acts as a functional antagonist of neurotoxin site 5 on voltage-gated sodium channels in cerebellar granule neurons.

LePage KT, Rainier JD, Johnson HW, Baden DG, Murray TF.

J Pharmacol Exp Ther. 2007 Oct;323(1):174-9. Epub 2007 Jul 3.


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