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Items: 38

1.

Expression of UPR effector proteins ATF6 and XBP1 reduce colorectal cancer cell proliferation and stemness by activating PERK signaling.

Spaan CN, Smit WL, van Lidth de Jeude JF, Meijer BJ, Muncan V, van den Brink GR, Heijmans J.

Cell Death Dis. 2019 Jun 21;10(7):490. doi: 10.1038/s41419-019-1729-4.

2.

The P4-ATPase ATP9A is a novel determinant of exosome release.

Naik J, Hau CM, Ten Bloemendaal L, Mok KS, Hajji N, Wehman AM, Meisner S, Muncan V, Paauw NJ, de Vries HE, Nieuwland R, Paulusma CC, Bosma PJ.

PLoS One. 2019 Apr 4;14(4):e0213069. doi: 10.1371/journal.pone.0213069. eCollection 2019.

3.

Colonic CD90+ Crypt Fibroblasts Secrete Semaphorins to Support Epithelial Growth.

Karpus ON, Westendorp BF, Vermeulen JLM, Meisner S, Koster J, Muncan V, Wildenberg ME, van den Brink GR.

Cell Rep. 2019 Mar 26;26(13):3698-3708.e5. doi: 10.1016/j.celrep.2019.02.101.

4.

Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning.

Navis M, Martins Garcia T, Renes IB, Vermeulen JL, Meisner S, Wildenberg ME, van den Brink GR, van Elburg RM, Muncan V.

EMBO Rep. 2019 Feb;20(2). pii: e46221. doi: 10.15252/embr.201846221. Epub 2018 Dec 10.

5.

Correction for Muncan et al., "Rapid Loss of Intestinal Crypts upon Conditional Deletion of the Wnt/Tcf-4 Target Gene c-Myc".

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, Moreno de Alboran I, Clevers H, Clarke AR.

Mol Cell Biol. 2018 Nov 28;38(24). pii: e00482-18. doi: 10.1128/MCB.00482-18. Print 2018 Dec 15. No abstract available.

6.

Heterozygosity of Chaperone Grp78 Reduces Intestinal Stem Cell Regeneration Potential and Protects against Adenoma Formation.

van Lidth de Jeude JF, Spaan CN, Meijer BJ, Smit WL, Soeratram TTD, Wielenga MCB, Westendorp BF, Lee AS, Meisner S, Vermeulen JLM, Wildenberg ME, van den Brink GR, Muncan V, Heijmans J.

Cancer Res. 2018 Nov 1;78(21):6098-6106. doi: 10.1158/0008-5472.CAN-17-3600. Epub 2018 Sep 19.

7.

Colorectal tumor prevention by the progestin medroxyprogesterone acetate is critically dependent on postmenopausal status.

Meijer BJ, Wielenga MCB, Hoyer PB, Amos-Landgraf JM, Hakvoort TBM, Muncan V, Heijmans J, van den Brink GR.

Oncotarget. 2018 Jul 17;9(55):30561-30567. doi: 10.18632/oncotarget.25703. eCollection 2018 Jul 17.

8.

Fibrostenotic Phenotype of Myofibroblasts in Crohn's Disease is Dependent on Tissue Stiffness and Reversed by LOX Inhibition.

de Bruyn JR, van den Brink GR, Steenkamer J, Buskens CJ, Bemelman WA, Meisner S, Muncan V, Te Velde AA, D'Haens GR, Wildenberg ME.

J Crohns Colitis. 2018 Jun 28;12(7):849-859. doi: 10.1093/ecco-jcc/jjy036.

PMID:
29672662
9.

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response.

Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR.

Cell Mol Gastroenterol Hepatol. 2017 Sep 5;5(1):67-82.e1. doi: 10.1016/j.jcmgh.2017.08.004. eCollection 2018.

10.

Induction of endoplasmic reticulum stress by deletion of Grp78 depletes Apc mutant intestinal epithelial stem cells.

van Lidth de Jeude JF, Meijer BJ, Wielenga MCB, Spaan CN, Baan B, Rosekrans SL, Meisner S, Shen YH, Lee AS, Paton JC, Paton AW, Muncan V, van den Brink GR, Heijmans J.

Oncogene. 2017 Jun 15;36(24):3397-3405. doi: 10.1038/onc.2016.326. Epub 2016 Nov 7.

PMID:
27819675
11.

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC.

Schilderink R, Verseijden C, Seppen J, Muncan V, van den Brink GR, Lambers TT, van Tol EA, de Jonge WJ.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1138-46. doi: 10.1152/ajpgi.00411.2015. Epub 2016 May 5.

12.

Oral tolerance is inefficient in neonatal mice due to a physiological vitamin A deficiency.

Turfkruyer M, Rekima A, Macchiaverni P, Le Bourhis L, Muncan V, van den Brink GR, Tulic MK, Verhasselt V.

Mucosal Immunol. 2016 Mar;9(2):479-91. doi: 10.1038/mi.2015.114. Epub 2015 Nov 4.

PMID:
26530133
13.

Esophageal development and epithelial homeostasis.

Rosekrans SL, Baan B, Muncan V, van den Brink GR.

Am J Physiol Gastrointest Liver Physiol. 2015 Aug 15;309(4):G216-28. doi: 10.1152/ajpgi.00088.2015. Epub 2015 Jul 2. Review.

14.

Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis.

Wielenga MC, van Lidth de Jeude JF, Rosekrans SL, Levin AD, Schukking M, D'Haens GR, Heijmans J, Jansen M, Muncan V, van den Brink GR.

World J Gastroenterol. 2014 Nov 28;20(44):16683-9. doi: 10.3748/wjg.v20.i44.16683.

15.

Sex disparity in colonic adenomagenesis involves promotion by male hormones, not protection by female hormones.

Amos-Landgraf JM, Heijmans J, Wielenga MC, Dunkin E, Krentz KJ, Clipson L, Ederveen AG, Groothuis PG, Mosselman S, Muncan V, Hommes DW, Shedlovsky A, Dove WF, van den Brink GR.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16514-9. doi: 10.1073/pnas.1323064111. Epub 2014 Nov 3.

16.

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.

Büller NV, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JL, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GR, Wildenberg ME, de Sauvage FJ, Muncan V, van den Brink GR.

Gastroenterology. 2015 Jan;148(1):170-180.e6. doi: 10.1053/j.gastro.2014.10.006. Epub 2014 Oct 13.

PMID:
25307863
17.

Dichotomal effect of space flight-associated microgravity on stress-activated protein kinases in innate immunity.

Verhaar AP, Hoekstra E, Tjon AS, Utomo WK, Deuring JJ, Bakker ER, Muncan V, Peppelenbosch MP.

Sci Rep. 2014 Jun 27;4:5468. doi: 10.1038/srep05468.

18.

ER stress induces epithelial differentiation in the mouse oesophagus.

Rosekrans SL, Heijmans J, Büller NV, Westerlund J, Lee AS, Muncan V, van den Brink GR.

Gut. 2015 Feb;64(2):195-202. doi: 10.1136/gutjnl-2013-306347. Epub 2014 Apr 30.

PMID:
24789843
19.

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.

Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ.

Cell Death Differ. 2014 Jun;21(6):956-66. doi: 10.1038/cdd.2014.15. Epub 2014 Feb 28.

20.

Correction: Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models.

Heijmans J, Muncan V, Jacobs RJ, de Jonge-Muller ESM, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR.

PLoS One. 2013 Jun 5;8(6). doi: 10.1371/annotation/b60d4ec5-4c6f-43ab-9f63-322e3cd59636. eCollection 2013.

21.

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V, van den Brink GR.

Cell Rep. 2013 Apr 25;3(4):1128-39. doi: 10.1016/j.celrep.2013.02.031. Epub 2013 Mar 28.

22.

Oestrogens promote tumorigenesis in a mouse model for colitis-associated cancer.

Heijmans J, Wielenga MC, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ES, Biemond I, Hardwick JC, D'Haens G, Hommes DW, Muncan V, van den Brink GR.

Gut. 2014 Feb;63(2):310-6. doi: 10.1136/gutjnl-2012-304216. Epub 2013 Feb 13.

PMID:
23408349
23.

Rage mediated DAMP signaling in intestinal tumorigenesis.

Heijmans J, Büller NV, Muncan V, van den Brink GR.

Oncoimmunology. 2012 Oct 1;1(7):1165-1166.

24.

asb11 is a regulator of embryonic and adult regenerative myogenesis.

Tee JM, Sartori da Silva MA, Rygiel AM, Muncan V, Bink R, van den Brink GR, van Tijn P, Zivkovic D, Kodach LL, Guardavaccaro D, Diks SH, Peppelenbosch MP.

Stem Cells Dev. 2012 Nov 20;21(17):3091-103. doi: 10.1089/scd.2012.0123. Epub 2012 Jun 7.

25.

Rage signalling promotes intestinal tumourigenesis.

Heijmans J, Büller NV, Hoff E, Dihal AA, van der Poll T, van Zoelen MA, Bierhaus A, Biemond I, Hardwick JC, Hommes DW, Muncan V, van den Brink GR.

Oncogene. 2013 Feb 28;32(9):1202-6. doi: 10.1038/onc.2012.119. Epub 2012 Apr 2.

PMID:
22469986
26.

5-Aminosalicylic acid inhibits cell cycle progression in a phospholipase D dependent manner in colorectal cancer.

Baan B, Dihal AA, Hoff E, Bos CL, Voorneveld PW, Koelink PJ, Wildenberg ME, Muncan V, Heijmans J, Verspaget HW, Richel DJ, Hardwick JC, Hommes DW, Peppelenbosch MP, van den Brink GR.

Gut. 2012 Dec;61(12):1708-15. doi: 10.1136/gutjnl-2011-301626. Epub 2011 Dec 20.

PMID:
22187071
27.

Blimp1 regulates the transition of neonatal to adult intestinal epithelium.

Muncan V, Heijmans J, Krasinski SD, Büller NV, Wildenberg ME, Meisner S, Radonjic M, Stapleton KA, Lamers WH, Biemond I, van den Bergh Weerman MA, O'Carroll D, Hardwick JC, Hommes DW, van den Brink GR.

Nat Commun. 2011 Aug 30;2:452. doi: 10.1038/ncomms1463.

28.

Intestinal tumorigenesis is not affected by progesterone signaling in rodent models.

Heijmans J, Muncan V, Jacobs RJ, de Jonge-Muller ES, Graven L, Biemond I, Ederveen AG, Groothuis PG, Mosselman S, Hardwick JC, Hommes DW, van den Brink GR.

PLoS One. 2011;6(7):e22620. doi: 10.1371/journal.pone.0022620. Epub 2011 Jul 27. Erratum in: PLoS One. 2013 Jun 5;8(6):.

29.

Role of mast cells in colorectal cancer development, the jury is still out.

Heijmans J, Büller NV, Muncan V, van den Brink GR.

Biochim Biophys Acta. 2012 Jan;1822(1):9-13. doi: 10.1016/j.bbadis.2010.12.001. Epub 2010 Dec 9. Review.

30.

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ.

Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Erratum in: Cancer Res. 2013 Jan 1;73(1):469.

31.

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ.

Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015.

32.

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, Muncan V, Clarke AR, Sansom OJ.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18919-23. doi: 10.1073/pnas.0805778105. Epub 2008 Nov 24. Erratum in: Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1168.

33.

T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine.

Muncan V, Faro A, Haramis AP, Hurlstone AF, Wienholds E, van Es J, Korving J, Begthel H, Zivkovic D, Clevers H.

EMBO Rep. 2007 Oct;8(10):966-73. Epub 2007 Sep 7.

34.

Myc deletion rescues Apc deficiency in the small intestine.

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.

Nature. 2007 Apr 5;446(7136):676-9. Epub 2007 Mar 21.

PMID:
17377531
35.

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc.

Muncan V, Sansom OJ, Tertoolen L, Phesse TJ, Begthel H, Sancho E, Cole AM, Gregorieff A, de Alboran IM, Clevers H, Clarke AR.

Mol Cell Biol. 2006 Nov;26(22):8418-26. Epub 2006 Sep 5. Erratum in: Mol Cell Biol. 2018 Nov 28;38(24):.

36.

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine.

Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H, Clarke AR.

J Biol Chem. 2005 Aug 5;280(31):28463-7. Epub 2005 Jun 9.

37.

Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector.

van de Wetering M, Oving I, Muncan V, Pon Fong MT, Brantjes H, van Leenen D, Holstege FC, Brummelkamp TR, Agami R, Clevers H.

EMBO Rep. 2003 Jun;4(6):609-15.

38.

Enhanced inactivation and pH sensitivity of Na(+) channel mutations causing hypokalaemic periodic paralysis type II.

Kuzmenkin A, Muncan V, Jurkat-Rott K, Hang C, Lerche H, Lehmann-Horn F, Mitrovic N.

Brain. 2002 Apr;125(Pt 4):835-43.

PMID:
11912116

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