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Polyunsaturated Fatty Acids from Astrocytes Activate PPAR Gamma Signaling in Cancer Cells to Promote Brain Metastasis.

Zou Y, Watters A, Cheng N, Perry CE, Xu K, Alicea GM, Parris JLD, Baraban E, Ray P, Nayak A, Xu X, Herlyn M, Murphy ME, Weeraratna AT, Schug ZT, Chen Q.

Cancer Discov. 2019 Oct 2. pii: CD-19-0270. doi: 10.1158/2159-8290.CD-19-0270. [Epub ahead of print]


Toxicity related to standard TB therapy for pulmonary tuberculosis and treatment outcomes in the REMoxTB study according to HIV status.

Tweed CD, Crook AM, Dawson R, Diacon AH, McHugh TD, Mendel CM, Meredith SK, Mohapi L, Murphy ME, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Gillespie SH.

BMC Pulm Med. 2019 Aug 14;19(1):152. doi: 10.1186/s12890-019-0907-6.


Antibiotic stewardship - is there really an app for that?

Bhadresha S, Baldwin C, Santos R, Enoch D, Murphy ME.

Future Healthc J. 2019 Mar;6(Suppl 1):97. doi: 10.7861/futurehosp.6-1-s97. No abstract available.


Editorial: Double-Edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer.

Kung CP, Murphy ME, Lu H.

Front Endocrinol (Lausanne). 2019 Jul 3;10:425. doi: 10.3389/fendo.2019.00425. eCollection 2019. No abstract available.


Identification of functionally important residues and structural features in a bacterial lignostilbene dioxygenase.

Kuatsjah E, Verstraete MM, Kobylarz MJ, Liu AKN, Murphy MEP, Eltis LD.

J Biol Chem. 2019 Aug 30;294(35):12911-12920. doi: 10.1074/jbc.RA119.009428. Epub 2019 Jul 10.


The heme-sensitive regulator SbnI has a bifunctional role in staphyloferrin B production by Staphylococcus aureus.

Verstraete MM, Morales LD, Kobylarz MJ, Loutet SA, Laakso HA, Pinter TB, Stillman MJ, Heinrichs DE, Murphy MEP.

J Biol Chem. 2019 Jul 26;294(30):11622-11636. doi: 10.1074/jbc.RA119.007757. Epub 2019 Jun 13.


Common genetic variants in the TP53 pathway and their impact on cancer.

Barnoud T, Parris JLD, Murphy ME.

J Mol Cell Biol. 2019 Jul 19;11(7):578-585. doi: 10.1093/jmcb/mjz052.


Structural insight into the high reduction potentials observed for Fusobacterium nucleatum flavodoxin.

Mothersole RG, Macdonald M, Kolesnikov M, Murphy MEP, Wolthers KR.

Protein Sci. 2019 Aug;28(8):1460-1472. doi: 10.1002/pro.3661. Epub 2019 Jun 19.


A near fatal acute giant intracranial aneurysm re-rupture in a 7-month-old infant.

Lu VM, Kaszuba MC, Murphy ME, Lanzino G, Daniels DJ.

World Neurosurg. 2019 May 13. pii: S1878-8750(19)31315-4. doi: 10.1016/j.wneu.2019.05.041. [Epub ahead of print]


The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis.

Cho JH, Patel B, Bonala S, Mansouri H, Manne S, Vadrevu SK, Ghouse S, Kung CP, Murphy ME, Astrinidis A, Henske EP, Kwiatkowski DJ, Markiewski MM, Karbowniczek M.

Mol Cancer Res. 2019 Aug;17(8):1639-1651. doi: 10.1158/1541-7786.MCR-18-1292. Epub 2019 May 14.


Fatty acid transport protein 2 reprograms neutrophils in cancer.

Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI.

Nature. 2019 May;569(7754):73-78. doi: 10.1038/s41586-019-1118-2. Epub 2019 Apr 17.


Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53.

Leu JI, Murphy ME, George DL.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8390-8396. doi: 10.1073/pnas.1821277116. Epub 2019 Apr 8.


Staphylococcus aureus heme and siderophore-iron acquisition pathways.

Conroy BS, Grigg JC, Kolesnikov M, Morales LD, Murphy MEP.

Biometals. 2019 Jun;32(3):409-424. doi: 10.1007/s10534-019-00188-2. Epub 2019 Mar 25.


Unfractionated heparin dosing requirements in the presence of inflammation during the first six months of life.

Heizer JW, Schardt TQ, Murphy ME, Branchford BR.

Thromb Res. 2019 May;177:17-22. doi: 10.1016/j.thromres.2019.02.025. Epub 2019 Feb 27.


Tumor cells containing the African-Centric S47 variant of TP53 show increased Warburg metabolism.

Barnoud T, Parris JLD, Murphy ME.

Oncotarget. 2019 Feb 5;10(11):1217-1223. doi: 10.18632/oncotarget.26660. eCollection 2019 Feb 5.


Adherence to antibiotic guidelines and reported penicillin allergy: pooled cohort data on prescribing and allergy documentation from two English National Health Service (NHS) trusts.

Phillips CJ, Gilchrist M, Cooke FJ, Franklin BD, Enoch DA, Murphy ME, Santos R, Brannigan ET, Holmes AH.

BMJ Open. 2019 Mar 1;9(2):e026624. doi: 10.1136/bmjopen-2018-026624.


Peptides Containing meso-Oxa-Diaminopimelic Acid as Substrates for the Cell-Shape-Determining Proteases Csd6 and Pgp2.

Soni AS, Lin CS, Murphy MEP, Tanner ME.

Chembiochem. 2019 Jun 14;20(12):1591-1598. doi: 10.1002/cbic.201900011. Epub 2019 May 8.


The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.

Perez-Borrajero C, Lin CS, Okon M, Scheu K, Graves BJ, Murphy MEP, McIntosh LP.

J Mol Biol. 2019 Feb 1;431(3):593-614. doi: 10.1016/j.jmb.2018.12.011. Epub 2018 Dec 28.


A Cross-Sectional Study of Antibiotic Prescribing for Childhood Upper Respiratory Tract Infections in Irish General Practice

Maguire F, Murphy ME, Rourke M, Morgan F, Brady G, Byrne E, O’Callaghan ME.

Ir Med J. 2018 Dec 6;111(10):835.


Supporting general practitioner-based care for poorly controlled type 2 diabetes mellitus (the DECIDE study): feasibility study and protocol for a pilot cluster randomised controlled trial.

Murphy ME, Byrne M, Boland F, Corrigan D, Gillespie P, Fahey T, Smith SM.

Pilot Feasibility Stud. 2018 Oct 13;4:159. doi: 10.1186/s40814-018-0352-y. eCollection 2018.


Gender differences in tuberculosis treatment outcomes: a post hoc analysis of the REMoxTB study.

Murphy ME, Wills GH, Murthy S, Louw C, Bateson ALC, Hunt RD, McHugh TD, Nunn AJ, Meredith SK, Mendel CM, Spigelman M, Crook AM, Gillespie SH; REMoxTB consortium.

BMC Med. 2018 Oct 17;16(1):189. doi: 10.1186/s12916-018-1169-5.


Transmission of toxigenic Corynebacterium diphtheriae by a fully immunised resident returning from a visit to West Africa, United Kingdom, 2017.

Edwards D, Kent D, Lester C, Brown CS, Murphy ME, Brown NM, Sule O, Itani A, Chand M, Trindall A, Pearson C, Roddick I, Fry NK, Hoffmann J, Iyanger N, Kemp L, White J, Javid B, Ramsay ID, Zenner D, Ahmed A, Amirthalingam G, Salimee S, Litt D, Reacher M.

Euro Surveill. 2018 Sep;23(39). doi: 10.2807/1560-7917.ES.2018.23.39.1700681. Erratum in: Euro Surveill. 2018 Oct;23(42):.


Tailoring Chemotherapy for the African-Centric S47 Variant of TP53.

Barnoud T, Budina-Kolomets A, Basu S, Leu JI, Good M, Kung CP, Liu J, Liu Q, Villanueva J, Zhang R, George DL, Murphy ME.

Cancer Res. 2018 Oct 1;78(19):5694-5705. doi: 10.1158/0008-5472.CAN-18-1327. Epub 2018 Aug 16.


Investigating the Campylobacter jejuni Transcriptional Response to Host Intestinal Extracts Reveals the Involvement of a Widely Conserved Iron Uptake System.

Liu MM, Boinett CJ, Chan ACK, Parkhill J, Murphy MEP, Gaynor EC.

MBio. 2018 Aug 7;9(4). pii: e01347-18. doi: 10.1128/mBio.01347-18.


Crystallographic study of dioxygen chemistry in a copper-containing nitrite reductase from Geobacillus thermodenitrificans.

Fukuda Y, Matsusaki T, Tse KM, Mizohata E, Murphy MEP, Inoue T.

Acta Crystallogr D Struct Biol. 2018 Aug 1;74(Pt 8):769-777. doi: 10.1107/S2059798318010082. Epub 2018 Jul 24.


Putting our heads together: interpersonal neural synchronization as a biological mechanism for shared intentionality.

Fishburn FA, Murty VP, Hlutkowsky CO, MacGillivray CE, Bemis LM, Murphy ME, Huppert TJ, Perlman SB.

Soc Cogn Affect Neurosci. 2018 Sep 5;13(8):841-849. doi: 10.1093/scan/nsy060.


The transcription-independent mitochondrial cell death pathway is defective in non-transformed cells containing the Pro47Ser variant of p53.

Budina-Kolomets A, Barnoud T, Murphy ME.

Cancer Biol Ther. 2018;19(11):1033-1038. doi: 10.1080/15384047.2018.1472194. Epub 2018 Sep 27.


Toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

Tweed CD, Crook AM, Amukoye EI, Dawson R, Diacon AH, Hanekom M, McHugh TD, Mendel CM, Meredith SK, Murphy ME, Murthy SE, Nunn AJ, Phillips PPJ, Singh KP, Spigelman M, Wills GH, Gillespie SH.

BMC Infect Dis. 2018 Jul 11;18(1):317. doi: 10.1186/s12879-018-3230-6.


Micafungin use in a UK tertiary referral hospital.

Enoch DA, Murphy ME, Micallef C, Yang H, Brown NM, Aliyu SH.

J Glob Antimicrob Resist. 2018 Dec;15:82-87. doi: 10.1016/j.jgar.2018.06.009. Epub 2018 Jun 30.


Epistemic lenses and virtues, beyond evidence-based medicine.

Murphy ME.

Health Info Libr J. 2018 Jun;35(2):87-90. doi: 10.1111/hir.12218.


Pretreatment chest x-ray severity and its relation to bacterial burden in smear positive pulmonary tuberculosis.

Murthy SE, Chatterjee F, Crook A, Dawson R, Mendel C, Murphy ME, Murray SR, Nunn AJ, Phillips PPJ, Singh KP, McHugh TD, Gillespie SH; REMoxTB Consortium.

BMC Med. 2018 May 21;16(1):73. doi: 10.1186/s12916-018-1053-3.


Real-world use of fidaxomicin in a large UK tertiary hospital: how effective is it for treating recurrent disease?

Enoch DA, Santos R, Phillips CJ, Micallef C, Murphy ME, Aliyu SH, Massey D, Brown NM.

J Hosp Infect. 2018 Oct;100(2):142-146. doi: 10.1016/j.jhin.2018.05.001. Epub 2018 May 7.


The p53 Tumor Suppressor in the Control of Metabolism and Ferroptosis.

Gnanapradeepan K, Basu S, Barnoud T, Budina-Kolomets A, Kung CP, Murphy ME.

Front Endocrinol (Lausanne). 2018 Apr 11;9:124. doi: 10.3389/fendo.2018.00124. eCollection 2018. Review.


Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma.

Reyes-Uribe P, Adrianzen-Ruesta MP, Deng Z, Echevarria-Vargas I, Mender I, Saheb S, Liu Q, Altieri DC, Murphy ME, Shay JW, Lieberman PM, Villanueva J.

Oncogene. 2018 Jul;37(30):4058-4072. doi: 10.1038/s41388-018-0247-7. Epub 2018 Apr 26.


Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study.

Tweed CD, Wills GH, Crook AM, Dawson R, Diacon AH, Louw CE, McHugh TD, Mendel C, Meredith S, Mohapi L, Murphy ME, Murray S, Murthy S, Nunn AJ, Phillips PPJ, Singh K, Spigelman M, Gillespie SH.

BMC Med. 2018 Mar 28;16(1):46. doi: 10.1186/s12916-018-1033-7.


SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.

Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP.

J Biol Chem. 2018 Apr 20;293(16):6147-6160. doi: 10.1074/jbc.RA118.001875. Epub 2018 Feb 26.


Mutant p53 controls tumor metabolism and metastasis by regulating PGC-1α.

Basu S, Gnanapradeepan K, Barnoud T, Kung CP, Tavecchio M, Scott J, Watters A, Chen Q, Kossenkov AV, Murphy ME.

Genes Dev. 2018 Feb 1;32(3-4):230-243. doi: 10.1101/gad.309062.117. Epub 2018 Feb 20.


Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide.

Kaiser JC, King AN, Grigg JC, Sheldon JR, Edgell DR, Murphy MEP, Brinsmade SR, Heinrichs DE.

PLoS Genet. 2018 Jan 22;14(1):e1007159. doi: 10.1371/journal.pgen.1007159. eCollection 2018 Jan.


Corrigendum to "Coma and Stroke Following Surgical Treatment of Unruptured Intracranial Aneurysm: An American College of Surgeons National Surgical Quality Improvement Program Study" [World Neurosurgery (2016) 91:272-278].

McCutcheon BA, Kerezoudis P, Porter AL, Rinaldo L, Murphy ME, Maloney PR, Shepherd DS, Hirshman BR, Carter BS, Lanzino G, Bydon M, Meyer FB.

World Neurosurg. 2018 Feb;110:614-615. doi: 10.1016/j.wneu.2017.12.068. Epub 2017 Dec 26. No abstract available.


Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer.

Veglia F, Tyurin VA, Mohammadyani D, Blasi M, Duperret EK, Donthireddy L, Hashimoto A, Kapralov A, Amoscato A, Angelini R, Patel S, Alicea-Torres K, Weiner D, Murphy ME, Klein-Seetharaman J, Celis E, Kagan VE, Gabrilovich DI.

Nat Commun. 2017 Dec 14;8(1):2122. doi: 10.1038/s41467-017-02186-9.


Structure-function analyses reveal key features in Staphylococcus aureus IsdB-associated unfolding of the heme-binding pocket of human hemoglobin.

Bowden CFM, Chan ACK, Li EJW, Arrieta AL, Eltis LD, Murphy MEP.

J Biol Chem. 2018 Jan 5;293(1):177-190. doi: 10.1074/jbc.M117.806562. Epub 2017 Nov 6.


Skull base plasmacytoma: A unique case of POEMS syndrome with a plasmacytoma causing craniocervical instability.

Gilder H, Murphy ME, Alvi MA, Kerezoudis P, Shepherd D, Maloney PR, Yaszemski MJ, Morris JM, Dispenzieri A, Matsumoto JM, Bydon M.

J Clin Neurosci. 2018 Jan;47:254-257. doi: 10.1016/j.jocn.2017.10.038. Epub 2017 Oct 31.


Spot sputum samples are at least as good as early morning samples for identifying Mycobacterium tuberculosis.

Murphy ME, Phillips PPJ, Mendel CM, Bongard E, Bateson ALC, Hunt R, Murthy S, Singh KP, Brown M, Crook AM, Nunn AJ, Meredith SK, Lipman M, McHugh TD, Gillespie SH; REMoxTB Consortium.

BMC Med. 2017 Oct 27;15(1):192. doi: 10.1186/s12916-017-0947-9.


Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.

Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD.

Cell. 2017 Oct 5;171(2):273-285. doi: 10.1016/j.cell.2017.09.021. Review.


The bacterial meta-cleavage hydrolase LigY belongs to the amidohydrolase superfamily, not to the α/β-hydrolase superfamily.

Kuatsjah E, Chan ACK, Kobylarz MJ, Murphy MEP, Eltis LD.

J Biol Chem. 2017 Nov 3;292(44):18290-18302. doi: 10.1074/jbc.M117.797696. Epub 2017 Sep 20.


Development of a complex intervention to promote appropriate prescribing and medication intensification in poorly controlled type 2 diabetes mellitus in Irish general practice.

Murphy ME, Byrne M, Zarabzadeh A, Corrigan D, Fahey T, Smith SM.

Implement Sci. 2017 Sep 16;12(1):115. doi: 10.1186/s13012-017-0647-z.


A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles.

Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK.

Cancer Discov. 2017 Nov;7(11):1266-1283. doi: 10.1158/2159-8290.CD-17-0741. Epub 2017 Sep 12.


ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.

Ndoye A, Budina-Kolomets A, Kugel CH 3rd, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT.

Cancer Res. 2017 Nov 1;77(21):5873-5885. doi: 10.1158/0008-5472.CAN-17-0907. Epub 2017 Sep 8.


P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.

Gokare P, Finnberg NK, Abbosh PH, Dai J, Murphy ME, El-Deiry WS.

Sci Rep. 2017 Aug 29;7(1):9711. doi: 10.1038/s41598-017-09859-x.


Improving risk factor management for patients with poorly controlled type 2 diabetes: a systematic review of healthcare interventions in primary care and community settings.

Murphy ME, Byrne M, Galvin R, Boland F, Fahey T, Smith SM.

BMJ Open. 2017 Aug 4;7(8):e015135. doi: 10.1136/bmjopen-2016-015135. Review.

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