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Selective Ah receptor modulators attenuate NPC1L1-mediated cholesterol uptake through repression of SREBP-2 transcriptional activity.

Muku GE, Kusnadi A, Kuzu G, Tanos R, Murray IA, Gowda K, Amin S, Perdew GH.

Lab Invest. 2019 Aug 15. doi: 10.1038/s41374-019-0306-x. [Epub ahead of print]


Isolation and Identification of Aryl Hydrocarbon Receptor Modulators in White Button Mushrooms (Agaricus bisporus).

Tian Y, Gui W, Smith PB, Koo I, Murray IA, Cantorna MT, Perdew GH, Patterson AD.

J Agric Food Chem. 2019 Aug 21;67(33):9286-9294. doi: 10.1021/acs.jafc.9b03212. Epub 2019 Aug 8.


Selective Ah receptor ligands mediate enhanced SREBP1 proteolysis to restrict lipogenesis in sebocytes.

Muku GE, Blazanin N, Dong F, Smith PB, Thiboutot D, Gowda K, Amin S, Murray IA, Perdew GH.

Toxicol Sci. 2019 Jun 21. pii: kfz140. doi: 10.1093/toxsci/kfz140. [Epub ahead of print]


Microbiota Metabolism Promotes Synthesis of the Human Ah Receptor Agonist 2,8-Dihydroxyquinoline.

Hubbard TD, Liu Q, Murray IA, Dong F, Miller C 3rd, Smith PB, Gowda K, Lin JM, Amin S, Patterson AD, Perdew GH.

J Proteome Res. 2019 Apr 5;18(4):1715-1724. doi: 10.1021/acs.jproteome.8b00946. Epub 2019 Mar 4.


Urolithin A Is a Dietary Microbiota-Derived Human Aryl Hydrocarbon Receptor Antagonist.

Muku GE, Murray IA, Espín JC, Perdew GH.

Metabolites. 2018 Nov 29;8(4). pii: E86. doi: 10.3390/metabo8040086.


Prevalence of reduced bone mineral density in adults with coeliac disease - are we missing opportunities for detection in patients below 50 years of age?

Pritchard L, Wilson S, Griffin J, Pearce G, Murray IA, Lewis S.

Scand J Gastroenterol. 2018 Dec;53(12):1433-1436. doi: 10.1080/00365521.2018.1543447. Epub 2018 Dec 4.


Structural and Functional Analysis of the Gut Microbiome for Toxicologists.

Nichols RG, Cai J, Murray IA, Koo I, Smith PB, Perdew GH, Patterson AD.

Curr Protoc Toxicol. 2018 Nov;78(1):e54. doi: 10.1002/cptx.54. Epub 2018 Sep 19.


Previous Use of Antithrombotic Agents Reduces Mortality and Length of Hospital Stay in Patients With High-risk Upper Gastrointestinal Bleeding.

Dunne PDJ, Laursen SB, Laine L, Dalton HR, Ngu JH, Schultz M, Rahman A, Anderloni A, Murray IA, Stanley AJ.

Clin Gastroenterol Hepatol. 2019 Feb;17(3):440-447.e2. doi: 10.1016/j.cgh.2018.04.046. Epub 2018 Apr 26.


Oesophageal causes of dysphagia localised only to the pharynx: Implications for the suspected head and neck cancer pathway.

Nouraei SAR, Murray IA, Heathcote KJ, Dalton HR.

Clin Otolaryngol. 2018 Apr 10. doi: 10.1111/coa.13115. [Epub ahead of print]


Dietary Broccoli Impacts Microbial Community Structure and Attenuates Chemically Induced Colitis in Mice in an Ah receptor dependent manner.

Hubbard TD, Murray IA, Nichols RG, Cassel K, Podolsky M, Kuzu G, Tian Y, Smith P, Kennett MJ, Patterson AD, Perdew GH.

J Funct Foods. 2017 Oct;37:685-698. doi: 10.1016/j.jff.2017.08.038. Epub 2017 Sep 1.


International prospective observational study of upper gastrointestinal haemorrhage: Does weekend admission affect outcome?

Murray IA, Dalton HR, Stanley AJ, Ngu JH, Maybin B, Eid M, Madsen KG, Abazi R, Ashraf H, Abdelrahim M, Lissmann R, Herrod J, Khor CJ, Ong HS, Koay DS, Chin YK, Laursen SB.

United European Gastroenterol J. 2017 Dec;5(8):1082-1089. doi: 10.1177/2050640617700984. Epub 2017 Mar 16.


The non-specific adenine DNA methyltransferase M.EcoGII.

Murray IA, Morgan RD, Luyten Y, Fomenkov A, Corrêa IR Jr, Dai N, Allaw MB, Zhang X, Cheng X, Roberts RJ.

Nucleic Acids Res. 2018 Jan 25;46(2):840-848. doi: 10.1093/nar/gkx1191.


Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated skin inflammatory responses in SKH1 mice.

Smith KJ, Murray IA, Boyer JA, Perdew GH.

Toxicology. 2018 Feb 1;394:27-34. doi: 10.1016/j.tox.2017.11.020. Epub 2017 Nov 29.


Jaundice, abdominal pain, and fever in a young woman.

Norman SD, Murray IA, Shetty D, Bendall RP, Dalton HR.

Lancet. 2017 Oct 7;390(10103):1713-1714. doi: 10.1016/S0140-6736(17)31935-9. Epub 2017 Oct 5. No abstract available.


Editor's Highlight: Ah Receptor Activation Potentiates Neutrophil Chemoattractant (C-X-C Motif) Ligand 5 Expression in Keratinocytes and Skin.

Smith KJ, Boyer JA, Muku GE, Murray IA, Gowda K, Desai D, Amin SG, Glick AB, Perdew GH.

Toxicol Sci. 2017 Nov 1;160(1):83-94. doi: 10.1093/toxsci/kfx160.


Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis.

Murray IA, Perdew GH.

Curr Opin Toxicol. 2017 Feb;2:15-23. doi: 10.1016/j.cotox.2017.01.003. Epub 2017 Jan 19.


Ligand-mediated cytoplasmic retention of the Ah receptor inhibits macrophage-mediated acute inflammatory responses.

Muku GE, Lahoti TS, Murray IA, Podolsky MA, Smith KJ, Hubbard TD, Kuzu G, Gowda K, Amin SG, Perdew GH.

Lab Invest. 2017 Dec;97(12):1471-1487. doi: 10.1038/labinvest.2017.92. Epub 2017 Sep 11.


Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.

Moyer BJ, Rojas IY, Murray IA, Lee S, Hazlett HF, Perdew GH, Tomlinson CR.

Toxicol Appl Pharmacol. 2017 May 15;323:74-80. doi: 10.1016/j.taap.2017.03.012. Epub 2017 Mar 20.


Incidence and predictive factors for positive 75SeHCAT test: improving the diagnosis of bile acid diarrhoea.

Murray IA, Murray LK, Woolson KL, Sherfi H, Dixon I, Palmer J, Sulkin T.

Scand J Gastroenterol. 2017 Jun - Jul;52(6-7):698-703. doi: 10.1080/00365521.2017.1298153. Epub 2017 Mar 5.


Can patients determine the level of their dysphagia?

Ashraf HH, Palmer J, Dalton HR, Waters C, Luff T, Strugnell M, Murray IA.

World J Gastroenterol. 2017 Feb 14;23(6):1038-1043. doi: 10.3748/wjg.v23.i6.1038.


Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study.

Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB; International Gastrointestinal Bleeding Consortium.

BMJ. 2017 Jan 4;356:i6432. doi: 10.1136/bmj.i6432.


Regulation of Cytochrome P450 2B10 (CYP2B10) Expression in Liver by Peroxisome Proliferator-activated Receptor-β/δ Modulation of SP1 Promoter Occupancy.

Koga T, Yao PL, Goudarzi M, Murray IA, Balandaram G, Gonzalez FJ, Perdew GH, Fornace AJ Jr, Peters JM.

J Biol Chem. 2016 Nov 25;291(48):25255-25263. Epub 2016 Oct 20.


Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice.

Murray IA, Nichols RG, Zhang L, Patterson AD, Perdew GH.

Sci Rep. 2016 Sep 23;6:33969. doi: 10.1038/srep33969.


Divergent Ah Receptor Ligand Selectivity during Hominin Evolution.

Hubbard TD, Murray IA, Bisson WH, Sullivan AP, Sebastian A, Perry GH, Jablonski NG, Perdew GH.

Mol Biol Evol. 2016 Oct;33(10):2648-58. doi: 10.1093/molbev/msw143. Epub 2016 Aug 2.


Ligand activation of peroxisome proliferator-activated receptor-β/δ suppresses liver tumorigenesis in hepatitis B transgenic mice.

Balandaram G, Kramer LR, Kang BH, Murray IA, Perdew GH, Gonzalez FJ, Peters JM.

Toxicology. 2016 Jul 1;363-364:1-9. doi: 10.1016/j.tox.2016.07.010. Epub 2016 Jul 15.


Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression.

Girer NG, Murray IA, Omiecinski CJ, Perdew GH.

J Biol Chem. 2016 Jul 15;291(29):15378-87. doi: 10.1074/jbc.M116.715151. Epub 2016 May 25.


Incidence and features of eosinophilic esophagitis in dysphagia: a prospective observational study.

Murray IA, Joyce S, Palmer J, Lau M, Schultz M.

Scand J Gastroenterol. 2016 Mar;51(3):257-62. doi: 10.3109/00365521.2015.1093166. Epub 2015 Oct 8.


Aryl Hydrocarbon Receptor Activation Synergistically Induces Lipopolysaccharide-Mediated Expression of Proinflammatory Chemokine (c-c motif) Ligand 20.

Lahoti TS, Boyer JA, Kusnadi A, Muku GE, Murray IA, Perdew GH.

Toxicol Sci. 2015 Nov;148(1):229-40. doi: 10.1093/toxsci/kfv178. Epub 2015 Aug 10.


Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles.

Hubbard TD, Murray IA, Bisson WH, Lahoti TS, Gowda K, Amin SG, Patterson AD, Perdew GH.

Sci Rep. 2015 Aug 3;5:12689. doi: 10.1038/srep12689.


Does Preendoscopy Rockall Score Safely Identify Low Risk Patients following Upper Gastrointestinal Haemorrhage?

Johnston MR, Murray IA, Schultz M, McLeod P, O'Donnell N, Norton H, Baines C, Fawcett E, Fesaitu T, Leung H, Park JY, Salleh A, Zhang W, García JA.

Gastroenterol Res Pract. 2015;2015:410702. doi: 10.1155/2015/410702. Epub 2015 May 18.


Indole and Tryptophan Metabolism: Endogenous and Dietary Routes to Ah Receptor Activation.

Hubbard TD, Murray IA, Perdew GH.

Drug Metab Dispos. 2015 Oct;43(10):1522-35. doi: 10.1124/dmd.115.064246. Epub 2015 Jun 3. Review.


Education and imaging. Gastrointestinal: An abnormal MRI--remember the history.

Hutton MD, Strugnell M, Hopkins I, Murray IA.

J Gastroenterol Hepatol. 2015 Apr;30(4):647. doi: 10.1111/jgh.12818. No abstract available.


Persistent Organic Pollutants Modify Gut Microbiota-Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation.

Zhang L, Nichols RG, Correll J, Murray IA, Tanaka N, Smith PB, Hubbard TD, Sebastian A, Albert I, Hatzakis E, Gonzalez FJ, Perdew GH, Patterson AD.

Environ Health Perspect. 2015 Jul;123(7):679-88. doi: 10.1289/ehp.1409055. Epub 2015 Mar 13.


Restriction Cascade Exponential Amplification (RCEA) assay with an attomolar detection limit: a novel, highly specific, isothermal alternative to qPCR.

Ghindilis AL, Smith MW, Simon HM, Seoudi IA, Yazvenko NS, Murray IA, Fu X, Smith K, Jen-Jacobson L, Xu SY.

Sci Rep. 2015 Jan 13;5:7737. doi: 10.1038/srep07737.


Aryl hydrocarbon receptor ligands in cancer: friend and foe.

Murray IA, Patterson AD, Perdew GH.

Nat Rev Cancer. 2014 Dec;14(12):801-14. doi: 10.1038/nrc3846. Review.


Performance of new thresholds of the Glasgow Blatchford score in managing patients with upper gastrointestinal bleeding.

Laursen SB, Dalton HR, Murray IA, Michell N, Johnston MR, Schultz M, Hansen JM, Schaffalitzky de Muckadell OB, Blatchford O, Stanley AJ; Upper Gastrointestinal Hemorrhage International Consortium; Upper Gastrointestinal Hemorrhage International Consortium.

Clin Gastroenterol Hepatol. 2015 Jan;13(1):115-21.e2. doi: 10.1016/j.cgh.2014.07.023. Epub 2014 Jul 21.


The natural history of autoimmune hepatitis presenting with jaundice.

Panayi V, Froud OJ, Vine L, Laurent P, Woolson KL, Hunter JG, Madden RG, Miller C, Palmer J, Harris N, Mathew J, Stableforth B, Murray IA, Dalton HR.

Eur J Gastroenterol Hepatol. 2014 Jun;26(6):640-5. doi: 10.1097/MEG.0000000000000085.


Do high risk patients alter their lifestyle to reduce risk of colorectal cancer?

Tarr GP, Crowley A, John R, Kok JB, Lee HN, Mustafa H, Sii KM, Smith R, Son SE, Weaver LJ, Cameron C, Dockerty JD, Schultz M, Murray IA.

BMC Gastroenterol. 2014 Feb 7;14:22. doi: 10.1186/1471-230X-14-22.


Incidence and predictive features of pharyngeal pouch in a dysphagic population.

Murray IA, Grimes DR, Wilde AD, Palmer J, Waters C, Dalton HR.

Dysphagia. 2014 Jun;29(3):305-9. doi: 10.1007/s00455-013-9507-4. Epub 2014 Jan 3.


Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG, Perdew GH.

J Pharmacol Exp Ther. 2014 Feb;348(2):236-45. doi: 10.1124/jpet.113.209726. Epub 2013 Dec 5.


Perceived risks and benefits of surveillance colonoscopy in people undergoing surveillance for family history of colorectal cancer.

Tarr GP, Smith RA, John RA, Crowley AP, Kok JB, Lee HN, Mustafa MH, Sii KM, Son SE, Weaver LJ, Cameron C, Dockerty JD, Murray IA, Schultz M.

N Z Med J. 2013 Sep 13;126(1382):58-69.


Education and Imaging. Gastrointestinal: Capsule endoscopy of a very refractory celiac disease.

Kini GP, McAlindon ME, Schultz M, Collett J, Murray IA.

J Gastroenterol Hepatol. 2013 Aug;28(8):1254. doi: 10.1111/jgh.12298. No abstract available.


Clinical and laboratory features and natural history of seronegative hepatitis in a nontransplant centre.

Donaghy L, Barry FJ, Hunter JG, Stableforth W, Murray IA, Palmer J, Bendall RP, Elsharkawy AM, Dalton HR.

Eur J Gastroenterol Hepatol. 2013 Oct;25(10):1159-64. doi: 10.1097/MEG.0b013e3283610484.


Improved clinical outcomes and efficacy with a nurse-led dysphagia hotline service.

Murray IA, Waters C, Maskell G, Despott EJ, Palmer J, Dalton HR.

Frontline Gastroenterol. 2013 Apr;4(2):102-107. doi: 10.1136/flgastro-2012-100244. Epub 2012 Dec 14.


Aryl hydrocarbon receptor antagonism mitigates cytokine-mediated inflammatory signalling in primary human fibroblast-like synoviocytes.

Lahoti TS, John K, Hughes JM, Kusnadi A, Murray IA, Krishnegowda G, Amin S, Perdew GH.

Ann Rheum Dis. 2013 Oct;72(10):1708-16. doi: 10.1136/annrheumdis-2012-202639. Epub 2013 Jan 24.


Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing.

Fang G, Munera D, Friedman DI, Mandlik A, Chao MC, Banerjee O, Feng Z, Losic B, Mahajan MC, Jabado OJ, Deikus G, Clark TA, Luong K, Murray IA, Davis BM, Keren-Paz A, Chess A, Roberts RJ, Korlach J, Turner SW, Kumar V, Waldor MK, Schadt EE.

Nat Biotechnol. 2012 Dec;30(12):1232-9. doi: 10.1038/nbt.2432. Epub 2012 Nov 8. Erratum in: Nat Biotechnol. 2013 Jun;31(6):566.


The methylomes of six bacteria.

Murray IA, Clark TA, Morgan RD, Boitano M, Anton BP, Luong K, Fomenkov A, Turner SW, Korlach J, Roberts RJ.

Nucleic Acids Res. 2012 Dec;40(22):11450-62. doi: 10.1093/nar/gks891. Epub 2012 Oct 2. Erratum in: Nucleic Acids Res. 2014 Apr;42(6):4140.


Predictive value of symptoms and demographics in diagnosing malignancy or peptic stricture.

Murray IA, Palmer J, Waters C, Dalton HR.

World J Gastroenterol. 2012 Aug 28;18(32):4357-62. doi: 10.3748/wjg.v18.i32.4357.


Role of the Ah receptor in homeostatic control of fatty acid synthesis in the liver.

Tanos R, Murray IA, Smith PB, Patterson A, Perdew GH.

Toxicol Sci. 2012 Oct;129(2):372-9. doi: 10.1093/toxsci/kfs204. Epub 2012 Jun 13.


Selective aryl hydrocarbon receptor modulator-mediated repression of CD55 expression induced by cytokine exposure.

Narayanan GA, Murray IA, Krishnegowda G, Amin S, Perdew GH.

J Pharmacol Exp Ther. 2012 Aug;342(2):345-55. doi: 10.1124/jpet.112.193482. Epub 2012 May 2.

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