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Items: 1 to 50 of 121

1.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

2.

Defining new mechanistic roles for αII spectrin in cardiac function.

Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud G, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ.

J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7.

PMID:
31064843
3.

Letter to the Editor: "Alemtuzumab-Induced Thyroid Dysfunction Exhibits Distinctive Clinical and Immunological Features".

Garrahy A, Murphy NP, Byrne MM.

J Clin Endocrinol Metab. 2019 Sep 1;104(9):3624-3625. doi: 10.1210/jc.2018-02435. No abstract available.

PMID:
30977837
4.

Protein Phosphatase 2A Regulates Cardiac Na+ Channels.

El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ.

Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350.

PMID:
30602331
5.

Optimal Timing of Repeat Newborn Screening for Congenital Hypothyroidism in Preterm Infants to Detect Delayed Thyroid-Stimulating Hormone Elevation.

McGrath N, Hawkes CP, Mayne P, Murphy NP.

J Pediatr. 2019 Feb;205:77-82. doi: 10.1016/j.jpeds.2018.09.044. Epub 2018 Oct 24.

PMID:
30529133
6.

Are We Adhering To Paediatric DKA Guidelines?

Powell A, Carroll A, Mc Donnell CM, Murphy NP.

Ir Med J. 2018 Apr 19;111(4):745. No abstract available.

PMID:
30468365
7.

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.

8.

Incidence of Congenital Hypothyroidism Over 37 Years in Ireland.

McGrath N, Hawkes CP, McDonnell CM, Cody D, O'Connell SM, Mayne PD, Murphy NP.

Pediatrics. 2018 Oct;142(4). pii: e20181199. doi: 10.1542/peds.2018-1199.

9.

Junk Food Exposure Disrupts Selection of Food-Seeking Actions in Rats.

Kosheleff AR, Araki J, Tsan L, Chen G, Murphy NP, Maidment NT, Ostlund SB.

Front Psychiatry. 2018 Aug 16;9:350. doi: 10.3389/fpsyt.2018.00350. eCollection 2018.

10.

Outcomes of using flash glucose monitoring technology by children and young people with type 1 diabetes in a single arm study.

Campbell FM, Murphy NP, Stewart C, Biester T, Kordonouri O.

Pediatr Diabetes. 2018 Nov;19(7):1294-1301. doi: 10.1111/pedi.12735. Epub 2018 Aug 29.

PMID:
30054967
11.

Paediatric Type 2 Diabetes Still Rare in an Irish Tertiary Referral Unit.

Kernan R, Carroll A, McGrath N, Donnell CM, Murphy NP.

Ir Med J. 2018 Jan 10;111(1):679.

PMID:
29869860
12.

Coeliac screening in a high-risk population: paediatric type 1 diabetes-a review of current guidelines and practice.

Forde L, McGrath N, Devaney D, Awadalla S, McDonnell CM, Murphy NP.

Ir J Med Sci. 2019 Feb;188(1):135-139. doi: 10.1007/s11845-018-1831-0. Epub 2018 May 31.

PMID:
29855860
13.

Permanent Decompensated Congenital Hypothyroidism in Newborns with Whole-Blood Thyroid-Stimulating Hormone Concentrations between 8 and 10 mU/L: The Case for Lowering the Threshold.

McGrath N, Hawkes CP, Mayne P, Murphy NP.

Horm Res Paediatr. 2018;89(4):265-270. doi: 10.1159/000488288. Epub 2018 May 25.

PMID:
29804122
14.

Encapsulated oligodendrocyte precursor cell fate is dependent on PDGF-AA release kinetics in a 3D microparticle-hydrogel drug delivery system.

Pinezich MR, Russell LN, Murphy NP, Lampe KJ.

J Biomed Mater Res A. 2018 Sep;106(9):2402-2411. doi: 10.1002/jbm.a.36432. Epub 2018 May 14.

PMID:
29660252
15.

Pattern of access determines influence of junk food diet on cue sensitivity and palatability.

Kosheleff AR, Araki J, Hsueh J, Le A, Quizon K, Ostlund SB, Maidment NT, Murphy NP.

Appetite. 2018 Apr 1;123:135-145. doi: 10.1016/j.appet.2017.12.009. Epub 2017 Dec 14.

16.

Temporal genetic patterns of diversity and structure evidence chaotic genetic patchiness in a spiny lobster.

Villacorta-Rath C, Souza CA, Murphy NP, Green BS, Gardner C, Strugnell JM.

Mol Ecol. 2018 Jan;27(1):54-65. doi: 10.1111/mec.14427. Epub 2017 Dec 9.

PMID:
29134719
17.
18.

Sex-specific enhancement of palatability-driven feeding in adolescent rats.

Marshall AT, Liu AT, Murphy NP, Maidment NT, Ostlund SB.

PLoS One. 2017 Jul 14;12(7):e0180907. doi: 10.1371/journal.pone.0180907. eCollection 2017.

19.

Sensor Augmented Pump Therapy Use in Type 1 Diabetes Mellitus.

Carolan E, Murphy NP.

Ir Med J. 2016 Dec 12;109(10):477. No abstract available.

PMID:
28644582
20.

Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus.

Mavinkurve M, McGrath N, Johnston N, Moloney S, Murphy NP, Hawkes CP.

J Pediatr Endocrinol Metab. 2017 May 24;30(6):623-628. doi: 10.1515/jpem-2017-0051.

PMID:
28599389
21.

Advancements in the use of gene therapy for cardiac arrhythmia.

Murphy NP, Lubbers ER, Mohler PJ.

Heart Rhythm. 2017 Jul;14(7):1061-1062. doi: 10.1016/j.hrthm.2017.03.041. Epub 2017 Apr 4. No abstract available.

22.

Ts1Cje Down syndrome model mice exhibit environmental stimuli-triggered locomotor hyperactivity and sociability concurrent with increased flux through central dopamine and serotonin metabolism.

Shimohata A, Ishihara K, Hattori S, Miyamoto H, Morishita H, Ornthanalai G, Raveau M, Ebrahim AS, Amano K, Yamada K, Sago H, Akiba S, Mataga N, Murphy NP, Miyakawa T, Yamakawa K.

Exp Neurol. 2017 Jul;293:1-12. doi: 10.1016/j.expneurol.2017.03.009. Epub 2017 Mar 20.

PMID:
28336394
23.

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.

Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001537. doi: 10.1161/CIRCGENETICS.116.001537.

24.

A Rasch Analysis of the Charcot-Marie-Tooth Neuropathy Score (CMTNS) in a Cohort of Charcot-Marie-Tooth Type 1A Patients.

Wang W, Guedj M, Bertrand V, Foucquier J, Jouve E, Commenges D, Proust-Lima C, Murphy NP, Blin O, Magy L, Cohen D, Attarian S.

PLoS One. 2017 Jan 17;12(1):e0169878. doi: 10.1371/journal.pone.0169878. eCollection 2017.

25.

Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.

Richter F, Gabby L, McDowell KA, Mulligan CK, De La Rosa K, Sioshansi PC, Mortazavi F, Cely I, Ackerson LC, Tsan L, Murphy NP, Maidment NT, Chesselet MF.

Neurobiol Aging. 2017 Mar;51:54-66. doi: 10.1016/j.neurobiolaging.2016.11.015. Epub 2016 Dec 1.

26.

Expanding the clinical spectrum of chromosome 15q26 terminal deletions associated with IGF-1 resistance.

O'Riordan AM, McGrath N, Sharif F, Murphy NP, Franklin O, Lynch SA, O'Grady MJ.

Eur J Pediatr. 2017 Jan;176(1):137-142. doi: 10.1007/s00431-016-2802-y. Epub 2016 Nov 8.

PMID:
27826649
27.

Analyzing negative feedback using a synthetic gene network expressed in the Drosophila melanogaster embryo.

Jermusyk AA, Murphy NP, Reeves GT.

BMC Syst Biol. 2016 Aug 31;10(1):85. doi: 10.1186/s12918-016-0330-z.

28.

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ.

Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11.

PMID:
27298202
29.

Parsing the hedonic and motivational influences of nociceptin on feeding using licking microstructure analysis in mice.

Mendez IA, Maidment NT, Murphy NP.

Behav Pharmacol. 2016 Sep;27(6):516-27. doi: 10.1097/FBP.0000000000000240.

30.

Microglia disrupt mesolimbic reward circuitry in chronic pain.

Taylor AM, Castonguay A, Taylor AJ, Murphy NP, Ghogha A, Cook C, Xue L, Olmstead MC, De Koninck Y, Evans CJ, Cahill CM.

J Neurosci. 2015 Jun 3;35(22):8442-50. doi: 10.1523/JNEUROSCI.4036-14.2015.

31.

Defining the links between oxidative stress-based biomarkers and postoperative atrial fibrillation.

Lubbers ER, Murphy NP, Mohler PJ.

J Am Heart Assoc. 2015 May 20;4(5). pii: 002110. doi: 10.1161/JAHA.115.002110. No abstract available.

32.

Involvement of Endogenous Enkephalins and β-Endorphin in Feeding and Diet-Induced Obesity.

Mendez IA, Ostlund SB, Maidment NT, Murphy NP.

Neuropsychopharmacology. 2015 Aug;40(9):2103-12. doi: 10.1038/npp.2015.67. Epub 2015 Mar 10.

33.

Sideroblastic anaemia and primary adrenal insufficiency due to a mitochondrial respiratory chain disorder in the absence of mtDNA deletion.

O'Grady MJ, Monavari AA, Cotter M, Murphy NP.

BMJ Case Rep. 2015 Feb 26;2015. pii: bcr2014208514. doi: 10.1136/bcr-2014-208514.

34.

Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.

Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH.

Sci Transl Med. 2015 Jan 21;7(271):271ra8. doi: 10.1126/scitranslmed.3010257.

35.

Dynamic measurement of extracellular opioid activity: status quo, challenges, and significance in rewarded behaviors.

Murphy NP.

ACS Chem Neurosci. 2015 Jan 21;6(1):94-107. doi: 10.1021/cn500295q. Epub 2015 Jan 13. Review.

PMID:
25585132
36.

Operant assays for assessing pain in preclinical rodent models: highlights from an orofacial assay.

Murphy NP, Mills RH, Caudle RM, Neubert JK.

Curr Top Behav Neurosci. 2014;20:121-45. doi: 10.1007/7854_2014_332.

PMID:
25103871
37.

Correlation between ventral striatal catecholamine content and nociceptive thresholds in neuropathic mice.

Taylor AM, Murphy NP, Evans CJ, Cahill CM.

J Pain. 2014 Aug;15(8):878-85. doi: 10.1016/j.jpain.2014.05.006. Epub 2014 Jun 2.

38.

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.

Flanagan SE, Haapaniemi E, Russell MA, Caswell R, Allen HL, De Franco E, McDonald TJ, Rajala H, Ramelius A, Barton J, Heiskanen K, Heiskanen-Kosma T, Kajosaari M, Murphy NP, Milenkovic T, Seppänen M, Lernmark Å, Mustjoki S, Otonkoski T, Kere J, Morgan NG, Ellard S, Hattersley AT.

Nat Genet. 2014 Aug;46(8):812-814. doi: 10.1038/ng.3040. Epub 2014 Jul 20.

39.

Vitamin D status in Irish children and adolescents: value of fortification and supplementation.

Carroll A, Onwuneme C, McKenna MJ, Mayne PD, Molloy EJ, Murphy NP.

Clin Pediatr (Phila). 2014 Dec;53(14):1345-51. doi: 10.1177/0009922814541999. Epub 2014 Jul 7.

PMID:
25006113
40.

Paediatric type 1 diabetes in Ireland--results of the first national audit.

Hawkes CP, Murphy NP.

Ir Med J. 2014 Apr;107(4):102-4.

PMID:
24834580
41.

The redistribution of Drosophila vesicular monoamine transporter mutants from synaptic vesicles to large dense-core vesicles impairs amine-dependent behaviors.

Grygoruk A, Chen A, Martin CA, Lawal HO, Fei H, Gutierrez G, Biedermann T, Najibi R, Hadi R, Chouhan AK, Murphy NP, Schweizer FE, Macleod GT, Maidment NT, Krantz DE.

J Neurosci. 2014 May 14;34(20):6924-37. doi: 10.1523/JNEUROSCI.0694-14.2014.

42.

Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.

Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW.

Nat Neurosci. 2014 Feb;17(2):254-61. doi: 10.1038/nn.3622. Epub 2014 Jan 12.

43.

Low-coverage MiSeq next generation sequencing reveals the mitochondrial genome of the Eastern Rock Lobster, Sagmariasus verreauxi.

Doyle SR, Griffith IS, Murphy NP, Strugnell JM.

Mitochondrial DNA. 2015;26(6):844-5. doi: 10.3109/19401736.2013.855921. Epub 2014 Jan 10.

PMID:
24409935
44.

Investigation of genetic structure between deep and shallow populations of the southern Rock Lobster, Jasus edwardsii in Tasmania, Australia.

Morgan EM, Green BS, Murphy NP, Strugnell JM.

PLoS One. 2013 Oct 18;8(10):e77978. doi: 10.1371/journal.pone.0077978. eCollection 2013.

45.

Rines E3 ubiquitin ligase regulates MAO-A levels and emotional responses.

Kabayama M, Sakoori K, Yamada K, Ornthanalai VG, Ota M, Morimura N, Katayama K, Murphy NP, Aruga J.

J Neurosci. 2013 Aug 7;33(32):12940-53. doi: 10.1523/JNEUROSCI.5717-12.2013.

46.

The evolving course of HNF4A hyperinsulinaemic hypoglycaemia--a case series.

McGlacken-Byrne SM, Hawkes CP, Flanagan SE, Ellard S, McDonnell CM, Murphy NP.

Diabet Med. 2014 Jan;31(1):e1-5. doi: 10.1111/dme.12259.

PMID:
23796040
47.

Short stature in child with early-onset diabetes.

Hawkes CP, McGlacken-Byrne SM, Murphy NP.

Eur J Pediatr. 2013 Sep;172(9):1255-7. doi: 10.1007/s00431-013-2007-6. Epub 2013 May 5.

PMID:
23644647
48.

Targeted deletion of the mouse α2 nicotinic acetylcholine receptor subunit gene (Chrna2) potentiates nicotine-modulated behaviors.

Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J.

J Neurosci. 2013 May 1;33(18):7728-41. doi: 10.1523/JNEUROSCI.4731-12.2013.

49.

Decreased consumption of sweet fluids in μ opioid receptor knockout mice: a microstructural analysis of licking behavior.

Ostlund SB, Kosheleff A, Maidment NT, Murphy NP.

Psychopharmacology (Berl). 2013 Sep;229(1):105-13. doi: 10.1007/s00213-013-3077-x. Epub 2013 Apr 9.

50.

Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.

Kobayashi Y, Sano Y, Vannoni E, Goto H, Suzuki H, Oba A, Kawasaki H, Kanba S, Lipp HP, Murphy NP, Wolfer DP, Itohara S.

Front Behav Neurosci. 2013 Mar 12;7:17. doi: 10.3389/fnbeh.2013.00017. eCollection 2013.

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