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Items: 1 to 50 of 115


Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery.

Benhabbour SR, Kovarova M, Jones C, Copeland DJ, Shrivastava R, Swanson MD, Sykes C, Ho PT, Cottrell ML, Sridharan A, Fix SM, Thayer O, Long JM, Hazuda DJ, Dayton PA, Mumper RJ, Kashuba ADM, Victor Garcia J.

Nat Commun. 2019 Sep 20;10(1):4324. doi: 10.1038/s41467-019-12141-5.


Ultra-long-acting removable drug delivery system for HIV treatment and prevention.

Kovarova M, Benhabbour SR, Massud I, Spagnuolo RA, Skinner B, Baker CE, Sykes C, Mollan KR, Kashuba ADM, García-Lerma JG, Mumper RJ, Garcia JV.

Nat Commun. 2018 Oct 8;9(1):4156. doi: 10.1038/s41467-018-06490-w.


Synthesis and Characterization of Cetuximab-Docetaxel and Panitumumab-Docetaxel Antibody-Drug Conjugates for EGFR-Overexpressing Cancer Therapy.

Glatt DM, Beckford Vera DR, Prabhu SS, Mumper RJ, Luft JC, Benhabbour SR, Parrott MC.

Mol Pharm. 2018 Nov 5;15(11):5089-5102. doi: 10.1021/acs.molpharmaceut.8b00672. Epub 2018 Oct 1.


Synthesis and Physicochemical Characterization of a Diethyl Ester Prodrug of DTPA and Its Investigation as an Oral Decorporation Agent in Rats.

Huckle JE, Sadgrove MP, Leed MG, Yang YT, Mumper RJ, Semelka RC, Jay M.

AAPS J. 2016 Jul;18(4):972-80. doi: 10.1208/s12248-016-9916-z. Epub 2016 Apr 22.


The Interplay of Antigen Affinity, Internalization, and Pharmacokinetics on CD44-Positive Tumor Targeting of Monoclonal Antibodies.

Glatt DM, Beckford Vera DR, Parrott MC, Luft JC, Benhabbour SR, Mumper RJ.

Mol Pharm. 2016 Jun 6;13(6):1894-903. doi: 10.1021/acs.molpharmaceut.6b00063. Epub 2016 Apr 28.


Polymer-Drug Conjugates for Anticancer Drug Delivery.

Wadhwa S, Mumper RJ.

Crit Rev Ther Drug Carrier Syst. 2015;32(3):215-45. Review.


Orally administered DTPA di-ethyl ester for decorporation of (241)Am in dogs: Assessment of safety and efficacy in an inhalation-contamination model.

Huckle JE, Sadgrove MP, Pacyniak E, Leed MG, Weber WM, Doyle-Eisele M, Guilmette RA, Agha BJ, Susick RL, Mumper RJ, Jay M.

Int J Radiat Biol. 2015 Jul;91(7):568-75. doi: 10.3109/09553002.2015.1043753. Epub 2015 May 21.


Species-dependent chelation of (241)Am by DTPA Di-ethyl ester.

Huckle JE, Sadgrove MP, Mumper RJ, Jay M.

Health Phys. 2015 Apr;108(4):443-50. doi: 10.1097/HP.0000000000000230.


In reply to Spangler.

McLaughlin JE, Roth MT, Mumper RJ.

Acad Med. 2014 Nov;89(11):1429-30. doi: 10.1097/ACM.0000000000000497. No abstract available.


2'-(2-bromohexadecanoyl)-paclitaxel conjugate nanoparticles for the treatment of non-small cell lung cancer in an orthotopic xenograft mouse model.

Peng L, Schorzman AN, Ma P, Madden AJ, Zamboni WC, Benhabbour SR, Mumper RJ.

Int J Nanomedicine. 2014 Jul 30;9:3601-10. doi: 10.2147/IJN.S66040. eCollection 2014.


Retention of polyphenolic species in spray-dried blackberry extract using mannitol as a thermoprotectant.

Eldridge JA, Repko D, Mumper RJ.

J Med Food. 2014 Oct;17(10):1064-9. doi: 10.1089/jmf.2013.0177. Epub 2014 Jun 3.


Development of a novel orthotopic non-small cell lung cancer model and therapeutic benefit of 2'-(2-bromohexadecanoyl)-docetaxel conjugate nanoparticles.

Peng L, Feng L, Yuan H, Benhabbour SR, Mumper RJ.

Nanomedicine. 2014 Oct;10(7):1497-506. doi: 10.1016/j.nano.2014.03.016. Epub 2014 Apr 4.


Ultrasound molecular imaging of secreted frizzled related protein-2 expression in murine angiosarcoma.

Tsuruta JK, Klauber-DeMore N, Streeter J, Samples J, Patterson C, Mumper RJ, Ketelsen D, Dayton P.

PLoS One. 2014 Jan 29;9(1):e86642. doi: 10.1371/journal.pone.0086642. eCollection 2014.


A renaissance in pharmacy education at the University of North Carolina at Chapel Hill.

Roth MT, Mumper RJ, Singleton SF, Lee CR, Rodgers PT, Cox WC, McLaughlin JE, Joyner P, Blouin RA.

N C Med J. 2014 Jan-Feb;75(1):48-52.


A roadmap for educational research in pharmacy.

McLaughlin JE, Dean MJ, Mumper RJ, Blouin RA, Roth MT.

Am J Pharm Educ. 2013 Dec 16;77(10):218. doi: 10.5688/ajpe7710218.


The flipped classroom: a course redesign to foster learning and engagement in a health professions school.

McLaughlin JE, Roth MT, Glatt DM, Gharkholonarehe N, Davidson CA, Griffin LM, Esserman DA, Mumper RJ.

Acad Med. 2014 Feb;89(2):236-43. doi: 10.1097/ACM.0000000000000086.


Pharmacy student engagement, performance, and perception in a flipped satellite classroom.

McLaughlin JE, Griffin LM, Esserman DA, Davidson CA, Glatt DM, Roth MT, Gharkholonarehe N, Mumper RJ.

Am J Pharm Educ. 2013 Nov 12;77(9):196. doi: 10.5688/ajpe779196.


Paclitaxel Nano-Delivery Systems: A Comprehensive Review.

Ma P, Mumper RJ.

J Nanomed Nanotechnol. 2013 Feb 18;4(2):1000164.


Radionuclide decorporation: matching the biokinetics of actinides by transdermal delivery of pro-chelators.

Zhang Y, Sadgrove MP, Mumper RJ, Jay M.

AAPS J. 2013 Oct;15(4):1180-8. doi: 10.1208/s12248-013-9527-x. Epub 2013 Aug 30.


Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy.

Zhang Y, Peng L, Mumper RJ, Huang L.

Biomaterials. 2013 Nov;34(33):8459-68. doi: 10.1016/j.biomaterials.2013.07.050. Epub 2013 Aug 8.


D-penicillamine and other low molecular weight thiols: review of anticancer effects and related mechanisms.

Wadhwa S, Mumper RJ.

Cancer Lett. 2013 Aug 28;337(1):8-21. doi: 10.1016/j.canlet.2013.05.027. Epub 2013 May 29. Review.


Oil-filled lipid nanoparticles containing 2'-(2-bromohexadecanoyl)-docetaxel for the treatment of breast cancer.

Feng L, Benhabbour SR, Mumper RJ.

Adv Healthc Mater. 2013 Nov;2(11):1451-7. doi: 10.1002/adhm.201300017. Epub 2013 Apr 19.


Biotargeted nanomedicines for cancer: six tenets before you begin.

Goldberg MS, Hook SS, Wang AZ, Bulte JW, Patri AK, Uckun FM, Cryns VL, Hanes J, Akin D, Hall JB, Gharkholo N, Mumper RJ.

Nanomedicine (Lond). 2013 Feb;8(2):299-308. doi: 10.2217/nnm.13.3.


Nonaqueous gel for the transdermal delivery of a DTPA penta-ethyl ester prodrug.

Zhang Y, Sadgrove MP, Sueda K, Yang YT, Pacyniak EK, Kagel JR, Braun BA, Zamboni WC, Mumper RJ, Jay M.

AAPS J. 2013 Apr;15(2):523-32. doi: 10.1208/s12248-013-9459-5. Epub 2013 Feb 7.


In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery.

Liu D, Kobayashi T, Russo S, Li F, Plevy SE, Gambling TM, Carson JL, Mumper RJ.

AAPS J. 2013 Jan;15(1):288-98. doi: 10.1208/s12248-012-9441-7. Epub 2012 Nov 30.


2'-Behenoyl-paclitaxel conjugate containing lipid nanoparticles for the treatment of metastatic breast cancer.

Ma P, Rahima Benhabbour S, Feng L, Mumper RJ.

Cancer Lett. 2013 Jul 1;334(2):253-62. doi: 10.1016/j.canlet.2012.08.009. Epub 2012 Aug 16.


Effect of carbon coating on the physico-chemical properties and toxicity of copper and nickel nanoparticles.

Minocha S, Mumper RJ.

Small. 2012 Nov 5;8(21):3289-99. doi: 10.1002/smll.201200478. Epub 2012 Jul 26.


Antibacterial effects of blackberry extract target periodontopathogens.

González OA, Escamilla C, Danaher RJ, Dai J, Ebersole JL, Mumper RJ, Miller CS.

J Periodontal Res. 2013 Feb;48(1):80-6. doi: 10.1111/j.1600-0765.2012.01506.x. Epub 2012 Jul 19.


Large intestine-targeted, nanoparticle-releasing oral vaccine to control genitorectal viral infection.

Zhu Q, Talton J, Zhang G, Cunningham T, Wang Z, Waters RC, Kirk J, Eppler B, Klinman DM, Sui Y, Gagnon S, Belyakov IM, Mumper RJ, Berzofsky JA.

Nat Med. 2012 Aug;18(8):1291-6. doi: 10.1038/nm.2866. Epub 2012 Jul 15.


A critical review of lipid-based nanoparticles for taxane delivery.

Feng L, Mumper RJ.

Cancer Lett. 2013 Jul 1;334(2):157-75. doi: 10.1016/j.canlet.2012.07.006. Epub 2012 Jul 13. Review.


Molecular mechanisms in the dramatic enhancement of HIV-1 Tat transduction by cationic liposomes.

Li GH, Li W, Mumper RJ, Nath A.

FASEB J. 2012 Jul;26(7):2824-34. doi: 10.1096/fj.11-203315. Epub 2012 Mar 23.


Development and optimization of oil-filled lipid nanoparticles containing docetaxel conjugates designed to control the drug release rate in vitro and in vivo.

Feng L, Wu H, Ma P, Mumper RJ, Benhabbour SR.

Int J Nanomedicine. 2011;6:2545-56. doi: 10.2147/IJN.S24954. Epub 2011 Oct 21.


New directions in pharmacy education.

Falcione BA, Joyner PU, Blouin RA, Mumper RJ, Burcher K, Unterwagner W.

J Am Pharm Assoc (2003). 2011 Nov-Dec;51(6):678-82. doi: 10.1331/JAPhA.2011.11545. No abstract available.


Lipid nanocapsule as vaccine carriers for his-tagged proteins: evaluation of antigen-specific immune responses to HIV I His-Gag p41 and systemic inflammatory responses.

Wadhwa S, Jain A, Woodward JG, Mumper RJ.

Eur J Pharm Biopharm. 2012 Feb;80(2):315-22. doi: 10.1016/j.ejpb.2011.10.016. Epub 2011 Oct 31.


Polypeptide conjugates of D-penicillamine and idarubicin for anticancer therapy.

Wadhwa S, Mumper RJ.

J Control Release. 2012 Mar 10;158(2):215-23. doi: 10.1016/j.jconrel.2011.10.027. Epub 2011 Oct 29.


In vitro and in vivo assessment of targeting lipid-based nanoparticles to the epidermal growth factor-receptor (EGFR) using a novel Heptameric ZEGFR domain.

Benhabbour SR, Luft JC, Kim D, Jain A, Wadhwa S, Parrott MC, Liu R, DeSimone JM, Mumper RJ.

J Control Release. 2012 Feb 28;158(1):63-71. doi: 10.1016/j.jconrel.2011.10.013. Epub 2011 Oct 20.


Antiviral effects of blackberry extract against herpes simplex virus type 1.

Danaher RJ, Wang C, Dai J, Mumper RJ, Miller CS.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):e31-5. doi: 10.1016/j.tripleo.2011.04.007.


Anthocyanin-rich fractions of blackberry extracts reduce UV-induced free radicals and oxidative damage in keratinocytes.

Murapa P, Dai J, Chung M, Mumper RJ, D'Orazio J.

Phytother Res. 2012 Jan;26(1):106-12. doi: 10.1002/ptr.3510. Epub 2011 May 12.


Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse.

Moench TR, Mumper RJ, Hoen TE, Sun M, Cone RA.

BMC Infect Dis. 2010 Nov 18;10:331. doi: 10.1186/1471-2334-10-331.


Plant phenolics: extraction, analysis and their antioxidant and anticancer properties.

Dai J, Mumper RJ.

Molecules. 2010 Oct 21;15(10):7313-52. doi: 10.3390/molecules15107313. Review.


Quantitative nanostructure-activity relationship modeling.

Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A.

ACS Nano. 2010 Oct 26;4(10):5703-12. doi: 10.1021/nn1013484.


Tresyl-based conjugation of protein antigen to lipid nanoparticles increases antigen immunogenicity.

Jain A, Yan W, Miller KR, O'Carra R, Woodward JG, Mumper RJ.

Int J Pharm. 2010 Nov 30;401(1-2):87-92. doi: 10.1016/j.ijpharm.2010.09.003. Epub 2010 Sep 15.


Nanomedicinal strategies to treat multidrug-resistant tumors: current progress.

Dong X, Mumper RJ.

Nanomedicine (Lond). 2010 Jun;5(4):597-615. doi: 10.2217/nnm.10.35. Review.


Nanoparticles for local drug delivery to the oral mucosa: proof of principle studies.

Holpuch AS, Hummel GJ, Tong M, Seghi GA, Pei P, Ma P, Mumper RJ, Mallery SR.

Pharm Res. 2010 Jul;27(7):1224-36. doi: 10.1007/s11095-010-0121-y. Epub 2010 Mar 31.


Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia.

Ma P, Dong X, Swadley CL, Gupte A, Leggas M, Ledebur HC, Mumper RJ.

J Biomed Nanotechnol. 2009 Apr;5(2):151-61.


Lipid Nanoparticles with Accessible Nickel as a Vaccine Delivery System for Single and Multiple His-tagged HIV Antigens.

Yan W, Jain A, O'Carra R, Woodward JG, Li W, Li G, Nath A, Mumper RJ.

HIV AIDS (Auckl). 2009 Jul 1;2009(1):1-11.


Doxorubicin and paclitaxel-loaded lipid-based nanoparticles overcome multidrug resistance by inhibiting P-glycoprotein and depleting ATP.

Dong X, Mattingly CA, Tseng MT, Cho MJ, Liu Y, Adams VR, Mumper RJ.

Cancer Res. 2009 May 1;69(9):3918-26. doi: 10.1158/0008-5472.CAN-08-2747. Epub 2009 Apr 21.

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