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Items: 25


Evaluation of phthalazinone phosphodiesterase inhibitors with improved activity and selectivity against Trypanosoma cruzi.

De Araújo JS, da Silva PB, Batista MM, Peres RB, Cardoso-Santos C, Kalejaiye TD, Munday JC, De Heuvel E, Sterk GJ, Augustyns K, Salado IG, Matheeussen A, De Esch I, De Koning HP, Leurs R, Maes L, Soeiro MNC.

J Antimicrob Chemother. 2020 Apr 1;75(4):958-967. doi: 10.1093/jac/dkz516.


Discovery of novel Schistosoma mansoni PDE4A inhibitors as potential agents against schistosomiasis.

Sebastián-Pérez V, Schroeder S, Munday JC, van der Meer T, Zaldívar-Díez J, Siderius M, de Koning HP, Brown D, Martínez A, Campillo NE, Leurs R, Gil C.

Future Med Chem. 2019 Jul;11(14):1703-1720. doi: 10.4155/fmc-2018-0592. Epub 2019 Aug 2.


Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse Model.

Giordani F, Khalaf AI, Gillingwater K, Munday JC, de Koning HP, Suckling CJ, Barrett MP, Scott FJ.

J Med Chem. 2019 Mar 28;62(6):3021-3035. doi: 10.1021/acs.jmedchem.8b01847. Epub 2019 Mar 13.


Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity.

Botros SS, William S, Sabra AA, El-Lakkany NM, Seif El-Din SH, García-Rubia A, Sebastián-Pérez V, Blaazer AR, de Heuvel E, Sijm M, Zheng Y, Salado IG, Munday JC, Maes L, de Esch IJP, Sterk GJ, Augustyns K, Leurs R, Gil C, De Koning HP.

Int J Parasitol Drugs Drug Resist. 2019 Apr;9:35-43. doi: 10.1016/j.ijpddr.2019.01.001. Epub 2019 Jan 14.


Cyclic Nucleotide-Specific Phosphodiesterases as Potential Drug Targets for Anti-Leishmania Therapy.

Sebastián-Pérez V, Hendrickx S, Munday JC, Kalejaiye T, Martínez A, Campillo NE, de Koning H, Caljon G, Maes L, Gil C.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00603-18. doi: 10.1128/AAC.00603-18. Print 2018 Oct.


Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity.

Blaazer AR, Singh AK, de Heuvel E, Edink E, Orrling KM, Veerman JJN, van den Bergh T, Jansen C, Balasubramaniam E, Mooij WJ, Custers H, Sijm M, Tagoe DNA, Kalejaiye TD, Munday JC, Tenor H, Matheeussen A, Wijtmans M, Siderius M, de Graaf C, Maes L, de Koning HP, Bailey DS, Sterk GJ, de Esch IJP, Brown DG, Leurs R.

J Med Chem. 2018 May 10;61(9):3870-3888. doi: 10.1021/acs.jmedchem.7b01670. Epub 2018 May 1.


Trypanosoma brucei bloodstream forms express highly specific and separate transporters for adenine and hypoxanthine; evidence for a new protozoan purine transporter family?

Campagnaro GD, Alzahrani KJ, Munday JC, De Koning HP.

Mol Biochem Parasitol. 2018 Mar;220:46-56. doi: 10.1016/j.molbiopara.2018.01.005. Epub 2018 Jan 31.


Frederick Yi-Tung Cho (1939-2011) : His PhD days in Biophysics, the Photosynthesis Lab, and his patents in engineering physics.

Govindjee, Munday JC Jr, Papageorgiou GC.

Photosynth Res. 2017 Jun;132(3):227-234. doi: 10.1007/s11120-017-0391-x. Epub 2017 May 18.


Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

Eze AA, Gould MK, Munday JC, Tagoe DN, Stelmanis V, Schnaufer A, De Koning HP.

PLoS Negl Trop Dis. 2016 Aug 12;10(8):e0004791. doi: 10.1371/journal.pntd.0004791. eCollection 2016 Aug.


Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense.

Graf FE, Ludin P, Arquint C, Schmidt RS, Schaub N, Kunz Renggli C, Munday JC, Krezdorn J, Baker N, Horn D, Balmer O, Caccone A, de Koning HP, Mäser P.

Cell Mol Life Sci. 2016 Sep;73(17):3387-400. doi: 10.1007/s00018-016-2173-6. Epub 2016 Mar 14.


Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates.

Graf FE, Baker N, Munday JC, de Koning HP, Horn D, Mäser P.

Int J Parasitol Drugs Drug Resist. 2015 May 7;5(2):65-8. doi: 10.1016/j.ijpddr.2015.04.002. eCollection 2015 Aug.


Transport proteins determine drug sensitivity and resistance in a protozoan parasite, Trypanosoma brucei.

Munday JC, Settimo L, de Koning HP.

Front Pharmacol. 2015 Mar 9;6:32. doi: 10.3389/fphar.2015.00032. eCollection 2015. Review.


Functional analysis of drug resistance-associated mutations in the Trypanosoma brucei adenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein.

Munday JC, Tagoe DN, Eze AA, Krezdorn JA, Rojas López KE, Alkhaldi AA, McDonald F, Still J, Alzahrani KJ, Settimo L, De Koning HP.

Mol Microbiol. 2015 May;96(4):887-900. doi: 10.1111/mmi.12979. Epub 2015 Mar 21.


Functional expression of TcoAT1 reveals it to be a P1-type nucleoside transporter with no capacity for diminazene uptake.

Munday JC, Rojas López KE, Eze AA, Delespaux V, Van Den Abbeele J, Rowan T, Barrett MP, Morrison LJ, de Koning HP.

Int J Parasitol Drugs Drug Resist. 2013 Feb 10;3:69-76. doi: 10.1016/j.ijpddr.2013.01.004. eCollection 2013 Dec.


Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

Munday JC, Eze AA, Baker N, Glover L, Clucas C, Aguinaga Andrés D, Natto MJ, Teka IA, McDonald J, Lee RS, Graf FE, Ludin P, Burchmore RJ, Turner CM, Tait A, MacLeod A, Mäser P, Barrett MP, Horn D, De Koning HP.

J Antimicrob Chemother. 2014 Mar;69(3):651-63. doi: 10.1093/jac/dkt442. Epub 2013 Nov 13.


Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.

Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP.

Antimicrob Agents Chemother. 2013 Oct;57(10):4882-93. doi: 10.1128/AAC.00508-13. Epub 2013 Jul 22.


Pyrimidine biosynthesis is not an essential function for Trypanosoma brucei bloodstream forms.

Ali JA, Tagoe DN, Munday JC, Donachie A, Morrison LJ, de Koning HP.

PLoS One. 2013;8(3):e58034. doi: 10.1371/journal.pone.0058034. Epub 2013 Mar 7.


Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes.

Baker N, Glover L, Munday JC, Aguinaga Andrés D, Barrett MP, de Koning HP, Horn D.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10996-1001. doi: 10.1073/pnas.1202885109. Epub 2012 Jun 18.


The diamidine diminazene aceturate is a substrate for the high-affinity pentamidine transporter: implications for the development of high resistance levels in trypanosomes.

Teka IA, Kazibwe AJ, El-Sabbagh N, Al-Salabi MI, Ward CP, Eze AA, Munday JC, Mäser P, Matovu E, Barrett MP, de Koning HP.

Mol Pharmacol. 2011 Jul;80(1):110-6. doi: 10.1124/mol.111.071555. Epub 2011 Mar 24.


Oligopeptidase B deficient mutants of Leishmania major.

Munday JC, McLuskey K, Brown E, Coombs GH, Mottram JC.

Mol Biochem Parasitol. 2011 Jan;175(1):49-57. doi: 10.1016/j.molbiopara.2010.09.003. Epub 2010 Sep 29.


Appreciation for your editorial.

Munday JC Jr.

MedGenMed. 2001 Oct 25;3(5):13. No abstract available.


Time-dependent quenching of chlorophyll a fluorescence from (pigment) system II by (pigment) system I of photosynthesis in Chlorella.

Mohanty P, Munday JC Jr, Govindjee.

Biochim Biophys Acta. 1970 Nov 3;223(1):198-200. No abstract available.


Fluorescence studies with algae: changes with time and preillumination.

Govindjee, Munday JC Jr, Papageorgiou G.

Brookhaven Symp Biol. 1966;19:434-45. No abstract available.


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