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Items: 1 to 50 of 54

1.

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma.

Liu Y, Yin N, Wang X, Khoor A, Sambandam V, Ghosh AB, Fields ZA, Murray NR, Justilien V, Fields AP.

Cell Rep. 2020 Jan 21;30(3):771-782.e6. doi: 10.1016/j.celrep.2019.12.071.

2.

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.

Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP.

Cancer Cell. 2019 Dec 9;36(6):692-693. doi: 10.1016/j.ccell.2019.11.007. No abstract available.

3.

Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies.

Yin N, Liu Y, Murray NR, Fields AP.

Adv Biol Regul. 2020 Jan;75:100656. doi: 10.1016/j.jbior.2019.100656. Epub 2019 Sep 25.

PMID:
31623973
4.

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma.

Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP.

Cancer Cell. 2019 Aug 12;36(2):156-167.e7. doi: 10.1016/j.ccell.2019.07.002. Epub 2019 Aug 1. Erratum in: Cancer Cell. 2019 Dec 9;36(6):692-693.

PMID:
31378680
5.

Protein kinase Cι: A versatile oncogene in the lung.

Fields AP, Ali SA, Justilien V, Murray NR.

Mol Cell Oncol. 2018 May 10;5(5):e1190886. doi: 10.1080/23723556.2016.1190886. eCollection 2018.

6.

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC.

Justilien V, Lewis KC, Murray NR, Fields AP.

Small GTPases. 2019 Sep;10(5):388-394. doi: 10.1080/21541248.2017.1335274. Epub 2017 Jul 5.

7.

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.

Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP.

Cancer Cell. 2017 Feb 13;31(2):256-269. doi: 10.1016/j.ccell.2016.12.010. Epub 2017 Jan 19.

8.

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.

Murray NR, Justilien V, Fields AP.

Cancer Cell. 2016 Oct 10;30(4):505-507. doi: 10.1016/j.ccell.2016.09.012.

9.

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis.

Wang Y, Justilien V, Brennan KI, Jamieson L, Murray NR, Fields AP.

Oncogene. 2017 Jan 26;36(4):534-545. doi: 10.1038/onc.2016.224. Epub 2016 Jun 20.

10.

Oncogenic PKCι decides tumor-initiating cell fate.

Fields AP, Ali SA, Murray NR.

Cell Cycle. 2016 Sep 16;15(18):2383-4. doi: 10.1080/15384101.2016.1194624. Epub 2016 Jun 17. No abstract available.

11.

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.

Fields AP, Ali SA, Justilien V, Murray NR.

Small GTPases. 2017 Jan 2;8(1):58-64. doi: 10.1080/21541248.2016.1194953. Epub 2016 May 31.

12.

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma.

Ali SA, Justilien V, Jamieson L, Murray NR, Fields AP.

Cancer Cell. 2016 Mar 14;29(3):367-378. doi: 10.1016/j.ccell.2016.02.012.

13.

The chromosome 3q26 OncCassette: A multigenic driver of human cancer.

Fields AP, Justilien V, Murray NR.

Adv Biol Regul. 2016 Jan;60:47-63. doi: 10.1016/j.jbior.2015.10.009. Epub 2015 Dec 23.

14.

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion.

Butler AM, Scotti Buzhardt ML, Erdogan E, Li S, Inman KS, Fields AP, Murray NR.

Oncotarget. 2015 Jun 20;6(17):15297-310.

15.

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia.

Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P.

Nat Commun. 2015 Feb 20;6:6200. doi: 10.1038/ncomms7200.

16.

Complex role for the immune system in initiation and progression of pancreatic cancer.

Inman KS, Francis AA, Murray NR.

World J Gastroenterol. 2014 Aug 28;20(32):11160-81. doi: 10.3748/wjg.v20.i32.11160. Review.

17.

The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.

Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, Fields AP.

Cancer Cell. 2014 Feb 10;25(2):139-51. doi: 10.1016/j.ccr.2014.01.008.

18.

Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.

Butler AM, Scotti Buzhardt ML, Li S, Smith KE, Fields AP, Murray NR.

PLoS One. 2013 Aug 28;8(8):e72061. doi: 10.1371/journal.pone.0072061. eCollection 2013.

19.

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis.

Hill KS, Erdogan E, Khoor A, Walsh MP, Leitges M, Murray NR, Fields AP.

Oncogene. 2014 Apr 17;33(16):2134-44. doi: 10.1038/onc.2013.147. Epub 2013 Apr 22.

20.

EGF receptor is required for KRAS-induced pancreatic tumorigenesis.

Ardito CM, Grüner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, Delgiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC, Siveke JT.

Cancer Cell. 2012 Sep 11;22(3):304-17. doi: 10.1016/j.ccr.2012.07.024.

21.

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.

Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP.

PLoS One. 2012;7(4):e35040. doi: 10.1371/journal.pone.0035040. Epub 2012 Apr 24.

22.

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.

Scotti ML, Smith KE, Butler AM, Calcagno SR, Crawford HC, Leitges M, Fields AP, Murray NR.

PLoS One. 2012;7(2):e30509. doi: 10.1371/journal.pone.0030509. Epub 2012 Feb 16.

23.

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.

Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP.

PLoS One. 2011;6(10):e26439. doi: 10.1371/journal.pone.0026439. Epub 2011 Oct 17.

24.

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis.

Calcagno SR, Li S, Shahid MW, Wallace MB, Leitges M, Fields AP, Murray NR.

Inflamm Bowel Dis. 2011 Aug;17(8):1685-97. doi: 10.1002/ibd.21547. Epub 2010 Nov 15.

25.

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.

Murray NR, Kalari KR, Fields AP.

J Cell Physiol. 2011 Apr;226(4):879-87. doi: 10.1002/jcp.22463. Review.

26.

Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.

Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR.

Cancer Res. 2010 Mar 1;70(5):2064-74. doi: 10.1158/0008-5472.CAN-09-2684. Epub 2010 Feb 23.

27.

Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.

Fields AP, Calcagno SR, Krishna M, Rak S, Leitges M, Murray NR.

Cancer Res. 2009 Feb 15;69(4):1643-50. doi: 10.1158/0008-5472.CAN-08-3187.

28.

Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.

Murray NR, Weems J, Braun U, Leitges M, Fields AP.

Cancer Res. 2009 Jan 15;69(2):656-62. doi: 10.1158/0008-5472.CAN-08-3001.

29.

The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.

Su W, Necela BM, Fujiwara K, Kurakata S, Murray NR, Fields AP, Thompson EA.

Int J Cancer. 2008 Sep 1;123(5):991-7. doi: 10.1002/ijc.23640.

30.

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.

Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP, Murray NR.

Int J Cancer. 2008 Jun 1;122(11):2462-70. doi: 10.1002/ijc.23383.

31.

Protein kinase C isozymes as therapeutic targets for treatment of human cancers.

Fields AP, Murray NR.

Adv Enzyme Regul. 2008;48:166-78. doi: 10.1016/j.advenzreg.2007.11.014. Epub 2008 Mar 18. No abstract available.

32.

Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon.

Su W, Bush CR, Necela BM, Calcagno SR, Murray NR, Fields AP, Thompson EA.

Physiol Genomics. 2007 Aug 20;30(3):342-53. Epub 2007 May 22.

PMID:
17519361
33.

A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells.

Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, Fields AP.

Cancer Res. 2006 Feb 1;66(3):1767-74.

34.

Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.

Liu Y, Su W, Thompson EA, Leitges M, Murray NR, Fields AP.

J Biol Chem. 2004 Oct 29;279(44):45556-63. Epub 2004 Aug 20.

35.

Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.

Murray NR, Jamieson L, Yu W, Zhang J, Gökmen-Polar Y, Sier D, Anastasiadis P, Gatalica Z, Thompson EA, Fields AP.

J Cell Biol. 2004 Mar 15;164(6):797-802.

36.

Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.

Fields AP, Murray NR, Gustafson WC.

Methods Mol Biol. 2003;233:539-53. No abstract available.

PMID:
12840533
37.

Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis.

Yu W, Murray NR, Weems C, Chen L, Guo H, Ethridge R, Ceci JD, Evers BM, Thompson EA, Fields AP.

J Biol Chem. 2003 Mar 28;278(13):11167-74. Epub 2002 Dec 11.

38.

Carboplatin and vinblastine for the treatment of metastatic transitional cell carcinoma of the urothelial tract.

Al-Karim HA, Tan KE, Chi KN, Bryce CJ, Murray NR, Coppin C.

Am J Clin Oncol. 2002 Oct;25(5):515-9.

PMID:
12393996
39.

Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis.

Murray NR, Weems C, Chen L, Leon J, Yu W, Davidson LA, Jamieson L, Chapkin RS, Thompson EA, Fields AP.

J Cell Biol. 2002 Jun 10;157(6):915-20. Epub 2002 Jun 10.

40.

Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis.

Gökmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP.

Cancer Res. 2001 Feb 15;61(4):1375-81.

41.

Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis.

Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DG, Fields AP.

J Cell Biol. 1999 May 17;145(4):699-711.

42.

Protein kinase calpha regulates human monocyte O-2 production and low density lipoprotein lipid oxidation.

Li Q, Subbulakshmi V, Fields AP, Murray NR, Cathcart MK.

J Biol Chem. 1999 Feb 5;274(6):3764-71.

44.

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C.

Murray NR, Fields AP.

J Biol Chem. 1998 May 8;273(19):11514-20.

45.
46.

A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition.

Sun B, Murray NR, Fields AP.

J Biol Chem. 1997 Oct 17;272(42):26313-7.

47.
48.
49.

Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation.

Huntley CC, De BP, Murray NR, Fields AP, Banerjee AK.

Virology. 1995 Aug 20;211(2):561-7.

50.

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