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Items: 35


Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics.

Meir A, Lepechkin-Zilbermintz V, Kahremany S, Schwerdtfeger F, Gevorkyan-Airapetov L, Munder A, Viskind O, Gruzman A, Ruthstein S.

PLoS One. 2019 Dec 30;14(12):e0227070. doi: 10.1371/journal.pone.0227070. eCollection 2019.


Lung infection caused by Pseudomonas aeruginosa in a CD26/DPP4 deficient F344 rat model.

Neuhaus M, Munder A, Schipke J, Schmiedl A.

Inflamm Res. 2019 Jul;68(7):529-544. doi: 10.1007/s00011-019-01236-w. Epub 2019 May 14.


Neuroligin-2-derived peptide-covered polyamidoamine-based (PAMAM) dendrimers enhance pancreatic β-cells' proliferation and functions.

Munder A, Moskovitz Y, Meir A, Kahremany S, Levy L, Kolitz-Domb M, Cohen G, Shtriker E, Viskind O, Lellouche JP, Senderowitz H, Chessler SD, Korshin EE, Ruthstein S, Gruzman A.

Medchemcomm. 2018 Dec 13;10(2):280-293. doi: 10.1039/c8md00419f. eCollection 2019 Feb 1.


Self-assembled peptide-poloxamine nanoparticles enable in vitro and in vivo genome restoration for cystic fibrosis.

Guan S, Munder A, Hedtfeld S, Braubach P, Glage S, Zhang L, Lienenklaus S, Schultze A, Hasenpusch G, Garrels W, Stanke F, Miskey C, Johler SM, Kumar Y, Tümmler B, Rudolph C, Ivics Z, Rosenecker J.

Nat Nanotechnol. 2019 Mar;14(3):287-297. doi: 10.1038/s41565-018-0358-x. Epub 2019 Jan 28.


Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Ackermann M, Kempf H, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, Kühnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N.

Nat Commun. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.


Insulin regulates POMC neuronal plasticity to control glucose metabolism.

Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T.

Elife. 2018 Sep 19;7. pii: e38704. doi: 10.7554/eLife.38704.


The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model.

Kloth C, Schirmer B, Munder A, Stelzer T, Rothschuh J, Seifert R.

Toxins (Basel). 2018 May 4;10(5). pii: E185. doi: 10.3390/toxins10050185.


The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates.

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C.

Open Biol. 2018 Jan;8(1). pii: 170250. doi: 10.1098/rsob.170250.


A Novel Phenylchromane Derivative Increases the Rate of Glucose Uptake in L6 Myotubes and Augments Insulin Secretion from Pancreatic Beta-Cells by Activating AMPK.

Rozentul N, Avrahami Y, Shubely M, Levy L, Munder A, Cohen G, Cerasi E, Sasson S, Gruzman A.

Pharm Res. 2017 Dec;34(12):2873-2890. doi: 10.1007/s11095-017-2271-7. Epub 2017 Oct 5.


The impact of ageing, fasting and high-fat diet on central and peripheral glucose tolerance and glucose-sensing neural networks in the arcuate nucleus.

van den Top M, Zhao FY, Viriyapong R, Michael NJ, Munder AC, Pryor JT, Renaud LP, Spanswick D.

J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12528.


Mimicking Neuroligin-2 Functions in β-Cells by Functionalized Nanoparticles as a Novel Approach for Antidiabetic Therapy.

Munder A, Israel LL, Kahremany S, Ben-Shabat-Binyamini R, Zhang C, Kolitz-Domb M, Viskind O, Levine A, Senderowitz H, Chessler S, Lellouche JP, Gruzman A.

ACS Appl Mater Interfaces. 2017 Jan 18;9(2):1189-1206. doi: 10.1021/acsami.6b10568. Epub 2017 Jan 3.


Key role of an ADP - ribose - dependent transcriptional regulator of NAD metabolism for fitness and virulence of Pseudomonas aeruginosa.

Okon E, Dethlefsen S, Pelnikevich A, Barneveld AV, Munder A, Tümmler B.

Int J Med Microbiol. 2017 Jan;307(1):83-94. doi: 10.1016/j.ijmm.2016.09.007. Epub 2016 Nov 5.


Origins of cystic fibrosis lung disease.

Munder A, Tümmler B.

N Engl J Med. 2015 Apr 16;372(16):1574. doi: 10.1056/NEJMc1502191. No abstract available.


cCMP and cUMP occur in vivo.

Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R.

Biochem Biophys Res Commun. 2015 May 15;460(4):909-14. doi: 10.1016/j.bbrc.2015.03.115. Epub 2015 Mar 31.


Antiproliferative Effect of Novel Aminoacridine-based Compounds.

Munder A, Moskovitz Y, Redko B, Levy AR, Ruthstein S, Gellerman G, Gruzman A.

Med Chem. 2015;11(4):373-82.


The histamine H4 -receptor (H4 R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice.

Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, Neumann D.

Eur J Immunol. 2015 Apr;45(4):1129-40. doi: 10.1002/eji.201445179. Epub 2015 Jan 19.


Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro.

Chillappagari S, Venkatesan S, Garapati V, Mahavadi P, Munder A, Seubert A, Sarode G, Guenther A, Schmeck BT, Tümmler B, Henke MO.

Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L791-9. doi: 10.1152/ajplung.00167.2014. Epub 2014 Sep 19.


Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment.

Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B.

Environ Microbiol. 2015 Jan;17(1):29-46. doi: 10.1111/1462-2920.12606. Epub 2014 Sep 29.


AhR sensing of bacterial pigments regulates antibacterial defence.

Moura-Alves P, Faé K, Houthuys E, Dorhoi A, Kreuchwig A, Furkert J, Barison N, Diehl A, Munder A, Constant P, Skrahina T, Guhlich-Bornhof U, Klemm M, Koehler AB, Bandermann S, Goosmann C, Mollenkopf HJ, Hurwitz R, Brinkmann V, Fillatreau S, Daffe M, Tümmler B, Kolbe M, Oschkinat H, Krause G, Kaufmann SH.

Nature. 2014 Aug 28;512(7515):387-92. doi: 10.1038/nature13684. Epub 2014 Aug 13.


In vivo imaging of bioluminescent Pseudomonas aeruginosa in an acute murine airway infection model.

Munder A, Wölbeling F, Klockgether J, Wiehlmann L, Tümmler B.

Pathog Dis. 2014 Oct;72(1):74-7. doi: 10.1111/2049-632X.12184. Epub 2014 Jun 30.


Assessing Pseudomonas virulence using mammalian models: acute infection model.

Munder A, Tümmler B.

Methods Mol Biol. 2014;1149:773-91. doi: 10.1007/978-1-4939-0473-0_59.


A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.

Bode J, Dutow P, Sommer K, Janik K, Glage S, Tümmler B, Munder A, Laudeley R, Sachse KW, Klos A.

PLoS One. 2012;7(11):e50327. doi: 10.1371/journal.pone.0050327. Epub 2012 Nov 26.


Friend or foe: genetic and functional characterization of plant endophytic Pseudomonas aeruginosa.

Kumar A, Munder A, Aravind R, Eapen SJ, Tümmler B, Raaijmakers JM.

Environ Microbiol. 2013 Mar;15(3):764-79. doi: 10.1111/1462-2920.12031. Epub 2012 Nov 22.


Acute intratracheal Pseudomonas aeruginosa infection in cystic fibrosis mice is age-independent.

Munder A, Wölbeling F, Kerber-Momot T, Wedekind D, Baumann U, Gulbins E, Tümmler B.

Respir Res. 2011 Nov 7;12:148. doi: 10.1186/1465-9921-12-148.


Lung function and inflammation during murine Pseudomonas aeruginosa airway infection.

Wölbeling F, Munder A, Kerber-Momot T, Neumann D, Hennig C, Hansen G, Tümmler B, Baumann U.

Immunobiology. 2011 Aug;216(8):901-8. doi: 10.1016/j.imbio.2011.02.003. Epub 2011 Feb 22.


Bacterial distribution in lung parenchyma early after pulmonary infection with Pseudomonas aeruginosa.

Schmiedl A, Kerber-Momot T, Munder A, Pabst R, Tschernig T.

Cell Tissue Res. 2010 Oct;342(1):67-73. doi: 10.1007/s00441-010-1036-y. Epub 2010 Sep 14.


Head-out spirometry accurately monitors the course of Pseudomonas aeruginosa lung infection in mice.

Wölbeling F, Munder A, Stanke F, Tümmler B, Baumann U.

Respiration. 2010;80(4):340-6. doi: 10.1159/000319442. Epub 2010 Jul 21.


Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains.

Klockgether J, Munder A, Neugebauer J, Davenport CF, Stanke F, Larbig KD, Heeb S, Schöck U, Pohl TM, Wiehlmann L, Tümmler B.

J Bacteriol. 2010 Feb;192(4):1113-21. doi: 10.1128/JB.01515-09. Epub 2009 Dec 18.


Beneficial effects of TLR-2/6 ligation in pulmonary bacterial infection and immunization with Pseudomonas aeruginosa.

Kerber-Momot T, Leemhuis D, Lührmann A, Munder A, Tümmler B, Pabst R, Tschernig T.

Inflammation. 2010 Feb;33(1):58-64. doi: 10.1007/s10753-009-9158-7.


Caenorhabditis elegans semi-automated liquid screen reveals a specialized role for the chemotaxis gene cheB2 in Pseudomonas aeruginosa virulence.

Garvis S, Munder A, Ball G, de Bentzmann S, Wiehlmann L, Ewbank JJ, Tümmler B, Filloux A.

PLoS Pathog. 2009 Aug;5(8):e1000540. doi: 10.1371/journal.ppat.1000540. Epub 2009 Aug 7.


Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection.

Bohn YS, Brandes G, Rakhimova E, Horatzek S, Salunkhe P, Munder A, van Barneveld A, Jordan D, Bredenbruch F, Häussler S, Riedel K, Eberl L, Jensen PØ, Bjarnsholt T, Moser C, Hoiby N, Tümmler B, Wiehlmann L.

Mol Microbiol. 2009 Feb;71(3):730-47. doi: 10.1111/j.1365-2958.2008.06559.x. Epub 2008 Dec 1.


Fitness of isogenic colony morphology variants of Pseudomonas aeruginosa in murine airway infection.

Rakhimova E, Munder A, Wiehlmann L, Bredenbruch F, Tümmler B.

PLoS One. 2008 Feb 27;3(2):e1685. doi: 10.1371/journal.pone.0001685.


Functional genomics of Pseudomonas aeruginosa to identify habitat-specific determinants of pathogenicity.

Wiehlmann L, Munder A, Adams T, Juhas M, Kolmar H, Salunkhe P, Tümmler B.

Int J Med Microbiol. 2007 Nov;297(7-8):615-23. Epub 2007 May 4.


Murine pulmonary infection with Listeria monocytogenes: differential susceptibility of BALB/c, C57BL/6 and DBA/2 mice.

Munder A, Zelmer A, Schmiedl A, Dittmar KE, Rohde M, Dorsch M, Otto K, Hedrich HJ, Tümmler B, Weiss S, Tschernig T.

Microbes Infect. 2005 Apr;7(4):600-11. Epub 2005 Mar 16.


Pulmonary microbial infection in mice: comparison of different application methods and correlation of bacterial numbers and histopathology.

Munder A, Krusch S, Tschernig T, Dorsch M, Lührmann A, van Griensven M, Tümmler B, Weiss S, Hedrich HJ.

Exp Toxicol Pathol. 2002 Aug;54(2):127-33.


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