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Items: 24


Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V, De Angeli P, Páleníková P, Khodak A, Kiselev V, Kosicki M, Bassett AR, Harding H, Galanty Y, Muñoz-Martínez F, Metzakopian E, Jackson SP, Parts L.

Nat Biotechnol. 2018 Nov 27. doi: 10.1038/nbt.4317. [Epub ahead of print]


Map of synthetic rescue interactions for the Fanconi anemia DNA repair pathway identifies USP48.

Velimezi G, Robinson-Garcia L, Muñoz-Martínez F, Wiegant WW, Ferreira da Silva J, Owusu M, Moder M, Wiedner M, Rosenthal SB, Fisch KM, Moffat J, Menche J, van Attikum H, Jackson SP, Loizou JI.

Nat Commun. 2018 Jun 11;9(1):2280. doi: 10.1038/s41467-018-04649-z.


Effectiveness of Resistance Circuit-Based Training for Maximum Oxygen Uptake and Upper-Body One-Repetition Maximum Improvements: A Systematic Review and Meta-Analysis.

Muñoz-Martínez FA, Rubio-Arias JÁ, Ramos-Campo DJ, Alcaraz PE.

Sports Med. 2017 Dec;47(12):2553-2568. doi: 10.1007/s40279-017-0773-4. Review.


Purification, crystallization and preliminary crystallographic analysis of the ligand-binding regions of the PctA and PctB chemoreceptors from Pseudomonas aeruginosa in complex with amino acids.

Rico-Jiménez M, Muñoz-Martínez F, Krell T, Gavira JA, Pineda-Molina E.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec;69(Pt 12):1431-5. doi: 10.1107/S1744309113023592. Epub 2013 Nov 29.


High specificity in CheR methyltransferase function: CheR2 of Pseudomonas putida is essential for chemotaxis, whereas CheR1 is involved in biofilm formation.

García-Fontana C, Reyes-Darias JA, Muñoz-Martínez F, Alfonso C, Morel B, Ramos JL, Krell T.

J Biol Chem. 2013 Jun 28;288(26):18987-99. doi: 10.1074/jbc.M113.472605. Epub 2013 May 15.


Paralogous chemoreceptors mediate chemotaxis towards protein amino acids and the non-protein amino acid gamma-aminobutyrate (GABA).

Rico-Jiménez M, Muñoz-Martínez F, García-Fontana C, Fernandez M, Morel B, Ortega A, Ramos JL, Krell T.

Mol Microbiol. 2013 Jun;88(6):1230-43. doi: 10.1111/mmi.12255. Epub 2013 May 22.


Genes encoding Cher-TPR fusion proteins are predominantly found in gene clusters encoding chemosensory pathways with alternative cellular functions.

Muñoz-Martínez F, García-Fontana C, Rico-Jiménez M, Alfonso C, Krell T.

PLoS One. 2012;7(9):e45810. doi: 10.1371/journal.pone.0045810. Epub 2012 Sep 20.


Responses of Pseudomonas putida to toxic aromatic carbon sources.

Krell T, Lacal J, Guazzaroni ME, Busch A, Silva-Jiménez H, Fillet S, Reyes-Darías JA, Muñoz-Martínez F, Rico-Jiménez M, García-Fontana C, Duque E, Segura A, Ramos JL.

J Biotechnol. 2012 Jul 31;160(1-2):25-32. doi: 10.1016/j.jbiotec.2012.01.026. Epub 2012 Feb 1.


Bacterial chemotaxis towards aromatic hydrocarbons in Pseudomonas.

Lacal J, Muñoz-Martínez F, Reyes-Darías JA, Duque E, Matilla M, Segura A, Calvo JJ, Jímenez-Sánchez C, Krell T, Ramos JL.

Environ Microbiol. 2011 Jul;13(7):1733-44. doi: 10.1111/j.1462-2920.2011.02493.x. Epub 2011 May 23.


Diversity at its best: bacterial taxis.

Krell T, Lacal J, Muñoz-Martínez F, Reyes-Darias JA, Cadirci BH, García-Fontana C, Ramos JL.

Environ Microbiol. 2011 May;13(5):1115-24. doi: 10.1111/j.1462-2920.2010.02383.x. Epub 2010 Nov 18. Review.


Sensing of environmental signals: classification of chemoreceptors according to the size of their ligand binding regions.

Lacal J, García-Fontana C, Muñoz-Martínez F, Ramos JL, Krell T.

Environ Microbiol. 2010 Nov;12(11):2873-84. doi: 10.1111/j.1462-2920.2010.02325.x. Epub 2010 Aug 25. Review.


CDC50A plays a key role in the uptake of the anticancer drug perifosine in human carcinoma cells.

Muñoz-Martínez F, Torres C, Castanys S, Gamarro F.

Biochem Pharmacol. 2010 Sep 15;80(6):793-800. doi: 10.1016/j.bcp.2010.05.017. Epub 2010 May 25.


Novel dihydro-beta-agarofuran sesquiterpenes as potent modulators of human P-glycoprotein dependent multidrug resistance.

Torres-Romero D, Muñoz-Martínez F, Jiménez IA, Castanys S, Gamarro F, Bazzocchi IL.

Org Biomol Chem. 2009 Dec 21;7(24):5166-72. doi: 10.1039/b915678j. Epub 2009 Oct 15.


Bis-pyranobenzoquinones as a new family of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in mammalian cells and the protozoan parasite Leishmania.

Jiménez-Alonso S, Pérez-Lomas AL, Estévez-Braun A, Muñoz Martinez F, Chávez Orellana H, Ravelo AG, Gamarro F, Castanys S, López M.

J Med Chem. 2008 Nov 27;51(22):7132-43. doi: 10.1021/jm800403b.


The anti-tumor alkylphospholipid perifosine is internalized by an ATP-dependent translocase activity across the plasma membrane of human KB carcinoma cells.

Muñoz-Martínez F, Torres C, Castanys S, Gamarro F.

Biochim Biophys Acta. 2008 Feb;1778(2):530-40. Epub 2007 Oct 25.


Biological evaluation, structure-activity relationships, and three-dimensional quantitative structure-activity relationship studies of dihydro-beta-agarofuran sesquiterpenes as modulators of P-glycoprotein-dependent multidrug resistance.

Reyes CP, Muñoz-Martínez F, Torrecillas IR, Mendoza CR, Gamarro F, Bazzocchi IL, Núñez MJ, Pardo L, Castanys S, Campillo M, Jiménez IA.

J Med Chem. 2007 Oct 4;50(20):4808-17. Epub 2007 Sep 12.


Combination of suboptimal doses of inhibitors targeting different domains of LtrMDR1 efficiently overcomes resistance of Leishmania spp. to Miltefosine by inhibiting drug efflux.

Pérez-Victoria JM, Cortés-Selva F, Parodi-Talice A, Bavchvarov BI, Pérez-Victoria FJ, Muñoz-Martínez F, Maitrejean M, Costi MP, Barron D, Di Pietro A, Castanys S, Gamarro F.

Antimicrob Agents Chemother. 2006 Sep;50(9):3102-10.


Insights into the molecular mechanism of action of Celastraceae sesquiterpenes as specific, non-transported inhibitors of human P-glycoprotein.

Muñoz-Martínez F, Reyes CP, Pérez-Lomas AL, Jiménez IA, Gamarro F, Castanys S.

Biochim Biophys Acta. 2006 Jan;1758(1):98-110. Epub 2006 Jan 11.


Dihydro-beta-agarofuran sesquiterpenes: a new class of reversal agents of the multidrug resistance phenotype mediated by P-glycoprotein in the protozoan parasite Leishmania.

Cortés-Selva F, Jiménez IA, Munoz-Martínez F, Campillo M, Bazzocchi IL, Pardo L, Ravelo AG, Castanys S, Gamarro F.

Curr Pharm Des. 2005;11(24):3125-39. Review.


Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.

Muñoz-Martínez F, Mendoza CR, Bazzocchi IL, Castanys S, Jiménez IA, Gamarro F.

J Med Chem. 2005 Jun 30;48(13):4266-75.


Flavonoid structure-activity studies identify 6-prenylchrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2.

Ahmed-Belkacem A, Pozza A, Muñoz-Martínez F, Bates SE, Castanys S, Gamarro F, Di Pietro A, Pérez-Victoria JM.

Cancer Res. 2005 Jun 1;65(11):4852-60.


Functional expression of a multidrug P-glycoprotein transporter of Leishmania.

Cortés-Selva F, Muñoz-Martínez F, Iliás A, Jiménez AI, Váradi A, Gamarro F, Castanys S.

Biochem Biophys Res Commun. 2005 Apr 8;329(2):502-7.


Celastraceae sesquiterpenes as a new class of modulators that bind specifically to human P-glycoprotein and reverse cellular multidrug resistance.

Muñoz-Martínez F, Lu P, Cortés-Selva F, Pérez-Victoria JM, Jiménez IA, Ravelo AG, Sharom FJ, Gamarro F, Castanys S.

Cancer Res. 2004 Oct 1;64(19):7130-8.


RU49953: a non-hormonal steroid derivative that potently inhibits P-glycoprotein and reverts cellular multidrug resistance.

Perez-Victorias FJ, Conseil G, Munoz-Martinez F, Perez-Victoria JM, Dayan G, Marsaud V, Castanys S, Gamarro F, Renoir JM, Di Pietro A.

Cell Mol Life Sci. 2003 Mar;60(3):526-35.


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