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Items: 1 to 50 of 618

1.

Correction: Control of mitochondrial superoxide production by reverse electron transport at complex I.

Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP.

J Biol Chem. 2019 May 10;294(19):7966. doi: 10.1074/jbc.AAC119.008929. No abstract available.

2.

Detection of changes in mitochondrial hydrogen sulfide i n vivo in the fish model Poecilia mexicana (Poeciliidae).

Lau GY, Barts N, Hartley RC, Tobler M, Richards JG, Murphy MP, Arndt S.

Biol Open. 2019 May 9;8(5). pii: bio041467. doi: 10.1242/bio.041467.

3.

The db mutation improves memory in younger mice in a model of Alzheimer's disease.

Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Apr 26. pii: S0925-4439(19)30124-3. doi: 10.1016/j.bbadis.2019.04.013. [Epub ahead of print]

PMID:
31034991
4.

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.

Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.

5.

The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage.

Murphy MP, Niedziela DA, Leonard FC, Keane OM.

Sci Rep. 2019 Apr 16;9(1):6134. doi: 10.1038/s41598-019-42424-2.

6.

Correction to: Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T.

Basic Res Cardiol. 2019 Apr 9;114(3):24. doi: 10.1007/s00395-019-0731-4.

PMID:
30968226
7.

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T.

Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0. Erratum in: Basic Res Cardiol. 2019 Apr 9;114(3):24.

8.

Exploring the Doctor of Nursing Practice project facilitator/mentor role.

Staffileno BA, Murphy MP, Hinch B, Carlson E.

Nurs Outlook. 2019 Feb 2. pii: S0029-6554(18)30498-6. doi: 10.1016/j.outlook.2019.01.005. [Epub ahead of print]

PMID:
30819506
9.

The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.

Escribano-Lopez I, Bañuls C, Diaz-Morales N, Iannantuoni F, Rovira-Llopis S, Gomis R, Rocha M, Hernandez-Mijares A, Murphy MP, Victor VM.

Cell Physiol Biochem. 2019;52(2):186-197. doi: 10.33594/000000013. Epub 2019 Feb 28.

10.

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.

Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A.

Sci Rep. 2019 Feb 26;9(1):2850. doi: 10.1038/s41598-019-39836-5.

11.

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.

Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T.

Free Radic Biol Med. 2019 Feb 4;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. [Epub ahead of print]

12.

Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells.

Gómez-Cabañas L, López-Cotarelo P, Criado-García O, Murphy MP, Boya P, Rodríguez-Fernández JL.

J Immunol. 2019 Mar 15;202(6):1715-1723. doi: 10.4049/jimmunol.1800575. Epub 2019 Feb 4.

PMID:
30718295
13.

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP.

Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.

14.

Aggressive Surveillance Is Needed to Detect Endoleaks and Junctional Separation between Device Components after Zenith Fenestrated Aortic Reconstruction.

Wang SK, Lemmon GW, Gupta AK, Dalsing MC, Sawchuk AP, Motaganahalli RL, Murphy MP, Fajardo A.

Ann Vasc Surg. 2019 May;57:129-136. doi: 10.1016/j.avsg.2018.09.038. Epub 2019 Jan 24.

PMID:
30684629
15.

Malonylation of GAPDH is an inflammatory signal in macrophages.

Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA.

Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6.

16.

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.

van Golen RF, Reiniers MJ, Marsman G, Alles LK, van Rooyen DM, Petri B, Van der Mark VA, van Beek AA, Meijer B, Maas MA, Zeerleder S, Verheij J, Farrell GC, Luken BM, Teoh NC, van Gulik TM, Murphy MP, Heger M.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1192-1200. doi: 10.1016/j.bbadis.2019.01.014. Epub 2019 Jan 15.

PMID:
30658161
17.

Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction.

Wang SK, Lemmon GW, Gupta AK, Dalsing MC, Sawchuk AP, Motaganahalli RL, Murphy MP, Fajardo A.

J Vasc Surg. 2019 Jun;69(6):1679-1684. doi: 10.1016/j.jvs.2018.09.044. Epub 2018 Dec 24.

PMID:
30591295
18.

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.

Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M.

Elife. 2018 Dec 27;7. pii: e41044. doi: 10.7554/eLife.41044.

19.

Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.

Moore AL, desJardins-Park HE, Duoto BA, Mascharak S, Murphy MP, Irizarry DM, Foster DS, Jones RE, Barnes LA, Marshall CD, Ransom RC, Wernig G, Longaker MT.

Ann Surg. 2018 Dec 21. doi: 10.1097/SLA.0000000000003172. [Epub ahead of print]

PMID:
30585822
20.

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M.

EMBO Mol Med. 2019 Jan;11(1). pii: e9582. doi: 10.15252/emmm.201809582.

21.

Promoting DNP-PhD collaboration in doctoral education: Forming a DNP project team.

Carlson EA, Staffileno BA, Murphy MP.

J Prof Nurs. 2018 Nov - Dec;34(6):433-436. doi: 10.1016/j.profnurs.2017.12.011. Epub 2017 Dec 22.

PMID:
30527689
22.

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Kim YR, Baek JI, Kim SH, Kim MA, Lee B, Ryu N, Kim KH, Choi DG, Kim HM, Murphy MP, Macpherson G, Choo YS, Bok J, Lee KY, Park JW, Kim UK.

Redox Biol. 2019 Jan;20:544-555. doi: 10.1016/j.redox.2018.11.013. Epub 2018 Nov 20.

23.

Inverse Kinematic Assessment of Rehabilitative Therapy in Children Using Orthotics.

Murphy MP, Rammer JR, Vinehout KL, Caballero MR, Cornwell CM, Fritz JM, Harris GF.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2813-2816. doi: 10.1109/EMBC.2018.8512863.

PMID:
30440986
24.

Mitochondria as a therapeutic target for common pathologies.

Murphy MP, Hartley RC.

Nat Rev Drug Discov. 2018 Nov 5. doi: 10.1038/nrd.2018.174. [Epub ahead of print] Review.

PMID:
30393373
25.

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.

Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA.

Free Radic Biol Med. 2019 Jan;130:318-327. doi: 10.1016/j.freeradbiomed.2018.10.446. Epub 2018 Oct 31.

26.

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration.

Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT.

Nature. 2018 Nov;563(7732):514-521. doi: 10.1038/s41586-018-0650-9. Epub 2018 Oct 24.

27.

Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage.

Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN.

Stroke. 2018 Nov;49(11):2652-2658. doi: 10.1161/STROKEAHA.118.021799.

PMID:
30355194
28.

Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes.

Ransom RC, Foster DS, Salhotra A, Jones RE, Marshall CD, Leavitt T, Murphy MP, Moore AL, Blackshear CP, Brett EA, Wan DC, Longaker MT.

Nat Commun. 2018 Oct 19;9(1):4411. doi: 10.1038/s41467-018-06927-2.

29.

Outcomes associated with a transcarotid artery revascularization-centered protocol in high-risk carotid revascularizations using the ENROUTE neuroprotection system.

Wang SK, Fajardo A, Sawchuk AP, Lemmon GW, Dalsing MC, Gupta AK, Murphy MP, Motaganahalli RL.

J Vasc Surg. 2019 Mar;69(3):807-813. doi: 10.1016/j.jvs.2018.06.222. Epub 2018 Oct 6.

PMID:
30301690
30.

Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.

Nuzzo AM, Camm EJ, Sferruzzi-Perri AN, Ashmore TJ, Yung HW, Cindrova-Davies T, Spiroski AM, Sutherland MR, Logan A, Austin-Williams S, Burton GJ, Rolfo A, Todros T, Murphy MP, Giussani DA.

Am J Pathol. 2018 Dec;188(12):2704-2716. doi: 10.1016/j.ajpath.2018.07.027. Epub 2018 Sep 22.

31.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP.

J Biol Chem. 2018 Nov 2;293(44):17208-17217. doi: 10.1074/jbc.RA118.002579. Epub 2018 Sep 19.

32.

Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI.

Stovell MG, Mada MO, Carpenter TA, Yan JL, Guilfoyle MR, Jalloh I, Welsh KE, Helmy A, Howe DJ, Grice P, Mason A, Giorgi-Coll S, Gallagher CN, Murphy MP, Menon DK, Hutchinson PJ, Carpenter KL.

J Cereb Blood Flow Metab. 2018 Sep 18:271678X18799176. doi: 10.1177/0271678X18799176. [Epub ahead of print]

PMID:
30226401
33.

Metabolic control of ferroptosis in cancer.

Murphy MP.

Nat Cell Biol. 2018 Oct;20(10):1104-1105. doi: 10.1038/s41556-018-0209-x. No abstract available.

PMID:
30224762
34.

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.

Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A, Winyard PG.

Free Radic Biol Med. 2018 Oct;126:322-333. doi: 10.1016/j.freeradbiomed.2018.08.025. Epub 2018 Aug 22.

35.

The Causes and Consequences of Nonenzymatic Protein Acylation.

James AM, Smith CL, Smith AC, Robinson AJ, Hoogewijs K, Murphy MP.

Trends Biochem Sci. 2018 Nov;43(11):921-932. doi: 10.1016/j.tibs.2018.07.002. Epub 2018 Aug 18. Review.

PMID:
30131192
36.

Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.

Pell VR, Spiroski AM, Mulvey J, Burger N, Costa ASH, Logan A, Gruszczyk AV, Rosa T, James AM, Frezza C, Murphy MP, Krieg T.

J Mol Cell Cardiol. 2018 Oct;123:88-91. doi: 10.1016/j.yjmcc.2018.08.010. Epub 2018 Aug 15.

37.

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Murphy MP, O'Neill LAJ.

Cell. 2018 Aug 9;174(4):780-784. doi: 10.1016/j.cell.2018.07.030. Review.

PMID:
30096309
38.

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species.

James AM, Smith AC, Smith CL, Robinson AJ, Murphy MP.

Cell Rep. 2018 Aug 7;24(6):1445-1455. doi: 10.1016/j.celrep.2018.07.007.

39.

Newly made mitochondrial DNA drives inflammation.

Murphy MP.

Nature. 2018 Aug;560(7717):176-177. doi: 10.1038/d41586-018-05764-z. No abstract available.

PMID:
30076376
40.

Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes.

Ransom RC, Foster DS, Salhotra A, Jones RE, Marshall CD, Leavitt T, Murphy MP, Moore AL, Blackshear CP, Brett EA, Wan DC, Longaker MT.

Nat Commun. 2018 Jul 30;9(1):2971. doi: 10.1038/s41467-018-05436-6. Erratum in: Nat Commun. 2018 Oct 19;9(1):4411.

41.

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy.

Kim JH, Choi TG, Park S, Yun HR, Nguyen NNY, Jo YH, Jang M, Kim J, Kim J, Kang I, Ha J, Murphy MP, Tang DG, Kim SS.

Cell Death Differ. 2018 Nov;25(11):1921-1937. doi: 10.1038/s41418-018-0165-9. Epub 2018 Jul 24.

PMID:
30042494
42.

The effect of succinate on brain NADH/NAD+ redox state and high energy phosphate metabolism in acute traumatic brain injury.

Stovell MG, Mada MO, Helmy A, Carpenter TA, Thelin EP, Yan JL, Guilfoyle MR, Jalloh I, Howe DJ, Grice P, Mason A, Giorgi-Coll S, Gallagher CN, Murphy MP, Menon DK, Hutchinson PJ, Carpenter KLH.

Sci Rep. 2018 Jul 24;8(1):11140. doi: 10.1038/s41598-018-29255-3.

43.

Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury.

Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten VS.

Free Radic Biol Med. 2018 Aug 20;124:517-524. doi: 10.1016/j.freeradbiomed.2018.06.040. Epub 2018 Jul 3.

44.

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.

Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18.

PMID:
30022159
45.

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium .

Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Erratum in: Brain. 2019 Jun 1;142(6):e25.

46.

Adjunctive visceral artery chimney in patients undergoing Zenith Fenestrated aortic repair.

Wang SK, Drucker NA, Dalsing MC, Sawchuk AP, Gupta AK, Motaganahalli RL, Murphy MP, Fajardo A.

J Vasc Surg. 2018 Dec;68(6):1688-1695. doi: 10.1016/j.jvs.2018.03.421.

PMID:
29929822
47.

Metformin does not reduce inflammation in diabetics with abdominal aortic aneurysm or at high risk of abdominal aortic aneurysm formation.

Wang SK, Green LA, Gutwein AR, Kenyon B, Motaganahalli RL, Fajardo A, Gupta AK, Murphy MP.

Vascular. 2018 Dec;26(6):608-614. doi: 10.1177/1708538118777657. Epub 2018 Jun 5.

PMID:
29871586
48.

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury.

Martin JL, Gruszczyk AV, Beach TE, Murphy MP, Saeb-Parsy K.

Pediatr Nephrol. 2019 Jul;34(7):1167-1174. doi: 10.1007/s00467-018-3984-5. Epub 2018 Jun 2. Review.

49.

MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α.

Xi Y, Feng D, Tao K, Wang R, Shi Y, Qin H, Murphy MP, Yang Q, Zhao G.

Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2859-2870. doi: 10.1016/j.bbadis.2018.05.018. Epub 2018 May 26.

PMID:
29842922
50.

Use of the Zenith Fenestrated platform to rescue failing endovascular and open aortic reconstructions is safe and technically feasible.

Wang SK, Drucker NA, Sawchuk AP, Lemmon GW, Dalsing MC, Motaganahalli RL, Murphy MP, Fajardo A.

J Vasc Surg. 2018 Oct;68(4):1017-1022. doi: 10.1016/j.jvs.2018.01.038. Epub 2018 May 18.

PMID:
29784569

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