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Items: 24


A multimodal molecular imaging study evaluates pharmacological alteration of the tumor microenvironment to improve radiation response.

Takakusagi Y, Naz S, Takakusagi K, Ishima M, Murata H, Ohta K, Miura M, Sugawara F, Sakaguchi K, Kishimoto S, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2018 Oct 9. pii: canres.1654.2018. doi: 10.1158/0008-5472.CAN-18-1654. [Epub ahead of print]


Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice.

Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart CP, Gillies RJ, Mitchell JB, Krishna MC.

Cancer Res. 2018 Jul 15;78(14):3783-3792. doi: 10.1158/0008-5472.CAN-18-0491. Epub 2018 May 23.


Hyperpolarized [1-13C]-Pyruvate Magnetic Resonance Spectroscopic Imaging of Prostate Cancer In Vivo Predicts Efficacy of Targeting the Warburg Effect.

Scroggins BT, Matsuo M, White AO, Saito K, Munasinghe JP, Sourbier C, Yamamoto K, Diaz V, Takakusagi Y, Ichikawa K, Mitchell JB, Krishna MC, Citrin DE.

Clin Cancer Res. 2018 Jul 1;24(13):3137-3148. doi: 10.1158/1078-0432.CCR-17-1957. Epub 2018 Mar 29.


On the detection of cerebral metabolic depression in experimental traumatic brain injury using Chemical Exchange Saturation Transfer (CEST)-weighted MRI.

Tu TW, Ibrahim WG, Jikaria N, Munasinghe JP, Witko JA, Hammoud DA, Frank JA.

Sci Rep. 2018 Jan 12;8(1):669. doi: 10.1038/s41598-017-19094-z.


Preclinical evaluation of an 18F-trifluoroborate methionine derivative for glioma imaging.

Yang X, Liu Z, Zhang H, Li Z, Munasinghe JP, Niu G, Teng G, Chen X.

Eur J Nucl Med Mol Imaging. 2018 Apr;45(4):585-592. doi: 10.1007/s00259-017-3910-2. Epub 2017 Dec 29.


Epidermal growth factor receptor as a novel molecular target for aggressive papillary tumors in the middle ear and temporal bone.

Kawabata S, Hollander MC, Munasinghe JP, Brinster LR, Mercado-Matos JR, Li J, Regales L, Pao W, Jänne PA, Wong KK, Butman JA, Lonser RR, Hansen MR, Gurgel RK, Vortmeyer AO, Dennis PA.

Oncotarget. 2015 May 10;6(13):11357-68.


13C-MR Spectroscopic Imaging with Hyperpolarized [1-13C]pyruvate Detects Early Response to Radiotherapy in SCC Tumors and HT-29 Tumors.

Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Clin Cancer Res. 2015 Nov 15;21(22):5073-81. doi: 10.1158/1078-0432.CCR-14-1717. Epub 2015 Feb 11.


Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302.

Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC.

PLoS One. 2014 Sep 25;9(9):e107995. doi: 10.1371/journal.pone.0107995. eCollection 2014.


In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization.

Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe JP, Morris HD, Lizak MJ, Merkle H, Yasukawa K, Devasahayam N, Suburamanian S, Mitchell JB, Krishna MC.

Antioxid Redox Signal. 2014 Sep 10;21(8):1145-55. doi: 10.1089/ars.2013.5725. Epub 2014 Apr 7.


Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

Saito K, Matsumoto S, Yasui H, Devasahayam N, Subramanian S, Munasinghe JP, Patel V, Gutkind JS, Mitchell JB, Krishna MC.

PLoS One. 2012;7(11):e49456. doi: 10.1371/journal.pone.0049456. Epub 2012 Nov 20.


EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate.

Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC.

Magn Reson Med. 2013 May;69(5):1443-50. doi: 10.1002/mrm.24355. Epub 2012 Jun 12.


Reporting of quantitative oxygen mapping in EPR imaging.

Subramanian S, Devasahayam N, McMillan A, Matsumoto S, Munasinghe JP, Saito K, Mitchell JB, Chandramouli GV, Krishna MC.

J Magn Reson. 2012 Jan;214(1):244-51. doi: 10.1016/j.jmr.2011.11.013. Epub 2011 Nov 28.


Transient decrease in tumor oxygenation after intravenous administration of pyruvate.

Saito K, Matsumoto S, Devasahayam N, Subramanian S, Munasinghe JP, Morris HD, Lizak MJ, Ardenkjaer-Larsen JH, Mitchell JB, Krishna MC.

Magn Reson Med. 2012 Mar;67(3):801-7. doi: 10.1002/mrm.23065. Epub 2011 Oct 17.


Antiangiogenic agent sunitinib transiently increases tumor oxygenation and suppresses cycling hypoxia.

Matsumoto S, Batra S, Saito K, Yasui H, Choudhuri R, Gadisetti C, Subramanian S, Devasahayam N, Munasinghe JP, Mitchell JB, Krishna MC.

Cancer Res. 2011 Oct 15;71(20):6350-9. doi: 10.1158/0008-5472.CAN-11-2025. Epub 2011 Aug 30.


Infusion-based manganese-enhanced MRI: a new imaging technique to visualize the mouse brain.

Mok SI, Munasinghe JP, Young WS.

Brain Struct Funct. 2012 Jan;217(1):107-14. doi: 10.1007/s00429-011-0324-y. Epub 2011 May 20.


Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice.

Yasui H, Matsumoto S, Devasahayam N, Munasinghe JP, Choudhuri R, Saito K, Subramanian S, Mitchell JB, Krishna MC.

Cancer Res. 2010 Aug 15;70(16):6427-36. doi: 10.1158/0008-5472.CAN-10-1350. Epub 2010 Jul 20.


Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation.

Munasinghe JP, Banerjee M, Acosta MT, Banks M, Heffer A, Silva AC, Koretsky A, Theodore WH.

Acta Neurol Scand. 2010 Mar;121(3):209-16. doi: 10.1111/j.1600-0404.2009.01188.x. Epub 2009 Nov 25.


Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI.

Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17898-903. doi: 10.1073/pnas.0908447106. Epub 2009 Oct 6.


Estimation of tumor microvessel density by MRI using a blood pool contrast agent.

Hyodo F, Chandramouli GV, Matsumoto S, Matsumoto K, Mitchell JB, Krishna MC, Munasinghe JP.

Int J Oncol. 2009 Oct;35(4):797-804.


Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I.

Dezfulian C, Shiva S, Alekseyenko A, Pendyal A, Beiser DG, Munasinghe JP, Anderson SA, Chesley CF, Vanden Hoek TL, Gladwin MT.

Circulation. 2009 Sep 8;120(10):897-905. doi: 10.1161/CIRCULATIONAHA.109.853267. Epub 2009 Aug 24.


Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy.

Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, Porter FD.

Hum Mol Genet. 2006 Mar 15;15(6):839-51. Epub 2006 Jan 30.


Magnetic resonance imaging, histology, and x-ray of three stages of damage to the knees of STR/ORT mice.

Munasinghe JP, Tyler JA, Hodgson RJ, Barry MA, Gresham GA, Evans R, Hall LD.

Invest Radiol. 1996 Oct;31(10):630-8.


Magnetic resonance imaging of the normal mouse brain: comparison with histologic sections.

Munasinghe JP, Gresham GA, Carpenter TA, Hall LD.

Lab Anim Sci. 1995 Dec;45(6):674-9.


High resolution MR imaging of joint degeneration in the knee of the STR/ORT mouse.

Munasinghe JP, Tyler JA, Carpenter TA, Hall LD.

Magn Reson Imaging. 1995;13(3):421-8.


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