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Items: 45

1.

G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases.

Murga C, Arcones AC, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr.

Front Pharmacol. 2019 Feb 19;10:112. doi: 10.3389/fphar.2019.00112. eCollection 2019. Review.

2.

Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.

Cruces-Sande M, Vila-Bedmar R, Arcones AC, González-Rodríguez Á, Rada P, Gutiérrez-de-Juan V, Vargas-Castrillón J, Iruzubieta P, Sánchez-González C, Formentini L, Crespo J, García-Monzón C, Martínez-Chantar ML, Valverde ÁM, Mayor F Jr, Murga C.

Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3655-3667. doi: 10.1016/j.bbadis.2018.09.027. Epub 2018 Sep 24.

PMID:
30261289
3.

Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK.

Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F Jr, Murga C.

Curr Biol. 2018 Aug 6;28(15):2513. doi: 10.1016/j.cub.2018.07.033. No abstract available.

PMID:
30086307
4.

G protein-coupled receptor kinase 2 (GRK2) as an integrative signalling node in the regulation of cardiovascular function and metabolic homeostasis.

Mayor F Jr, Cruces-Sande M, Arcones AC, Vila-Bedmar R, Briones AM, Salaices M, Murga C.

Cell Signal. 2018 Jan;41:25-32. doi: 10.1016/j.cellsig.2017.04.002. Epub 2017 Apr 4. Review.

PMID:
28389415
5.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

6.

Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.

Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F Jr, Murga C, Heijnen CJ, Kavelaars A.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3036-41. doi: 10.1073/pnas.1516036113. Epub 2016 Feb 29.

7.

Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.

Lucas E, Cruces-Sande M, Briones AM, Salaices M, Mayor F Jr, Murga C, Vila-Bedmar R.

Arch Physiol Biochem. 2015;121(5):163-77. doi: 10.3109/13813455.2015.1107589. Epub 2015 Dec 7. Review.

8.

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2.

Vila-Bedmar R, Cruces-Sande M, Lucas E, Willemen HL, Heijnen CJ, Kavelaars A, Mayor F Jr, Murga C.

Sci Signal. 2015 Jul 21;8(386):ra73. doi: 10.1126/scisignal.aaa4374.

9.

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2448-56. doi: 10.1016/j.bbadis.2014.09.004. Epub 2014 Sep 18.

10.

Skeletal muscle myogenesis is regulated by G protein-coupled receptor kinase 2.

Garcia-Guerra L, Vila-Bedmar R, Carrasco-Rando M, Cruces-Sande M, Martín M, Ruiz-Gómez A, Ruiz-Gómez M, Lorenzo M, Fernández-Veledo S, Mayor F Jr, Murga C, Nieto-Vázquez I.

J Mol Cell Biol. 2014 Aug;6(4):299-311. doi: 10.1093/jmcb/mju025. Epub 2014 Jun 13.

11.

A novel p38 MAPK docking-groove-targeted compound is a potent inhibitor of inflammatory hyperalgesia.

Willemen HL, Campos PM, Lucas E, Morreale A, Gil-Redondo R, Agut J, González FV, Ramos P, Heijnen C, Mayor F Jr, Kavelaars A, Murga C.

Biochem J. 2014 May 1;459(3):427-39. doi: 10.1042/BJ20130172.

12.

Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension.

Avendaño MS, Lucas E, Jurado-Pueyo M, Martínez-Revelles S, Vila-Bedmar R, Mayor F Jr, Salaices M, Briones AM, Murga C.

Hypertension. 2014 Feb;63(2):369-75. doi: 10.1161/HYPERTENSIONAHA.113.01991. Epub 2013 Nov 4.

13.

Roles of GRK2 in cell signaling beyond GPCR desensitization: GRK2-HDAC6 interaction modulates cell spreading and motility.

Penela P, Lafarga V, Tapia O, Rivas V, Nogués L, Lucas E, Vila-Bedmar R, Murga C, Mayor F Jr.

Sci Signal. 2012 May 15;5(224):pt3. doi: 10.1126/scisignal.2003098.

PMID:
22589388
14.

GRK2 contribution to the regulation of energy expenditure and brown fat function.

Vila-Bedmar R, Garcia-Guerra L, Nieto-Vazquez I, Mayor F Jr, Lorenzo M, Murga C, Fernández-Veledo S.

FASEB J. 2012 Aug;26(8):3503-14. doi: 10.1096/fj.11-202267. Epub 2012 Apr 19.

PMID:
22516294
15.

The origin of behavioral bursts in decision-making circuitry.

Sorribes A, Armendariz BG, Lopez-Pigozzi D, Murga C, de Polavieja GG.

PLoS Comput Biol. 2011 Jun;7(6):e1002075. doi: 10.1371/journal.pcbi.1002075. Epub 2011 Jun 23.

16.

G Protein-coupled receptor kinase 2 (GRK2): A novel modulator of insulin resistance.

Mayor F Jr, Lucas E, Jurado-Pueyo M, Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Fernández-Veledo S, Murga C.

Arch Physiol Biochem. 2011 Jul;117(3):125-30. doi: 10.3109/13813455.2011.584693. Epub 2011 May 26. Review.

PMID:
21615207
17.

Receptors, signaling networks, and disease.

Cuesta N, Martín-Cófreces NB, Murga C, van Santen HM.

Sci Signal. 2011 Feb 22;4(161):mr3. doi: 10.1126/scisignal.2001687.

PMID:
21343616
18.

Aural myiasis in an infant.

Casanova-Roman M, Sanchez-Legaza E, Sanchez-Porto A, Murga C.

Infez Med. 2010 Sep;18(3):175-6.

19.

G protein-coupled receptor kinase 2 plays a relevant role in insulin resistance and obesity.

Garcia-Guerra L, Nieto-Vazquez I, Vila-Bedmar R, Jurado-Pueyo M, Zalba G, Díez J, Murga C, Fernández-Veledo S, Mayor F Jr, Lorenzo M.

Diabetes. 2010 Oct;59(10):2407-17. doi: 10.2337/db10-0771. Epub 2010 Jul 13.

20.

The complex G protein-coupled receptor kinase 2 (GRK2) interactome unveils new physiopathological targets.

Penela P, Murga C, Ribas C, Lafarga V, Mayor F Jr.

Br J Pharmacol. 2010 Jun;160(4):821-32. doi: 10.1111/j.1476-5381.2010.00727.x. Review.

21.

GRK6, a gatekeeper of visceral hyperalgesia.

Murga C, Mayor F Jr.

Brain Behav Immun. 2009 Jan;23(1):16-7. doi: 10.1016/j.bbi.2008.10.002. Epub 2008 Oct 17. No abstract available.

PMID:
18977289
22.

G protein-coupled receptor kinase 2 (GRK2) in migration and inflammation.

Penela P, Murga C, Ribas C, Salcedo A, Jurado-Pueyo M, Rivas V, Aymerich I, Mayor F Jr.

Arch Physiol Biochem. 2008 Jul;114(3):195-200. doi: 10.1080/13813450802181039 . Review.

PMID:
18618354
23.

GRK2-dependent desensitization downstream of G proteins.

Jurado-Pueyo M, Campos PM, Mayor F, Murga C.

J Recept Signal Transduct Res. 2008;28(1-2):59-70. doi: 10.1080/10799890801941939 . Review.

PMID:
18437630
24.

Physiological changes in GRK2 regulate CCL2-induced signaling to ERK1/2 and Akt but not to MEK1/2 and calcium.

Kleibeuker W, Jurado-Pueyo M, Murga C, Eijkelkamp N, Mayor F Jr, Heijnen CJ, Kavelaars A.

J Neurochem. 2008 Feb;104(4):979-92. Epub 2007 Oct 30.

25.

Interfering with MAP kinase docking interactions: implications and perspective for the p38 route.

Mayor F Jr, Jurado-Pueyo M, Campos PM, Murga C.

Cell Cycle. 2007 Mar 1;6(5):528-33. Epub 2007 Mar 25. Review.

PMID:
17351337
26.

The G protein-coupled receptor kinase (GRK) interactome: role of GRKs in GPCR regulation and signaling.

Ribas C, Penela P, Murga C, Salcedo A, García-Hoz C, Jurado-Pueyo M, Aymerich I, Mayor F Jr.

Biochim Biophys Acta. 2007 Apr;1768(4):913-22. Epub 2006 Sep 30. Review.

27.

Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.

Peregrin S, Jurado-Pueyo M, Campos PM, Sanz-Moreno V, Ruiz-Gomez A, Crespo P, Mayor F Jr, Murga C.

Curr Biol. 2006 Oct 24;16(20):2042-7. Erratum in: Curr Biol. 2018 Aug 6;28(15):2513.

28.

Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease.

Penela P, Murga C, Ribas C, Tutor AS, Peregrín S, Mayor F Jr.

Cardiovasc Res. 2006 Jan;69(1):46-56. Epub 2005 Nov 8. Review.

PMID:
16288730
29.

G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits.

Jiménez-Sainz MC, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad BF, Heijnen CJ, Mayor F Jr, Aragay AM.

Mol Biol Cell. 2006 Jan;17(1):25-31. Epub 2005 Oct 12.

30.

Involvement of intramolecular interactions in the regulation of G protein-coupled receptor kinase 2.

Sarnago S, Roca R, de Blasi A, Valencia A, Mayor F Jr, Murga C.

Mol Pharmacol. 2003 Sep;64(3):629-39.

PMID:
12920199
31.

PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.

Choi Y, Zhang J, Murga C, Yu H, Koller E, Monia BP, Gutkind JS, Li W.

Oncogene. 2002 Aug 8;21(34):5289-300.

32.

Molecular mechanisms of pre-T cell receptor-induced survival.

Murga C, Barber DF.

J Biol Chem. 2002 Oct 18;277(42):39156-62. Epub 2002 Jul 11.

33.
34.

Functional roles of Akt signaling in mouse skin tumorigenesis.

Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martínez J, Larcher F, Slaga TJ, Gutkind JS, Jorcano JL, Paramio JM.

Oncogene. 2002 Jan 3;21(1):53-64.

35.

Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2.

Ruiz-Gómez A, Humrich J, Murga C, Quitterer U, Lohse MJ, Mayor F Jr.

J Biol Chem. 2000 Sep 22;275(38):29724-30.

36.

A novel role for phosphatidylinositol 3-kinase beta in signaling from G protein-coupled receptors to Akt.

Murga C, Fukuhara S, Gutkind JS.

J Biol Chem. 2000 Apr 21;275(16):12069-73.

38.

Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades.

Murga C, Fukuhara S, Gutkind JS.

Trends Endocrinol Metab. 1999 May;10(4):122-127.

PMID:
10322405
39.

A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.

Fukuhara S, Murga C, Zohar M, Igishi T, Gutkind JS.

J Biol Chem. 1999 Feb 26;274(9):5868-79.

40.

The subcellular and cellular distribution of G protein-coupled receptor kinase 2 in rat brain.

Murga C, Penela P, Zafra F, Mayor F Jr.

Neuroscience. 1998 Dec;87(3):631-7.

PMID:
9758229
42.

Regulation of G protein-coupled receptor kinase 2 in brains of opiate-treated rats and human opiate addicts.

Ozaita A, Escribá PV, Ventayol P, Murga C, Mayor F Jr, García-Sevilla JA.

J Neurochem. 1998 Mar;70(3):1249-57.

43.
44.

High affinity binding of beta-adrenergic receptor kinase to microsomal membranes. Modulation of the activity of bound kinase by heterotrimeric G protein activation.

Murga C, Ruiz-Gómez A, García-Higuera I, Kim CM, Benovic JL, Mayor F Jr.

J Biol Chem. 1996 Jan 12;271(2):985-94.

45.

Association of the regulatory beta-adrenergic receptor kinase with rat liver microsomal membranes.

García-Higuera I, Penela P, Murga C, Egea G, Bonay P, Benovic JL, Mayor F Jr.

J Biol Chem. 1994 Jan 14;269(2):1348-55.

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