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Higher-Order Thalamic Circuits Channel Parallel Streams of Visual Information in Mice.

Bennett C, Gale SD, Garrett ME, Newton ML, Callaway EM, Murphy GJ, Olsen SR.

Neuron. 2019 Feb 27. pii: S0896-6273(19)30119-9. doi: 10.1016/j.neuron.2019.02.010. [Epub ahead of print]


Systematic review and meta-analysis of experimental studies evaluating the organ protective effects of histone deacetylase inhibitors.

Yusoff SI, Roman M, Lai FY, Eagle-Hemming B, Murphy GJ, Kumar T, Wozniak M.

Transl Res. 2019 Mar;205:1-16. doi: 10.1016/j.trsl.2018.11.002. Epub 2018 Nov 22. Review.


Systematic Review of Studies That Have Evaluated Screening Tests in Relatives of Patients Affected by Nonsyndromic Thoracic Aortic Disease.

Mariscalco G, Debiec R, Elefteriades JA, Samani NJ, Murphy GJ.

J Am Heart Assoc. 2018 Aug 7;7(15):e009302. doi: 10.1161/JAHA.118.009302.


Effect of sildenafil (Revatio) on postcardiac surgery acute kidney injury: a randomised, placebo-controlled clinical trial: the REVAKI-2 trial protocol.

Aujla H, Kumar T, Woźniak M, Dott W, Sullo N, Joel-David L, Morris T, Brookes C, Barber S, Murphy GJ.

Open Heart. 2018 Oct 18;5(2):e000838. doi: 10.1136/openhrt-2018-000838. eCollection 2018.


Meta-analysis of the influence of lifestyle changes for preoperative weight loss on surgical outcomes.

Roman M, Monaghan A, Serraino GF, Miller D, Pathak S, Lai F, Zaccardi F, Ghanchi A, Khunti K, Davies MJ, Murphy GJ.

Br J Surg. 2019 Feb;106(3):181-189. doi: 10.1002/bjs.11001. Epub 2018 Oct 17. Review.


A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.

Seo H, Chen SJ, Hashimoto K, Endo H, Nishi Y, Ohta A, Yamamoto T, Hotta A, Sawaguchi A, Hayashi H, Koseki N, Murphy GJ, Fukuda K, Sugimoto N, Eto K.

Blood Adv. 2018 Sep 11;2(17):2262-2272. doi: 10.1182/bloodadvances.2018019547.


Restrictive transfusion practice in cardiac surgery patients is safe, but what transfusion threshold is safe for my patient?

Patel NN, Murphy GJ.

Eur Heart J. 2018 Aug 21. doi: 10.1093/eurheartj/ehy505. [Epub ahead of print] No abstract available.


Induced pluripotent stem cell-based mapping of β-globin expression throughout human erythropoietic development.

Vanuytsel K, Matte T, Leung A, Naing ZH, Morrison T, Chui DHK, Steinberg MH, Murphy GJ.

Blood Adv. 2018 Aug 14;2(15):1998-2011. doi: 10.1182/bloodadvances.2018020560.


Near-patient coagulation testing to predict bleeding after cardiac surgery: a cohort study.

Mumford AD, Harris J, Plummer Z, Lee K, Verheyden V, Reeves BC, Rogers CA, Angelini GD, Murphy GJ.

Res Pract Thromb Haemost. 2017 Jul 25;1(2):242-251. doi: 10.1002/rth2.12024. eCollection 2017 Oct.


A library of ATTR amyloidosis patient-specific induced pluripotent stem cells for disease modelling and in vitro testing of novel therapeutics.

Giadone RM, Rosarda JD, Akepati PR, Thomas AC, Boldbaatar B, James MF, Wilson AA, Sanchorawala V, Connors LH, Berk JL, Wiseman RL, Murphy GJ.

Amyloid. 2018 Sep;25(3):148-155. doi: 10.1080/13506129.2018.1489228. Epub 2018 Jul 21.


A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality.

Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H.

Cell. 2018 Jul 12;174(2):465-480.e22. doi: 10.1016/j.cell.2018.06.035.


An Observational Cohort Feasibility Study to Identify Microvesicle and Micro-RNA Biomarkers of Acute Kidney Injury Following Pediatric Cardiac Surgery.

Sullo N, Mariani S, JnTala M, Kumar T, Woźniak MJ, Smallwood D, Pais P, Westrope C, Lotto A, Murphy GJ.

Pediatr Crit Care Med. 2018 Sep;19(9):816-830. doi: 10.1097/PCC.0000000000001604.


Distinct cell types in the superficial superior colliculus project to the dorsal lateral geniculate and lateral posterior thalamic nuclei.

Gale SD, Murphy GJ.

J Neurophysiol. 2018 Sep 1;120(3):1286-1292. doi: 10.1152/jn.00248.2018. Epub 2018 Jun 13.


Rejuvenation of allogenic red cells: benefits and risks.

Aujla H, Woźniak M, Kumar T, Murphy GJ; REDJUVENATE Investigators.

Vox Sang. 2018 Jun 4. doi: 10.1111/vox.12666. [Epub ahead of print] Review.


Transfusion triggers in cardiac surgery: Where do we go from here?

Patel NN, Murphy GJ.

Can J Anaesth. 2018 Aug;65(8):868-872. doi: 10.1007/s12630-018-1150-y. Epub 2018 May 21. No abstract available.


Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells.

Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ.

Stem Cells. 2018 Jul;36(7):1004-1019. doi: 10.1002/stem.2822. Epub 2018 Apr 1.


Response to 'Lack of benefit of near-infrared spectroscopy monitoring for improving patient outcomes. Case closed?'

Murphy GJ.

Br J Anaesth. 2018 Feb;120(2):406-407. doi: 10.1016/j.bja.2017.12.004. Epub 2018 Jan 6. No abstract available.


Vascular endothelial cell changes in postcardiac surgery acute kidney injury.

Qureshi SH, Patel NN, Murphy GJ.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F726-F735. doi: 10.1152/ajprenal.00319.2017. Epub 2017 Dec 20.


A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.

Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK.

Blood Cells Mol Dis. 2018 Mar;69:1-9. doi: 10.1016/j.bcmd.2017.11.003. Epub 2017 Nov 29.


A Comparison of Red Cell Rejuvenation versus Mechanical Washing for the Prevention of Transfusion-associated Organ Injury in Swine.

Woźniak MJ, Qureshi S, Sullo N, Dott W, Cardigan R, Wiltshire M, Nath M, Patel NN, Kumar T, Goodall AH, Murphy GJ.

Anesthesiology. 2018 Feb;128(2):375-385. doi: 10.1097/ALN.0000000000001973.


Diagnostic and therapeutic medical devices for safer blood management in cardiac surgery: systematic reviews, observational studies and randomised controlled trials.

Murphy GJ, Mumford AD, Rogers CA, Wordsworth S, Stokes EA, Verheyden V, Kumar T, Harris J, Clayton G, Ellis L, Plummer Z, Dott W, Serraino F, Wozniak M, Morris T, Nath M, Sterne JA, Angelini GD, Reeves BC.

Southampton (UK): NIHR Journals Library; 2017 Sep.


Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery.

Rogers CA, Stoica S, Ellis L, Stokes EA, Wordsworth S, Dabner L, Clayton G, Downes R, Nicholson E, Bennett S, Angelini GD, Reeves BC, Murphy GJ.

Br J Anaesth. 2017 Sep 1;119(3):384-393. doi: 10.1093/bja/aex182.


Evidence-Based Red Blood Cell Transfusion Practices in Cardiac Surgery.

Patel NN, Murphy GJ.

Transfus Med Rev. 2017 Oct;31(4):230-235. doi: 10.1016/j.tmrv.2017.06.001. Epub 2017 Jun 21. Review.


A phased SNP-based classification of sickle cell anemia HBB haplotypes.

Shaikho EM, Farrell JJ, Alsultan A, Qutub H, Al-Ali AK, Figueiredo MS, Chui DHK, Farrer LA, Murphy GJ, Mostoslavsky G, Sebastiani P, Steinberg MH.

BMC Genomics. 2017 Aug 11;18(1):608. doi: 10.1186/s12864-017-4013-y.


Dioxins and related environmental contaminants increase TDP-43 levels.

Ash PEA, Stanford EA, Al Abdulatif A, Ramirez-Cardenas A, Ballance HI, Boudeau S, Jeh A, Murithi JM, Tripodis Y, Murphy GJ, Sherr DH, Wolozin B.

Mol Neurodegener. 2017 May 5;12(1):35. doi: 10.1186/s13024-017-0177-9.


Randomized trial of red cell washing for the prevention of transfusion-associated organ injury in cardiac surgery.

Wozniak MJ, Sullo N, Qureshi S, Dott W, Cardigan R, Wiltshire M, Morris T, Nath M, Bittar N, Bhudia SK, Kumar T, Goodall AH, Murphy GJ.

Br J Anaesth. 2017 May 1;118(5):689-698. doi: 10.1093/bja/aex083.


Unwarranted Variation in the Quality of Care for Patients With Diseases of the Thoracic Aorta.

Bottle A, Mariscalco G, Shaw MA, Benedetto U, Saratzis A, Mariani S, Bashir M, Aylin P, Jenkins D, Oo AY, Murphy GJ; UK Aortic Forum.

J Am Heart Assoc. 2017 Mar 14;6(3). pii: e004913. doi: 10.1161/JAHA.116.004913. Review.


A Comprehensive, Ethnically Diverse Library of Sickle Cell Disease-Specific Induced Pluripotent Stem Cells.

Park S, Gianotti-Sommer A, Molina-Estevez FJ, Vanuytsel K, Skvir N, Leung A, Rozelle SS, Shaikho EM, Weir I, Jiang Z, Luo HY, Chui DHK, Figueiredo MS, Alsultan A, Al-Ali A, Sebastiani P, Steinberg MH, Mostoslavsky G, Murphy GJ.

Stem Cell Reports. 2017 Apr 11;8(4):1076-1085. doi: 10.1016/j.stemcr.2016.12.017. Epub 2017 Jan 19.


Body Mass Index and Mortality Among Adults Undergoing Cardiac Surgery: A Nationwide Study With a Systematic Review and Meta-Analysis.

Mariscalco G, Wozniak MJ, Dawson AG, Serraino GF, Porter R, Nath M, Klersy C, Kumar T, Murphy GJ.

Circulation. 2017 Feb 28;135(9):850-863. doi: 10.1161/CIRCULATIONAHA.116.022840. Epub 2016 Dec 28. Review.


Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies.

Zaccardi F, Dhalwani NN, Papamargaritis D, Webb DR, Murphy GJ, Davies MJ, Khunti K.

Diabetologia. 2017 Feb;60(2):240-248. doi: 10.1007/s00125-016-4162-6. Epub 2016 Nov 25. Review.


A Phase I study to determine the pharmacokinetic profile, safety and tolerability of sildenafil (Revatio® ) in cardiac surgery: the REVAKI-1 study.

Ring A, Morris T, Wozniak M, Sullo N, Dott W, Verheyden V, Kumar T, Brunskill N, Vaja R, Murphy GJ.

Br J Clin Pharmacol. 2017 Apr;83(4):709-720. doi: 10.1111/bcp.13162. Epub 2016 Dec 1.


A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.

Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH.

Am J Hematol. 2016 Nov;91(11):1118-1122. doi: 10.1002/ajh.24527. Epub 2016 Aug 22.


Active Dendritic Properties and Local Inhibitory Input Enable Selectivity for Object Motion in Mouse Superior Colliculus Neurons.

Gale SD, Murphy GJ.

J Neurosci. 2016 Aug 31;36(35):9111-23. doi: 10.1523/JNEUROSCI.0645-16.2016.


A multicentre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and health-care resource use following cardiac surgery (TITRe2).

Reeves BC, Pike K, Rogers CA, Brierley RC, Stokes EA, Wordsworth S, Nash RL, Miles A, Mumford AD, Cohen A, Angelini GD, Murphy GJ.

Health Technol Assess. 2016 Aug;20(60):1-260. doi: 10.3310/hta20600.


Are lower levels of red blood cell transfusion more cost-effective than liberal levels after cardiac surgery? Findings from the TITRe2 randomised controlled trial.

Stokes EA, Wordsworth S, Bargo D, Pike K, Rogers CA, Brierley RC, Angelini GD, Murphy GJ, Reeves BC; TITRe2 Investigators.

BMJ Open. 2016 Aug 1;6(8):e011311. doi: 10.1136/bmjopen-2016-011311.


Adherence to transfusion strategies in a randomized controlled trial: experiences from the TITRe2 trial.

Pike K, Maishman RL, Brierley RCM, Rogers CA, Murphy GJ, Reeves BC.

Br J Haematol. 2017 Oct;179(2):346-349. doi: 10.1111/bjh.14220. Epub 2016 Jul 5. No abstract available.


Shared and distinct retinal input to the mouse superior colliculus and dorsal lateral geniculate nucleus.

Ellis EM, Gauvain G, Sivyer B, Murphy GJ.

J Neurophysiol. 2016 Aug 1;116(2):602-10. doi: 10.1152/jn.00227.2016. Epub 2016 May 11.


Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development.

Smith BW, Stanford EA, Sherr DH, Murphy GJ.

Stem Cells Int. 2016;2016:2574152. doi: 10.1155/2016/2574152. Epub 2016 Apr 11.


Systematic review and meta-analysis of iron therapy in anaemic adults without chronic kidney disease: updated and abridged Cochrane review.

Clevenger B, Gurusamy K, Klein AA, Murphy GJ, Anker SD, Richards T.

Eur J Heart Fail. 2016 Jul;18(7):774-85. doi: 10.1002/ejhf.514. Epub 2016 Apr 28. Review.


The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.

Stanford EA, Wang Z, Novikov O, Mulas F, Landesman-Bollag E, Monti S, Smith BW, Seldin DC, Murphy GJ, Sherr DH.

BMC Biol. 2016 Mar 16;14:20. doi: 10.1186/s12915-016-0240-y.


Trial protocol for a randomised controlled trial of red cell washing for the attenuation of transfusion-associated organ injury in cardiac surgery: the REDWASH trial.

Murphy GJ, Verheyden V, Wozniak M, Sullo N, Dott W, Bhudia S, Bittar N, Morris T, Ring A, Tebbatt A, Kumar T.

Open Heart. 2016 Mar 7;3(1):e000344. doi: 10.1136/openhrt-2015-000344. eCollection 2016.


Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57.

Thomas DD, Sommer AG, Balazs AB, Beerman I, Murphy GJ, Rossi D, Mostoslavsky G.

Exp Hematol. 2016 May;44(5):422-433.e1. doi: 10.1016/j.exphem.2016.01.010. Epub 2016 Feb 10.


Indications for red blood cell transfusion in cardiac surgery: a systematic review and meta-analysis.

Patel NN, Avlonitis VS, Jones HE, Reeves BC, Sterne JA, Murphy GJ.

Lancet Haematol. 2015 Dec;2(12):e543-53. doi: 10.1016/S2352-3026(15)00198-2. Epub 2015 Nov 17. Review.


The Effect of Patient-Specific Cerebral Oxygenation Monitoring on Postoperative Cognitive Function: A Multicenter Randomized Controlled Trial.

Ellis L, Murphy GJ, Culliford L, Dreyer L, Clayton G, Downes R, Nicholson E, Stoica S, Reeves BC, Rogers CA.

JMIR Res Protoc. 2015 Dec 18;4(4):e137. doi: 10.2196/resprot.4562.


Meta-analysis of colloids versus crystalloids in critically ill, trauma and surgical patients.

Qureshi SH, Rizvi SI, Patel NN, Murphy GJ.

Br J Surg. 2016 Jan;103(1):14-26. doi: 10.1002/bjs.9943. Epub 2015 Nov 2. Review.


Liberal or Restrictive Transfusion after Cardiac Surgery.

Reeves BC, Rogers CA, Murphy GJ.

N Engl J Med. 2015 Jul 9;373(2):193. doi: 10.1056/NEJMc1505810. No abstract available.


Projection-specific characteristics of retinal input to the brain.

Gauvain G, Murphy GJ.

J Neurosci. 2015 Apr 22;35(16):6575-83. doi: 10.1523/JNEUROSCI.4298-14.2015.

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