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Cryptic activation of an Irf8 enhancer governs cDC1 fate specification.

Durai V, Bagadia P, Granja JM, Satpathy AT, Kulkarni DH, Davidson JT 4th, Wu R, Patel SJ, Iwata A, Liu TT, Huang X, Briseño CG, Grajales-Reyes GE, Wöhner M, Tagoh H, Kee BL, Newberry RD, Busslinger M, Chang HY, Murphy TL, Murphy KM.

Nat Immunol. 2019 Sep;20(9):1161-1173. doi: 10.1038/s41590-019-0450-x. Epub 2019 Aug 12.


An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development.

Bagadia P, Huang X, Liu TT, Durai V, Grajales-Reyes GE, Nitschké M, Modrusan Z, Granja JM, Satpathy AT, Briseño CG, Gargaro M, Iwata A, Kim S, Chang HY, Shaw AS, Murphy TL, Murphy KM.

Nat Immunol. 2019 Sep;20(9):1174-1185. doi: 10.1038/s41590-019-0449-3. Epub 2019 Aug 12.


Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation.

Theisen DJ, Ferris ST, Briseño CG, Kretzer N, Iwata A, Murphy KM, Murphy TL.

Cancer Immunol Res. 2019 Jan;7(1):29-39. doi: 10.1158/2326-6066.CIR-18-0138. Epub 2018 Nov 27.


WDFY4 is required for cross-presentation in response to viral and tumor antigens.

Theisen DJ, Davidson JT 4th, Briseño CG, Gargaro M, Lauron EJ, Wang Q, Desai P, Durai V, Bagadia P, Brickner JR, Beatty WL, Virgin HW, Gillanders WE, Mosammaparast N, Diamond MS, Sibley LD, Yokoyama W, Schreiber RD, Murphy TL, Murphy KM.

Science. 2018 Nov 9;362(6415):694-699. doi: 10.1126/science.aat5030.


Notch2-dependent DC2s mediate splenic germinal center responses.

Briseño CG, Satpathy AT, Davidson JT 4th, Ferris ST, Durai V, Bagadia P, O'Connor KW, Theisen DJ, Murphy TL, Murphy KM.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10726-10731. doi: 10.1073/pnas.1809925115. Epub 2018 Oct 2.


Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice.

Durai V, Bagadia P, Briseño CG, Theisen DJ, Iwata A, Davidson JT 4th, Gargaro M, Fremont DH, Murphy TL, Murphy KM.

J Exp Med. 2018 May 7;215(5):1417-1435. doi: 10.1084/jem.20171784. Epub 2018 Mar 23.


Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo.

Anderson DA 3rd, Grajales-Reyes GE, Satpathy AT, Vasquez Hueichucura CE, Murphy TL, Murphy KM.

Eur J Immunol. 2017 Aug;47(8):1317-1323. doi: 10.1002/eji.201747050. Epub 2017 Jul 14.


Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach.

Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V, Shin EY, Song DH, Song J, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, King RA, Tischfield JA, Heiman GA, Hoekstra PJ, Dietrich A.

Eur Arch Psychiatry Clin Neurosci. 2018 Apr;268(3):301-316. doi: 10.1007/s00406-017-0808-8. Epub 2017 May 29.


Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms.

Briseño CG, Gargaro M, Durai V, Davidson JT, Theisen DJ, Anderson DA 3rd, Novack DV, Murphy TL, Murphy KM.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3957-3962. doi: 10.1073/pnas.1619863114. Epub 2017 Mar 27.


Quality of TCR signaling determined by differential affinities of enhancers for the composite BATF-IRF4 transcription factor complex.

Iwata A, Durai V, Tussiwand R, Briseño CG, Wu X, Grajales-Reyes GE, Egawa T, Murphy TL, Murphy KM.

Nat Immunol. 2017 May;18(5):563-572. doi: 10.1038/ni.3714. Epub 2017 Mar 27.


Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.

Wu X, Briseño CG, Grajales-Reyes GE, Haldar M, Iwata A, Kretzer NM, Kc W, Tussiwand R, Higashi Y, Murphy TL, Murphy KM.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14775-14780. doi: 10.1073/pnas.1611408114. Epub 2016 Dec 5.


RAB43 facilitates cross-presentation of cell-associated antigens by CD8α+ dendritic cells.

Kretzer NM, Theisen DJ, Tussiwand R, Briseño CG, Grajales-Reyes GE, Wu X, Durai V, Albring J, Bagadia P, Murphy TL, Murphy KM.

J Exp Med. 2016 Dec 12;213(13):2871-2883. Epub 2016 Nov 29.


Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells.

Wu X, Briseño CG, Durai V, Albring JC, Haldar M, Bagadia P, Kim KW, Randolph GJ, Murphy TL, Murphy KM.

J Exp Med. 2016 Nov 14;213(12):2553-2565. Epub 2016 Oct 17.


Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder.

Abdulkadir M, Tischfield JA, King RA, Fernandez TV, Brown LW, Cheon KA, Coffey BJ, de Bruijn SF, Elzerman L, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh YJ, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Messchendorp MD, Mir P, Morer A, Münchau A, Murphy TL, Openneer TJ, Plessen KJ, Rath JJ, Roessner V, Fründt O, Shin EY, Sival DA, Song DH, Song J, Stolte AM, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, State MW, Heiman GA, Hoekstra PJ, Dietrich A.

J Psychiatr Res. 2016 Nov;82:126-35. doi: 10.1016/j.jpsychires.2016.07.017. Epub 2016 Jul 22.


Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells.

Briseño CG, Haldar M, Kretzer NM, Wu X, Theisen DJ, Kc W, Durai V, Grajales-Reyes GE, Iwata A, Bagadia P, Murphy TL, Murphy KM.

Cell Rep. 2016 Jun 14;15(11):2462-74. doi: 10.1016/j.celrep.2016.05.025. Epub 2016 Jun 2.


Transcriptional Control of Dendritic Cell Development.

Murphy TL, Grajales-Reyes GE, Wu X, Tussiwand R, Briseño CG, Iwata A, Kretzer NM, Durai V, Murphy KM.

Annu Rev Immunol. 2016 May 20;34:93-119. doi: 10.1146/annurev-immunol-032713-120204. Epub 2015 Dec 23. Review.


Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor.

Grajales-Reyes GE, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, Kretzer NM, Briseño CG, Durai V, Bagadia P, Haldar M, Schönheit J, Rosenbauer F, Murphy TL, Murphy KM.

Nat Immunol. 2015 Jul;16(7):708-17. doi: 10.1038/ni.3197. Epub 2015 Jun 8.


Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses.

Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM.

Immunity. 2015 May 19;42(5):916-28. doi: 10.1016/j.immuni.2015.04.017.


Complementary diversification of dendritic cells and innate lymphoid cells.

Briseño CG, Murphy TL, Murphy KM.

Curr Opin Immunol. 2014 Aug;29:69-78. doi: 10.1016/j.coi.2014.04.006. Epub 2014 May 27. Review.


Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation.

Lin CC, Bradstreet TR, Schwarzkopf EA, Sim J, Carrero JA, Chou C, Cook LE, Egawa T, Taneja R, Murphy TL, Russell JH, Edelson BT.

Nat Commun. 2014 Apr 3;5:3551. doi: 10.1038/ncomms4551.


Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.

Haldar M, Kohyama M, So AY, Kc W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM.

Cell. 2014 Mar 13;156(6):1223-1234. doi: 10.1016/j.cell.2014.01.069.


L-Myc expression by dendritic cells is required for optimal T-cell priming.

KC W, Satpathy AT, Rapaport AS, Briseño CG, Wu X, Albring JC, Russler-Germain EV, Kretzer NM, Durai V, Persaud SP, Edelson BT, Loschko J, Cella M, Allen PM, Nussenzweig MC, Colonna M, Sleckman BP, Murphy TL, Murphy KM.

Nature. 2014 Mar 13;507(7491):243-7. doi: 10.1038/nature12967. Epub 2014 Feb 9.


Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.

Satpathy AT, Briseño CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM.

Nat Immunol. 2013 Sep;14(9):937-48. doi: 10.1038/ni.2679. Epub 2013 Aug 4.


Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks.

Murphy TL, Tussiwand R, Murphy KM.

Nat Rev Immunol. 2013 Jul;13(7):499-509. doi: 10.1038/nri3470. Epub 2013 Jun 21. Review.


A corn oil-based diet protects against combined ethanol and iron-induced liver injury in a mouse model of hemochromatosis.

Tan TC, Crawford DH, Jaskowski LA, Murphy TL, Santrampurwala N, Crane D, Clouston AD, Subramaniam VN, Anderson GJ, Fletcher LM.

Alcohol Clin Exp Res. 2013 Oct;37(10):1619-31. doi: 10.1111/acer.12155. Epub 2013 Jun 6.


Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo.

Wu X, Satpathy AT, Kc W, Liu P, Murphy TL, Murphy KM.

PLoS One. 2013 May 31;8(5):e64800. doi: 10.1371/journal.pone.0064800. Print 2013.


Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity.

Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H.

J Invest Dermatol. 2013 Mar;133(3):702-711. doi: 10.1038/jid.2012.396. Epub 2012 Nov 29.


Compensatory dendritic cell development mediated by BATF-IRF interactions.

Tussiwand R, Lee WL, Murphy TL, Mashayekhi M, KC W, Albring JC, Satpathy AT, Rotondo JA, Edelson BT, Kretzer NM, Wu X, Weiss LA, Glasmacher E, Li P, Liao W, Behnke M, Lam SS, Aurthur CT, Leonard WJ, Singh H, Stallings CL, Sibley LD, Schreiber RD, Murphy KM.

Nature. 2012 Oct 25;490(7421):502-7. doi: 10.1038/nature11531. Epub 2012 Sep 19.


BATF-JUN is critical for IRF4-mediated transcription in T cells.

Li P, Spolski R, Liao W, Wang L, Murphy TL, Murphy KM, Leonard WJ.

Nature. 2012 Oct 25;490(7421):543-6. doi: 10.1038/nature11530. Epub 2012 Sep 19.


A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes.

Glasmacher E, Agrawal S, Chang AB, Murphy TL, Zeng W, Vander Lugt B, Khan AA, Ciofani M, Spooner CJ, Rutz S, Hackney J, Nurieva R, Escalante CR, Ouyang W, Littman DR, Murphy KM, Singh H.

Science. 2012 Nov 16;338(6109):975-80. doi: 10.1126/science.1228309. Epub 2012 Sep 13.


Dual actions of Meis1 inhibit erythroid progenitor development and sustain general hematopoietic cell proliferation.

Cai M, Langer EM, Gill JG, Satpathy AT, Albring JC, KC W, Murphy TL, Murphy KM.

Blood. 2012 Jul 12;120(2):335-46. doi: 10.1182/blood-2012-01-403139. Epub 2012 Jun 4.


Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.

Satpathy AT, KC W, Albring JC, Edelson BT, Kretzer NM, Bhattacharya D, Murphy TL, Murphy KM.

J Exp Med. 2012 Jun 4;209(6):1135-52. doi: 10.1084/jem.20120030. Epub 2012 May 21.


Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.

Edelson BT, Bradstreet TR, KC W, Hildner K, Herzog JW, Sim J, Russell JH, Murphy TL, Unanue ER, Murphy KM.

PLoS One. 2011;6(10):e25660. doi: 10.1371/journal.pone.0025660. Epub 2011 Oct 17.


B and T lymphocyte attenuator restricts the protective immune response against experimental malaria.

Adler G, Steeg C, Pfeffer K, Murphy TL, Murphy KM, Langhorne J, Jacobs T.

J Immunol. 2011 Nov 15;187(10):5310-9. doi: 10.4049/jimmunol.1101456. Epub 2011 Oct 12. Erratum in: J Immunol. 2012 Jan 15;188(2):923.


CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites.

Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM.

Immunity. 2011 Aug 26;35(2):249-59. doi: 10.1016/j.immuni.2011.08.008.


CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.

Edelson BT, Bradstreet TR, Hildner K, Carrero JA, Frederick KE, KC W, Belizaire R, Aoshi T, Schreiber RD, Miller MJ, Murphy TL, Unanue ER, Murphy KM.

Immunity. 2011 Aug 26;35(2):236-48. doi: 10.1016/j.immuni.2011.06.012.


Snail promotes the cell-autonomous generation of Flk1(+) endothelial cells through the repression of the microRNA-200 family.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Murphy KM.

Stem Cells Dev. 2012 Jan 20;21(2):167-76. doi: 10.1089/scd.2011.0194. Epub 2011 Oct 18.


The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells.

Ise W, Kohyama M, Schraml BU, Zhang T, Schwer B, Basu U, Alt FW, Tang J, Oltz EM, Murphy TL, Murphy KM.

Nat Immunol. 2011 Jun;12(6):536-43. doi: 10.1038/ni.2037. Epub 2011 May 15.


Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs.

Gill JG, Langer EM, Lindsley RC, Cai M, Murphy TL, Kyba M, Murphy KM.

Stem Cells. 2011 May;29(5):764-76. doi: 10.1002/stem.628.


Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression.

Albring JC, Sandau MM, Rapaport AS, Edelson BT, Satpathy A, Mashayekhi M, Lathrop SK, Hsieh CS, Stelljes M, Colonna M, Murphy TL, Murphy KM.

J Exp Med. 2010 Nov 22;207(12):2551-9. doi: 10.1084/jem.20102017. Epub 2010 Nov 15.


Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.

Edelson BT, KC W, Juang R, Kohyama M, Benoit LA, Klekotka PA, Moon C, Albring JC, Ise W, Michael DG, Bhattacharya D, Stappenbeck TS, Holtzman MJ, Sung SS, Murphy TL, Hildner K, Murphy KM.

J Exp Med. 2010 Apr 12;207(4):823-36. doi: 10.1084/jem.20091627. Epub 2010 Mar 29.


Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM.

Murphy TL, Murphy KM.

Annu Rev Immunol. 2010;28:389-411. doi: 10.1146/annurev-immunol-030409-101202. Review.


CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms.

Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM.

Nat Immunol. 2010 Feb;11(2):129-35. doi: 10.1038/ni.1835. Epub 2009 Dec 27.


Distinct and complementary functions of MDA5 and TLR3 in poly(I:C)-mediated activation of mouse NK cells.

McCartney S, Vermi W, Gilfillan S, Cella M, Murphy TL, Schreiber RD, Murphy KM, Colonna M.

J Exp Med. 2009 Dec 21;206(13):2967-76. doi: 10.1084/jem.20091181. Epub 2009 Dec 7.


Activation-induced accumulation of B and T lymphocyte attenuator at the immunological synapse in CD4+ T cells.

Owada T, Watanabe N, Oki M, Oya Y, Saito Y, Saito T, Iwamoto I, Murphy TL, Murphy KM, Nakajima H.

J Leukoc Biol. 2010 Mar;87(3):425-32. doi: 10.1189/jlb.0309138. Epub 2009 Nov 5.


Interleukin-10 production by Th1 cells requires interleukin-12-induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose.

Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, O'Garra A.

Immunity. 2009 Aug 21;31(2):209-19. doi: 10.1016/j.immuni.2009.05.012. Epub 2009 Jul 30.


The AP-1 transcription factor Batf controls T(H)17 differentiation.

Schraml BU, Hildner K, Ise W, Lee WL, Smith WA, Solomon B, Sahota G, Sim J, Mukasa R, Cemerski S, Hatton RD, Stormo GD, Weaver CT, Russell JH, Murphy TL, Murphy KM.

Nature. 2009 Jul 16;460(7253):405-9. doi: 10.1038/nature08114. Epub 2009 Jul 5.


Hepcidin regulation in wild-type and Hfe knockout mice in response to alcohol consumption: evidence for an alcohol-induced hypoxic response.

Heritage ML, Murphy TL, Bridle KR, Anderson GJ, Crawford DH, Fletcher LM.

Alcohol Clin Exp Res. 2009 Aug;33(8):1391-400. doi: 10.1111/j.1530-0277.2009.00969.x. Epub 2009 May 4.


Serum hyaluronic acid with serum ferritin accurately predicts cirrhosis and reduces the need for liver biopsy in C282Y hemochromatosis.

Crawford DH, Murphy TL, Ramm LE, Fletcher LM, Clouston AD, Anderson GJ, Subramaniam VN, Powell LW, Ramm GA.

Hepatology. 2009 Feb;49(2):418-25. doi: 10.1002/hep.22650.


Definitive establishment of airway control is critical for optimal outcome in lower cervical spinal cord injury.

Hassid VJ, Schinco MA, Tepas JJ, Griffen MM, Murphy TL, Frykberg ER, Kerwin AJ.

J Trauma. 2008 Dec;65(6):1328-32. doi: 10.1097/TA.0b013e31818d07e4.


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