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Items: 1 to 50 of 258

1.

Lymphoblast-derived hiPS cell lines generated from four individuals of a family of genetically unrelated parents and their female monozygotic twins.

Bouma MJ, Freund C, IJzerman AP, Boomsma DI, Mummery CL, Raymond K.

Stem Cell Res. 2019 Dec;41:101654. doi: 10.1016/j.scr.2019.101654. Epub 2019 Nov 8.

2.

Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Tiemeier GL, Wang G, Dumas SJ, Sol WMPJ, Avramut MC, Karakach T, Orlova VV, van den Berg CW, Mummery CL, Carmeliet P, van den Berg BM, Rabelink TJ.

Stem Cell Reports. 2019 Nov 12;13(5):803-816. doi: 10.1016/j.stemcr.2019.10.005. Epub 2019 Oct 31.

3.

Inherited cardiac diseases, pluripotent stem cells and genome editing combined - the past, present and future.

van den Brink L, Grandela C, Mummery CL, Davis RP.

Stem Cells. 2019 Oct 30. doi: 10.1002/stem.3110. [Epub ahead of print] Review.

PMID:
31664757
4.

Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes.

van Meer BJ, Krotenberg A, Sala L, Davis RP, Eschenhagen T, Denning C, Tertoolen LGJ, Mummery CL.

Nat Commun. 2019 Sep 20;10(1):4325. doi: 10.1038/s41467-019-12354-8.

5.

Unlocking Personalized Biomedicine and Drug Discovery with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Fit for Purpose or Forever Elusive?

de Korte T, Katili PA, Mohd Yusof NAN, van Meer BJ, Saleem U, Burton FL, Smith GL, Clements P, Mummery CL, Eschenhagen T, Hansen A, Denning C.

Annu Rev Pharmacol Toxicol. 2019 Sep 10. doi: 10.1146/annurev-pharmtox-010919-023309. [Epub ahead of print]

PMID:
31506008
6.

Expandable human cardiovascular progenitors from stem cells for regenerating mouse heart after myocardial infarction.

Schwach V, Fernandes MG, Maas S, Gerhardt S, Tsonaka R, van der Weerd L, Passier R, Mummery CL, Birket MJ, Salvatori DCF.

Cardiovasc Res. 2019 Jul 9. pii: cvz181. doi: 10.1093/cvr/cvz181. [Epub ahead of print]

PMID:
31287499
7.

Scalable microphysiological system to model three-dimensional blood vessels.

de Graaf MNS, Cochrane A, van den Hil FE, Buijsman W, van der Meer AD, van den Berg A, Mummery CL, Orlova VV.

APL Bioeng. 2019 Jun 21;3(2):026105. doi: 10.1063/1.5090986. eCollection 2019 Jun.

8.

Differentiation and Functional Comparison of Monocytes and Macrophages from hiPSCs with Peripheral Blood Derivatives.

Cao X, Yakala GK, van den Hil FE, Cochrane A, Mummery CL, Orlova VV.

Stem Cell Reports. 2019 Jun 11;12(6):1282-1297. doi: 10.1016/j.stemcr.2019.05.003.

9.

Quantifying Ca2+ signaling and contraction in vascular pericytes and smooth muscle cells.

Halaidych OV, Mummery CL, Orlova VV.

Biochem Biophys Res Commun. 2019 May 21;513(1):112-118. doi: 10.1016/j.bbrc.2019.03.143. Epub 2019 Mar 30.

10.

Quantitative Analysis of Intracellular Ca2+ Release and Contraction in hiPSC-Derived Vascular Smooth Muscle Cells.

Halaidych OV, Cochrane A, van den Hil FE, Mummery CL, Orlova VV.

Stem Cell Reports. 2019 Apr 9;12(4):647-656. doi: 10.1016/j.stemcr.2019.02.003. Epub 2019 Mar 7.

11.

Decreased Expression of Vascular Endothelial Growth Factor Receptor 1 Contributes to the Pathogenesis of Hereditary Hemorrhagic Telangiectasia Type 2.

Thalgott JH, Dos-Santos-Luis D, Hosman AE, Martin S, Lamandé N, Bracquart D, Srun S, Galaris G, de Boer HC, Tual-Chalot S, Kroon S, Arthur HM, Cao Y, Snijder RJ, Disch F, Mager JJ, Rabelink TJ, Mummery CL, Raymond K, Lebrin F.

Circulation. 2018 Dec 4;138(23):2698-2712. doi: 10.1161/CIRCULATIONAHA.117.033062.

PMID:
30571259
12.

Perspectives on the Use of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Biomedical Research.

Mummery CL.

Stem Cell Reports. 2018 Dec 11;11(6):1306-1311. doi: 10.1016/j.stemcr.2018.11.011. Review.

13.

Microfluidic Assay for the Assessment of Leukocyte Adhesion to Human Induced Pluripotent Stem Cell-derived Endothelial Cells (hiPSC-ECs).

Halaidych OV, van den Hil F, Mummery CL, Orlova VV.

J Vis Exp. 2018 Nov 26;(141). doi: 10.3791/58678.

PMID:
30531715
14.

Personalised organs-on-chips: functional testing for precision medicine.

van den Berg A, Mummery CL, Passier R, van der Meer AD.

Lab Chip. 2019 Jan 15;19(2):198-205. doi: 10.1039/c8lc00827b. Review.

15.

Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts.

van Meer BJ, Sala L, Tertoolen LGJ, Smith GL, Burton FL, Mummery CL.

Curr Protoc Hum Genet. 2018 Oct;99(1):e67. doi: 10.1002/cphg.67. Epub 2018 Sep 25.

PMID:
30253059
16.

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology.

Cochrane A, Albers HJ, Passier R, Mummery CL, van den Berg A, Orlova VV, van der Meer AD.

Adv Drug Deliv Rev. 2019 Feb 1;140:68-77. doi: 10.1016/j.addr.2018.06.007. Epub 2018 Jun 23. Review.

17.

Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells.

Halaidych OV, Freund C, van den Hil F, Salvatori DCF, Riminucci M, Mummery CL, Orlova VV.

Stem Cell Reports. 2018 May 8;10(5):1642-1656. doi: 10.1016/j.stemcr.2018.03.012. Epub 2018 Apr 12.

18.

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Anderson DJ, Kaplan DI, Bell KM, Koutsis K, Haynes JM, Mills RJ, Phelan DG, Qian EL, Leitoguinho AR, Arasaratnam D, Labonne T, Ng ES, Davis RP, Casini S, Passier R, Hudson JE, Porrello ER, Costa MW, Rafii A, Curl CL, Delbridge LM, Harvey RP, Oshlack A, Cheung MM, Mummery CL, Petrou S, Elefanty AG, Stanley EG, Elliott DA.

Nat Commun. 2018 Apr 10;9(1):1373. doi: 10.1038/s41467-018-03714-x.

19.

Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives.

Tong C, Liu T, Saez Talens V, Noteborn WEM, Sharp TH, Hendrix MMRM, Voets IK, Mummery CL, Orlova VV, Kieltyka RE.

Biomacromolecules. 2018 Apr 9;19(4):1091-1099. doi: 10.1021/acs.biomac.7b01614. Epub 2018 Mar 12.

20.

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo.

Sala L, van Meer BJ, Tertoolen LGJ, Bakkers J, Bellin M, Davis RP, Denning C, Dieben MAE, Eschenhagen T, Giacomelli E, Grandela C, Hansen A, Holman ER, Jongbloed MRM, Kamel SM, Koopman CD, Lachaud Q, Mannhardt I, Mol MPH, Mosqueira D, Orlova VV, Passier R, Ribeiro MC, Saleem U, Smith GL, Burton FL, Mummery CL.

Circ Res. 2018 Feb 2;122(3):e5-e16. doi: 10.1161/CIRCRESAHA.117.312067. Epub 2017 Dec 27. Review.

21.

Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells.

Guadix JA, Orlova VV, Giacomelli E, Bellin M, Ribeiro MC, Mummery CL, Pérez-Pomares JM, Passier R.

Stem Cell Reports. 2017 Dec 12;9(6):1754-1764. doi: 10.1016/j.stemcr.2017.10.023. Epub 2017 Nov 22.

22.

A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes.

Schwach V, Verkerk AO, Mol M, Monshouwer-Kloots JJ, Devalla HD, Orlova VV, Anastassiadis K, Mummery CL, Davis RP, Passier R.

Stem Cell Reports. 2017 Dec 12;9(6):1765-1779. doi: 10.1016/j.stemcr.2017.10.024. Epub 2017 Nov 22.

23.

Executive summary of the 12th HHT international scientific conference.

Andrejecsk JW, Hosman AE, Botella LM, Shovlin CL, Arthur HM, Dupuis-Girod S, Buscarini E, Hughes CCW, Lebrin F, Mummery CL, Post MC, Mager JJ.

Angiogenesis. 2018 Feb;21(1):169-181. doi: 10.1007/s10456-017-9585-2.

24.

Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue.

Giacomelli E, Bellin M, Orlova VV, Mummery CL.

Curr Protoc Hum Genet. 2017 Oct 18;95:21.9.1-21.9.22. doi: 10.1002/cphg.46.

PMID:
29044469
25.

DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells.

Roost MS, Slieker RC, Bialecka M, van Iperen L, Gomes Fernandes MM, He N, Suchiman HED, Szuhai K, Carlotti F, de Koning EJP, Mummery CL, Heijmans BT, Chuva de Sousa Lopes SM.

Nat Commun. 2017 Oct 13;8(1):908. doi: 10.1038/s41467-017-01077-3.

26.

Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies.

Brandão KO, Tabel VA, Atsma DE, Mummery CL, Davis RP.

Dis Model Mech. 2017 Sep 1;10(9):1039-1059. doi: 10.1242/dmm.030320. Review.

27.

FANTOM5 CAGE profiles of human and mouse samples.

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y.

Sci Data. 2017 Aug 29;4:170112. doi: 10.1038/sdata.2017.112.

28.

Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes.

Giacomelli E, Mummery CL, Bellin M.

Cell Mol Life Sci. 2017 Oct;74(20):3711-3739. doi: 10.1007/s00018-017-2546-5. Epub 2017 Jun 1. Review.

29.

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55587.

30.

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays.

Bouma MJ, van Iterson M, Janssen B, Mummery CL, Salvatori DCF, Freund C.

Stem Cell Reports. 2017 May 9;8(5):1340-1353. doi: 10.1016/j.stemcr.2017.03.009.

31.

Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells.

Giacomelli E, Bellin M, Sala L, van Meer BJ, Tertoolen LG, Orlova VV, Mummery CL.

Development. 2017 Mar 15;144(6):1008-1017. doi: 10.1242/dev.143438.

32.

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

33.

Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes.

Tertoolen LGJ, Braam SR, van Meer BJ, Passier R, Mummery CL.

Biochem Biophys Res Commun. 2018 Mar 18;497(4):1135-1141. doi: 10.1016/j.bbrc.2017.01.151. Epub 2017 Jan 30.

34.

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.

Devalla HD, Gélinas R, Aburawi EH, Beqqali A, Goyette P, Freund C, Chaix MA, Tadros R, Jiang H, Le Béchec A, Monshouwer-Kloots JJ, Zwetsloot T, Kosmidis G, Latour F, Alikashani A, Hoekstra M, Schlaepfer J, Mummery CL, Stevenson B, Kutalik Z, de Vries AA, Rivard L, Wilde AA, Talajic M, Verkerk AO, Al-Gazali L, Rioux JD, Bhuiyan ZA, Passier R.

EMBO Mol Med. 2016 Dec 1;8(12):1390-1408. doi: 10.15252/emmm.201505719. Print 2016 Dec.

35.

Small molecule absorption by PDMS in the context of drug response bioassays.

van Meer BJ, de Vries H, Firth KSA, van Weerd J, Tertoolen LGJ, Karperien HBJ, Jonkheijm P, Denning C, IJzerman AP, Mummery CL.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):323-328. doi: 10.1016/j.bbrc.2016.11.062. Epub 2016 Nov 14.

36.

Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A.

Kosmidis G, Veerman CC, Casini S, Verkerk AO, van de Pas S, Bellin M, Wilde AA, Mummery CL, Bezzina CR.

Circ Arrhythm Electrophysiol. 2016 Nov;9(11). pii: e004227.

PMID:
27784737
37.

CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy.

Falke LL, Leeuwis JW, Lyons KM, Mummery CL, Nguyen TQ, Goldschmeding R.

J Cell Commun Signal. 2017 Mar;11(1):39-48. doi: 10.1007/s12079-016-0358-2. Epub 2016 Oct 20.

38.

Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

Sala L, Bellin M, Mummery CL.

Br J Pharmacol. 2017 Nov;174(21):3749-3765. doi: 10.1111/bph.13577. Epub 2016 Sep 20. Review.

39.

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M.

EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. Print 2016 Sep.

40.

Inherited heart disease - what can we expect from the second decade of human iPS cell research?

Bellin M, Mummery CL.

FEBS Lett. 2016 Aug;590(15):2482-93. doi: 10.1002/1873-3468.12285. Epub 2016 Jul 22. Review.

41.

Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease.

van Meer BJ, Tertoolen LG, Mummery CL.

Stem Cells. 2016 Aug;34(8):2008-15. doi: 10.1002/stem.2403. Epub 2016 Jun 30. Review.

42.

Stem cells: The cancer's gone, but did chemotherapy damage your heart?

Bellin M, Mummery CL.

Nat Rev Cardiol. 2016 Jul;13(7):383-4. doi: 10.1038/nrcardio.2016.88. Epub 2016 May 26. No abstract available.

PMID:
27226155
43.

Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure.

Madonna R, Van Laake LW, Davidson SM, Engel FB, Hausenloy DJ, Lecour S, Leor J, Perrino C, Schulz R, Ytrehus K, Landmesser U, Mummery CL, Janssens S, Willerson J, Eschenhagen T, Ferdinandy P, Sluijter JP.

Eur Heart J. 2016 Jun 14;37(23):1789-98. doi: 10.1093/eurheartj/ehw113. Epub 2016 Apr 7. Review.

44.

The avian embryo to study development of the cardiac conduction system.

Kelder TP, Vicente-Steijn R, Poelmann RE, Mummery CL, DeRuiter MC, Jongbloed MR.

Differentiation. 2016 Apr-Jun;91(4-5):90-103. doi: 10.1016/j.diff.2016.01.006. Epub 2016 Feb 5. Review.

PMID:
26856662
45.

Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations.

Gkatzis K, Thalgott J, Dos-Santos-Luis D, Martin S, Lamandé N, Carette MF, Disch F, Snijder RJ, Westermann CJ, Mager JJ, Oh SP, Miquerol L, Arthur HM, Mummery CL, Lebrin F.

Arterioscler Thromb Vasc Biol. 2016 Apr;36(4):707-17. doi: 10.1161/ATVBAHA.115.306719. Epub 2016 Jan 28.

PMID:
26821948
46.

Advantages of the avian model for human ovarian cancer.

Bernardo AM, Thorsteinsdóttir S, Mummery CL.

Mol Clin Oncol. 2015 Nov;3(6):1191-1198. Epub 2015 Aug 11.

47.

A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.

den Hartogh SC, Wolstencroft K, Mummery CL, Passier R.

Sci Rep. 2016 Jan 19;6:19386. doi: 10.1038/srep19386.

48.

Follow-up of Thalidomide treatment in patients with Hereditary Haemorrhagic Telangiectasia.

Hosman A, Westermann CJ, Snijder R, Disch F, Mummery CL, Mager JJ.

Rhinology. 2015 Dec;53(4):340-4. doi: 10.4193/Rhin14.289.

PMID:
26735132
49.

Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva.

Cai J, Orlova VV, Cai X, Eekhoff EMW, Zhang K, Pei D, Pan G, Mummery CL, Ten Dijke P.

Stem Cell Reports. 2015 Dec 8;5(6):963-970. doi: 10.1016/j.stemcr.2015.10.020. Epub 2015 Nov 26.

50.

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function.

Birket MJ, Ribeiro MC, Kosmidis G, Ward D, Leitoguinho AR, van de Pol V, Dambrot C, Devalla HD, Davis RP, Mastroberardino PG, Atsma DE, Passier R, Mummery CL.

Cell Rep. 2015 Oct 27;13(4):733-745. doi: 10.1016/j.celrep.2015.09.025. Epub 2015 Oct 17.

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