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Nervous system-wide profiling of presynaptic mRNAs reveals regulators of associative memory.

Arey RN, Kaletsky R, Murphy CT.

Sci Rep. 2019 Dec 30;9(1):20314. doi: 10.1038/s41598-019-56908-8.


Being open to the unexpected.

Murphy CT.

Mol Biol Cell. 2019 Nov 1;30(23):2862-2864. doi: 10.1091/mbc.E19-07-0380.


Insulin-like peptides and the mTOR-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death.

Shi C, Booth LN, Murphy CT.

Elife. 2019 Jul 8;8. pii: e46413. doi: 10.7554/eLife.46413.


Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance.

Moore RS, Kaletsky R, Murphy CT.

Cell. 2019 Jun 13;177(7):1827-1841.e12. doi: 10.1016/j.cell.2019.05.024. Epub 2019 Jun 6.


A PBX/MEIS Complex Balances Reproduction and Somatic Resilience.

Heimbucher T, Murphy CT.

Dev Cell. 2019 Apr 22;49(2):157-158. doi: 10.1016/j.devcel.2019.04.005.


Investigating Mechanisms that Control Ubiquitin-Mediated DAF-16/FOXO Protein Turnover.

Heimbucher T, Murphy CT.

Methods Mol Biol. 2019;1890:41-49. doi: 10.1007/978-1-4939-8900-3_4.


An integrative tissue-network approach to identify and test human disease genes.

Yao V, Kaletsky R, Keyes W, Mor DE, Wong AK, Sohrabi S, Murphy CT, Troyanskaya OG.

Nat Biotechnol. 2018 Oct 22. doi: 10.1038/nbt.4246. [Epub ahead of print]


Caenorhabditis elegans sperm carry a histone-based epigenetic memory of both spermatogenesis and oogenesis.

Tabuchi TM, Rechtsteiner A, Jeffers TE, Egelhofer TA, Murphy CT, Strome S.

Nat Commun. 2018 Oct 17;9(1):4310. doi: 10.1038/s41467-018-06236-8.


Transcriptome analysis of adult Caenorhabditis elegans cells reveals tissue-specific gene and isoform expression.

Kaletsky R, Yao V, Williams A, Runnels AM, Tadych A, Zhou S, Troyanskaya OG, Murphy CT.

PLoS Genet. 2018 Aug 10;14(8):e1007559. doi: 10.1371/journal.pgen.1007559. eCollection 2018 Aug.


Activation of Gαq Signaling Enhances Memory Consolidation and Slows Cognitive Decline.

Arey RN, Stein GM, Kaletsky R, Kauffman A, Murphy CT.

Neuron. 2018 May 2;98(3):562-574.e5. doi: 10.1016/j.neuron.2018.03.039. Epub 2018 Apr 12.


Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity.

Templeman NM, Luo S, Kaletsky R, Shi C, Ashraf J, Keyes W, Murphy CT.

Curr Biol. 2018 Mar 5;28(5):753-760.e4. doi: 10.1016/j.cub.2018.01.052. Epub 2018 Feb 22.


γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue.

Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL.

Molecules. 2017 Dec 2;22(12). pii: E2117. doi: 10.3390/molecules22122117.


Regulation of reproduction and longevity by nutrient-sensing pathways.

Templeman NM, Murphy CT.

J Cell Biol. 2018 Jan 2;217(1):93-106. doi: 10.1083/jcb.201707168. Epub 2017 Oct 26. Review.


Seal Whiskers Vibrate Over Broad Frequencies During Hydrodynamic Tracking.

Murphy CT, Reichmuth C, Eberhardt WC, Calhoun BH, Mann DA.

Sci Rep. 2017 Aug 21;7(1):8350. doi: 10.1038/s41598-017-07676-w.


Mating and male pheromone kill Caenorhabditis males through distinct mechanisms.

Shi C, Runnels AM, Murphy CT.

Elife. 2017 Mar 14;6. pii: e23493. doi: 10.7554/eLife.23493.


RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans.

Son HG, Seo M, Ham S, Hwang W, Lee D, An SW, Artan M, Seo K, Kaletsky R, Arey RN, Ryu Y, Ha CM, Kim YK, Murphy CT, Roh TY, Nam HG, Lee SV.

Nat Commun. 2017 Mar 9;8:14749. doi: 10.1038/ncomms14749.


The Impact of Radiation Treatment Time on Survival in Patients With Head and Neck Cancer.

Shaikh T, Handorf EA, Murphy CT, Mehra R, Ridge JA, Galloway TJ.

Int J Radiat Oncol Biol Phys. 2016 Dec 1;96(5):967-975. doi: 10.1016/j.ijrobp.2016.08.046. Epub 2016 Sep 6.


Erratum to: Patterns of multidisciplinary care in the management of non-metastatic invasive breast cancer in the United States Medicare patient.

Churilla TM, Egleston BL, Murphy CT, Sigurdson ER, Hayes SB, Goldstein LJ, Bleicher RJ.

Breast Cancer Res Treat. 2016 Dec;160(3):573. doi: 10.1007/s10549-016-4023-5. No abstract available.


Patterns of multidisciplinary care in the management of non-metastatic invasive breast cancer in the United States Medicare patient.

Churilla TM, Egleston BL, Murphy CT, Sigurdson ER, Hayes SB, Goldstein LJ, Bleicher RJ.

Breast Cancer Res Treat. 2016 Nov;160(1):153-162. Epub 2016 Sep 17. Erratum in: Breast Cancer Res Treat. 2016 Dec;160(3):573.


Development of an artificial sensor for hydrodynamic detection inspired by a seal's whisker array.

Eberhardt WC, Wakefield BF, Murphy CT, Casey C, Shakhsheer Y, Calhoun BH, Reichmuth C.

Bioinspir Biomim. 2016 Aug 31;11(5):056011. doi: 10.1088/1748-3190/11/5/056011.


Comparison of outcomes and toxicities among radiation therapy treatment options for prostate cancer.

Zaorsky NG, Shaikh T, Murphy CT, Hallman MA, Hayes SB, Sobczak ML, Horwitz EM.

Cancer Treat Rev. 2016 Jul;48:50-60. doi: 10.1016/j.ctrv.2016.06.006. Epub 2016 Jun 17. Review.


Conserved regulators of cognitive aging: From worms to humans.

Arey RN, Murphy CT.

Behav Brain Res. 2017 Mar 30;322(Pt B):299-310. doi: 10.1016/j.bbr.2016.06.035. Epub 2016 Jun 18. Review.


Cell-Type-Specific Transcriptome Analysis in the Drosophila Mushroom Body Reveals Memory-Related Changes in Gene Expression.

Crocker A, Guan XJ, Murphy CT, Murthy M.

Cell Rep. 2016 May 17;15(7):1580-1596. doi: 10.1016/j.celrep.2016.04.046. Epub 2016 May 5.


Reply to P. Blanchard et al.

Murphy CT, Galloway TJ, Handorf EA, Egleston BL, Ridge JA.

J Clin Oncol. 2016 Jul 1;34(19):2318-9. doi: 10.1200/JCO.2016.67.2832. Epub 2016 Apr 25. No abstract available.


Absence of Pathological Proof of Cancer Associated with Improved Outcomes in Early-Stage Lung Cancer.

Shaikh T, Churilla TM, Murphy CT, Zaorsky NG, Haber A, Hallman MA, Meyer JE.

J Thorac Oncol. 2016 Jul;11(7):1112-20. doi: 10.1016/j.jtho.2016.03.024. Epub 2016 Apr 20.


Importance of Surgical Margin Status in Ductal Carcinoma In Situ.

Shaikh T, Li T, Murphy CT, Zaorsky NG, Bleicher RJ, Sigurdson ER, Carlson R, Hayes SB, Anderson P.

Clin Breast Cancer. 2016 Aug;16(4):312-8. doi: 10.1016/j.clbc.2016.02.002. Epub 2016 Feb 12.


The Neuronal Kinesin UNC-104/KIF1A Is a Key Regulator of Synaptic Aging and Insulin Signaling-Regulated Memory.

Li LB, Lei H, Arey RN, Li P, Liu J, Murphy CT, Xu XZ, Shen K.

Curr Biol. 2016 Mar 7;26(5):605-15. doi: 10.1016/j.cub.2015.12.068. Epub 2016 Feb 11.


Feeding the germline.

Shi C, Murphy CT.

Genes Dev. 2016 Feb 1;30(3):249-50. doi: 10.1101/gad.276980.115.


Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis.

Wang J, Kaletsky R, Silva M, Williams A, Haas LA, Androwski RJ, Landis JN, Patrick C, Rashid A, Santiago-Martinez D, Gravato-Nobre M, Hodgkin J, Hall DH, Murphy CT, Barr MM.

Curr Biol. 2015 Dec 21;25(24):3232-8. doi: 10.1016/j.cub.2015.10.057. Epub 2015 Dec 10.


The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators.

Kaletsky R, Lakhina V, Arey R, Williams A, Landis J, Ashraf J, Murphy CT.

Nature. 2016 Jan 7;529(7584):92-6. doi: 10.1038/nature16483. Epub 2015 Dec 14.


The cell biology of aging.

DiLoreto R, Murphy CT.

Mol Biol Cell. 2015 Dec 15;26(25):4524-31. doi: 10.1091/mbc.E14-06-1084. Review.


Genome Sequencing Fishes out Longevity Genes.

Lakhina V, Murphy CT.

Cell. 2015 Dec 3;163(6):1312-3. doi: 10.1016/j.cell.2015.11.040.


Survival Impact of Increasing Time to Treatment Initiation for Patients With Head and Neck Cancer in the United States.

Murphy CT, Galloway TJ, Handorf EA, Egleston BL, Wang LS, Mehra R, Flieder DB, Ridge JA.

J Clin Oncol. 2016 Jan 10;34(2):169-78. doi: 10.1200/JCO.2015.61.5906. Epub 2015 Nov 30.


C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation.

Hahm JH, Kim S, DiLoreto R, Shi C, Lee SJ, Murphy CT, Nam HG.

Nat Commun. 2015 Nov 20;6:8919. doi: 10.1038/ncomms9919.


Local bacteria affect the efficacy of chemotherapeutic drugs.

Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G, Urbaniak C, Byrne WL, Tangney M.

Sci Rep. 2015 Sep 29;5:14554. doi: 10.1038/srep14554.


Pre-treatment tumor-specific growth rate as a temporal biomarker that predicts treatment failure and improves risk stratification for oropharyngeal cancer.

Murphy CT, Devarajan K, Wang LS, Mehra R, Ridge JA, Fundakowski C, Galloway TJ.

Oral Oncol. 2015 Nov;51(11):1034-1040. doi: 10.1016/j.oraloncology.2015.09.001. Epub 2015 Oct 5.


Contemporary Trends in the Utilization of Radiotherapy in Patients With Renal Cell Carcinoma.

Shaikh T, Handorf EA, Murphy CT, Kutikov A, Uzzo RG, Hallman M, Horwitz EM, Smaldone MC.

Urology. 2015 Dec;86(6):1165-73. doi: 10.1016/j.urology.2015.08.012. Epub 2015 Sep 14.


Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts.

Parikh D, Fouquerel E, Murphy CT, Wang H, Opresko PL.

Nat Commun. 2015 Sep 9;6:8214. doi: 10.1038/ncomms9214.


Vibrissal sensitivity in a harbor seal (Phoca vitulina).

Murphy CT, Reichmuth C, Mann D.

J Exp Biol. 2015 Aug;218(Pt 15):2463-71. doi: 10.1242/jeb.118240. Epub 2015 Jun 8.


Impact of obesity on outcomes after definitive dose-escalated intensity-modulated radiotherapy for localized prostate cancer.

Wang LS, Murphy CT, Ruth K, Zaorsky NG, Smaldone MC, Sobczak ML, Kutikov A, Viterbo R, Horwitz EM.

Cancer. 2015 Sep 1;121(17):3010-7. doi: 10.1002/cncr.29472. Epub 2015 May 29.


Use of Postprostatectomy Radiation Therapy at an NCI-Designated Comprehensive Cancer Center.

Martin JM, Li T, Johnson ME, Murphy CT, Howald AG, Smaldone MC, Kutikov A, Chen DY, Viterbo R, Greenberg RE, Uzzo RG, Horwitz EM.

J Natl Compr Canc Netw. 2015 May;13(5):525-30.


Comparison of Adjuvant Radiation Therapy Alone Versus Radiation Therapy and Endocrine Therapy in Elderly Women With Early-Stage, Hormone Receptor-Positive Breast Cancer Treated With Breast-Conserving Surgery.

Murphy CT, Li T, Wang LS, Obeid EI, Bleicher RJ, Eastwick G, Johnson ME, Hayes SB, Weiss SE, Anderson PR.

Clin Breast Cancer. 2015 Oct;15(5):381-9. doi: 10.1016/j.clbc.2015.02.005. Epub 2015 Mar 2.


For longevity, perception is everything.

Lakhina V, Murphy CT.

Cell. 2015 Feb 26;160(5):807-809. doi: 10.1016/j.cell.2015.02.027.


Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs.

Lakhina V, Arey RN, Kaletsky R, Kauffman A, Stein G, Keyes W, Xu D, Murphy CT.

Neuron. 2015 Jan 21;85(2):330-45. doi: 10.1016/j.neuron.2014.12.029.


Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.

Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15.


Increasing time to treatment initiation for head and neck cancer: an analysis of the National Cancer Database.

Murphy CT, Galloway TJ, Handorf EA, Wang L, Mehra R, Flieder DB, Ridge JA.

Cancer. 2015 Apr 15;121(8):1204-13. doi: 10.1002/cncr.29191. Epub 2014 Dec 9.


Bacterial-mediated DNA delivery to tumour associated phagocytic cells.

Byrne WL, Murphy CT, Cronin M, Wirth T, Tangney M.

J Control Release. 2014 Dec 28;196:384-93. doi: 10.1016/j.jconrel.2014.10.030. Epub 2014 Nov 17.


Evaluating toxicity from definitive radiation therapy for prostate cancer in men with inflammatory bowel disease: Patient selection and dosimetric parameters with modern treatment techniques.

Murphy CT, Heller S, Ruth K, Buyyounouski MK, Weinberg D, Uzzo RG, Plimack E, Kutikov A, Chen DY, Horwitz EM.

Pract Radiat Oncol. 2015 May-Jun;5(3):e215-22. doi: 10.1016/j.prro.2014.09.004. Epub 2014 Oct 30.


A microfluidic device and automatic counting system for the study of C. elegans reproductive aging.

Li S, Stone HA, Murphy CT.

Lab Chip. 2015 Jan 21;15(2):524-31. doi: 10.1039/c4lc01028k.


Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis.

Pham HH, Murphy CT, Sureshkumar G, Ly DH, Opresko PL, Armitage BA.

Org Biomol Chem. 2014 Oct 7;12(37):7345-7354. doi: 10.1039/c4ob00953c.

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