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Items: 1 to 50 of 629

1.

The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice.

Pinho BR, Duarte AI, Canas PM, Moreira PI, Murphy MP, Oliveira JA.

Free Radic Biol Med. 2019 Nov 18. pii: S0891-5849(19)31675-2. doi: 10.1016/j.freeradbiomed.2019.11.021. [Epub ahead of print]

PMID:
31751762
2.

The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart.

Tate M, Higgins GC, De Blasio MJ, Lindblom R, Prakoso D, Deo M, Kiriazis H, Park M, Baeza-Garza CD, Caldwell ST, Hartley RC, Krieg T, Murphy MP, Coughlan MT, Ritchie RH.

Cardiovasc Drugs Ther. 2019 Oct 25. doi: 10.1007/s10557-019-06914-9. [Epub ahead of print]

PMID:
31654171
3.

Species and tissue specific differences in ROS metabolism to hypoxia- and hyperoxia-recovery exposure in marine sculpins.

Lau GY, Arndt S, Murphy MP, Richards JG.

J Exp Biol. 2019 Oct 18. pii: jeb.206896. doi: 10.1242/jeb.206896. [Epub ahead of print]

PMID:
31628206
4.

Much-Needed Clarification and Guidance on Cell-Based Therapies for Musculoskeletal Disorders - Secondary Publication.

Murphy MP, Wan DC, Longaker MT.

J Orthop Res. 2019 Oct 1. doi: 10.1002/jor.24486. [Epub ahead of print] No abstract available.

PMID:
31573106
5.

Much-Needed Clarification and Guidance on Cell-Based Therapies for Musculoskeletal Disorders.

Murphy MP, Wan DC, Longaker MT.

J Bone Miner Res. 2019 Sep 23. doi: 10.1002/jbmr.3841. [Epub ahead of print] No abstract available.

PMID:
31545871
6.

A precise method for determining acetabular component anteversion after total hip arthroplasty.

Murphy MP, Killen CJ, Ralles SJ, Brown NM, Hopkinson WJ, Wu K.

Bone Joint J. 2019 Sep;101-B(9):1042-1049. doi: 10.1302/0301-620X.101B9.BJJ-2019-0085.R1.

PMID:
31474147
7.

The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors.

Zhu F, Feng M, Sinha R, Murphy MP, Luo F, Kao KS, Szade K, Seita J, Weissman IL.

Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18416-18422. doi: 10.1073/pnas.1906251116. Epub 2019 Aug 26.

PMID:
31451629
8.

Procedural Complexity of TransCarotid Artery Revascularization Is Not Increased in Irradiated and Reoperative Necks.

Wang SK, Miladore JN, Drucker NA, Fajardo A, Lemmon GW, Dalsing MC, Murphy MP, Motaganahalli RL.

Ann Vasc Surg. 2019 Aug 5. pii: S0890-5096(19)30563-1. doi: 10.1016/j.avsg.2019.05.063. [Epub ahead of print]

PMID:
31394232
9.

Rerouting metabolism to activate macrophages.

Murphy MP.

Nat Immunol. 2019 Sep;20(9):1097-1099. doi: 10.1038/s41590-019-0455-5. No abstract available.

PMID:
31384059
10.

Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.

Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H.

Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13.

11.

Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.

Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA.

Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1.

PMID:
31263025
12.

Correction: Control of mitochondrial superoxide production by reverse electron transport at complex I.

Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP.

J Biol Chem. 2019 May 10;294(19):7966. doi: 10.1074/jbc.AAC119.008929. No abstract available.

13.

Detection of changes in mitochondrial hydrogen sulfide i n vivo in the fish model Poecilia mexicana (Poeciliidae).

Lau GY, Barts N, Hartley RC, Tobler M, Richards JG, Murphy MP, Arndt S.

Biol Open. 2019 May 9;8(5). pii: bio041467. doi: 10.1242/bio.041467.

14.

The db mutation improves memory in younger mice in a model of Alzheimer's disease.

Zhang L, Fernandez-Kim SO, Beckett TL, Niedowicz DM, Kohler K, Dasuri K, Bruce-Keller AJ, Murphy MP, Keller JN.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2157-2167. doi: 10.1016/j.bbadis.2019.04.013. Epub 2019 Apr 26.

PMID:
31034991
15.

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.

Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.

16.

The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage.

Murphy MP, Niedziela DA, Leonard FC, Keane OM.

Sci Rep. 2019 Apr 16;9(1):6134. doi: 10.1038/s41598-019-42424-2.

17.

Correction to: Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T.

Basic Res Cardiol. 2019 Apr 9;114(3):24. doi: 10.1007/s00395-019-0731-4.

18.

Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive.

Kohlhauer M, Pell VR, Burger N, Spiroski AM, Gruszczyk A, Mulvey JF, Mottahedin A, Costa ASH, Frezza C, Ghaleh B, Murphy MP, Tissier R, Krieg T.

Basic Res Cardiol. 2019 Mar 15;114(3):18. doi: 10.1007/s00395-019-0727-0. Erratum in: Basic Res Cardiol. 2019 Apr 9;114(3):24.

19.

Exploring the Doctor of Nursing Practice project facilitator/mentor role.

Staffileno BA, Murphy MP, Hinch B, Carlson E.

Nurs Outlook. 2019 Jul - Aug;67(4):433-440. doi: 10.1016/j.outlook.2019.01.005. Epub 2019 Feb 2.

PMID:
30819506
20.

The Mitochondria-Targeted Antioxidant MitoQ Modulates Mitochondrial Function and Endoplasmic Reticulum Stress in Pancreatic β Cells Exposed to Hyperglycaemia.

Escribano-Lopez I, Bañuls C, Diaz-Morales N, Iannantuoni F, Rovira-Llopis S, Gomis R, Rocha M, Hernandez-Mijares A, Murphy MP, Victor VM.

Cell Physiol Biochem. 2019;52(2):186-197. doi: 10.33594/000000013. Epub 2019 Feb 28.

21.

Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury.

Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A.

Sci Rep. 2019 Feb 26;9(1):2850. doi: 10.1038/s41598-019-39836-5.

22.

Selective mitochondrial superoxide generation in vivo is cardioprotective through hormesis.

Antonucci S, Mulvey JF, Burger N, Di Sante M, Hall AR, Hinchy EC, Caldwell ST, Gruszczyk AV, Deshwal S, Hartley RC, Kaludercic N, Murphy MP, Di Lisa F, Krieg T.

Free Radic Biol Med. 2019 Apr;134:678-687. doi: 10.1016/j.freeradbiomed.2019.01.034. Epub 2019 Feb 4.

23.

Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells.

Gómez-Cabañas L, López-Cotarelo P, Criado-García O, Murphy MP, Boya P, Rodríguez-Fernández JL.

J Immunol. 2019 Mar 15;202(6):1715-1723. doi: 10.4049/jimmunol.1800575. Epub 2019 Feb 4.

PMID:
30718295
24.

Selective Disruption of Mitochondrial Thiol Redox State in Cells and In Vivo.

Booty LM, Gawel JM, Cvetko F, Caldwell ST, Hall AR, Mulvey JF, James AM, Hinchy EC, Prime TA, Arndt S, Beninca C, Bright TP, Clatworthy MR, Ferdinand JR, Prag HA, Logan A, Prudent J, Krieg T, Hartley RC, Murphy MP.

Cell Chem Biol. 2019 Mar 21;26(3):449-461.e8. doi: 10.1016/j.chembiol.2018.12.002. Epub 2019 Jan 31.

25.

Aggressive Surveillance Is Needed to Detect Endoleaks and Junctional Separation between Device Components after Zenith Fenestrated Aortic Reconstruction.

Wang SK, Lemmon GW, Gupta AK, Dalsing MC, Sawchuk AP, Motaganahalli RL, Murphy MP, Fajardo A.

Ann Vasc Surg. 2019 May;57:129-136. doi: 10.1016/j.avsg.2018.09.038. Epub 2019 Jan 24.

PMID:
30684629
26.

Malonylation of GAPDH is an inflammatory signal in macrophages.

Galván-Peña S, Carroll RG, Newman C, Hinchy EC, Palsson-McDermott E, Robinson EK, Covarrubias S, Nadin A, James AM, Haneklaus M, Carpenter S, Kelly VP, Murphy MP, Modis LK, O'Neill LA.

Nat Commun. 2019 Jan 18;10(1):338. doi: 10.1038/s41467-018-08187-6.

27.

The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion.

van Golen RF, Reiniers MJ, Marsman G, Alles LK, van Rooyen DM, Petri B, Van der Mark VA, van Beek AA, Meijer B, Maas MA, Zeerleder S, Verheij J, Farrell GC, Luken BM, Teoh NC, van Gulik TM, Murphy MP, Heger M.

Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1192-1200. doi: 10.1016/j.bbadis.2019.01.014. Epub 2019 Jan 15.

PMID:
30658161
28.

Fenestrated endovascular aneurysm repair-induced acute kidney injury does not result in chronic renal dysfunction.

Wang SK, Lemmon GW, Gupta AK, Dalsing MC, Sawchuk AP, Motaganahalli RL, Murphy MP, Fajardo A.

J Vasc Surg. 2019 Jun;69(6):1679-1684. doi: 10.1016/j.jvs.2018.09.044. Epub 2018 Dec 24.

PMID:
30591295
29.

Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise.

Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M.

Elife. 2018 Dec 27;7. pii: e41044. doi: 10.7554/eLife.41044.

30.

Doxycycline Reduces Scar Thickness and Improves Collagen Architecture.

Moore AL, desJardins-Park HE, Duoto BA, Mascharak S, Murphy MP, Irizarry DM, Foster DS, Jones RE, Barnes LA, Marshall CD, Ransom RC, Wernig G, Longaker MT.

Ann Surg. 2018 Dec 21. doi: 10.1097/SLA.0000000000003172. [Epub ahead of print]

PMID:
30585822
31.

APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.

Signes A, Cerutti R, Dickson AS, Benincá C, Hinchy EC, Ghezzi D, Carrozzo R, Bertini E, Murphy MP, Nathan JA, Viscomi C, Fernandez-Vizarra E, Zeviani M.

EMBO Mol Med. 2019 Jan;11(1). pii: e9582. doi: 10.15252/emmm.201809582.

32.

Promoting DNP-PhD collaboration in doctoral education: Forming a DNP project team.

Carlson EA, Staffileno BA, Murphy MP.

J Prof Nurs. 2018 Nov - Dec;34(6):433-436. doi: 10.1016/j.profnurs.2017.12.011. Epub 2017 Dec 22.

PMID:
30527689
33.

Therapeutic potential of the mitochondria-targeted antioxidant MitoQ in mitochondrial-ROS induced sensorineural hearing loss caused by Idh2 deficiency.

Kim YR, Baek JI, Kim SH, Kim MA, Lee B, Ryu N, Kim KH, Choi DG, Kim HM, Murphy MP, Macpherson G, Choo YS, Bok J, Lee KY, Park JW, Kim UK.

Redox Biol. 2019 Jan;20:544-555. doi: 10.1016/j.redox.2018.11.013. Epub 2018 Nov 20.

34.

Inverse Kinematic Assessment of Rehabilitative Therapy in Children Using Orthotics.

Murphy MP, Rammer JR, Vinehout KL, Caballero MR, Cornwell CM, Fritz JM, Harris GF.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:2813-2816. doi: 10.1109/EMBC.2018.8512863.

PMID:
30440986
35.

Mitochondria as a therapeutic target for common pathologies.

Murphy MP, Hartley RC.

Nat Rev Drug Discov. 2018 Dec;17(12):865-886. doi: 10.1038/nrd.2018.174. Epub 2018 Nov 5. Review.

PMID:
30393373
36.

Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.

Pinho BR, Reis SD, Hartley RC, Murphy MP, Oliveira JMA.

Free Radic Biol Med. 2019 Jan;130:318-327. doi: 10.1016/j.freeradbiomed.2018.10.446. Epub 2018 Oct 31.

37.

Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration.

Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT.

Nature. 2018 Nov;563(7732):514-521. doi: 10.1038/s41586-018-0650-9. Epub 2018 Oct 24.

38.

Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage.

Murphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN.

Stroke. 2018 Nov;49(11):2652-2658. doi: 10.1161/STROKEAHA.118.021799.

39.

Author Correction: Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes.

Ransom RC, Foster DS, Salhotra A, Jones RE, Marshall CD, Leavitt T, Murphy MP, Moore AL, Blackshear CP, Brett EA, Wan DC, Longaker MT.

Nat Commun. 2018 Oct 19;9(1):4411. doi: 10.1038/s41467-018-06927-2.

40.

Outcomes associated with a transcarotid artery revascularization-centered protocol in high-risk carotid revascularizations using the ENROUTE neuroprotection system.

Wang SK, Fajardo A, Sawchuk AP, Lemmon GW, Dalsing MC, Gupta AK, Murphy MP, Motaganahalli RL.

J Vasc Surg. 2019 Mar;69(3):807-813. doi: 10.1016/j.jvs.2018.06.222. Epub 2018 Oct 6.

PMID:
30301690
41.

Placental Adaptation to Early-Onset Hypoxic Pregnancy and Mitochondria-Targeted Antioxidant Therapy in a Rodent Model.

Nuzzo AM, Camm EJ, Sferruzzi-Perri AN, Ashmore TJ, Yung HW, Cindrova-Davies T, Spiroski AM, Sutherland MR, Logan A, Austin-Williams S, Burton GJ, Rolfo A, Todros T, Murphy MP, Giussani DA.

Am J Pathol. 2018 Dec;188(12):2704-2716. doi: 10.1016/j.ajpath.2018.07.027. Epub 2018 Sep 22.

42.

Mitochondria-derived ROS activate AMP-activated protein kinase (AMPK) indirectly.

Hinchy EC, Gruszczyk AV, Willows R, Navaratnam N, Hall AR, Bates G, Bright TP, Krieg T, Carling D, Murphy MP.

J Biol Chem. 2018 Nov 2;293(44):17208-17217. doi: 10.1074/jbc.RA118.002579. Epub 2018 Sep 19.

43.

Phosphorus spectroscopy in acute TBI demonstrates metabolic changes that relate to outcome in the presence of normal structural MRI.

Stovell MG, Mada MO, Carpenter TA, Yan JL, Guilfoyle MR, Jalloh I, Welsh KE, Helmy A, Howe DJ, Grice P, Mason A, Giorgi-Coll S, Gallagher CN, Murphy MP, Menon DK, Hutchinson PJ, Carpenter KL.

J Cereb Blood Flow Metab. 2018 Sep 18:271678X18799176. doi: 10.1177/0271678X18799176. [Epub ahead of print]

PMID:
30226401
44.

Metabolic control of ferroptosis in cancer.

Murphy MP.

Nat Cell Biol. 2018 Oct;20(10):1104-1105. doi: 10.1038/s41556-018-0209-x. No abstract available.

PMID:
30224762
45.

Altered cellular redox homeostasis and redox responses under standard oxygen cell culture conditions versus physioxia.

Ferguson DCJ, Smerdon GR, Harries LW, Dodd NJF, Murphy MP, Curnow A, Winyard PG.

Free Radic Biol Med. 2018 Oct;126:322-333. doi: 10.1016/j.freeradbiomed.2018.08.025. Epub 2018 Aug 22.

46.

The Causes and Consequences of Nonenzymatic Protein Acylation.

James AM, Smith CL, Smith AC, Robinson AJ, Hoogewijs K, Murphy MP.

Trends Biochem Sci. 2018 Nov;43(11):921-932. doi: 10.1016/j.tibs.2018.07.002. Epub 2018 Aug 18. Review.

PMID:
30131192
47.

Ischemic preconditioning protects against cardiac ischemia reperfusion injury without affecting succinate accumulation or oxidation.

Pell VR, Spiroski AM, Mulvey J, Burger N, Costa ASH, Logan A, Gruszczyk AV, Rosa T, James AM, Frezza C, Murphy MP, Krieg T.

J Mol Cell Cardiol. 2018 Oct;123:88-91. doi: 10.1016/j.yjmcc.2018.08.010. Epub 2018 Aug 15.

48.

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers.

Murphy MP, O'Neill LAJ.

Cell. 2018 Aug 9;174(4):780-784. doi: 10.1016/j.cell.2018.07.030. Review.

49.

Proximal Cysteines that Enhance Lysine N-Acetylation of Cytosolic Proteins in Mice Are Less Conserved in Longer-Living Species.

James AM, Smith AC, Smith CL, Robinson AJ, Murphy MP.

Cell Rep. 2018 Aug 7;24(6):1445-1455. doi: 10.1016/j.celrep.2018.07.007.

50.

Newly made mitochondrial DNA drives inflammation.

Murphy MP.

Nature. 2018 Aug;560(7717):176-177. doi: 10.1038/d41586-018-05764-z. No abstract available.

PMID:
30076376

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