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Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy.

Althaus AL, Moore SJ, Zhang H, Du X, Murphy GG, Parent JM.

J Neurosci. 2019 Sep 18;39(38):7604-7614. doi: 10.1523/JNEUROSCI.0654-18.2019. Epub 2019 Jul 3.


Environmental variables that ameliorate extinction learning deficits in the 129S1/SvlmJ mouse strain.

Cazares VA, Rodriguez G, Parent R, Ouillette L, Glanowska KM, Moore SJ, Murphy GG.

Genes Brain Behav. 2019 Sep;18(7):e12575. doi: 10.1111/gbb.12575. Epub 2019 May 7.


Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease.

McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, Raykin J, Johe K, Murphy GG, Feldman EL.

Sci Rep. 2018 Oct 3;8(1):14776. doi: 10.1038/s41598-018-33017-6.


Uneven balance of power between hypothalamic peptidergic neurons in the control of feeding.

Wei Q, Krolewski DM, Moore S, Kumar V, Li F, Martin B, Tomer R, Murphy GG, Deisseroth K, Watson SJ Jr, Akil H.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9489-E9498. doi: 10.1073/pnas.1802237115. Epub 2018 Sep 17.


Somatic Depdc5 deletion recapitulates electroclinical features of human focal cortical dysplasia type IIA.

Hu S, Knowlton RC, Watson BO, Glanowska KM, Murphy GG, Parent JM, Wang Y.

Ann Neurol. 2018 Jul;84(1):140-146. doi: 10.1002/ana.25272. Epub 2018 Aug 6.


Targeting potassium channels to treat cerebellar ataxia.

Bushart DD, Chopra R, Singh V, Murphy GG, Wulff H, Shakkottai VG.

Ann Clin Transl Neurol. 2018 Jan 22;5(3):297-314. doi: 10.1002/acn3.527. eCollection 2018 Mar.


Critical roles of αII spectrin in brain development and epileptic encephalopathy.

Wang Y, Ji T, Nelson AD, Glanowska K, Murphy GG, Jenkins PM, Parent JM.

J Clin Invest. 2018 Feb 1;128(2):760-773. doi: 10.1172/JCI95743. Epub 2018 Jan 16.


PlexinA2 Forward Signaling through Rap1 GTPases Regulates Dentate Gyrus Development and Schizophrenia-like Behaviors.

Zhao XF, Kohen R, Parent R, Duan Y, Fisher GL, Korn MJ, Ji L, Wan G, Jin J, Püschel AW, Dolan DF, Parent JM, Corfas G, Murphy GG, Giger RJ.

Cell Rep. 2018 Jan 9;22(2):456-470. doi: 10.1016/j.celrep.2017.12.044.


Leaks That Could Kill.

Murphy GG.

Epilepsy Curr. 2017 Sep-Oct;17(5):301-302. doi: 10.5698/1535-7597.17.5.301. No abstract available.


The L-type voltage-gated calcium channel CaV1.2 mediates fear extinction and modulates synaptic tone in the lateral amygdala.

Temme SJ, Murphy GG.

Learn Mem. 2017 Oct 16;24(11):580-588. doi: 10.1101/lm.045773.117. Print 2017 Nov.


Conditional Deletion of the L-Type Calcium Channel Cav1.2 in NG2-Positive Cells Impairs Remyelination in Mice.

Santiago González DA, Cheli VT, Zamora NN, Lama TN, Spreuer V, Murphy GG, Paez PM.

J Neurosci. 2017 Oct 18;37(42):10038-10051. doi: 10.1523/JNEUROSCI.1787-17.2017. Epub 2017 Sep 12.


Proteolytic processing of the L-type Ca 2+ channel alpha 11.2 subunit in neurons.

Buonarati OR, Henderson PB, Murphy GG, Horne MC, Hell JW.

Version 2. F1000Res. 2017 Jul 21 [revised 2018 Jan 1];6:1166. doi: 10.12688/f1000research.11808.2. eCollection 2017.


A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.

Ramani B, Harris GM, Huang R, Seki T, Murphy GG, Carmo Costa MD, Fischer S, Saunders TL, Xia G, McEachin RC, Paulson HL.

Hum Mol Genet. 2017 Aug 15;26(16):3232-3233. doi: 10.1093/hmg/ddx176. No abstract available.


In vivo imaging of prodromal hippocampus CA1 subfield oxidative stress in models of Alzheimer disease and Angelman syndrome.

Berkowitz BA, Lenning J, Khetarpal N, Tran C, Wu JY, Berri AM, Dernay K, Haacke EM, Shafie-Khorassani F, Podolsky RH, Gant JC, Maimaiti S, Thibault O, Murphy GG, Bennett BM, Roberts R.

FASEB J. 2017 Sep;31(9):4179-4186. doi: 10.1096/fj.201700229R. Epub 2017 Jun 7.


Deletion of the Mouse Homolog of CACNA1C Disrupts Discrete Forms of Hippocampal-Dependent Memory and Neurogenesis within the Dentate Gyrus.

Temme SJ, Bell RZ, Fisher GL, Murphy GG.

eNeuro. 2016 Nov 28;3(6). pii: ENEURO.0118-16.2016. eCollection 2016 Nov-Dec.


Conditional Deletion of the L-Type Calcium Channel Cav1.2 in Oligodendrocyte Progenitor Cells Affects Postnatal Myelination in Mice.

Cheli VT, Santiago González DA, Namgyal Lama T, Spreuer V, Handley V, Murphy GG, Paez PM.

J Neurosci. 2016 Oct 19;36(42):10853-10869.


Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life.

Sims-Robinson C, Bakeman A, Bruno E, Jackson S, Glasser R, Murphy GG, Feldman EL.

PLoS One. 2016 Sep 27;11(9):e0163883. doi: 10.1371/journal.pone.0163883. eCollection 2016.


A novel mouse model of the aged brain: Over-expression of the L-type voltage-gated calcium channel CaV1.3.

Krueger JN, Moore SJ, Parent R, McKinney BC, Lee A, Murphy GG.

Behav Brain Res. 2017 Mar 30;322(Pt B):241-249. doi: 10.1016/j.bbr.2016.06.054. Epub 2016 Jun 28.


The Rac-GAP alpha2-chimaerin regulates hippocampal dendrite and spine morphogenesis.

Valdez CM, Murphy GG, Beg AA.

Mol Cell Neurosci. 2016 Sep;75:14-26. doi: 10.1016/j.mcn.2016.06.002. Epub 2016 Jun 11.


L-type voltage-operated calcium channels contribute to astrocyte activation In vitro.

Cheli VT, Santiago González DA, Smith J, Spreuer V, Murphy GG, Paez PM.

Glia. 2016 Aug;64(8):1396-415. doi: 10.1002/glia.23013. Epub 2016 Jun 1.


Phosphorylation of Cav1.2 on S1928 uncouples the L-type Ca2+ channel from the β2 adrenergic receptor.

Patriarchi T, Qian H, Di Biase V, Malik ZA, Chowdhury D, Price JL, Hammes EA, Buonarati OR, Westenbroek RE, Catterall WA, Hofmann F, Xiang YK, Murphy GG, Chen CY, Navedo MF, Hell JW.

EMBO J. 2016 Jun 15;35(12):1330-45. doi: 10.15252/embj.201593409. Epub 2016 Apr 21.


Deletion of fibroblast growth factor 22 (FGF22) causes a depression-like phenotype in adult mice.

Williams AJ, Yee P, Smith MC, Murphy GG, Umemori H.

Behav Brain Res. 2016 Jul 1;307:11-7. doi: 10.1016/j.bbr.2016.03.047. Epub 2016 Mar 29.


Precision medicine in spinocerebellar ataxias: treatment based on common mechanisms of disease.

Bushart DD, Murphy GG, Shakkottai VG.

Ann Transl Med. 2016 Jan;4(2):25. doi: 10.3978/j.issn.2305-5839.2016.01.06. Review.


Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation.

Singer BH, Newstead MW, Zeng X, Cooke CL, Thompson RC, Singer K, Ghantasala R, Parent JM, Murphy GG, Iwashyna TJ, Standiford TJ.

PLoS One. 2016 Feb 10;11(2):e0149136. doi: 10.1371/journal.pone.0149136. eCollection 2016.


Single amino acid deletion in transmembrane segment D4S6 of sodium channel Scn8a (Nav1.6) in a mouse mutant with a chronic movement disorder.

Jones JM, Dionne L, Dell'Orco J, Parent R, Krueger JN, Cheng X, Dib-Hajj SD, Bunton-Stasyshyn RK, Sharkey LM, Dowling JJ, Murphy GG, Shakkottai VG, Shrager P, Meisler MH.

Neurobiol Dis. 2016 May;89:36-45. doi: 10.1016/j.nbd.2016.01.018. Epub 2016 Jan 22.


Imatinib treatment reduces brain injury in a murine model of traumatic brain injury.

Su EJ, Fredriksson L, Kanzawa M, Moore S, Folestad E, Stevenson TK, Nilsson I, Sashindranath M, Schielke GP, Warnock M, Ragsdale M, Mann K, Lawrence AL, Medcalf RL, Eriksson U, Murphy GG, Lawrence DA.

Front Cell Neurosci. 2015 Oct 7;9:385. doi: 10.3389/fncel.2015.00385. eCollection 2015.


Excitability governs neural development in a hippocampal region-specific manner.

Johnson-Venkatesh EM, Khan MN, Murphy GG, Sutton MA, Umemori H.

Development. 2015 Nov 15;142(22):3879-91. doi: 10.1242/dev.121202. Epub 2015 Sep 28.


Go Out and Play; Your Brain Needs the Exercise.

Murphy GG.

Epilepsy Curr. 2015 Jul-Aug;15(4):223-4. doi: 10.5698/1535-7511-15.4.223. No abstract available.


Identification of a neurovascular signaling pathway regulating seizures in mice.

Fredriksson L, Stevenson TK, Su EJ, Ragsdale M, Moore S, Craciun S, Schielke GP, Murphy GG, Lawrence DA.

Ann Clin Transl Neurol. 2015 Jul;2(7):722-38. doi: 10.1002/acn3.209. Epub 2015 May 1.


Genetic dissection of horizontal cell inhibitory signaling in mice in complete darkness in vivo.

Berkowitz BA, Murphy GG, Craft CM, Surmeier DJ, Roberts R.

Invest Ophthalmol Vis Sci. 2015 May;56(5):3132-9. doi: 10.1167/iovs.15-16581.


Increased prefrontal cortex neurogranin enhances plasticity and extinction learning.

Zhong L, Brown J, Kramer A, Kaleka K, Petersen A, Krueger JN, Florence M, Muelbl MJ, Battle M, Murphy GG, Olsen CM, Gerges NZ.

J Neurosci. 2015 May 13;35(19):7503-8. doi: 10.1523/JNEUROSCI.0274-15.2015.


Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity.

Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H.

J Neurosci. 2015 Apr 15;35(15):6165-78. doi: 10.1523/JNEUROSCI.3013-14.2015.


Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1.

Kim E, Wang Y, Kim SJ, Bornhorst M, Jecrois ES, Anthony TE, Wang C, Li YE, Guan JL, Murphy GG, Zhu Y.

Elife. 2014 Dec 23;3. doi: 10.7554/eLife.05151.


Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.

Althaus AL, Sagher O, Parent JM, Murphy GG.

J Neurophysiol. 2015 Feb 15;113(4):1184-94. doi: 10.1152/jn.00835.2014. Epub 2014 Nov 26.


A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.

Ramani B, Harris GM, Huang R, Seki T, Murphy GG, Costa Mdo C, Fischer S, Saunders TL, Xia G, McEachin RC, Paulson HL.

Hum Mol Genet. 2015 Mar 1;24(5):1211-24. doi: 10.1093/hmg/ddu532. Epub 2014 Oct 15. Erratum in: Hum Mol Genet. 2017 Aug 15;26(16):3232-3233.


Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy.

Wagnon JL, Korn MJ, Parent R, Tarpey TA, Jones JM, Hammer MF, Murphy GG, Parent JM, Meisler MH.

Hum Mol Genet. 2015 Jan 15;24(2):506-15. doi: 10.1093/hmg/ddu470. Epub 2014 Sep 16.


Comparison of inbred mouse substrains reveals segregation of maladaptive fear phenotypes.

Temme SJ, Bell RZ, Pahumi R, Murphy GG.

Front Behav Neurosci. 2014 Aug 20;8:282. doi: 10.3389/fnbeh.2014.00282. eCollection 2014.


The Heat is On: L-type Calcium Channels and Febrile Seizures.

Murphy GG.

Epilepsy Curr. 2014 Mar;14(2):93-4. doi: 10.5698/1535-7597-14.2.93. No abstract available.


Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice.

Renoux AJ, Sala-Hamrick KJ, Carducci NM, Frazer M, Halsey KE, Sutton MA, Dolan DF, Murphy GG, Todd PK.

Behav Brain Res. 2014 Jul 1;267:42-5. doi: 10.1016/j.bbr.2014.03.013. Epub 2014 Mar 19.


Conversion of short-term to long-term memory in the novel object recognition paradigm.

Moore SJ, Deshpande K, Stinnett GS, Seasholtz AF, Murphy GG.

Neurobiol Learn Mem. 2013 Oct;105:174-85. doi: 10.1016/j.nlm.2013.06.014. Epub 2013 Jul 5.


Ganglionic eminence graft pre-eminence in epilepsy.

Parent JM, Murphy GG.

Nat Neurosci. 2013 Jun;16(6):656-8. doi: 10.1038/nn.3406. No abstract available.


A dynamical role for acetylcholine in synaptic renormalization.

Fink CG, Murphy GG, Zochowski M, Booth V.

PLoS Comput Biol. 2013;9(3):e1002939. doi: 10.1371/journal.pcbi.1002939. Epub 2013 Mar 14.


Spatial Learning and Memory-What's TLE Got To Do With It?

Murphy GG.

Epilepsy Curr. 2013 Jan;13(1):26-9. doi: 10.5698/1535-7511-13.1.26.


Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation.

Rose RA, Sellan M, Simpson JA, Izaddoustdar F, Cifelli C, Panama BK, Davis M, Zhao D, Markhani M, Murphy GG, Striessnig J, Liu PP, Heximer SP, Backx PH.

Circ Arrhythm Electrophysiol. 2011 Oct;4(5):733-42. doi: 10.1161/CIRCEP.110.960401. Epub 2011 Jul 11.


Of mice and intrinsic excitability: genetic background affects the size of the postburst afterhyperpolarization in CA1 pyramidal neurons.

Moore SJ, Throesch BT, Murphy GG.

J Neurophysiol. 2011 Sep;106(3):1570-80. doi: 10.1152/jn.00257.2011. Epub 2011 Jun 22.


Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice.

Singer BH, Gamelli AE, Fuller CL, Temme SJ, Parent JM, Murphy GG.

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5437-42. doi: 10.1073/pnas.1015425108. Epub 2011 Mar 14.


Direct transcriptional induction of Gadd45gamma by Ascl1 during neuronal differentiation.

Huang HS, Kubish GM, Redmond TM, Turner DL, Thompson RC, Murphy GG, Uhler MD.

Mol Cell Neurosci. 2010 Jul;44(3):282-96. doi: 10.1016/j.mcn.2010.03.014. Epub 2010 Apr 9.


Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.

Gamelli AE, McKinney BC, White JA, Murphy GG.

Hippocampus. 2011 Feb;21(2):133-41. doi: 10.1002/hipo.20728.


Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout mice.

McKinney BC, Sze W, Lee B, Murphy GG.

Neurobiol Learn Mem. 2009 Nov;92(4):519-28. doi: 10.1016/j.nlm.2009.06.012. Epub 2009 Jul 10.

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