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Items: 1 to 50 of 113

1.

Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics.

Baltussen LL, Negraes PD, Silvestre M, Claxton S, Moeskops M, Christodoulou E, Flynn HR, Snijders AP, Muotri AR, Ultanir SK.

EMBO J. 2018 Sep 28. pii: e99763. doi: 10.15252/embj.201899763. [Epub ahead of print]

2.

Frequency and association of mitochondrial genetic variants with neurological disorders.

Cruz ACP, Ferrasa A, Muotri AR, Herai RH.

Mitochondrion. 2018 Sep 12. pii: S1567-7249(18)30113-2. doi: 10.1016/j.mito.2018.09.005. [Epub ahead of print] Review.

PMID:
30218715
3.

Direct Generation of Human Cortical Organoids from Primary Cells.

Schukking M, Miranda HC, Trujillo CA, Negraes PD, Muotri AR.

Stem Cells Dev. 2018 Sep 22. doi: 10.1089/scd.2018.0112. [Epub ahead of print]

PMID:
30142987
4.

Author Correction: Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR.

Sci Rep. 2018 Jun 5;8(1):8794. doi: 10.1038/s41598-018-26959-4.

5.

Survival of syngeneic and allogeneic iPSC-derived neural precursors after spinal grafting in minipigs.

Strnadel J, Carromeu C, Bardy C, Navarro M, Platoshyn O, Glud AN, Marsala S, Kafka J, Miyanohara A, Kato T Jr, Tadokoro T, Hefferan MP, Kamizato K, Yoshizumi T, Juhas S, Juhasova J, Ho CS, Kheradmand T, Chen P, Bohaciakova D, Hruska-Plochan M, Todd AJ, Driscoll SP, Glenn TD, Pfaff SL, Klima J, Ciacci J, Curtis E, Gage FH, Bui J, Yamada K, Muotri AR, Marsala M.

Sci Transl Med. 2018 May 9;10(440). pii: eaam6651. doi: 10.1126/scitranslmed.aam6651.

PMID:
29743351
6.

Author Correction: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2018 Jul;21(7):1016. doi: 10.1038/s41593-018-0131-3.

PMID:
29703932
7.

Paternally inherited cis-regulatory structural variants are associated with autism.

Brandler WM, Antaki D, Gujral M, Kleiber ML, Whitney J, Maile MS, Hong O, Chapman TR, Tan S, Tandon P, Pang T, Tang SC, Vaux KK, Yang Y, Harrington E, Juul S, Turner DJ, Thiruvahindrapuram B, Kaur G, Wang Z, Kingsmore SF, Gleeson JG, Bisson D, Kakaradov B, Telenti A, Venter JC, Corominas R, Toma C, Cormand B, Rueda I, Guijarro S, Messer KS, Nievergelt CM, Arranz MJ, Courchesne E, Pierce K, Muotri AR, Iakoucheva LM, Hervas A, Scherer SW, Corsello C, Sebat J.

Science. 2018 Apr 20;360(6386):327-331. doi: 10.1126/science.aan2261.

8.

Autism spectrum disorders: Challenges and perspectives.

Muotri AR.

Dev Neurobiol. 2018 May;78(5):431-433. doi: 10.1002/dneu.22586. Epub 2018 Mar 23. No abstract available.

PMID:
29516662
9.

Genetic variations on SETD5 underlying autistic conditions.

Fernandes IR, Cruz ACP, Ferrasa A, Phan D, Herai RH, Muotri AR.

Dev Neurobiol. 2018 May;78(5):500-518. doi: 10.1002/dneu.22584. Epub 2018 Mar 5. Review.

PMID:
29484850
10.

Blocking Zika virus vertical transmission.

Mesci P, Macia A, Moore SM, Shiryaev SA, Pinto A, Huang CT, Tejwani L, Fernandes IR, Suarez NA, Kolar MJ, Montefusco S, Rosenberg SC, Herai RH, Cugola FR, Russo FB, Sheets N, Saghatelian A, Shresta S, Momper JD, Siqueira-Neto JL, Corbett KD, Beltrão-Braga PCB, Terskikh AV, Muotri AR.

Sci Rep. 2018 Jan 19;8(1):1218. doi: 10.1038/s41598-018-19526-4. Erratum in: Sci Rep. 2018 Jun 5;8(1):8794.

11.

The contribution of GTF2I haploinsufficiency to Williams syndrome.

Chailangkarn T, Noree C, Muotri AR.

Mol Cell Probes. 2018 Aug;40:45-51. doi: 10.1016/j.mcp.2017.12.005. Epub 2018 Jan 3. Review.

PMID:
29305905
12.

LINE-1 retrotransposons in healthy and diseased human brain.

Suarez NA, Macia A, Muotri AR.

Dev Neurobiol. 2018 May;78(5):434-455. doi: 10.1002/dneu.22567. Epub 2017 Dec 29. Review.

PMID:
29239145
13.

Repurposing of the anti-malaria drug chloroquine for Zika Virus treatment and prophylaxis.

Shiryaev SA, Mesci P, Pinto A, Fernandes I, Sheets N, Shresta S, Farhy C, Huang CT, Strongin AY, Muotri AR, Terskikh AV.

Sci Rep. 2017 Nov 17;7(1):15771. doi: 10.1038/s41598-017-15467-6.

14.

Modeling the Interplay Between Neurons and Astrocytes in Autism Using Human Induced Pluripotent Stem Cells.

Russo FB, Freitas BC, Pignatari GC, Fernandes IR, Sebat J, Muotri AR, Beltrão-Braga PCB.

Biol Psychiatry. 2018 Apr 1;83(7):569-578. doi: 10.1016/j.biopsych.2017.09.021. Epub 2017 Oct 3.

PMID:
29129319
15.

Modeling neuro-immune interactions during Zika virus infection.

Mesci P, Macia A, LaRock CN, Tejwani L, Fernandes IR, Suarez NA, de A Zanotto PM, Beltrão-Braga PCB, Nizet V, Muotri AR.

Hum Mol Genet. 2018 Jan 1;27(1):41-52. doi: 10.1093/hmg/ddx382.

PMID:
29048558
16.

Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation.

van der Vaart M, Svoboda O, Weijts BG, Espín-Palazón R, Sapp V, Pietri T, Bagnat M, Muotri AR, Traver D.

Dis Model Mech. 2017 Dec 19;10(12):1439-1451. doi: 10.1242/dmm.026922.

17.

Corrigendum: L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola ACM, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FIA, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2017 Sep 28;20(10):1427. doi: 10.1038/nn1017-1427a. No abstract available.

PMID:
28949329
18.

Autism spectrum disorders and disease modeling using stem cells.

Brito A, Russo FB, Muotri AR, Beltrão-Braga PCB.

Cell Tissue Res. 2018 Jan;371(1):153-160. doi: 10.1007/s00441-017-2685-x. Epub 2017 Sep 16. Review.

PMID:
28918504
19.

Modeling of TREX1-Dependent Autoimmune Disease using Human Stem Cells Highlights L1 Accumulation as a Source of Neuroinflammation.

Thomas CA, Tejwani L, Trujillo CA, Negraes PD, Herai RH, Mesci P, Macia A, Crow YJ, Muotri AR.

Cell Stem Cell. 2017 Sep 7;21(3):319-331.e8. doi: 10.1016/j.stem.2017.07.009. Epub 2017 Aug 10.

20.

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

Herai RH, Negraes PD, Muotri AR.

Hum Mol Genet. 2017 Jul 1;26(13):2590. doi: 10.1093/hmg/ddx220. No abstract available.

PMID:
28637317
21.

Intact piRNA pathway prevents L1 mobilization in male meiosis.

Newkirk SJ, Lee S, Grandi FC, Gaysinskaya V, Rosser JM, Vanden Berg N, Hogarth CA, Marchetto MCN, Muotri AR, Griswold MD, Ye P, Bortvin A, Gage FH, Boeke JD, An W.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5635-E5644. doi: 10.1073/pnas.1701069114. Epub 2017 Jun 19.

22.

Stem cell contributions to neurological disease modeling and personalized medicine.

Liang N, Trujillo CA, Negraes PD, Muotri AR, Lameu C, Ulrich H.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jan 3;80(Pt A):54-62. doi: 10.1016/j.pnpbp.2017.05.025. Epub 2017 May 31. Review.

PMID:
28576415
23.

TRPC Channels and Mental Disorders.

Griesi-Oliveira K, Suzuki AM, Muotri AR.

Adv Exp Med Biol. 2017;976:137-148. doi: 10.1007/978-94-024-1088-4_12. Review.

PMID:
28508319
24.

Evidence of nuclei-encoded spliceosome mediating splicing of mitochondrial RNA.

Herai RH, Negraes PD, Muotri AR.

Hum Mol Genet. 2017 Jul 1;26(13):2472-2479. doi: 10.1093/hmg/ddx142. Erratum in: Hum Mol Genet. 2017 Jul 1;26(13):2590.

25.

Modeling anorexia nervosa: transcriptional insights from human iPSC-derived neurons.

Negraes PD, Cugola FR, Herai RH, Trujillo CA, Cristino AS, Chailangkarn T, Muotri AR, Duvvuri V.

Transl Psychiatry. 2017 Mar 14;7(3):e1060. doi: 10.1038/tp.2017.37.

26.

Modeling Williams syndrome with induced pluripotent stem cells.

Chailangkarn T, Muotri AR.

Neurogenesis (Austin). 2017 Feb 6;4(1):e1283187. doi: 10.1080/23262133.2017.1283187. eCollection 2017.

27.

IGF1 neuronal response in the absence of MECP2 is dependent on TRalpha 3.

de Souza JS, Carromeu C, Torres LB, Araujo BH, Cugola FR, Maciel RM, Muotri AR, Giannocco G.

Hum Mol Genet. 2017 Jan 15;26(2):270-281. doi: 10.1093/hmg/ddw384.

28.

Towards a 21st-century roadmap for biomedical research and drug discovery: consensus report and recommendations.

Langley GR, Adcock IM, Busquet F, Crofton KM, Csernok E, Giese C, Heinonen T, Herrmann K, Hofmann-Apitius M, Landesmann B, Marshall LJ, McIvor E, Muotri AR, Noor F, Schutte K, Seidle T, van de Stolpe A, Van Esch H, Willett C, Woszczek G.

Drug Discov Today. 2017 Feb;22(2):327-339. doi: 10.1016/j.drudis.2016.10.011. Epub 2016 Oct 29. Review.

29.

Engineered LINE-1 retrotransposition in nondividing human neurons.

Macia A, Widmann TJ, Heras SR, Ayllon V, Sanchez L, Benkaddour-Boumzaouad M, Muñoz-Lopez M, Rubio A, Amador-Cubero S, Blanco-Jimenez E, Garcia-Castro J, Menendez P, Ng P, Muotri AR, Goodier JL, Garcia-Perez JL.

Genome Res. 2017 Mar;27(3):335-348. doi: 10.1101/gr.206805.116. Epub 2016 Dec 13.

30.

The Na+/HCO3- co-transporter is protective during ischemia in astrocytes.

Yao H, Azad P, Zhao HW, Wang J, Poulsen O, Freitas BC, Muotri AR, Haddad GG.

Neuroscience. 2016 Dec 17;339:329-337. doi: 10.1016/j.neuroscience.2016.09.050. Epub 2016 Oct 4.

31.

L1-associated genomic regions are deleted in somatic cells of the healthy human brain.

Erwin JA, Paquola AC, Singer T, Gallina I, Novotny M, Quayle C, Bedrosian TA, Alves FI, Butcher CR, Herdy JR, Sarkar A, Lasken RS, Muotri AR, Gage FH.

Nat Neurosci. 2016 Dec;19(12):1583-1591. doi: 10.1038/nn.4388. Epub 2016 Sep 12. Erratum in: Nat Neurosci. 2017 Sep 28;20(10 ):1427. Nat Neurosci. 2018 Apr 27;:.

32.

Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation.

Pillat MM, Lameu C, Trujillo CA, Glaser T, Cappellari AR, Negraes PD, Battastini AM, Schwindt TT, Muotri AR, Ulrich H.

J Cell Sci. 2016 Sep 15;129(18):3437-48. doi: 10.1242/jcs.192534. Epub 2016 Aug 15.

33.

A human neurodevelopmental model for Williams syndrome.

Chailangkarn T, Trujillo CA, Freitas BC, Hrvoj-Mihic B, Herai RH, Yu DX, Brown TT, Marchetto MC, Bardy C, McHenry L, Stefanacci L, Järvinen A, Searcy YM, DeWitt M, Wong W, Lai P, Ard MC, Hanson KL, Romero S, Jacobs B, Dale AM, Dai L, Korenberg JR, Gage FH, Bellugi U, Halgren E, Semendeferi K, Muotri AR.

Nature. 2016 Aug 18;536(7616):338-43. Epub 2016 Aug 10.

34.

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals.

Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo CA, Mendes APD, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes CC, Courchesne E, Geschwind DH, Gage FH, Wynshaw-Boris A, Muotri AR.

Mol Psychiatry. 2017 Jun;22(6):820-835. doi: 10.1038/mp.2016.95. Epub 2016 Jul 5.

35.

The Brazilian Zika virus strain causes birth defects in experimental models.

Cugola FR, Fernandes IR, Russo FB, Freitas BC, Dias JL, Guimarães KP, Benazzato C, Almeida N, Pignatari GC, Romero S, Polonio CM, Cunha I, Freitas CL, Brandão WN, Rossato C, Andrade DG, Faria Dde P, Garcez AT, Buchpigel CA, Braconi CT, Mendes E, Sall AA, Zanotto PM, Peron JP, Muotri AR, Beltrão-Braga PC.

Nature. 2016 Jun 9;534(7606):267-71. doi: 10.1038/nature18296. Epub 2016 May 11.

36.

Frequency and Complexity of De Novo Structural Mutation in Autism.

Brandler WM, Antaki D, Gujral M, Noor A, Rosanio G, Chapman TR, Barrera DJ, Lin GN, Malhotra D, Watts AC, Wong LC, Estabillo JA, Gadomski TE, Hong O, Fajardo KV, Bhandari A, Owen R, Baughn M, Yuan J, Solomon T, Moyzis AG, Maile MS, Sanders SJ, Reiner GE, Vaux KK, Strom CM, Zhang K, Muotri AR, Akshoomoff N, Leal SM, Pierce K, Courchesne E, Iakoucheva LM, Corsello C, Sebat J.

Am J Hum Genet. 2016 Apr 7;98(4):667-79. doi: 10.1016/j.ajhg.2016.02.018. Epub 2016 Mar 24.

37.

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction.

Zhang ZN, Freitas BC, Qian H, Lux J, Acab A, Trujillo CA, Herai RH, Nguyen Huu VA, Wen JH, Joshi-Barr S, Karpiak JV, Engler AJ, Fu XD, Muotri AR, Almutairi A.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3185-90. doi: 10.1073/pnas.1521255113. Epub 2016 Mar 4.

38.

L1 Retrotransposition in Neural Progenitor Cells.

Muotri AR.

Methods Mol Biol. 2016;1400:157-63. doi: 10.1007/978-1-4939-3372-3_11.

PMID:
26895053
39.

Modeling autism spectrum disorders with human neurons.

Beltrão-Braga PC, Muotri AR.

Brain Res. 2017 Feb 1;1656:49-54. doi: 10.1016/j.brainres.2016.01.057. Epub 2016 Feb 5. Review.

40.

XPC deficiency is related to APE1 and OGG1 expression and function.

de Melo JT, de Souza Timoteo AR, Lajus TB, Brandão JA, de Souza-Pinto NC, Menck CF, Campalans A, Radicella JP, Vessoni AT, Muotri AR, Agnez-Lima LF.

Mutat Res. 2016 Feb-Mar;784-785:25-33. doi: 10.1016/j.mrfmmm.2016.01.004. Epub 2016 Jan 16.

PMID:
26811994
41.

Cockayne syndrome-derived neurons display reduced synapse density and altered neural network synchrony.

Vessoni AT, Herai RH, Karpiak JV, Leal AM, Trujillo CA, Quinet A, Agnez Lima LF, Menck CF, Muotri AR.

Hum Mol Genet. 2016 Apr 1;25(7):1271-80. doi: 10.1093/hmg/ddw008. Epub 2016 Jan 10.

42.

KCC2 rescues functional deficits in human neurons derived from patients with Rett syndrome.

Tang X, Kim J, Zhou L, Wengert E, Zhang L, Wu Z, Carromeu C, Muotri AR, Marchetto MC, Gage FH, Chen G.

Proc Natl Acad Sci U S A. 2016 Jan 19;113(3):751-6. doi: 10.1073/pnas.1524013113. Epub 2016 Jan 5.

43.

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders.

Brennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Izpisua Belmonte JC, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R.

Stem Cell Reports. 2015 Dec 8;5(6):933-945. doi: 10.1016/j.stemcr.2015.10.011. Epub 2015 Nov 21.

44.

Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research.

Langley G, Austin CP, Balapure AK, Birnbaum LS, Bucher JR, Fentem J, Fitzpatrick SC, Fowle JR 3rd, Kavlock RJ, Kitano H, Lidbury BA, Muotri AR, Peng SQ, Sakharov D, Seidle T, Trez T, Tonevitsky A, van de Stolpe A, Whelan M, Willett C.

Environ Health Perspect. 2015 Nov;123(11):A268-72. doi: 10.1289/ehp.1510345.

45.

Neurotoxic Methamphetamine Doses Increase LINE-1 Expression in the Neurogenic Zones of the Adult Rat Brain.

Moszczynska A, Flack A, Qiu P, Muotri AR, Killinger BA.

Sci Rep. 2015 Oct 14;5:14356. doi: 10.1038/srep14356.

46.

Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.

Melo US, Macedo-Souza LI, Figueiredo T, Muotri AR, Gleeson JG, Coux G, Armas P, Calcaterra NB, Kitajima JP, Amorim S, Olávio TR, Griesi-Oliveira K, Coatti GC, Rocha CR, Martins-Pinheiro M, Menck CF, Zaki MS, Kok F, Zatz M, Santos S.

Hum Mol Genet. 2015 Dec 15;24(24):6877-85. doi: 10.1093/hmg/ddv388. Epub 2015 Sep 18.

PMID:
26385635
47.

Altered neuronal network and rescue in a human MECP2 duplication model.

Nageshappa S, Carromeu C, Trujillo CA, Mesci P, Espuny-Camacho I, Pasciuto E, Vanderhaeghen P, Verfaillie CM, Raitano S, Kumar A, Carvalho CM, Bagni C, Ramocki MB, Araujo BH, Torres LB, Lupski JR, Van Esch H, Muotri AR.

Mol Psychiatry. 2016 Feb;21(2):178-88. doi: 10.1038/mp.2015.128. Epub 2015 Sep 8.

48.

Systematic optimization of human pluripotent stem cells media using Design of Experiments.

Marinho PA, Chailangkarn T, Muotri AR.

Sci Rep. 2015 May 5;5:9834. doi: 10.1038/srep09834.

49.

The Human Model: Changing Focus on Autism Research.

Muotri AR.

Biol Psychiatry. 2016 Apr 15;79(8):642-9. doi: 10.1016/j.biopsych.2015.03.012. Epub 2015 Mar 17. Review.

50.

The Use of Induced Pluripotent Stem Cell Technology to Advance Autism Research and Treatment.

Acab A, Muotri AR.

Neurotherapeutics. 2015 Jul;12(3):534-45. doi: 10.1007/s13311-015-0354-x. Review.

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