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Items: 37

1.

A Comprehensive Biophysical Analysis of the Effect of DNA Binding Drugs on Protamine-induced DNA Condensation.

Gupta S, Tiwari N, Munde M.

Sci Rep. 2019 Apr 10;9(1):5891. doi: 10.1038/s41598-019-41975-8.

2.

Leishmania donovani Parasites Are Inhibited by the Benzoxaborole AN2690 Targeting Leucyl-tRNA Synthetase.

Manhas R, Tandon S, Sen SS, Tiwari N, Munde M, Madhubala R.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00079-18. doi: 10.1128/AAC.00079-18. Print 2018 Sep.

3.

Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target.

Chadha S, Vijayan R, Gupta S, Munde M, Gourinath S, Madhubala R.

PLoS Negl Trop Dis. 2018 Jun 13;12(6):e0006575. doi: 10.1371/journal.pntd.0006575. eCollection 2018 Jun.

4.

Molecular insights into trypanothione reductase-inhibitor interaction: A structure-based review.

Tiwari N, Tanwar N, Munde M.

Arch Pharm (Weinheim). 2018 Jun;351(6):e1700373. doi: 10.1002/ardp.201700373. Epub 2018 Apr 19. Review.

PMID:
29672908
5.

Thermodynamic and conformational analysis of the interaction between antibody binding proteins and IgG.

Tanwar N, Munde M.

Int J Biol Macromol. 2018 Jun;112:1084-1092. doi: 10.1016/j.ijbiomac.2018.01.208. Epub 2018 Feb 1.

PMID:
29410106
6.

Biophysical insight into the heparin-peptide interaction and its modulation by a small molecule.

Tiwari N, Srivastava A, Kundu B, Munde M.

J Mol Recognit. 2018 Jan;31(1). doi: 10.1002/jmr.2674. Epub 2017 Sep 29.

PMID:
28961341
7.

Intrinsic Resistance Switching in Amorphous Silicon Suboxides: The Role of Columnar Microstructure.

Munde MS, Mehonic A, Ng WH, Buckwell M, Montesi L, Bosman M, Shluger AL, Kenyon AJ.

Sci Rep. 2017 Aug 24;7(1):9274. doi: 10.1038/s41598-017-09565-8.

8.

Impact of Module-X2 and Carbohydrate Binding Module-3 on the catalytic activity of associated glycoside hydrolases towards plant biomass.

Pasari N, Adlakha N, Gupta M, Bashir Z, Rajacharya GH, Verma G, Munde M, Bhatnagar R, Yazdani SS.

Sci Rep. 2017 Jun 16;7(1):3700. doi: 10.1038/s41598-017-03927-y.

9.

Diffusion and aggregation of oxygen vacancies in amorphous silica.

Munde MS, Gao DZ, Shluger AL.

J Phys Condens Matter. 2017 Jun 21;29(24):245701. doi: 10.1088/1361-648X/aa6f9a. Epub 2017 May 15.

PMID:
28504974
10.

Nanoscale Transformations in Metastable, Amorphous, Silicon-Rich Silica.

Mehonic A, Buckwell M, Montesi L, Munde MS, Gao D, Hudziak S, Chater RJ, Fearn S, McPhail D, Bosman M, Shluger AL, Kenyon AJ.

Adv Mater. 2016 Sep;28(34):7486-93. doi: 10.1002/adma.201601208. Epub 2016 Jun 23.

PMID:
27334656
11.

Mechanistic heterogeneity in site recognition by the structurally homologous DNA-binding domains of the ETS family transcription factors Ets-1 and PU.1.

Wang S, Linde MH, Munde M, Carvalho VD, Wilson WD, Poon GM.

J Biol Chem. 2014 Aug 1;289(31):21605-16. doi: 10.1074/jbc.M114.575340. Epub 2014 Jun 21.

12.

The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine.

Munde M, Kumar A, Peixoto P, Depauw S, Ismail MA, Farahat AA, Paul A, Say MV, David-Cordonnier MH, Boykin DW, Wilson WD.

Biochemistry. 2014 Feb 25;53(7):1218-27. doi: 10.1021/bi401582t. Epub 2014 Feb 13.

13.

Green fluorescent diamidines as diagnostic probes for trypanosomes.

Giordani F, Munde M, Wilson WD, Ismail MA, Kumar A, Boykin DW, Barrett MP.

Antimicrob Agents Chemother. 2014;58(3):1793-6. doi: 10.1128/AAC.02024-13. Epub 2013 Dec 23.

14.

On and off-target effects of telomere uncapping G-quadruplex selective ligands based on pentacyclic acridinium salts.

Iachettini S, Stevens MF, Frigerio M, Hummersone MG, Hutchinson I, Garner TP, Searle MS, Wilson DW, Munde M, Nanjunda R, D'Angelo C, Zizza P, Rizzo A, Cingolani C, De Cicco F, Porru M, D'Incalci M, Leonetti C, Biroccio A, Salvati E.

J Exp Clin Cancer Res. 2013 Sep 19;32:68. doi: 10.1186/1756-9966-32-68.

15.

Structure-dependent binding of arylimidamides to the DNA minor groove.

Chai Y, Munde M, Kumar A, Mickelson L, Lin S, Campbell NH, Banerjee M, Akay S, Liu Z, Farahat AA, Nhili R, Depauw S, David-Cordonnier MH, Neidle S, Wilson WD, Boykin DW.

Chembiochem. 2014 Jan 3;15(1):68-79. doi: 10.1002/cbic.201300622. Epub 2013 Dec 9.

16.

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines.

Munde M, Wang S, Kumar A, Stephens CE, Farahat AA, Boykin DW, Wilson WD, Poon GM.

Nucleic Acids Res. 2014 Jan;42(2):1379-90. doi: 10.1093/nar/gkt955. Epub 2013 Oct 23.

17.

Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.

Hu L, Patel A, Bondada L, Yang S, Wang MZ, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW.

Bioorg Med Chem. 2013 Nov 1;21(21):6732-41. doi: 10.1016/j.bmc.2013.08.006. Epub 2013 Aug 13.

18.

Design, synthesis, and antihyperlipidemic evaluation of novel 2-[1-(substitutedphenyl)-4-oxo-azetidin-2-yl]-5,6-disubstitutedthieno[2,3-d]pyrimidin-4(3H)-ones.

Arya N, Munde MK, Dwivedi J, Jagdale AY, Jain KS.

Arch Pharm (Weinheim). 2013 Aug;346(8):588-95. doi: 10.1002/ardp.201300001. Epub 2013 Jul 24.

PMID:
23881664
20.

8,8-dialkyldihydroberberines with potent antiprotozoal activity.

Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, Drew ME, Werbovetz KA.

J Nat Prod. 2013 Mar 22;76(3):311-5. doi: 10.1021/np300638f. Epub 2012 Nov 20.

PMID:
23167812
21.

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines.

Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde MM, Ismail MA, Kumar A, Farahat AA, Stephens CE, Duterque-Coquillaud M, David Wilson W, Boykin DW, David-Cordonnier MH.

Nucleic Acids Res. 2013 Jan 7;41(1):125-38. doi: 10.1093/nar/gks971. Epub 2012 Oct 23.

22.

Synthesis, DNA binding and antileishmanial activity of low molecular weight bis-arylimidamides.

Banerjee M, Farahat AA, Kumar A, Wenzler T, Brun R, Munde MM, Wilson WD, Zhu X, Werbovetz KA, Boykin DW.

Eur J Med Chem. 2012 Sep;55:449-54. doi: 10.1016/j.ejmech.2012.06.058. Epub 2012 Jul 14.

23.

Microscopic rearrangement of bound minor groove binders detected by NMR.

Rettig M, Germann MW, Ismail MA, Batista-Parra A, Munde M, Boykin DW, Wilson WD.

J Phys Chem B. 2012 May 17;116(19):5620-7. doi: 10.1021/jp301143e. Epub 2012 May 2.

24.

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.

Zhu X, Liu Q, Yang S, Parman T, Green CE, Mirsalis JC, de Nazaré Correia Soeiro M, Mello de Souza E, da Silva CF, da Gama Jaen Batista D, Stephens CE, Banerjee M, Farahat AA, Munde M, Wilson WD, Boykin DW, Wang MZ, Werbovetz KA.

Antimicrob Agents Chemother. 2012 Jul;56(7):3690-9. doi: 10.1128/AAC.06404-11. Epub 2012 Apr 16.

25.

Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site.

Lewis EA, Munde M, Wang S, Rettig M, Le V, Machha V, Wilson WD.

Nucleic Acids Res. 2011 Dec;39(22):9649-58. doi: 10.1093/nar/gkr699. Epub 2011 Sep 3.

26.

The trypanocidal activity of amidine compounds does not correlate with their binding affinity to Trypanosoma cruzi kinetoplast DNA.

Daliry A, Pires MQ, Silva CF, Pacheco RS, Munde M, Stephens CE, Kumar A, Ismail MA, Liu Z, Farahat AA, Akay S, Som P, Hu Q, Boykin DW, Wilson WD, De Castro SL, Soeiro MN.

Antimicrob Agents Chemother. 2011 Oct;55(10):4765-73. doi: 10.1128/AAC.00229-11. Epub 2011 Aug 1.

27.

Minor groove to major groove, an unusual DNA sequence-dependent change in bend directionality by a distamycin dimer.

Wang S, Munde M, Wang S, Wilson WD.

Biochemistry. 2011 Sep 6;50(35):7674-83. doi: 10.1021/bi201010g. Epub 2011 Aug 10.

28.

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures.

Hunt RA, Munde M, Kumar A, Ismail MA, Farahat AA, Arafa RK, Say M, Batista-Parra A, Tevis D, Boykin DW, Wilson WD.

Nucleic Acids Res. 2011 May;39(10):4265-74. doi: 10.1093/nar/gkq1362. Epub 2011 Jan 25.

29.

DNA minor groove induced dimerization of heterocyclic cations: compound structure, binding affinity, and specificity for a TTAA site.

Munde M, Kumar A, Nhili R, Depauw S, David-Cordonnier MH, Ismail MA, Stephens CE, Farahat AA, Batista-Parra A, Boykin DW, Wilson WD.

J Mol Biol. 2010 Oct 8;402(5):847-64. doi: 10.1016/j.jmb.2010.08.018. Epub 2010 Aug 14.

30.

DNA recognition: design, synthesis and biophysical characteristics of pyrrole(H) based polyamides.

Chavda S, Mulder K, Brown T, Mackay H, Babu B, Westrate L, Ferguson A, Lin S, Kiakos K, Ramos JP, Munde M, Wilson WD, Hartley JA, Lee M.

Med Chem. 2010 May;6(3):150-8.

PMID:
20632976
31.

Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.

Franks A, Tronrud C, Kiakos K, Kluza J, Munde M, Brown T, Mackay H, Wilson WD, Hochhauser D, Hartley JA, Lee M.

Bioorg Med Chem. 2010 Aug 1;18(15):5553-61. doi: 10.1016/j.bmc.2010.06.041. Epub 2010 Jun 17.

PMID:
20615712
32.

Novel arylimidamides for treatment of visceral leishmaniasis.

Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA.

Antimicrob Agents Chemother. 2010 Jun;54(6):2507-16. doi: 10.1128/AAC.00250-10. Epub 2010 Apr 5.

33.

Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Hu L, Arafa RK, Ismail MA, Patel A, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW.

Bioorg Med Chem. 2009 Sep 15;17(18):6651-8. doi: 10.1016/j.bmc.2009.07.080. Epub 2009 Aug 7.

34.

Novel linear triaryl guanidines, N-substituted guanidines and potential prodrugs as antiprotozoal agents.

Arafa RK, Ismail MA, Munde M, Wilson WD, Wenzler T, Brun R, Boykin DW.

Eur J Med Chem. 2008 Dec;43(12):2901-8. doi: 10.1016/j.ejmech.2008.02.008. Epub 2008 Feb 29.

35.

Azaterphenyl diamidines as antileishmanial agents.

Hu L, Arafa RK, Ismail MA, Wenzler T, Brun R, Munde M, Wilson WD, Nzimiro S, Samyesudhas S, Werbovetz KA, Boykin DW.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):247-51. Epub 2007 Oct 30.

PMID:
18006310
36.

Design of DNA minor groove binding diamidines that recognize GC base pair sequences: a dimeric-hinge interaction motif.

Munde M, Ismail MA, Arafa R, Peixoto P, Collar CJ, Liu Y, Hu L, David-Cordonnier MH, Lansiaux A, Bailly C, Boykin DW, Wilson WD.

J Am Chem Soc. 2007 Nov 7;129(44):13732-43. Epub 2007 Oct 13.

37.

Induced fit conformational changes of a "reversed amidine" heterocycle: optimized interactions in a DNA minor groove complex.

Munde M, Lee M, Neidle S, Arafa R, Boykin DW, Liu Y, Bailly C, Wilson WD.

J Am Chem Soc. 2007 May 2;129(17):5688-98. Epub 2007 Apr 11.

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