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Items: 1 to 50 of 77

1.

First-in-class allosteric inhibitors of bacterial IMPDHs.

Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H.

Eur J Med Chem. 2019 Apr 1;167:124-132. doi: 10.1016/j.ejmech.2019.01.064. Epub 2019 Feb 2.

PMID:
30769241
2.

Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay.

Thieulent CJ, Hue ES, Fortier CI, Dallemagne P, Zientara S, Munier-Lehmann H, Hans A, Fortier GD, Pitel PH, Vidalain PO, Pronost SL.

Virology. 2019 Jan 2;526:105-116. doi: 10.1016/j.virol.2018.10.013. Epub 2018 Oct 26.

PMID:
30388626
3.

A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.

Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun.

4.

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S.

J Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021/acs.jmedchem.7b01570. Epub 2018 Mar 15.

PMID:
29510037
5.

Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis.

Suthagar K, Jiao W, Munier-Lehmann H, Fairbanks AJ.

Carbohydr Res. 2018 Mar 2;457:32-40. doi: 10.1016/j.carres.2018.01.001. Epub 2018 Jan 11.

PMID:
29348046
6.

Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A.

Harigua-Souiai E, Abdelkrim YZ, Bassoumi-Jamoussi I, Zakraoui O, Bouvier G, Essafi-Benkhadir K, Banroques J, Desdouits N, Munier-Lehmann H, Barhoumi M, Tanner NK, Nilges M, Blondel A, Guizani I.

PLoS Negl Trop Dis. 2018 Jan 18;12(1):e0006160. doi: 10.1371/journal.pntd.0006160. eCollection 2018 Jan.

7.

Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT.

Dabo S, Maillard P, Collados Rodriguez M, Hansen MD, Mazouz S, Bigot DJ, Tible M, Janvier G, Helynck O, Cassonnet P, Jacob Y, Bellalou J, Gatignol A, Patel RC, Hugon J, Munier-Lehmann H, Meurs EF.

Sci Rep. 2017 Nov 23;7(1):16129. doi: 10.1038/s41598-017-16089-8.

8.

Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis.

Buchieri MV, Cimino M, Rebollo-Ramirez S, Beauvineau C, Cascioferro A, Favre-Rochex S, Helynck O, Naud-Martin D, Larrouy-Maumus G, Munier-Lehmann H, Gicquel B.

J Med Chem. 2017 Sep 14;60(17):7425-7433. doi: 10.1021/acs.jmedchem.7b00726. Epub 2017 Aug 28.

PMID:
28846409
9.

Corrigenda to "Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents" [Bioorg Med Chem 24 (2016) 5172-5182].

Song L, Risseeuw MDP, Froeyen M, Karalic I, Goeman J, Cappoen D, Van der Eycken J, Cos P, Munier-Lehmann H, Van Calenbergh S.

Bioorg Med Chem. 2017 Oct 15;25(20):5889. doi: 10.1016/j.bmc.2017.08.023. Epub 2017 Aug 18. No abstract available.

PMID:
28826595
10.

Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response.

Lucas-Hourani M, Dauzonne D, Munier-Lehmann H, Khiar S, Nisole S, Dairou J, Helynck O, Afonso PV, Tangy F, Vidalain PO.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00383-17. doi: 10.1128/AAC.00383-17. Print 2017 Oct.

11.

Identification of a small molecule that primes the type I interferon response to cytosolic DNA.

Khiar S, Lucas-Hourani M, Nisole S, Smith N, Helynck O, Bourgine M, Ruffié C, Herbeuval JP, Munier-Lehmann H, Tangy F, Vidalain PO.

Sci Rep. 2017 May 31;7(1):2561. doi: 10.1038/s41598-017-02776-z.

12.

Tetrahydro-2-furanyl-2,4(1H,3H)-pyrimidinedione derivatives as novel antibacterial compounds against Mycobacterium.

Koseki Y, Kanetaka H, Tsunosaki J, Munier-Lehmann H, Aoki S.

Int J Mycobacteriol. 2017 Jan-Mar;6(1):61-69. doi: 10.4103/2212-5531.201893.

13.

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.

Song L, Risseeuw MDP, Froeyen M, Karalic I, Goeman J, Cappoen D, Van der Eycken J, Cos P, Munier-Lehmann H, Van Calenbergh S.

Bioorg Med Chem. 2016 Nov 1;24(21):5172-5182. doi: 10.1016/j.bmc.2016.08.041. Epub 2016 Aug 24. Erratum in: Bioorg Med Chem. 2017 Oct 15;25(20):5889.

14.

Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.

Laskaris P, Atrouni A, Calera JA, d'Enfert C, Munier-Lehmann H, Cavaillon JM, Latgé JP, Ibrahim-Granet O.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5631-9. doi: 10.1128/AAC.00324-16. Print 2016 Oct.

15.

Anti-mycobacterial activity of thymine derivatives bearing boron clusters.

Adamska A, Rumijowska-Galewicz A, Ruszczynska A, Studzińska M, Jabłońska A, Paradowska E, Bulska E, Munier-Lehmann H, Dziadek J, Leśnikowski ZJ, Olejniczak AB.

Eur J Med Chem. 2016 Oct 4;121:71-81. doi: 10.1016/j.ejmech.2016.05.030. Epub 2016 May 15.

PMID:
27236064
16.

The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components.

Raj S, Krishnan K, Askew DS, Helynck O, Suzanne P, Lesnard A, Rault S, Zeidler U, d'Enfert C, Latgé JP, Munier-Lehmann H, Saveanu C.

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1438-49. doi: 10.1128/AAC.02239-15.

17.

Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.

Grandin C, Hourani ML, Janin YL, Dauzonne D, Munier-Lehmann H, Paturet A, Taborik F, Vabret A, Contamin H, Tangy F, Vidalain PO.

Antiviral Res. 2016 Jan;125:58-62. doi: 10.1016/j.antiviral.2015.11.006. Epub 2015 Nov 22.

PMID:
26593978
18.

Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation.

Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1890-9. doi: 10.1107/S1399004715013115. Epub 2015 Aug 25.

PMID:
26327379
19.

Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).

Lucas-Hourani M, Munier-Lehmann H, El Mazouni F, Malmquist NA, Harpon J, Coutant EP, Guillou S, Helynck O, Noel A, Scherf A, Phillips MA, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jul 23;58(14):5579-98. doi: 10.1021/acs.jmedchem.5b00606. Epub 2015 Jun 30.

20.

Correction: Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties.

Alexandre T, Raynal B, Munier-Lehmann H.

PLoS One. 2015 Apr 29;10(4):e0125884. doi: 10.1371/journal.pone.0125884. eCollection 2015. No abstract available.

21.

Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties.

Alexandre T, Raynal B, Munier-Lehmann H.

PLoS One. 2015 Feb 23;10(2):e0116578. doi: 10.1371/journal.pone.0116578. eCollection 2015. Erratum in: PLoS One. 2015;10(4):e0125884. Rayna, Bertrand [corrected to Raynal, Bertrand].

22.

[Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening].

Vidalain PO, Lucas-Hourani M, Helynck O, Tangy F, Munier-Lehmann H.

Med Sci (Paris). 2015 Jan;31(1):98-104. doi: 10.1051/medsci/20153101019. Epub 2015 Feb 6. Review. French.

23.

Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH).

Munier-Lehmann H, Lucas-Hourani M, Guillou S, Helynck O, Zanghi G, Noel A, Tangy F, Vidalain PO, Janin YL.

J Med Chem. 2015 Jan 22;58(2):860-77. doi: 10.1021/jm501446r. Epub 2015 Jan 6.

PMID:
25558988
24.

High-throughput screening for broad-spectrum chemical inhibitors of RNA viruses.

Lucas-Hourani M, Munier-Lehmann H, Helynck O, Komarova A, Desprès P, Tangy F, Vidalain PO.

J Vis Exp. 2014 May 5;(87). doi: 10.3791/51222.

25.

Inhibition of pyrimidine biosynthesis pathway suppresses viral growth through innate immunity.

Lucas-Hourani M, Dauzonne D, Jorda P, Cousin G, Lupan A, Helynck O, Caignard G, Janvier G, André-Leroux G, Khiar S, Escriou N, Desprès P, Jacob Y, Munier-Lehmann H, Tangy F, Vidalain PO.

PLoS Pathog. 2013;9(10):e1003678. doi: 10.1371/journal.ppat.1003678. Epub 2013 Oct 3.

26.

AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity.

Carré C, Jacquier C, Bougé AL, de Chaumont F, Besnard-Guerin C, Thomassin H, Pidoux J, Da Silva B, Chalatsi E, Zahra S, Olivo-Marin JC, Munier-Lehmann H, Antoniewski C.

PLoS One. 2013 Sep 3;8(9):e74296. doi: 10.1371/journal.pone.0074296. eCollection 2013.

27.

MgATP regulates allostery and fiber formation in IMPDHs.

Labesse G, Alexandre T, Vaupré L, Salard-Arnaud I, Him JL, Raynal B, Bron P, Munier-Lehmann H.

Structure. 2013 Jun 4;21(6):975-85. doi: 10.1016/j.str.2013.03.011. Epub 2013 May 2.

28.

High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.

Aulner N, Danckaert A, Rouault-Hardoin E, Desrivot J, Helynck O, Commere PH, Munier-Lehmann H, Späth GF, Shorte SL, Milon G, Prina E.

PLoS Negl Trop Dis. 2013 Apr 4;7(4):e2154. doi: 10.1371/journal.pntd.0002154. Print 2013.

29.

On dihydroorotate dehydrogenases and their inhibitors and uses.

Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL.

J Med Chem. 2013 Apr 25;56(8):3148-67. doi: 10.1021/jm301848w. Epub 2013 Mar 20. Review.

PMID:
23452331
30.

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.

Zeidler U, Bougnoux ME, Lupan A, Helynck O, Doyen A, Garcia Z, Sertour N, Clavaud C, Munier-Lehmann H, Saveanu C, d'Enfert C.

J Antimicrob Chemother. 2013 Jun;68(6):1285-96. doi: 10.1093/jac/dks538. Epub 2013 Feb 1.

31.

Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.

Toti KS, Verbeke F, Risseeuw MD, Frecer V, Munier-Lehmann H, Van Calenbergh S.

Bioorg Med Chem. 2013 Jan 1;21(1):257-68. doi: 10.1016/j.bmc.2012.10.018. Epub 2012 Nov 5.

PMID:
23199481
32.

A phenotypic assay to identify Chikungunya virus inhibitors targeting the nonstructural protein nsP2.

Lucas-Hourani M, Lupan A, Desprès P, Thoret S, Pamlard O, Dubois J, Guillou C, Tangy F, Vidalain PO, Munier-Lehmann H.

J Biomol Screen. 2013 Feb;18(2):172-9. doi: 10.1177/1087057112460091. Epub 2012 Sep 14.

PMID:
22983165
33.

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

Kögler M, Busson R, De Jonghe S, Rozenski J, Van Belle K, Louat T, Munier-Lehmann H, Herdewijn P.

Chem Biodivers. 2012 Mar;9(3):536-56. doi: 10.1002/cbdv.201100285.

PMID:
22422522
34.

The composition of the culture medium influences the β-1,3-glucan metabolism of Aspergillus fumigatus and the antifungal activity of inhibitors of β-1,3-glucan synthesis.

Clavaud C, Beauvais A, Barbin L, Munier-Lehmann H, Latgé JP.

Antimicrob Agents Chemother. 2012 Jun;56(6):3428-31. doi: 10.1128/AAC.05661-11. Epub 2012 Mar 5.

35.

Drug design and identification of potent leads against mycobacterium tuberculosis thymidine monophosphate kinase.

Van Calenbergh S, Pochet S, Munier-Lehmann H.

Curr Top Med Chem. 2012;12(7):694-705. Review.

PMID:
22283813
36.

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.

Van Poecke S, Munier-Lehmann H, Helynck O, Froeyen M, Van Calenbergh S.

Bioorg Med Chem. 2011 Dec 15;19(24):7603-11. doi: 10.1016/j.bmc.2011.10.021. Epub 2011 Oct 18.

PMID:
22061826
37.

Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.

Labesse G, Benkali K, Salard-Arnaud I, Gilles AM, Munier-Lehmann H.

Nucleic Acids Res. 2011 Apr;39(8):3458-72. doi: 10.1093/nar/gkq1250. Epub 2010 Dec 10.

38.

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.

Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ.

Eur J Med Chem. 2010 Dec;45(12):5910-8. doi: 10.1016/j.ejmech.2010.09.056. Epub 2010 Oct 15.

PMID:
20951473
39.

Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.

Auvynet C, Topalis D, Caillat C, Munier-Lehmann H, Seclaman E, Balzarini J, Agrofoglio LA, Kaminski PA, Meyer P, Deville-Bonne D, El Amri C.

Biochem Biophys Res Commun. 2009 Oct 9;388(1):6-11. doi: 10.1016/j.bbrc.2009.07.089. Epub 2009 Jul 23.

PMID:
19631609
40.

Metalloprotease vsm is the major determinant of toxicity for extracellular products of Vibrio splendidus.

Binesse J, Delsert C, Saulnier D, Champomier-Vergès MC, Zagorec M, Munier-Lehmann H, Mazel D, Le Roux F.

Appl Environ Microbiol. 2008 Dec;74(23):7108-17. doi: 10.1128/AEM.01261-08. Epub 2008 Oct 3.

41.

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: synthesis and in vitro anti-mycobacterial activity.

Gasse C, Douguet D, Huteau V, Marchal G, Munier-Lehmann H, Pochet S.

Bioorg Med Chem. 2008 Jun 1;16(11):6075-85. doi: 10.1016/j.bmc.2008.04.045. Epub 2008 Apr 25.

PMID:
18467107
42.

Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.

Familiar O, Munier-Lehmann H, Negri A, Gago F, Douguet D, Rigouts L, Hernández AI, Camarasa MJ, Pérez-Pérez MJ.

ChemMedChem. 2008 Jul;3(7):1083-93. doi: 10.1002/cmdc.200800060.

PMID:
18418833
43.

Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

Topalis D, Alvarez K, Barral K, Munier-Lehmann H, Schneider B, Véron M, Guerreiro C, Mulard L, El-Amri C, Canard B, Deville-Bonne D.

Nucleosides Nucleotides Nucleic Acids. 2008 Apr;27(4):319-31. doi: 10.1080/15257770801941952.

PMID:
18404568
44.

A new family of inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.

Gasse C, Huteau V, Douguet D, Munier-Lehmann H, Pochet S.

Nucleosides Nucleotides Nucleic Acids. 2007;26(8-9):1057-61. No abstract available.

PMID:
18058536
45.

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.

Van Daele I, Munier-Lehmann H, Froeyen M, Balzarini J, Van Calenbergh S.

J Med Chem. 2007 Nov 1;50(22):5281-92. Epub 2007 Oct 2.

PMID:
17910427
46.

Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.

Pochet S, Dugue L, Douguet D, Labesse G, Munier-Lehmann H.

Chembiochem. 2002 Jan 4;3(1):108-10. No abstract available.

PMID:
17590962
47.

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.

Ofiteru A, Bucurenci N, Alexov E, Bertrand T, Briozzo P, Munier-Lehmann H, Gilles AM.

FEBS J. 2007 Jul;274(13):3363-73. Epub 2007 Jun 3.

48.

Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.

Van Daele I, Munier-Lehmann H, Hendrickx PM, Marchal G, Chavarot P, Froeyen M, Qing L, Martins JC, Van Calenbergh S.

ChemMedChem. 2006 Oct;1(10):1081-90.

PMID:
16921580
50.

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM.

Protein Sci. 2006 Jun;15(6):1489-93. Epub 2006 May 2.

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