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Trends in Diabetic Retinopathy, Visual Acuity, and Treatment Outcomes for Patients Living With Diabetes in a Fundus Photograph-Based Diabetic Retinopathy Screening Program in Bangladesh.

Muqit MMK, Kourgialis N, Jackson-deGraffenried M, Talukder Z, Khetran ER, Rahman A, Chan WO, Chowdury FA, Nag D, Ahmad J, Friedman DS.

JAMA Netw Open. 2019 Nov 1;2(11):e1916285. doi: 10.1001/jamanetworkopen.2019.16285.


Artisan-style iris-claw intraocular lens implantation in patients with uveitis.

Negretti GS, Chan WO, Pavesio C, Muqit MMK.

J Cataract Refract Surg. 2019 Nov;45(11):1645-1649. doi: 10.1016/j.jcrs.2019.07.032. Epub 2019 Oct 1.


QUALITY IMPROVEMENT OF LASER TREATMENT (QUILT)A New Retinal Laser Simulation System for Training in Resource-Poor Countries.

Muqit MMK, Aldington SJ, Scanlon PH.

Retina. 2019 Jul;39(7):1430-1434. doi: 10.1097/IAE.0000000000002586. No abstract available.


A 21-Year Study of Vitreoretinal Surgery for Aphakic Retinal Detachment: Long-Term Surgical Outcomes and Complications.

Bhardwaj G, Walker RJE, Ezra E, Mirza Z, Muqit MMK.

Ophthalmol Retina. 2019 Sep;3(9):784-790. doi: 10.1016/j.oret.2019.04.002. Epub 2019 Apr 6.


Therapeutic approaches to enhance PINK1/Parkin mediated mitophagy for the treatment of Parkinson's disease.

Miller S, Muqit MMK.

Neurosci Lett. 2019 Jul 13;705:7-13. doi: 10.1016/j.neulet.2019.04.029. Epub 2019 Apr 14. Review.


Six-Month Safety and Efficacy of the Intelligent Retinal Implant System II Device in Retinitis Pigmentosa.

Muqit MMK, Velikay-Parel M, Weber M, Dupeyron G, Audemard D, Corcostegui B, Sahel J, Le Mer Y.

Ophthalmology. 2019 Apr;126(4):637-639. doi: 10.1016/j.ophtha.2018.11.010. Epub 2018 Dec 24. No abstract available.


Are PARKIN patients ideal candidates for dopaminergic cell replacement therapies?

Kunath T, Natalwala A, Chan C, Chen Y, Stecher B, Taylor M, Khan S, Muqit MMK.

Eur J Neurosci. 2019 Feb;49(4):453-462. doi: 10.1111/ejn.14314. Epub 2019 Jan 23.


Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK.

Open Biol. 2018 Nov 7;8(11). pii: 180108. doi: 10.1098/rsob.180108.



Brennan N, Chan WO, Reekie I, Ezra E, Barton K, Viswanathan A, Muqit MMK.

Retina. 2018 Oct;38(10):e86-e87. doi: 10.1097/IAE.0000000000002330. No abstract available.


A comparison of 23-gauge and 20-gauge vitrectomy for proliferative sickle cell retinopathy - clinical outcomes and surgical management.

Ho J, Grabowska A, Ugarte M, Muqit MM.

Eye (Lond). 2018 Sep;32(9):1449-1454. doi: 10.1038/s41433-018-0127-y. Epub 2018 May 22.


Guidelines on Diabetic Eye Care: The International Council of Ophthalmology Recommendations for Screening, Follow-up, Referral, and Treatment Based on Resource Settings.

Wong TY, Sun J, Kawasaki R, Ruamviboonsuk P, Gupta N, Lansingh VC, Maia M, Mathenge W, Moreker S, Muqit MMK, Resnikoff S, Verdaguer J, Zhao P, Ferris F, Aiello LP, Taylor HR.

Ophthalmology. 2018 Oct;125(10):1608-1622. doi: 10.1016/j.ophtha.2018.04.007. Epub 2018 May 24. Review.


Intravitreal ocriplasmin for the treatment of vitreomacular traction and macular hole- A study of efficacy and safety based on NICE guidance.

Muqit MMK, Hamilton R, Ho J, Tucker S, Buck H.

PLoS One. 2018 May 16;13(5):e0197072. doi: 10.1371/journal.pone.0197072. eCollection 2018.


Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.

McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG.

Cell Metab. 2018 Feb 6;27(2):439-449.e5. doi: 10.1016/j.cmet.2017.12.008. Epub 2018 Jan 11.


The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

Barini E, Miccoli A, Tinarelli F, Mulholland K, Kadri H, Khanim F, Stojanovski L, Read KD, Burness K, Blow JJ, Mehellou Y, Muqit MMK.

Chembiochem. 2018 Mar 2;19(5):425-429. doi: 10.1002/cbic.201700500. Epub 2018 Jan 24.


Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations.

Kumar A, Tamjar J, Waddell AD, Woodroof HI, Raimi OG, Shaw AM, Peggie M, Muqit MM, van Aalten DM.

Elife. 2017 Oct 5;6. pii: e29985. doi: 10.7554/eLife.29985.


Intraoperative Optical Coherence Tomography-Guided Retrolenticular Vitreous Peeling in Diabetic Vitreous Hemorrhage.

Muqit MMK.

Retina. 2019 Oct;39 Suppl 1:S160-S161. doi: 10.1097/IAE.0000000000001770. No abstract available.


PINK1 and Parkin: emerging themes in mitochondrial homeostasis.

McWilliams TG, Muqit MM.

Curr Opin Cell Biol. 2017 Apr;45:83-91. doi: 10.1016/ Epub 2017 Apr 22. Review.


Ubiquitin and Parkinson's disease through the looking glass of genetics.

Walden H, Muqit MM.

Biochem J. 2017 Apr 13;474(9):1439-1451. doi: 10.1042/BCJ20160498. Review.


Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization.

Osgerby L, Lai YC, Thornton PJ, Amalfitano J, Le Duff CS, Jabeen I, Kadri H, Miccoli A, Tucker JHR, Muqit MMK, Mehellou Y.

J Med Chem. 2017 Apr 27;60(8):3518-3524. doi: 10.1021/acs.jmedchem.6b01897. Epub 2017 Mar 28.


The role of day one postoperative review of intraocular pressure in modern vitrectomy surgery.

Brennan N, Reekie I, Ezra E, Barton K, Viswanathan A, Muqit MM.

Br J Ophthalmol. 2017 Sep;101(9):1281-1284. doi: 10.1136/bjophthalmol-2016-309664. Epub 2017 Jan 20.


Incidence, mechanism and outcomes of schisis retinal detachments revealed through a prospective population-based study.

Xue K, Muqit MMK, Ezra E, Charles SJ, Yorston D, Mitra A, Patel CK.

Br J Ophthalmol. 2017 Aug;101(8):1022-1026. doi: 10.1136/bjophthalmol-2016-309750. Epub 2017 Jan 5.


mito-QC illuminates mitophagy and mitochondrial architecture in vivo.

McWilliams TG, Prescott AR, Allen GF, Tamjar J, Munson MJ, Thomson C, Muqit MM, Ganley IG.

J Cell Biol. 2016 Aug 1;214(3):333-45. doi: 10.1083/jcb.201603039. Epub 2016 Jul 25.


Rhegmatogenous retinal detachment following intravitreal ocriplasmin.

Madi HA, Haynes RJ, Depla D, de la Cour MD, Lesnik-Oberstein S, Muqit MM, Patton N, Price N, Steel DH.

Graefes Arch Clin Exp Ophthalmol. 2016 Dec;254(12):2333-2338. Epub 2016 Jun 8.


Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation.

Pao KC, Stanley M, Han C, Lai YC, Murphy P, Balk K, Wood NT, Corti O, Corvol JC, Muqit MM, Virdee S.

Nat Chem Biol. 2016 May;12(5):324-31. doi: 10.1038/nchembio.2045. Epub 2016 Mar 7.


Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1.

Lai YC, Kondapalli C, Lehneck R, Procter JB, Dill BD, Woodroof HI, Gourlay R, Peggie M, Macartney TJ, Corti O, Corvol JC, Campbell DG, Itzen A, Trost M, Muqit MM.

EMBO J. 2015 Nov 12;34(22):2840-61. doi: 10.15252/embj.201591593. Epub 2015 Oct 15.


Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.


Efficient genetic encoding of phosphoserine and its nonhydrolyzable analog.

Rogerson DT, Sachdeva A, Wang K, Haq T, Kazlauskaite A, Hancock SM, Huguenin-Dezot N, Muqit MM, Fry AM, Bayliss R, Chin JW.

Nat Chem Biol. 2015 Jul;11(7):496-503. doi: 10.1038/nchembio.1823. Epub 2015 Jun 1.


A Versatile Strategy for the Semisynthetic Production of Ser65 Phosphorylated Ubiquitin and Its Biochemical and Structural Characterisation.

Han C, Pao KC, Kazlauskaite A, Muqit MM, Virdee S.

Chembiochem. 2015 Jul 27;16(11):1574-9. doi: 10.1002/cbic.201500185. Epub 2015 Jun 18.


PINK1 and Parkin – mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson's disease.

Kazlauskaite A, Muqit MM.

FEBS J. 2015 Jan;282(2):215-23. doi: 10.1111/febs.13127. Epub 2014 Nov 20. Review.


Vitreoretinal surgery for inadvertent intralenticular Ozurdex implant.

Chalioulias K, Muqit MM.

Eye (Lond). 2014 Dec;28(12):1523-4. doi: 10.1038/eye.2014.192. Epub 2014 Aug 8. No abstract available.


Swept-source optical coherence tomography imaging in conservative and surgical management of premacular haemorrhages showing inflammatory response.

Tanawade RG, Muqit MM, McLeod D, Stanga PE.

Clin Exp Ophthalmol. 2015 Jan-Feb;43(1):77-9. doi: 10.1111/ceo.12368. Epub 2014 Aug 13. No abstract available.


Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM.

Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334.


Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM.

Open Biol. 2014 Mar 19;4:130213. doi: 10.1098/rsob.130213.


Spatial changes of central field loss in diabetic retinopathy after laser.

Wang Y, Muqit MM, Stanga PE, Young LB, Henson DB.

Optom Vis Sci. 2014 Jan;91(1):111-20. doi: 10.1097/OPX.0000000000000103.


The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons.

Iovino M, Pfisterer U, Holton JL, Lashley T, Swingler RJ, Calo L, Treacy R, Revesz T, Parmar M, Goedert M, Muqit MM, Spillantini MG.

Acta Neuropathol. 2014 Feb;127(2):283-95. doi: 10.1007/s00401-013-1219-1. Epub 2013 Nov 30.


Noncontact high-resolution ultra-wide-field oral fluorescein angiography in premature infants with retinopathy of prematurity.

Fung TH, Muqit MM, Mordant DJ, Smith LM, Patel CK.

JAMA Ophthalmol. 2014 Jan;132(1):108-10. doi: 10.1001/jamaophthalmol.2013.6102.


Fourier-domain optical coherence tomography evaluation of retinal and optic nerve head neovascularisation in proliferative diabetic retinopathy.

Muqit MM, Stanga PE.

Br J Ophthalmol. 2014 Jan;98(1):65-72. doi: 10.1136/bjophthalmol-2013-303941. Epub 2013 Oct 24. Erratum in: Br J Ophthalmol. 2014 May;98(5):713.


National survey of progressive symptomatic retinal detachment complicating retinoschisis in the United Kingdom.

Muqit MM, Xue K, Patel CK.

Eye (Lond). 2013 Dec;27(12):1425-6. doi: 10.1038/eye.2013.230. Epub 2013 Oct 18. No abstract available.


TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.

Flinn LJ, Keatinge M, Bretaud S, Mortiboys H, Matsui H, De Felice E, Woodroof HI, Brown L, McTighe A, Soellner R, Allen CE, Heath PR, Milo M, Muqit MM, Reichert AS, Köster RW, Ingham PW, Bandmann O.

Ann Neurol. 2013 Dec;74(6):837-47. doi: 10.1002/ana.23999.


Non-contact ultra-widefield retinal imaging and fundus fluorescein angiography of an infant with incontinentia pigmenti without sedation in an ophthalmic office setting.

Patel CK, Fung TH, Muqit MM, Mordant DJ, Geh V.

J AAPOS. 2013 Jun;17(3):309-11. doi: 10.1016/j.jaapos.2012.12.152. Epub 2013 Apr 19.


Non-contact ultra-widefield imaging of retinopathy of prematurity using the Optos dual wavelength scanning laser ophthalmoscope.

Patel CK, Fung TH, Muqit MM, Mordant DJ, Brett J, Smith L, Adams E.

Eye (Lond). 2013 May;27(5):589-96. doi: 10.1038/eye.2013.45. Epub 2013 Mar 22.


Pilot randomised clinical trial of Pascal TargETEd Retinal versus variable fluence PANretinal 20 ms laser in diabetic retinopathy: PETER PAN study.

Muqit MM, Young LB, McKenzie R, John B, Marcellino GR, Henson DB, Turner GS, Stanga PE.

Br J Ophthalmol. 2013 Feb;97(2):220-7. doi: 10.1136/bjophthalmol-2012-302189. Epub 2012 Nov 24.


Observational prospective cohort study of patients with newly-diagnosed ocular sebaceous carcinoma.

Muqit MM, Foot B, Walters SJ, Mudhar HS, Roberts F, Rennie IG.

Br J Ophthalmol. 2013 Jan;97(1):47-51. doi: 10.1136/bjophthalmol-2012-302443. Epub 2012 Oct 31.


PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM.

Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080.


Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM.

Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012.


Is axial length a risk factor for idiopathic macular hole formation?

Singh AJ, Muqit MM, Woon WH.

Int Ophthalmol. 2012 Aug;32(4):393-6. doi: 10.1007/s10792-012-9568-7. Epub 2012 May 8.


Optos-guided pattern scan laser (Pascal)-targeted retinal photocoagulation in proliferative diabetic retinopathy.

Muqit MM, Marcellino GR, Henson DB, Young LB, Patton N, Charles SJ, Turner GS, Stanga PE.

Acta Ophthalmol. 2013 May;91(3):251-8. doi: 10.1111/j.1755-3768.2011.02307.x. Epub 2011 Dec 16.


Pascal panretinal laser ablation and regression analysis in proliferative diabetic retinopathy: Manchester Pascal Study Report 4.

Muqit MM, Marcellino GR, Henson DB, Young LB, Turner GS, Stanga PE.

Eye (Lond). 2011 Nov;25(11):1447-56. doi: 10.1038/eye.2011.188. Epub 2011 Aug 5.


Microstructural changes following inadvertent multi-spot laser photocoagulation of the fovea.

Stanga PE, Muqit MM, Marcellino GR.

Graefes Arch Clin Exp Ophthalmol. 2012 Jun;250(6):945-7. doi: 10.1007/s00417-011-1719-4. Epub 2011 Jun 10. No abstract available.


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