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Items: 1 to 50 of 94

1.

Countering Breast Cancer's Counterpunch.

Murray BW.

Mol Cancer Ther. 2019 Oct;18(10):1682-1683. doi: 10.1158/1535-7163.MCT-19-0875. No abstract available.

PMID:
31575758
2.

Robotic transanal minimally invasive surgery (TAMIS) with the newest robotic surgical platform: a multi-institutional North American experience.

Liu S, Suzuki T, Murray BW, Parry L, Johnson CS, Horgan S, Ramamoorthy S, Eisenstein S.

Surg Endosc. 2019 Feb;33(2):543-548. doi: 10.1007/s00464-018-6329-3. Epub 2018 Jul 13.

PMID:
30006844
3.

Selection of the sex-linked inhibitor of apoptosis in mountain pine beetle (Dendroctonus ponderosae) driven by enhanced expression during early overwintering.

Horianopoulos LC, Boone CK, Samarasekera GDNG, Kandola GK, Murray BW.

Ecol Evol. 2018 May 24;8(12):6253-6264. doi: 10.1002/ece3.4164. eCollection 2018 Jun.

4.

Discovery of a Novel and Selective Indoleamine 2,3-Dioxygenase (IDO-1) Inhibitor 3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione (EOS200271/PF-06840003) and Its Characterization as a Potential Clinical Candidate.

Crosignani S, Bingham P, Bottemanne P, Cannelle H, Cauwenberghs S, Cordonnier M, Dalvie D, Deroose F, Feng JL, Gomes B, Greasley S, Kaiser SE, Kraus M, Négrerie M, Maegley K, Miller N, Murray BW, Schneider M, Soloweij J, Stewart AE, Tumang J, Torti VR, Van Den Eynde B, Wythes M.

J Med Chem. 2017 Dec 14;60(23):9617-9629. doi: 10.1021/acs.jmedchem.7b00974. Epub 2017 Nov 21.

PMID:
29111717
5.

The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase.

Gajiwala KS, Grodsky N, Bolaños B, Feng J, Ferre R, Timofeevski S, Xu M, Murray BW, Johnson TW, Stewart A.

J Biol Chem. 2017 Sep 22;292(38):15705-15716. doi: 10.1074/jbc.M116.771485. Epub 2017 Jul 19.

6.

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR.

Planken S, Behenna DC, Nair SK, Johnson TO, Nagata A, Almaden C, Bailey S, Ballard TE, Bernier L, Cheng H, Cho-Schultz S, Dalvie D, Deal JG, Dinh DM, Edwards MP, Ferre RA, Gajiwala KS, Hemkens M, Kania RS, Kath JC, Matthews J, Murray BW, Niessen S, Orr ST, Pairish M, Sach NW, Shen H, Shi M, Solowiej J, Tran K, Tseng E, Vicini P, Wang Y, Weinrich SL, Zhou R, Zientek M, Liu L, Luo Y, Xin S, Zhang C, Lafontaine J.

J Med Chem. 2017 Apr 13;60(7):3002-3019. doi: 10.1021/acs.jmedchem.6b01894. Epub 2017 Mar 29.

PMID:
28287730
7.

Analysis of Cysteine Redox Post-Translational Modifications in Cell Biology and Drug Pharmacology.

Wani R, Murray BW.

Methods Mol Biol. 2017;1558:191-212. doi: 10.1007/978-1-4939-6783-4_9.

PMID:
28150239
8.

Adaptive and neutral markers both show continent-wide population structure of mountain pine beetle (Dendroctonus ponderosae).

Batista PD, Janes JK, Boone CK, Murray BW, Sperling FA.

Ecol Evol. 2016 Aug 8;6(17):6292-300. doi: 10.1002/ece3.2367. eCollection 2016 Sep.

9.

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.

Chen P, Lee NV, Hu W, Xu M, Ferre RA, Lam H, Bergqvist S, Solowiej J, Diehl W, He YA, Yu X, Nagata A, VanArsdale T, Murray BW.

Mol Cancer Ther. 2016 Oct;15(10):2273-2281. Epub 2016 Aug 5.

10.

Recent progress on third generation covalent EGFR inhibitors.

Cheng H, Nair SK, Murray BW.

Bioorg Med Chem Lett. 2016 Apr 15;26(8):1861-8. doi: 10.1016/j.bmcl.2016.02.067. Epub 2016 Feb 23. Review.

PMID:
26968253
11.

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.

Cheng H, Nair SK, Murray BW, Almaden C, Bailey S, Baxi S, Behenna D, Cho-Schultz S, Dalvie D, Dinh DM, Edwards MP, Feng JL, Ferre RA, Gajiwala KS, Hemkens MD, Jackson-Fisher A, Jalaie M, Johnson TO, Kania RS, Kephart S, Lafontaine J, Lunney B, Liu KK, Liu Z, Matthews J, Nagata A, Niessen S, Ornelas MA, Orr ST, Pairish M, Planken S, Ren S, Richter D, Ryan K, Sach N, Shen H, Smeal T, Solowiej J, Sutton S, Tran K, Tseng E, Vernier W, Walls M, Wang S, Weinrich SL, Xin S, Xu H, Yin MJ, Zientek M, Zhou R, Kath JC.

J Med Chem. 2016 Mar 10;59(5):2005-24. doi: 10.1021/acs.jmedchem.5b01633. Epub 2016 Jan 28.

PMID:
26756222
12.

Mitotic Checkpoint Kinase Mps1 Has a Role in Normal Physiology which Impacts Clinical Utility.

Martinez R, Blasina A, Hallin JF, Hu W, Rymer I, Fan J, Hoffman RL, Murphy S, Marx M, Yanochko G, Trajkovic D, Dinh D, Timofeevski S, Zhu Z, Sun P, Lappin PB, Murray BW.

PLoS One. 2015 Sep 23;10(9):e0138616. doi: 10.1371/journal.pone.0138616. eCollection 2015.

13.

Durability of Kinase-Directed Therapies--A Network Perspective on Response and Resistance.

Murray BW, Miller N.

Mol Cancer Ther. 2015 Sep;14(9):1975-84. doi: 10.1158/1535-7163.MCT-15-0088. Epub 2015 Aug 11. Review.

14.
15.

Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.

Pemovska T, Johnson E, Kontro M, Repasky GA, Chen J, Wells P, Cronin CN, McTigue M, Kallioniemi O, Porkka K, Murray BW, Wennerberg K.

Nature. 2015 Mar 5;519(7541):102-5. doi: 10.1038/nature14119. Epub 2015 Feb 9.

PMID:
25686603
16.

Maleimide-based method for elaboration of cysteine-containing peptide phage libraries.

Santoso B, Murray BW.

Methods Mol Biol. 2015;1248:267-76. doi: 10.1007/978-1-4939-2020-4_18. Review.

PMID:
25616339
17.

An algebraic model for the kinetics of covalent enzyme inhibition at low substrate concentrations.

Kuzmič P, Solowiej J, Murray BW.

Anal Biochem. 2015 Sep 1;484:82-90. doi: 10.1016/j.ab.2014.11.014. Epub 2014 Nov 27.

PMID:
25433146
18.

Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology.

Wani R, Nagata A, Murray BW.

Front Pharmacol. 2014 Oct 6;5:224. doi: 10.3389/fphar.2014.00224. eCollection 2014.

19.

Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.

Guo C, Hou X, Dong L, Marakovits J, Greasley S, Dagostino E, Ferre R, Johnson MC, Humphries PS, Li H, Paderes GD, Piraino J, Kraynov E, Murray BW.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4187-91. doi: 10.1016/j.bmcl.2014.07.044. Epub 2014 Jul 22.

PMID:
25091930
20.

Chemogenetic evaluation of the mitotic kinesin CENP-E reveals a critical role in triple-negative breast cancer.

Kung PP, Martinez R, Zhu Z, Zager M, Blasina A, Rymer I, Hallin J, Xu M, Carroll C, Chionis J, Wells P, Kozminski K, Fan J, Guicherit O, Huang B, Cui M, Liu C, Huang Z, Sistla A, Yang J, Murray BW.

Mol Cancer Ther. 2014 Aug;13(8):2104-15. doi: 10.1158/1535-7163.MCT-14-0083-T. Epub 2014 Jun 13.

21.

How the mountain pine beetle (Dendroctonus ponderosae) breached the Canadian Rocky Mountains.

Janes JK, Li Y, Keeling CI, Yuen MM, Boone CK, Cooke JE, Bohlmann J, Huber DP, Murray BW, Coltman DW, Sperling FA.

Mol Biol Evol. 2014 Jul;31(7):1803-15. doi: 10.1093/molbev/msu135. Epub 2014 Apr 22.

22.

Characterization of class I- and class II-like major histocompatibility complex loci in pedigrees of North Atlantic right whales.

Gillett RM, Murray BW, White BN.

J Hered. 2014 Mar-Apr;105(2):188-202. doi: 10.1093/jhered/est095. Epub 2013 Dec 31.

PMID:
24381183
23.

Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance.

Schwartz PA, Kuzmic P, Solowiej J, Bergqvist S, Bolanos B, Almaden C, Nagata A, Ryan K, Feng J, Dalvie D, Kath JC, Xu M, Wani R, Murray BW.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):173-8. doi: 10.1073/pnas.1313733111. Epub 2013 Dec 17.

24.

A simple and efficient maleimide-based approach for peptide extension with a cysteine-containing peptide phage library.

Santoso B, Lam S, Murray BW, Chen G.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5680-3. doi: 10.1016/j.bmcl.2013.08.032. Epub 2013 Aug 13.

PMID:
23992863
25.

Permanent genetic resources added to molecular ecology resources database 1 April 2013-31 May 2013.

Molecular Ecology Resources Primer Development Consortium, Agostini C, Albaladejo RG, Aparicio A, Arthofer W, Berrebi P, Boag PT, Carbone I, Conroy GC, Cortesero AM, Costa Gonçalves E, Costa D, Couto A, De Girolamo M, Du H, Fu SJ, Garrido-Garduño T, Gettová L, Gilles A, Guerreiro Hamoy I, Herrera CM, Heussler C, Isidro E, Josso C, Krapf P, Lamont RW, Le Ralec A, Lopes S, Luís C, Luo H, Mahéo F, Marino IA, Mieuzet L, Murray BW, Ogbourne SM, Pallavicini A, Parejo-Farnés C, Patarnello T, Paty C, Pereira C, Pinho C, Pinto P, Poinsot D, Powell A, Putman AI, Santoro A, Santos S, Schlick-Steiner BC, Scott C, Silvanira Barbosa M, Šimková A, Simon JC, Solé-Cava A, Steiner FM, Sun Z, Torboli V, Tredway LP, Van Coeverden de Groot PJ, Vasconcellos A, Vázquez-Domínguez E, Wang DQ, Wang YX, Wei QW, Zane L, Zhang SH.

Mol Ecol Resour. 2013 Sep;13(5):966-8. doi: 10.1111/1755-0998.12140. Erratum in: Mol Ecol Resour. 2017 May;17 (3):581.

PMID:
23937578
26.

Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.

Pitts TM, Kulikowski GN, Tan AC, Murray BW, Arcaroli JJ, Tentler JJ, Spreafico A, Selby HM, Kachaeva MI, McPhillips KL, Britt BC, Bradshaw-Pierce EL, Messersmith WA, Varella-Garcia M, Eckhardt SG.

Front Pharmacol. 2013 Mar 28;4:35. doi: 10.3389/fphar.2013.00035. eCollection 2013.

27.

Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer.

Bradshaw-Pierce EL, Pitts TM, Tan AC, McPhillips K, West M, Gustafson DL, Halsey C, Nguyen L, Lee NV, Kan JL, Murray BW, Eckhardt SG.

Front Pharmacol. 2013 Mar 22;4:22. doi: 10.3389/fphar.2013.00022. eCollection 2013.

28.

Substrate-specific conformational regulation of the receptor tyrosine kinase VEGFR2 catalytic domain.

Solowiej J, Chen JH, Zou HY, Grant SK, Murray BW.

ACS Chem Biol. 2013 May 17;8(5):978-86. doi: 10.1021/cb400040z. Epub 2013 Mar 6.

PMID:
23441851
29.

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors.

McTigue M, Murray BW, Chen JH, Deng YL, Solowiej J, Kania RS.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18281-9. doi: 10.1073/pnas.1207759109. Epub 2012 Sep 17.

30.

Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer.

Cui JJ, McTigue M, Nambu M, Tran-Dubé M, Pairish M, Shen H, Jia L, Cheng H, Hoffman J, Le P, Jalaie M, Goetz GH, Ryan K, Grodsky N, Deng YL, Parker M, Timofeevski S, Murray BW, Yamazaki S, Aguirre S, Li Q, Zou H, Christensen J.

J Med Chem. 2012 Sep 27;55(18):8091-109. Epub 2012 Sep 10. Erratum in: J Med Chem. 2012 Nov 26;55(22):10314.

PMID:
22924734
31.

Spatial genetic structure of the mountain pine beetle (Dendroctonus ponderosae) outbreak in western Canada: historical patterns and contemporary dispersal.

Gayathri Samarasekera GD, Bartell NV, Lindgren BS, Cooke JE, Davis CS, James PM, Coltman DW, Mock KE, Murray BW.

Mol Ecol. 2012 Jun;21(12):2931-48. doi: 10.1111/j.1365-294X.2012.05587.x. Epub 2012 May 3.

PMID:
22554298
32.

Discovery of pyrroloaminopyrazoles as novel PAK inhibitors.

Guo C, McAlpine I, Zhang J, Knighton DD, Kephart S, Johnson MC, Li H, Bouzida D, Yang A, Dong L, Marakovits J, Tikhe J, Richardson P, Guo LC, Kania R, Edwards MP, Kraynov E, Christensen J, Piraino J, Lee J, Dagostino E, Del-Carmen C, Deng YL, Smeal T, Murray BW.

J Med Chem. 2012 May 24;55(10):4728-39. doi: 10.1021/jm300204j. Epub 2012 May 14.

PMID:
22554206
33.

Spatial genetic structure of a symbiotic beetle-fungal system: toward multi-taxa integrated landscape genetics.

James PM, Coltman DW, Murray BW, Hamelin RC, Sperling FA.

PLoS One. 2011;6(10):e25359. doi: 10.1371/journal.pone.0025359. Epub 2011 Oct 4. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/33c0f48a-2519-4621-b7b8-a9bf84502ce5.

34.

The impact of surgical site infection on the development of incisional hernia and small bowel obstruction in colorectal surgery.

Murray BW, Cipher DJ, Pham T, Anthony T.

Am J Surg. 2011 Nov;202(5):558-60. doi: 10.1016/j.amjsurg.2011.06.014. Epub 2011 Sep 14.

PMID:
21924402
35.

Protein kinase biochemistry and drug discovery.

Schwartz PA, Murray BW.

Bioorg Chem. 2011 Dec;39(5-6):192-210. doi: 10.1016/j.bioorg.2011.07.004. Epub 2011 Aug 3. Review.

PMID:
21872901
36.

A strategy for reducing surgical backlogs: lessons from a veterans administration hospital.

Murray BW, Huerta S, Anthony T.

Am Surg. 2011 May;77(5):597-601.

PMID:
21679594
37.

Permanent genetic resources added to Molecular Ecology Resources Database 1 December 2010-31 January 2011.

Molecular Ecology Resources Primer Development Consortium, Agata K, Alasaad S, Almeida-Val VM, Alvarez-Dios JA, Barbisan F, Beadell JS, Beltrán JF, Benítez M, Bino G, Bleay C, Bloor P, Bohlmann J, Booth W, Boscari E, Caccone A, Campos T, Carvalho BM, Climaco GT, Clobert J, Congiu L, Cowger C, Dias G, Doadrio I, Farias IP, Ferrand N, Freitas PD, Fusco G, Galetti PM, Gallardo-Escárate C, Gaunt MW, Ocampo ZG, Gonçalves H, Gonzalez EG, Haye P, Honnay O, Hyseni C, Jacquemyn H, Jowers MJ, Kakezawa A, Kawaguchi E, Keeling CI, Kwan YS, La Spina M, Lee WO, Leśniewska M, Li Y, Liu H, Liu X, Lopes S, Martínez P, Meeus S, Murray BW, Nunes AG, Okedi LM, Ouma JO, Pardo BG, Parks R, Paula-Silva MN, Pedraza-Lara C, Perera OP, Pino-Querido A, Richard M, Rossini BC, Samarasekera NG, Sánchez A, Sanchez JA, Santos CH, Shinohara W, Soriguer RC, Sousa AC, Sousa CF, Stevens VM, Tejedo M, Valenzuela-Bustamante M, Van de Vliet MS, Vandepitte K, Vera M, Wandeler P, Wang W, Won YJ, Yamashiro A, Yamashiro T, Zhu C.

Mol Ecol Resour. 2011 May;11(3):586-9. doi: 10.1111/j.1755-0998.2011.03004.x. Epub 2011 Apr 1.

PMID:
21457476
38.

Phylogeography and conservation genetics of Lake Qinghai scaleless carp Gymnocypris przewalskii.

O'Bryan DM, Xie Z, Wang Y, Du J, Brauner CJ, Richards JG, Wood CM, Chen XQ, Murray BW.

J Fish Biol. 2010 Dec;77(9):2072-92. doi: 10.1111/j.1095-8649.2010.02792.x.

PMID:
21133917
39.

Evaluating an evidence-based bundle for preventing surgical site infection: a randomized trial.

Anthony T, Murray BW, Sum-Ping JT, Lenkovsky F, Vornik VD, Parker BJ, McFarlin JE, Hartless K, Huerta S.

Arch Surg. 2011 Mar;146(3):263-9. doi: 10.1001/archsurg.2010.249. Epub 2010 Nov 15.

PMID:
21079110
40.

Surgical site infection in colorectal surgery: a review of the nonpharmacologic tools of prevention.

Murray BW, Huerta S, Dineen S, Anthony T.

J Am Coll Surg. 2010 Dec;211(6):812-22. doi: 10.1016/j.jamcollsurg.2010.07.025. Epub 2010 Oct 25. Review. No abstract available.

PMID:
20980173
41.

Sexual reproduction and gene flow in the pine pathogen Dothistroma septosporum in British Columbia.

Dale AL, Lewis KJ, Murray BW.

Phytopathology. 2011 Jan;101(1):68-76. doi: 10.1094/PHYTO-04-10-0121.

42.

Rapid identification and detection of pine pathogenic fungi associated with mountain pine beetles by padlock probes.

Tsui CK, Wang B, Khadempour L, Alamouti SM, Bohlmann J, Murray BW, Hamelin RC.

J Microbiol Methods. 2010 Oct;83(1):26-33. doi: 10.1016/j.mimet.2010.07.016. Epub 2010 Jul 25.

PMID:
20650291
43.
44.

Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.

Murray BW, Guo C, Piraino J, Westwick JK, Zhang C, Lamerdin J, Dagostino E, Knighton D, Loi CM, Zager M, Kraynov E, Popoff I, Christensen JG, Martinez R, Kephart SE, Marakovits J, Karlicek S, Bergqvist S, Smeal T.

Proc Natl Acad Sci U S A. 2010 May 18;107(20):9446-51. doi: 10.1073/pnas.0911863107. Epub 2010 May 3.

45.

Structure-based design of novel human Pin1 inhibitors (II).

Dong L, Marakovits J, Hou X, Guo C, Greasley S, Dagostino E, Ferre R, Johnson MC, Kraynov E, Thomson J, Pathak V, Murray BW.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2210-4. doi: 10.1016/j.bmcl.2010.02.033. Epub 2010 Feb 14.

PMID:
20207139
46.

Structure-based design of novel human Pin1 inhibitors (I).

Guo C, Hou X, Dong L, Dagostino E, Greasley S, Ferre R, Marakovits J, Johnson MC, Matthews D, Mroczkowski B, Parge H, Vanarsdale T, Popoff I, Piraino J, Margosiak S, Thomson J, Los G, Murray BW.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5613-6. doi: 10.1016/j.bmcl.2009.08.034. Epub 2009 Aug 13.

PMID:
19729306
47.

Characterizing the effects of the juxtamembrane domain on vascular endothelial growth factor receptor-2 enzymatic activity, autophosphorylation, and inhibition by axitinib.

Solowiej J, Bergqvist S, McTigue MA, Marrone T, Quenzer T, Cobbs M, Ryan K, Kania RS, Diehl W, Murray BW.

Biochemistry. 2009 Jul 28;48(29):7019-31. doi: 10.1021/bi900522y.

PMID:
19526984
48.

PAK signaling in oncogenesis.

Molli PR, Li DQ, Murray BW, Rayala SK, Kumar R.

Oncogene. 2009 Jul 16;28(28):2545-55. doi: 10.1038/onc.2009.119. Epub 2009 May 25. Review.

49.

Enzymatic characterization of c-Met receptor tyrosine kinase oncogenic mutants and kinetic studies with aminopyridine and triazolopyrazine inhibitors.

Timofeevski SL, McTigue MA, Ryan K, Cui J, Zou HY, Zhu JX, Chau F, Alton G, Karlicek S, Christensen JG, Murray BW.

Biochemistry. 2009 Jun 16;48(23):5339-49. doi: 10.1021/bi900438w.

PMID:
19459657
50.

Isolation and characterization of 16 microsatellite loci in the mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae: Scolytinae).

Davis CS, Mock KE, Bentz BJ, Bromilow SM, Bartell NV, Murray BW, Roe AD, Cooke JE.

Mol Ecol Resour. 2009 May;9(3):1071-3. doi: 10.1111/j.1755-0998.2009.02579.x. Epub 2009 Mar 2.

PMID:
21564842

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