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Items: 12

1.

A 13-week research-based biochemistry laboratory curriculum.

Lefurgy ST, Mundorff EC.

Biochem Mol Biol Educ. 2017 Sep;45(5):437-448. doi: 10.1002/bmb.21054. Epub 2017 Mar 2.

2.

Biochemical characterization of two haloalkane dehalogenases: DccA from Caulobacter crescentus and DsaA from Saccharomonospora azurea.

Carlucci L, Zhou E, Malashkevich VN, Almo SC, Mundorff EC.

Protein Sci. 2016 Apr;25(4):877-86. doi: 10.1002/pro.2895. Epub 2016 Feb 21.

3.

Analysis of the Structure and Function of FOX-4 Cephamycinase.

Lefurgy ST, Malashkevich VN, Aguilan JT, Nieves E, Mundorff EC, Biju B, Noel MA, Toro R, Baiwir D, Papp-Wallace KM, Almo SC, Frere JM, Bou G, Bonomo RA.

Antimicrob Agents Chemother. 2015 Nov 2;60(2):717-28. doi: 10.1128/AAC.01887-15. Print 2016 Feb.

4.

Alteration of substrate specificity of alanine dehydrogenase.

Fernandes P, Aldeborgh H, Carlucci L, Walsh L, Wasserman J, Zhou E, Lefurgy ST, Mundorff EC.

Protein Eng Des Sel. 2015 Feb;28(2):29-35. doi: 10.1093/protein/gzu053. Epub 2014 Dec 23.

5.

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Savile CK, Janey JM, Mundorff EC, Moore JC, Tam S, Jarvis WR, Colbeck JC, Krebber A, Fleitz FJ, Brands J, Devine PN, Huisman GW, Hughes GJ.

Science. 2010 Jul 16;329(5989):305-9. doi: 10.1126/science.1188934. Epub 2010 Jun 17.

6.

Improving catalytic function by ProSAR-driven enzyme evolution.

Fox RJ, Davis SC, Mundorff EC, Newman LM, Gavrilovic V, Ma SK, Chung LM, Ching C, Tam S, Muley S, Grate J, Gruber J, Whitman JC, Sheldon RA, Huisman GW.

Nat Biotechnol. 2007 Mar;25(3):338-44. Epub 2007 Feb 18.

PMID:
17322872
7.

Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily.

Schmidt DM, Mundorff EC, Dojka M, Bermudez E, Ness JE, Govindarajan S, Babbitt PC, Minshull J, Gerlt JA.

Biochemistry. 2003 Jul 22;42(28):8387-93.

PMID:
12859183
8.

Systematic variation of amino acid substitutions for stringent assessment of pairwise covariation.

Govindarajan S, Ness JE, Kim S, Mundorff EC, Minshull J, Gustafsson C.

J Mol Biol. 2003 May 16;328(5):1061-9.

PMID:
12729741
9.

Synthetic shuffling expands functional protein diversity by allowing amino acids to recombine independently.

Ness JE, Kim S, Gottman A, Pak R, Krebber A, Borchert TV, Govindarajan S, Mundorff EC, Minshull J.

Nat Biotechnol. 2002 Dec;20(12):1251-5. Epub 2002 Nov 11.

PMID:
12426575
10.

A comparative analysis of the immunological evolution of antibody 28B4.

Yin J, Mundorff EC, Yang PL, Wendt KU, Hanway D, Stevens RC, Schultz PG.

Biochemistry. 2001 Sep 11;40(36):10764-73.

PMID:
11535051
11.

Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.

Mundorff EC, Hanson MA, Varvak A, Ulrich H, Schultz PG, Stevens RC.

Biochemistry. 2000 Feb 1;39(4):627-32.

PMID:
10651626
12.

The interplay between binding energy and catalysis in the evolution of a catalytic antibody.

Ulrich HD, Mundorff E, Santarsiero BD, Driggers EM, Stevens RC, Schultz PG.

Nature. 1997 Sep 18;389(6648):271-5.

PMID:
9305839

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