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Items: 1 to 50 of 365

1.

The polyphenol resveratrol promotes skeletal growth in mice through a sirtuin 1-bone morphogenic protein 2 longevity axis.

Zhao M, Ko SY, Garrett IR, Mundy GR, Gutierrez GE, Edwards JR.

Br J Pharmacol. 2018 Nov;175(21):4183-4192. doi: 10.1111/bph.14477. Epub 2018 Sep 18.

2.

Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells.

Yang W, Guo D, Harris MA, Cui Y, Gluhak-Heinrich J, Wu J, Chen XD, Skinner C, Nyman JS, Edwards JR, Mundy GR, Lichtler A, Kream BE, Rowe DW, Kalajzic I, David V, Quarles DL, Villareal D, Scott G, Ray M, Liu S, Martin JF, Mishina Y, Harris SE.

J Cell Sci. 2013 Sep 15;126(Pt 18):4085-98. doi: 10.1242/jcs.118596. Epub 2013 Jul 10.

3.

Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells.

Zhuang J, Zhang J, Lwin ST, Edwards JR, Edwards CM, Mundy GR, Yang X.

PLoS One. 2012;7(11):e48871. doi: 10.1371/journal.pone.0048871. Epub 2012 Nov 16.

4.

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling.

Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F.

J Bone Miner Res. 2013 Apr;28(4):960-9. doi: 10.1002/jbmr.1824.

5.

Bone-derived IGF mediates crosstalk between bone and breast cancer cells in bony metastases.

Hiraga T, Myoui A, Hashimoto N, Sasaki A, Hata K, Morita Y, Yoshikawa H, Rosen CJ, Mundy GR, Yoneda T.

Cancer Res. 2012 Aug 15;72(16):4238-49. Epub 2012 Jun 27.

6.

Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1.

Fowler JA, Mundy GR, Lwin ST, Edwards CM.

Cancer Res. 2012 May 1;72(9):2183-9. doi: 10.1158/0008-5472.CAN-11-2067. Epub 2012 Feb 28.

7.

Anti-transforming growth factor ß antibody treatment rescues bone loss and prevents breast cancer metastasis to bone.

Biswas S, Nyman JS, Alvarez J, Chakrabarti A, Ayres A, Sterling J, Edwards J, Rana T, Johnson R, Perrien DS, Lonning S, Shyr Y, Matrisian LM, Mundy GR.

PLoS One. 2011;6(11):e27090. doi: 10.1371/journal.pone.0027090. Epub 2011 Nov 11.

8.

Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease.

Fowler JA, Lwin ST, Drake MT, Edwards JR, Kyle RA, Mundy GR, Edwards CM.

Blood. 2011 Nov 24;118(22):5872-82. doi: 10.1182/blood-2011-01-330407. Epub 2011 Sep 8.

9.

6-Thioguanine inhibition of parathyroid hormone-related protein expression is mediated by GLI2.

Johnson RW, Merkel AR, Danilin S, Nguyen MP, Mundy GR, Sterling JA.

Anticancer Res. 2011 Sep;31(9):2705-12.

10.

Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone.

Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O'Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR.

J Bone Miner Res. 2011 Jun;26(6):1252-60. doi: 10.1002/jbmr.326.

11.

Advances in osteoclast biology: old findings and new insights from mouse models.

Edwards JR, Mundy GR.

Nat Rev Rheumatol. 2011 Apr;7(4):235-43. doi: 10.1038/nrrheum.2011.23. Epub 2011 Mar 8. Review.

PMID:
21386794
12.

TGF-beta promotion of Gli2-induced expression of parathyroid hormone-related protein, an important osteolytic factor in bone metastasis, is independent of canonical Hedgehog signaling.

Johnson RW, Nguyen MP, Padalecki SS, Grubbs BG, Merkel AR, Oyajobi BO, Matrisian LM, Mundy GR, Sterling JA.

Cancer Res. 2011 Feb 1;71(3):822-31. doi: 10.1158/0008-5472.CAN-10-2993. Epub 2010 Dec 28.

13.

Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells.

Ruppender NS, Merkel AR, Martin TJ, Mundy GR, Sterling JA, Guelcher SA.

PLoS One. 2010 Nov 15;5(11):e15451. doi: 10.1371/journal.pone.0015451.

14.

Longitudinal live animal micro-CT allows for quantitative analysis of tumor-induced bone destruction.

Johnson LC, Johnson RW, Munoz SA, Mundy GR, Peterson TE, Sterling JA.

Bone. 2011 Jan;48(1):141-51. doi: 10.1016/j.bone.2010.05.033. Epub 2010 Jun 1.

15.

Advances in the biology of bone metastasis: how the skeleton affects tumor behavior.

Sterling JA, Edwards JR, Martin TJ, Mundy GR.

Bone. 2011 Jan;48(1):6-15. doi: 10.1016/j.bone.2010.07.015. Epub 2010 Jul 17. Review.

PMID:
20643235
16.

Gr-1+CD11b+ myeloid-derived suppressor cells: formidable partners in tumor metastasis.

Yang L, Edwards CM, Mundy GR.

J Bone Miner Res. 2010 Aug;25(8):1701-6. doi: 10.1002/jbmr.154.

17.

Targeting the Transforming Growth Factor-beta pathway inhibits human basal-like breast cancer metastasis.

Ganapathy V, Ge R, Grazioli A, Xie W, Banach-Petrosky W, Kang Y, Lonning S, McPherson J, Yingling JM, Biswas S, Mundy GR, Reiss M.

Mol Cancer. 2010 May 26;9:122. doi: 10.1186/1476-4598-9-122.

18.

Inhibition of TGF-β signaling by 1D11 antibody treatment increases bone mass and quality in vivo.

Edwards JR, Nyman JS, Lwin ST, Moore MM, Esparza J, O'Quinn EC, Hart AJ, Biswas S, Patil CA, Lonning S, Mahadevan-Jansen A, Mundy GR.

J Bone Miner Res. 2010 Nov;25(11):2419-26. doi: 10.1002/jbmr.139.

19.

Metastasis and bone loss: advancing treatment and prevention.

Coleman RE, Lipton A, Roodman GD, Guise TA, Boyce BF, Brufsky AM, Clézardin P, Croucher PI, Gralow JR, Hadji P, Holen I, Mundy GR, Smith MR, Suva LJ.

Cancer Treat Rev. 2010 Dec;36(8):615-20. doi: 10.1016/j.ctrv.2010.04.003. Epub 2010 May 15. Review.

20.

A sustained release of lovastatin from biodegradable, elastomeric polyurethane scaffolds for enhanced bone regeneration.

Yoshii T, Hafeman AE, Nyman JS, Esparza JM, Shinomiya K, Spengler DM, Mundy GR, Gutierrez GE, Guelcher SA.

Tissue Eng Part A. 2010 Jul;16(7):2369-79. doi: 10.1089/ten.TEA.2009.0585.

PMID:
20205517
21.

Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts.

Wang W, Nyman JS, Moss HE, Gutierrez G, Mundy GR, Yang X, Elefteriou F.

J Bone Miner Res. 2010 Jul;25(7):1658-67. doi: 10.1002/jbmr.42.

22.

Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling.

Pivonka P, Zimak J, Smith DW, Gardiner BS, Dunstan CR, Sims NA, Martin TJ, Mundy GR.

J Theor Biol. 2010 Jan 21;262(2):306-16. doi: 10.1016/j.jtbi.2009.09.021. Epub 2009 Sep 25.

PMID:
19782692
23.

A murine model of myeloma that allows genetic manipulation of the host microenvironment.

Fowler JA, Mundy GR, Lwin ST, Lynch CC, Edwards CM.

Dis Model Mech. 2009 Nov-Dec;2(11-12):604-11. doi: 10.1242/dmm.003160. Epub 2009 Sep 24.

24.

New opportunities for the management of cancer-related bone complications.

Lipton A, Brown GA, Mundy GR, Roodman GD, Smith MR.

Clin Adv Hematol Oncol. 2009 May;7(5 Suppl 11):1-30; quiz 31. No abstract available.

PMID:
19741583
25.

Osteoclast-derived matrix metalloproteinase-7, but not matrix metalloproteinase-9, contributes to tumor-induced osteolysis.

Thiolloy S, Halpern J, Holt GE, Schwartz HS, Mundy GR, Matrisian LM, Lynch CC.

Cancer Res. 2009 Aug 15;69(16):6747-55. doi: 10.1158/0008-5472.CAN-08-3949.

26.

Genetic polymorphisms of EPHX1, Gsk3beta, TNFSF8 and myeloma cell DKK-1 expression linked to bone disease in myeloma.

Durie BG, Van Ness B, Ramos C, Stephens O, Haznadar M, Hoering A, Haessler J, Katz MS, Mundy GR, Kyle RA, Morgan GJ, Crowley J, Barlogie B, Shaughnessy J Jr.

Leukemia. 2009 Oct;23(10):1913-9. doi: 10.1038/leu.2009.129. Epub 2009 Aug 6.

27.

Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.

Edwards CM, Lwin ST, Fowler JA, Oyajobi BO, Zhuang J, Bates AL, Mundy GR.

Am J Hematol. 2009 May;84(5):268-72. doi: 10.1002/ajh.21374.

28.

Quantitative measures of femoral fracture repair in rats derived by micro-computed tomography.

Nyman JS, Munoz S, Jadhav S, Mansour A, Yoshii T, Mundy GR, Gutierrez GE.

J Biomech. 2009 May 11;42(7):891-7. doi: 10.1016/j.jbiomech.2009.01.016. Epub 2009 Mar 17.

PMID:
19281987
29.

Inhibition of microtubule assembly in osteoblasts stimulates bone morphogenetic protein 2 expression and bone formation through transcription factor Gli2.

Zhao M, Ko SY, Liu JH, Chen D, Zhang J, Wang B, Harris SE, Oyajobi BO, Mundy GR.

Mol Cell Biol. 2009 Mar;29(5):1291-305. doi: 10.1128/MCB.01566-08. Epub 2008 Dec 22.

30.

Eph receptors and ephrin signaling pathways: a role in bone homeostasis.

Edwards CM, Mundy GR.

Int J Med Sci. 2008 Sep 3;5(5):263-72. Review.

31.

Transdermal lovastatin enhances fracture repair in rats.

Gutierrez GE, Edwards JR, Garrett IR, Nyman JS, McCluskey B, Rossini G, Flores A, Neidre DB, Mundy GR.

J Bone Miner Res. 2008 Nov;23(11):1722-30. doi: 10.1359/jbmr.080603.

32.

Model structure and control of bone remodeling: a theoretical study.

Pivonka P, Zimak J, Smith DW, Gardiner BS, Dunstan CR, Sims NA, Martin TJ, Mundy GR.

Bone. 2008 Aug;43(2):249-63. doi: 10.1016/j.bone.2008.03.025. Epub 2008 Apr 15.

PMID:
18514606
33.

Hedgehog coordination of postnatal osteoclast and osteoblast activities.

Mundy GR, Yang X.

Dev Cell. 2008 May;14(5):637-8. doi: 10.1016/j.devcel.2008.04.010.

34.

The pathogenesis of the bone disease of multiple myeloma.

Edwards CM, Zhuang J, Mundy GR.

Bone. 2008 Jun;42(6):1007-13. doi: 10.1016/j.bone.2008.01.027. Epub 2008 Feb 21. Review.

35.

PTH-related peptide (PTHrP) in hypercalcemia.

Mundy GR, Edwards JR.

J Am Soc Nephrol. 2008 Apr;19(4):672-5. doi: 10.1681/ASN.2007090981. Epub 2008 Feb 6. Review.

36.

Osteoporosis and inflammation.

Mundy GR.

Nutr Rev. 2007 Dec;65(12 Pt 2):S147-51. Review.

PMID:
18240539
37.

Increasing Wnt signaling in the bone marrow microenvironment inhibits the development of myeloma bone disease and reduces tumor burden in bone in vivo.

Edwards CM, Edwards JR, Lwin ST, Esparza J, Oyajobi BO, McCluskey B, Munoz S, Grubbs B, Mundy GR.

Blood. 2008 Mar 1;111(5):2833-42. Epub 2007 Dec 19.

38.

Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease.

Oyajobi BO, Garrett IR, Gupta A, Flores A, Esparza J, Muñoz S, Zhao M, Mundy GR.

Br J Haematol. 2007 Nov;139(3):434-8.

39.

The osteoclast-not always guilty.

Mundy GR, Edwards JR.

Cell Metab. 2007 Sep;6(3):157-9.

40.

Detection of myeloma in skeleton of mice by whole-body optical fluorescence imaging.

Oyajobi BO, Muñoz S, Kakonen R, Williams PJ, Gupta A, Wideman CL, Story B, Grubbs B, Armstrong A, Dougall WC, Garrett IR, Mundy GR.

Mol Cancer Ther. 2007 Jun;6(6):1701-8. Epub 2007 May 31.

41.

Locally delivered lovastatin nanoparticles enhance fracture healing in rats.

Garrett IR, Gutierrez GE, Rossini G, Nyman J, McCluskey B, Flores A, Mundy GR.

J Orthop Res. 2007 Oct;25(10):1351-7.

42.

Bone metastasis: can osteoclasts be excluded?

Martin TJ, Mundy GR.

Nature. 2007 Feb 22;445(7130):E19; discussion E19-20.

PMID:
17314931
43.

Caspase-2 deficiency enhances aging-related traits in mice.

Zhang Y, Padalecki SS, Chaudhuri AR, De Waal E, Goins BA, Grubbs B, Ikeno Y, Richardson A, Mundy GR, Herman B.

Mech Ageing Dev. 2007 Feb;128(2):213-21. Epub 2006 Dec 22.

44.

Boning up on ephrin signaling.

Mundy GR, Elefteriou F.

Cell. 2006 Aug 11;126(3):441-3. Review.

45.

The hedgehog signaling molecule Gli2 induces parathyroid hormone-related peptide expression and osteolysis in metastatic human breast cancer cells.

Sterling JA, Oyajobi BO, Grubbs B, Padalecki SS, Munoz SA, Gupta A, Story B, Zhao M, Mundy GR.

Cancer Res. 2006 Aug 1;66(15):7548-53.

46.
47.

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor.

Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR, Sun LZ.

Cancer Res. 2006 Jul 1;66(13):6714-21.

48.

Transdermal application of lovastatin to rats causes profound increases in bone formation and plasma concentrations.

Gutierrez GE, Lalka D, Garrett IR, Rossini G, Mundy GR.

Osteoporos Int. 2006;17(7):1033-42. Epub 2006 May 3.

PMID:
16758140
49.

In memoriam; Dr. Gideon Rodan.

Mundy GR.

Bone. 2006 Mar;38(3):297-99. No abstract available.

PMID:
16649258
50.

Nutritional modulators of bone remodeling during aging.

Mundy GR.

Am J Clin Nutr. 2006 Feb;83(2):427S-430S. Review.

PMID:
16470007

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