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Junctional membrane Ca2+ dynamics in human muscle fibers are altered by malignant hyperthermia causative RyR mutation.

Cully TR, Choi RH, Bjorksten AR, Stephenson DG, Murphy RM, Launikonis BS.

Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8215-8220. doi: 10.1073/pnas.1800490115. Epub 2018 Jul 23.


Retinol-Binding Protein Interferes with Transthyretin-Mediated β-Amyloid Aggregation Inhibition.

Mangrolia P, Murphy RM.

Biochemistry. 2018 Aug 21;57(33):5029-5040. doi: 10.1021/acs.biochem.8b00517. Epub 2018 Aug 1.


Physiological and biochemical characteristics of skeletal muscles in sedentary and active rats.

Xu H, Ren X, Lamb GD, Murphy RM.

J Muscle Res Cell Motil. 2018 Jun 15. doi: 10.1007/s10974-018-9493-0. [Epub ahead of print]


Cold-water immersion after training sessions: effects on fiber type-specific adaptations in muscle K+ transport proteins to sprint-interval training in men.

Christiansen D, Bishop DJ, Broatch JR, Bangsbo J, McKenna MJ, Murphy RM.

J Appl Physiol (1985). 2018 Aug 1;125(2):429-444. doi: 10.1152/japplphysiol.00259.2018. Epub 2018 May 10.


Nanoparticle Tracking for Protein Aggregation Research.

Lu X, Murphy RM.

Methods Mol Biol. 2018;1777:145-158. doi: 10.1007/978-1-4939-7811-3_7.


Abundance of ClC-1 chloride channel in human skeletal muscle: fiber type specific differences and effect of training.

Thomassen M, Hostrup M, Murphy RM, Cromer BA, Skovgaard C, Gunnarsson TP, Christensen PM, Bangsbo J.

J Appl Physiol (1985). 2018 Aug 1;125(2):470-478. doi: 10.1152/japplphysiol.01042.2017. Epub 2018 May 3.


Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches.

Pate KM, Kim BJ, Shusta EV, Murphy RM.

ChemMedChem. 2018 May 8;13(9):968-979. doi: 10.1002/cmdc.201800031. Epub 2018 Apr 16.


Increased FXYD1 and PGC-1α mRNA after blood flow-restricted running is related to fibre type-specific AMPK signalling and oxidative stress in human muscle.

Christiansen D, Murphy RM, Bangsbo J, Stathis CG, Bishop DJ.

Acta Physiol (Oxf). 2018 Jun;223(2):e13045. doi: 10.1111/apha.13045. Epub 2018 Feb 27.


Mitochondrial content is preserved throughout disease progression in the mdx mouse model of Duchenne muscular dystrophy, regardless of taurine supplementation.

Barker RG, Wyckelsma VL, Xu H, Murphy RM.

Am J Physiol Cell Physiol. 2018 Apr 1;314(4):C483-C491. doi: 10.1152/ajpcell.00046.2017. Epub 2017 Dec 20.


Benefits of Prenatal Taurine Supplementation in Preventing the Onset of Acute Damage in the Mdx Mouse.

Barker RG, Horvath D, van der Poel C, Murphy RM.

PLoS Curr. 2017 Sep 22;9. pii: doi: 10.1371/


Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months.

Xu H, Lamb GD, Murphy RM.

J Muscle Res Cell Motil. 2017 Dec;38(5-6):405-420. doi: 10.1007/s10974-017-9484-6. Epub 2017 Nov 28.


Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity.

Pate KM, Murphy RM.

Isr J Chem. 2017 Jul;57(7-8):602-612. doi: 10.1002/ijch.201600078. Epub 2017 Jan 18.


A mechanistic model to predict effects of cathepsin B and cystatin C on β-amyloid aggregation and degradation.

Perlenfein TJ, Murphy RM.

J Biol Chem. 2017 Dec 22;292(51):21071-21082. doi: 10.1074/jbc.M117.811448. Epub 2017 Oct 18.


Effect of androgen deprivation therapy on the contractile properties of type I and type II skeletal muscle fibres in men with non-metastatic prostate cancer.

Lamboley CR, Xu H, Dutka TL, Hanson ED, Hayes A, Violet JA, Murphy RM, Lamb GD.

Clin Exp Pharmacol Physiol. 2018 Feb;45(2):146-154. doi: 10.1111/1440-1681.12873. Epub 2017 Nov 28.


Reply to "Letter to the editor: Comments on Wette et al. (2017): 'Characterization of muscle ankyrin repeat proteins in human skeletal muscle'".

Wette SG, Smith HK, Lamb GD, Murphy RM.

Am J Physiol Cell Physiol. 2017 Oct 1;313(4):C471-C472. doi: 10.1152/ajpcell.00180.2017. No abstract available.


All-optical nanopositioning of high-Q silica microspheres.

Murphy RMJ, Lei F, Ward JM, Yang Y, Chormaic SN.

Opt Express. 2017 Jun 12;25(12):13101-13106. doi: 10.1364/OE.25.013101.


Preaged remodeling of myofibrillar cytoarchitecture in skeletal muscle expressing R349P mutant desmin.

Diermeier S, Buttgereit A, Schürmann S, Winter L, Xu H, Murphy RM, Clemen CS, Schröder R, Friedrich O.

Neurobiol Aging. 2017 Oct;58:77-87. doi: 10.1016/j.neurobiolaging.2017.06.001. Epub 2017 Jun 13.


Characterization of muscle ankyrin repeat proteins in human skeletal muscle.

Wette SG, Smith HK, Lamb GD, Murphy RM.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C327-C339. doi: 10.1152/ajpcell.00077.2017. Epub 2017 Jun 14.


Insights into the mechanism of cystatin C oligomer and amyloid formation and its interaction with β-amyloid.

Perlenfein TJ, Mehlhoff JD, Murphy RM.

J Biol Chem. 2017 Jul 7;292(27):11485-11498. doi: 10.1074/jbc.M117.786558. Epub 2017 May 9.


Intense interval training in healthy older adults increases skeletal muscle [3H]ouabain-binding site content and elevates Na+,K+-ATPase α2 isoform abundance in Type II fibers.

Wyckelsma VL, Levinger I, Murphy RM, Petersen AC, Perry BD, Hedges CP, Anderson MJ, McKenna MJ.

Physiol Rep. 2017 Apr;5(7). pii: e13219. doi: 10.14814/phy2.13219.


Preservation of skeletal muscle mitochondrial content in older adults: relationship between mitochondria, fibre type and high-intensity exercise training.

Wyckelsma VL, Levinger I, McKenna MJ, Formosa LE, Ryan MT, Petersen AC, Anderson MJ, Murphy RM.

J Physiol. 2017 Jun 1;595(11):3345-3359. doi: 10.1113/JP273950. Epub 2017 Apr 23.


Human skeletal muscle plasmalemma alters its structure to change its Ca2+-handling following heavy-load resistance exercise.

Cully TR, Murphy RM, Roberts L, Raastad T, Fassett RG, Coombes JS, Jayasinghe ID, Launikonis BS.

Nat Commun. 2017 Feb 13;8:14266. doi: 10.1038/ncomms14266.


S-nitrosylation and S-glutathionylation of Cys134 on troponin I have opposing competitive actions on Ca2+ sensitivity in rat fast-twitch muscle fibers.

Dutka TL, Mollica JP, Lamboley CR, Weerakkody VC, Greening DW, Posterino GS, Murphy RM, Lamb GD.

Am J Physiol Cell Physiol. 2017 Mar 1;312(3):C316-C327. doi: 10.1152/ajpcell.00334.2016. Epub 2016 Dec 14.


Store-Operated Ca2+ Entry (SOCE) and Purinergic Receptor-Mediated Ca2+ Homeostasis in Murine bv2 Microglia Cells: Early Cellular Responses to ATP-Mediated Microglia Activation.

Gilbert DF, Stebbing MJ, Kuenzel K, Murphy RM, Zacharewicz E, Buttgereit A, Stokes L, Adams DJ, Friedrich O.

Front Mol Neurosci. 2016 Oct 28;9:111. eCollection 2016.


Insights into the role and regulation of TCTP in skeletal muscle.

Goodman CA, Coenen AM, Frey JW, You JS, Barker RG, Frankish BP, Murphy RM, Hornberger TA.

Oncotarget. 2017 Mar 21;8(12):18754-18772. doi: 10.18632/oncotarget.13009.


Dissociation between short-term unloading and resistance training effects on skeletal muscle Na+,K+-ATPase, muscle function, and fatigue in humans.

Perry BD, Wyckelsma VL, Murphy RM, Steward CH, Anderson M, Levinger I, Petersen AC, McKenna MJ.

J Appl Physiol (1985). 2016 Nov 1;121(5):1074-1086. doi: 10.1152/japplphysiol.00558.2016. Epub 2016 Sep 15.


The effect of taurine and β-alanine supplementation on taurine transporter protein and fatigue resistance in skeletal muscle from mdx mice.

Horvath DM, Murphy RM, Mollica JP, Hayes A, Goodman CA.

Amino Acids. 2016 Nov;48(11):2635-2645. Epub 2016 Jul 21.


Superior mitochondrial adaptations in human skeletal muscle after interval compared to continuous single-leg cycling matched for total work.

MacInnis MJ, Zacharewicz E, Martin BJ, Haikalis ME, Skelly LE, Tarnopolsky MA, Murphy RM, Gibala MJ.

J Physiol. 2017 May 1;595(9):2955-2968. doi: 10.1113/JP272570. Epub 2016 Aug 3.


TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides.

Lu X, Brickson CR, Murphy RM.

ACS Chem Neurosci. 2016 Sep 21;7(9):1264-74. doi: 10.1021/acschemneuro.6b00150. Epub 2016 Jul 11.


Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training.

Mohktar RA, Montgomery MK, Murphy RM, Watt MJ.

Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1):E128-37. doi: 10.1152/ajpendo.00084.2016. Epub 2016 May 17.


Transthyretin variants with improved inhibition of β-amyloid aggregation.

Mangrolia P, Yang DT, Murphy RM.

Protein Eng Des Sel. 2016 Jun;29(6):209-218. doi: 10.1093/protein/gzw008. Epub 2016 Apr 19.


When phosphorylated at Thr148, the β2-subunit of AMP-activated kinase does not associate with glycogen in skeletal muscle.

Xu H, Frankenberg NT, Lamb GD, Gooley PR, Stapleton DI, Murphy RM.

Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C35-42. doi: 10.1152/ajpcell.00047.2016. Epub 2016 Apr 20.


A quantitative description of tubular system Ca(2+) handling in fast- and slow-twitch muscle fibres.

Cully TR, Edwards JN, Murphy RM, Launikonis BS.

J Physiol. 2016 Jun 1;594(11):2795-810. doi: 10.1113/JP271658. Epub 2016 Feb 29.


Cell specific differences in the protein abundances of GAPDH and Na(+),K(+)-ATPase in skeletal muscle from aged individuals.

Wyckelsma VL, McKenna MJ, Levinger I, Petersen AC, Lamboley CR, Murphy RM.

Exp Gerontol. 2016 Mar;75:8-15. doi: 10.1016/j.exger.2015.12.010. Epub 2015 Dec 31.


Q&A: repeat-containing proteins.

Murphy RM.

Nat Struct Mol Biol. 2015 Dec;22(12):943-5. doi: 10.1038/nsmb.3135. No abstract available.


Ca(2+) leakage out of the sarcoplasmic reticulum is increased in type I skeletal muscle fibres in aged humans.

Lamboley CR, Wyckelsma VL, McKenna MJ, Murphy RM, Lamb GD.

J Physiol. 2016 Jan 15;594(2):469-81. doi: 10.1113/JP271382. Epub 2015 Dec 14.


Expression, purification, and characterization of human cystatin C monomers and oligomers.

Perlenfein TJ, Murphy RM.

Protein Expr Purif. 2016 Jan;117:35-43. doi: 10.1016/j.pep.2015.09.023. Epub 2015 Sep 25.


Maternal Nutrient Restriction Alters Ca2+ Handling Properties and Contractile Function of Isolated Left Ventricle Bundles in Male But Not Female Juvenile Rats.

Harvey TJ, Murphy RM, Morrison JL, Posterino GS.

PLoS One. 2015 Sep 25;10(9):e0138388. doi: 10.1371/journal.pone.0138388. eCollection 2015.


Asparagine Repeat Peptides: Aggregation Kinetics and Comparison with Glutamine Repeats.

Lu X, Murphy RM.

Biochemistry. 2015 Aug 11;54(31):4784-94. doi: 10.1021/acs.biochem.5b00644. Epub 2015 Jul 31.


Drug-induced Bilateral Secondary Angle-Closure Glaucoma: A Literature Synthesis.

Murphy RM, Bakir B, O'Brien C, Wiggs JL, Pasquale LR.

J Glaucoma. 2016 Feb;25(2):e99-105. doi: 10.1097/IJG.0000000000000270. Review.


Rat skeletal muscle glycogen degradation pathways reveal differential association of glycogen-related proteins with glycogen granules.

Xu H, Stapleton D, Murphy RM.

J Physiol Biochem. 2015 Jun;71(2):267-80. doi: 10.1007/s13105-015-0407-y. Epub 2015 Apr 15.


Clarity for 5'-AMP-activated protein kinase--dissecting out human skeletal muscle responses to exercise.

Murphy RM.

J Physiol. 2015 Apr 15;593(8):1769-70. doi: 10.1113/JP270272. No abstract available.


Evaluation of Nanoparticle Tracking for Characterization of Fibrillar Protein Aggregates.

Yang DT, Lu X, Fan Y, Murphy RM.

AIChE J. 2014 Apr 1;60(4):1236-1244.


Contractile properties and sarcoplasmic reticulum calcium content in type I and type II skeletal muscle fibres in active aged humans.

Lamboley CR, Wyckelsma VL, Dutka TL, McKenna MJ, Murphy RM, Lamb GD.

J Physiol. 2015 Jun 1;593(11):2499-514. doi: 10.1113/JP270179. Epub 2015 Apr 17.


Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice.

Hong YH, Frugier T, Zhang X, Murphy RM, Lynch GS, Betik AC, Rattigan S, McConell GK.

J Appl Physiol (1985). 2015 May 1;118(9):1113-21. doi: 10.1152/japplphysiol.00056.2015. Epub 2015 Mar 6.


A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin.

Cho PY, Joshi G, Boersma MD, Johnson JA, Murphy RM.

ACS Chem Neurosci. 2015 May 20;6(5):778-89. doi: 10.1021/cn500272a. Epub 2015 Mar 9.


Single-fiber expression and fiber-specific adaptability to short-term intense exercise training of Na+-K+-ATPase α- and β-isoforms in human skeletal muscle.

Wyckelsma VL, McKenna MJ, Serpiello FR, Lamboley CR, Aughey RJ, Stepto NK, Bishop DJ, Murphy RM.

J Appl Physiol (1985). 2015 Mar 15;118(6):699-706. doi: 10.1152/japplphysiol.00419.2014. Epub 2015 Jan 22.


Skeletal muscle atrophy in sedentary Zucker obese rats is not caused by calpain-mediated muscle damage or lipid peroxidation induced by oxidative stress.

Pompeani N, Rybalka E, Latchman H, Murphy RM, Croft K, Hayes A.

J Negat Results Biomed. 2014 Dec 30;13:19. doi: 10.1186/s12952-014-0019-z.


Mechanisms of exercise intolerance in heart failure with preserved ejection fraction: the role of abnormal peripheral oxygen extraction.

Dhakal BP, Malhotra R, Murphy RM, Pappagianopoulos PP, Baggish AL, Weiner RB, Houstis NE, Eisman AS, Hough SS, Lewis GD.

Circ Heart Fail. 2015 Mar;8(2):286-94. doi: 10.1161/CIRCHEARTFAILURE.114.001825. Epub 2014 Oct 24.

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