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Items: 1 to 50 of 90

1.

A specific proteinase 3 activity footprint in α1-antitrypsin deficiency.

Newby PR, Crossley D, Crisford H, Stockley JA, Mumford RA, Carter RI, Bolton CE, Hopkinson NS, Mahadeva R, Steiner MC, Wilkinson TMA, Sapey E, Stockley RA.

ERJ Open Res. 2019 Aug 5;5(3). pii: 00095-2019. doi: 10.1183/23120541.00095-2019. eCollection 2019 Jul.

2.

Plant viruses and viroids in the United Kingdom: An analysis of first detections and novel discoveries from 1980 to 2014.

Fox A, Mumford RA.

Virus Res. 2017 Sep 15;241:10-18. doi: 10.1016/j.virusres.2017.06.029. Epub 2017 Jul 6. Review.

PMID:
28690070
3.

Genome sequences of 12 isolates of the EU1 lineage of Phytophthora ramorum, a fungus-like pathogen that causes extensive damage and mortality to a wide range of trees and other plants.

Turner J, O'Neill P, Grant M, Mumford RA, Thwaites R, Studholme DJ.

Genom Data. 2017 Feb 6;12:17-21. doi: 10.1016/j.gdata.2017.02.006. eCollection 2017 Jun.

4.

Actigraphic investigation of circadian rhythm functioning and activity levels in children with mucopolysaccharidosis type III (Sanfilippo syndrome).

Mumford RA, Mahon LV, Jones S, Bigger B, Canal M, Hare DJ.

J Neurodev Disord. 2015;7(1):31. doi: 10.1186/s11689-015-9126-5. Epub 2015 Sep 1.

5.

The Relationship of the Fibrinogen Cleavage Biomarker Aα-Val360 With Disease Severity and Activity in α1-Antitrypsin Deficiency.

Carter RI, Ungurs MJ, Pillai A, Mumford RA, Stockley RA.

Chest. 2015 Aug;148(2):382-388. doi: 10.1378/chest.14-0520.

PMID:
25569856
6.

Aα-Val360: a marker of neutrophil elastase and COPD disease activity.

Carter RI, Ungurs MJ, Mumford RA, Stockley RA.

Eur Respir J. 2013 Jan;41(1):31-8. doi: 10.1183/09031936.00197411. Epub 2012 Apr 20.

7.

The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo.

Carter RI, Mumford RA, Treonze KM, Finke PE, Davies P, Si Q, Humes JL, Dirksen A, Piitulainen E, Ahmad A, Stockley RA.

Thorax. 2011 Aug;66(8):686-91. doi: 10.1136/thx.2010.154690. Epub 2011 May 26.

PMID:
21617168
8.

Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.

Reger TS, Zunic J, Stock N, Wang B, Smith ND, Munoz B, Green MD, Gardner MF, James JP, Chen W, Alves K, Si Q, Treonze KM, Lingham RB, Mumford RA.

Bioorg Med Chem Lett. 2010 Feb 1;20(3):1173-6. doi: 10.1016/j.bmcl.2009.12.009. Epub 2009 Dec 4.

PMID:
20022493
9.

Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.

Venkatraman S, Lebsack AD, Alves K, Gardner MF, James J, Lingham RB, Maniar S, Mumford RA, Si Q, Stock N, Treonze KM, Wang B, Zunic J, Munoz B.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5803-6. doi: 10.1016/j.bmcl.2009.07.111. Epub 2009 Jul 28.

PMID:
19713111
10.

Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.

Lin LS, Lanza T, Jewell JP, Liu P, Jones C, Kieczykowski GR, Treonze K, Si Q, Manior S, Koo G, Tong X, Wang J, Schuelke A, Pivnichny J, Wang R, Raab C, Vincent S, Davies P, Maccoss M, Mumford RA, Hagmann WK.

J Med Chem. 2009 Jun 11;52(11):3449-52. doi: 10.1021/jm900257b.

PMID:
19441819
11.

Characterization of alpha(4)beta(1) (CD49d/CD29) on equine leukocytes: potential utility of a potent alpha(4)beta(1) (CD49d/CD29) receptor antagonist in the treatment of equine heaves (recurrent airway obstruction).

Treonze KM, Alves K, Fischer P, Hagmann WK, Hora D, Kulick A, Vakerich K, Smith ND, Lingham RB, Maniar S, Reger TS, Zunic J, Munoz B, Prasit P, Nicholson D, Si Q, Judd K, Nicolich S, Kellerhouse P, Thompson D, Mumford RA.

Vet Immunol Immunopathol. 2009 Jul 15;130(1-2):79-87. doi: 10.1016/j.vetimm.2009.01.011. Epub 2009 Feb 4.

PMID:
19250687
12.

Detection of Potato mop top virus and Tobacco rattle virus Using a Multiplex Real-Time Fluorescent Reverse-Transcription Polymerase Chain Reaction Assay.

Mumford RA, Walsh K, Barker I, Boonham N.

Phytopathology. 2000 May;90(5):448-53. doi: 10.1094/PHYTO.2000.90.5.448.

13.

Constraining the amide bond in N-sulfonylated dipeptide VLA-4 antagonists.

Chang LL, Yang GX, McCauley E, Mumford RA, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1688-91. doi: 10.1016/j.bmcl.2008.01.045. Epub 2008 Jan 18.

PMID:
18242984
14.

Canna yellow streak virus: a new potyvirus associated with severe streaking symptoms in canna.

Monger WA, Harju V, Skelton A, Seal SE, Mumford RA.

Arch Virol. 2007;152(8):1527-30. Epub 2007 May 14.

PMID:
17497235
15.

Investigating the specificity of real-time PCR assays using synthetic oligonucleotides.

Boonham N, Fisher T, Mumford RA.

J Virol Methods. 2005 Dec;130(1-2):30-5. Epub 2005 Jul 26.

PMID:
16051376
16.

Influence of acid surrogates toward potency of VLA-4 antagonist.

Venkatraman S, Lim J, Cramer M, Gardner MF, James J, Alves K, Lingham RB, Mumford RA, Munoz B.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):4053-6.

PMID:
16039122
17.

Bicyclic amidine inhibitors of nitric oxide synthase: discovery of perhydro-iminopyrindine and perhydro-iminoquinoline as potent, orally active inhibitors of inducible nitric oxide synthase.

Guthikonda RN, Shah SK, Pacholok SG, Humes JL, Mumford RA, Grant SK, Chabin RM, Green BG, Tsou N, Ball R, Fletcher DS, Luell S, Euan MacIntyre D, Maccoss M.

Bioorg Med Chem Lett. 2005 Apr 15;15(8):1997-2001.

PMID:
15808455
18.
19.

Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4.

Lin LS, Lanza TJ Jr, Castonguay LA, Kamenecka T, McCauley E, Van Riper G, Egger LA, Mumford RA, Tong X, MacCoss M, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2004 May 3;14(9):2331-4.

PMID:
15081035
20.

Amidines as amide bond replacements in VLA-4 antagonists.

Kamenecka TM, Park YJ, Lin LS, de Laszlo S, McCauley ED, Van Riper G, Egger L, Kidambi U, Mumford RA, Tong S, Tang W, Colletti A, Teffera Y, Stearns R, MacCoss M, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2004 May 3;14(9):2323-6.

PMID:
15081033
21.

Development of a real-time RT-PCR assay for the detection of potato spindle tuber viroid.

Boonham N, Pérez LG, Mendez MS, Peralta EL, Blockley A, Walsh K, Barker I, Mumford RA.

J Virol Methods. 2004 Mar 15;116(2):139-46.

PMID:
14738980
22.

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.

Egger LA, Cao J, McCallum C, Kidambi U, Van Riper G, McCauley E, Mumford RA, Lanza TJ, Lin LS, de Laszlo SE, Young DN, Yang G, Dean DC, Raab CE, Wallace MA, Jones AN, Hagmann WK, Schmidt JA, Pepinsky RB, Scott DM, Lee WC, Cornebise MA, Detmers PA.

J Pharmacol Exp Ther. 2003 Sep;306(3):903-13. Epub 2003 May 23.

PMID:
12766251
23.

N-isonicotinoyl-(L)-4-aminophenylalanine derivatives as tight binding VLA-4 antagonists.

Doherty GA, Yang GX, Borges E, Tong S, McCauley ED, Treonz KM, Van Riper G, Pacholok S, Si Q, Koo GC, Shah K, Mumford RA, Hagmann WK.

Bioorg Med Chem Lett. 2003 Jun 2;13(11):1891-5. Erratum in: Bioorg Med Chem Lett. 2003 Sep 1;13(17):2937-8.

PMID:
12749892
24.

N-(3-phenylsulfonyl-3-piperidinoyl)-phenylalanine derivatives as potent, selective VLA-4 antagonists.

Gutteridge CE, de Laszlo SE, Kamenecka TM, McCauley E, van Riper G, Mumford RA, Kidambi U, Egger LA, Tong S, Hagmann WK.

Bioorg Med Chem Lett. 2003 Mar 10;13(5):885-90.

PMID:
12617914
25.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

Kopka IE, Lin LS, Mumford RA, Lanza T Jr, Magriotis PA, Young D, DeLaszlo SE, MacCoss M, Mills SG, Van Riper G, McCauley E, Lyons K, Vincent S, Egger LA, Kidambi U, Stearns R, Colletti A, Teffera Y, Tong S, Owens K, Levorse D, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2002 Sep 2;12(17):2415-8.

PMID:
12161146
26.

N-aryl-prolyl-dipeptides as potent antagonists of VLA-4.

Kamenecka TM, Lanza T Jr, de Laszlo SE, Li B, McCauley ED, Van Riper G, Egger LA, Kidambi U, Mumford RA, Tong S, MacCoss M, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2205-8.

PMID:
12127538
27.

N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists.

Li B, de Laszlo SE, Kamenecka TM, Kopka IE, Durette PL, Lanza T Jr, MacCoss M, Tong S, Mumford RA, McCauley ED, Van Riper G, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2002 Aug 19;12(16):2141-4.

PMID:
12127523
28.

Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow.

Egger LA, Kidambi U, Cao J, Van Riper G, McCauley E, Mumford RA, Amo S, Lingham R, Lanza T, Lin LS, De Laszlo SE, Young DN, Kopka IE, Tong S, Pikounis B, Benson E, Warwood S, Bargatze RF, Hagmann WK, Schmidt JA, Detmers PA.

J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. Erratum in: J Pharmacol Exp Ther. 2003 May;305(2):796.

PMID:
12065712
29.

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

Pepinsky RB, Mumford RA, Chen LL, Leone D, Amo SE, Riper GV, Whitty A, Dolinski B, Lobb RR, Dean DC, Chang LL, Raab CE, Si Q, Hagmann WK, Lingham RB.

Biochemistry. 2002 Jun 4;41(22):7125-41.

PMID:
12033947
30.

Substituted tetrahydrofuroyl-1-phenylalanine derivatives as potent and specific VLA-4 antagonists.

Doherty GA, Yang GX, Borges E, Chang LL, MacCoss M, Tong S, Kidambi U, Egger LA, McCauley E, Van Riper G, Mumford RA, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1501-5.

PMID:
12031329
31.

N-Tetrahydrofuroyl-(L)-phenylalanine derivatives as potent VLA-4 antagonists.

Yang GX, Chang LL, Truong Q, Doherty GA, Magriotis PA, de Laszlo SE, Li B, MacCoss M, Kidambi U, Egger LA, McCauley E, Van Riper G, Mumford RA, Schmidt JA, Hagmann WK.

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1497-500.

PMID:
12031328
32.

N-aryl 2,6-dimethoxybiphenylalanine analogues as VLA-4 antagonists.

Doherty GA, Kamenecka T, McCauley E, Van Riper G, Mumford RA, Tong S, Hagmann WK.

Bioorg Med Chem Lett. 2002 Mar 11;12(5):729-31.

PMID:
11858990
33.

Substituted N-(3,5-dichlorobenzenesulfonyl)-L-prolyl-phenylalanine analogues as potent VLA-4 antagonists.

Kopka IE, Young DN, Lin LS, Mumford RA, Magriotis PA, MacCoss M, Mills SG, Van Riper G, McCauley E, Egger LE, Kidambi U, Schmidt JA, Lyons K, Stearns R, Vincent S, Colletti A, Wang Z, Tong S, Wang J, Zheng S, Owens K, Levorse D, Hagmann WK.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):637-40.

PMID:
11844689
34.

The discovery of acylated beta-amino acids as potent and orally bioavailable VLA-4 antagonists.

Lin LS, Kopka IE, Mumford RA, Magriotis PA, Lanza T Jr, Durette PL, Kamenecka T, Young DN, de Laszlo SE, McCauley E, Riper GV, Kidambi U, Egger LA, Tong X, Lyons K, Vincent S, Stearns R, Colletti A, Teffera Y, Fenyk-Melody J, Schmidt JA, MacCoss M, Hagmann WK.

Bioorg Med Chem Lett. 2002 Feb 25;12(4):611-4. Erratum in: Bioorg Med Chem Lett. 2002 Jun 17;12(12):1695.

PMID:
11844683
35.

Effects of VLA-4 antagonists in rat whole embryo culture.

Spence S, Vetter C, Hagmann WK, Van Riper G, Williams H, Mumford RA, Lanza TJ, Lin LS, Schmidt JA.

Teratology. 2002 Jan;65(1):26-37.

PMID:
11835229
37.

The discovery of small molecule carbamates as potent dual alpha(4)beta(1)/alpha(4)beta(7) integrin antagonists.

Chang LL, Truong Q, Mumford RA, Egger LA, Kidambi U, Lyons K, McCauley E, Van Riper G, Vincent S, Schmidt JA, MacCoss M, Hagmann WK.

Bioorg Med Chem Lett. 2002 Jan 21;12(2):159-63.

PMID:
11755344
38.

Specific and dual antagonists of alpha(4)beta(1) and alpha(4)beta(7) integrins.

Lin LS, Lanza T Jr, McCauley E, Van Riper G, Kidambi U, Cao J, Egger LA, Mumford RA, Schmidt JA, MacCoss M, Hagmann WK.

Bioorg Med Chem Lett. 2002 Jan 21;12(2):133-6.

PMID:
11755338
39.

The discovery of sulfonylated dipeptides as potent VLA-4 antagonists.

Hagmann WK, Durette PL, Lanza T, Kevin NJ, de Laszlo SE, Kopka IE, Young D, Magriotis PA, Li B, Lin LS, Yang G, Kamenecka T, Chang LL, Wilson J, MacCoss M, Mills SG, Van Riper G, McCauley E, Egger LA, Kidambi U, Lyons K, Vincent S, Stearns R, Colletti A, Teffera J, Tong S, Fenyk-Melody J, Owens K, Levorse D, Kim P, Schmidt JA, Mumford RA.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2709-13.

PMID:
11591507
40.

Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.

Bayne EK, Flanagan J, Einstein M, Ayala J, Chang B, Azzolina B, Whiting DA, Mumford RA, Thiboutot D, Singer II, Harris G.

Br J Dermatol. 1999 Sep;141(3):481-91.

PMID:
10583052
41.

Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.

Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM.

Osteoarthritis Cartilage. 1997 Nov;5(6):407-18.

42.

Rapid single-tube immunocapture RT-PCR for the detection of two yam potyviruses.

Mumford RA, Seal SE.

J Virol Methods. 1997 Dec;69(1-2):73-9.

PMID:
9504753
43.

Inhibition of neutrophil elastase in CF sputum by L-658,758.

Rees DD, Brain JD, Wohl ME, Humes JL, Mumford RA.

J Pharmacol Exp Ther. 1997 Dec;283(3):1201-6.

PMID:
9399994
44.

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.

Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS.

J Clin Invest. 1997 Jul 1;100(1):93-106.

45.

Expression and immunoaffinity purification of human inducible nitric-oxide synthase. Inhibition studies with 2-amino-5,6-dihydro-4H-1,3-thiazine.

Calaycay JR, Kelly TM, MacNaul KL, McCauley ED, Qi H, Grant SK, Griffin PR, Klatt T, Raju SM, Nussler AK, Shah S, Weidner JR, Williams HR, Wolfe GC, Geller DA, Billiar TR, MacCoss M, Mumford RA, Tocci MJ, Schmidt JA, Wong KK, Hutchinson NI.

J Biol Chem. 1996 Nov 8;271(45):28212-9.

46.

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease.

Singer II, Kawka DW, Scott S, Weidner JR, Mumford RA, Riehl TE, Stenson WF.

Gastroenterology. 1996 Oct;111(4):871-85.

PMID:
8831582
47.

An improved method for the detection of Tospoviruses using the polymerase chain reaction.

Mumford RA, Barker I, Wood KR.

J Virol Methods. 1996 Mar;57(1):109-15.

PMID:
8919828
48.

Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage.

Olszewski JM, Moore VL, McDonnell J, Williams H, Saphos CA, Green BG, Knight WB, Chapman KT, Hagmann WK, Dorn CP, Hale JJ, Mumford RA.

Connect Tissue Res. 1996;33(4):291-9.

PMID:
8834447
50.

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.

Singer II, Kawka DW, Bayne EK, Donatelli SA, Weidner JR, Williams HR, Ayala JM, Mumford RA, Lark MW, Glant TT, et al.

J Clin Invest. 1995 May;95(5):2178-86.

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