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HIV-1 Vpu downregulates Tim-3 from the surface of infected CD4+ T cells.

Prévost J, Edgar CR, Richard J, Trothen SM, Jacob RA, Mumby MJ, Pickering S, Dubé M, Kaufmann DE, Kirchhoff F, Neil SJD, Finzi A, Dikeakos JD.

J Virol. 2020 Jan 15. pii: JVI.01999-19. doi: 10.1128/JVI.01999-19. [Epub ahead of print]


Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses.

Prévost J, Pickering S, Mumby MJ, Medjahed H, Gendron-Lepage G, Delgado GG, Dirk BS, Dikeakos JD, Stürzel CM, Sauter D, Kirchhoff F, Bibollet-Ruche F, Hahn BH, Dubé M, Kaufmann DE, Neil SJD, Finzi A, Richard J.

mBio. 2019 Jun 18;10(3). pii: e01113-19. doi: 10.1128/mBio.01113-19.


PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.

Hein AL, Seshacharyulu P, Rachagani S, Sheinin YM, Ouellette MM, Ponnusamy MP, Mumby MC, Batra SK, Yan Y.

Cancer Res. 2016 Apr 15;76(8):2243-2253. doi: 10.1158/0008-5472.CAN-15-2119. Epub 2016 Feb 18.


Structure of the Ca2+-dependent PP2A heterotrimer and insights into Cdc6 dephosphorylation.

Wlodarchak N, Guo F, Satyshur KA, Jiang L, Jeffrey PD, Sun T, Stanevich V, Mumby MC, Xing Y.

Cell Res. 2013 Jul;23(7):931-46. doi: 10.1038/cr.2013.77. Epub 2013 Jun 11.


Donor-acceptor cyclopropanes with Lawesson's and Woollins' reagents: formation of bisthiophenes and unprecedented cage-like molecules.

Kaschel J, Schmidt CD, Mumby M, Kratzert D, Stalke D, Werz DB.

Chem Commun (Camb). 2013 May 14;49(39):4403-5. doi: 10.1039/c2cc37631h. Epub 2012 Dec 18.


B55alpha PP2A holoenzymes modulate the phosphorylation status of the retinoblastoma-related protein p107 and its activation.

Jayadeva G, Kurimchak A, Garriga J, Sotillo E, Davis AJ, Haines DS, Mumby M, Graña X.

J Biol Chem. 2010 Sep 24;285(39):29863-73. doi: 10.1074/jbc.M110.162354. Epub 2010 Jul 27.


Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response.

Yan Y, Cao PT, Greer PM, Nagengast ES, Kolb RH, Mumby MC, Cowan KH.

Oncogene. 2010 Jul 29;29(30):4317-29. doi: 10.1038/onc.2010.187. Epub 2010 May 24.


Acute regulation of renal Na+/H+ exchanger NHE3 by dopamine: role of protein phosphatase 2A.

Bobulescu IA, Quiñones H, Gisler SM, Di Sole F, Hu MC, Shi M, Zhang J, Fuster DG, Wright N, Mumby M, Moe OW.

Am J Physiol Renal Physiol. 2010 May;298(5):F1205-13. doi: 10.1152/ajprenal.00708.2009. Epub 2010 Feb 24.


Protein phosphatase 2A is targeted to cell division control protein 6 by a calcium-binding regulatory subunit.

Davis AJ, Yan Z, Martinez B, Mumby MC.

J Biol Chem. 2008 Jun 6;283(23):16104-14. doi: 10.1074/jbc.M710313200. Epub 2008 Apr 8.


Mitochondrial protein phosphatase 2A regulates cell death induced by simulated ischemia in kidney NRK-52E cells.

Tsao CC, Nica AF, Kurinna SM, Jiffar T, Mumby M, Ruvolo PP.

Cell Cycle. 2007 Oct 1;6(19):2377-85. Epub 2007 Jul 12.


PP2A: unveiling a reluctant tumor suppressor.

Mumby M.

Cell. 2007 Jul 13;130(1):21-4. Review.


Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase.

Bielinski VA, Mumby MC.

Exp Cell Res. 2007 Aug 15;313(14):3117-26. Epub 2007 May 16.


The use of RNA interference to analyze protein phosphatase function in mammalian cells.

Fraser I, Liu W, Rebres R, Roach T, Zavzavadjian J, Santat L, Liu J, Wall E, Mumby M.

Methods Mol Biol. 2007;365:261-86.


A functional genomics analysis of the B56 isoforms of Drosophila protein phosphatase 2A.

Liu W, Silverstein AM, Shu H, Martinez B, Mumby MC.

Mol Cell Proteomics. 2007 Feb;6(2):319-32. Epub 2006 Nov 22.


The gatekeeper residue controls autoactivation of ERK2 via a pathway of intramolecular connectivity.

Emrick MA, Lee T, Starkey PJ, Mumby MC, Resing KA, Ahn NG.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18101-6. Epub 2006 Nov 17.


PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.

Tang Z, Shu H, Qi W, Mahmood NA, Mumby MC, Yu H.

Dev Cell. 2006 May;10(5):575-85. Epub 2006 Mar 30.


The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function.

Esplin ED, Ramos P, Martinez B, Tomlinson GE, Mumby MC, Evans GA.

Genes Chromosomes Cancer. 2006 Feb;45(2):182-90.


Phosphoproteomics: new insights into cellular signaling.

Mumby M, Brekken D.

Genome Biol. 2005;6(9):230. Epub 2005 Aug 17. Review.


InsPecT: identification of posttranslationally modified peptides from tandem mass spectra.

Tanner S, Shu H, Frank A, Wang LC, Zandi E, Mumby M, Pevzner PA, Bafna V.

Anal Chem. 2005 Jul 15;77(14):4626-39.


Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.

Shu H, Chen S, Bi Q, Mumby M, Brekken DL.

Mol Cell Proteomics. 2004 Mar;3(3):279-86. Epub 2004 Jan 17.


Analysis of protein phosphatase function in Drosophila cells using RNA interference.

Silverstein AM, Mumby MC.

Methods Enzymol. 2003;366:361-72.


Genetic modulation of tau phosphorylation in the mouse.

Brich J, Shie FS, Howell BW, Li R, Tus K, Wakeland EK, Jin LW, Mumby M, Churchill G, Herz J, Cooper JA.

J Neurosci. 2003 Jan 1;23(1):187-92.


Overview of the Alliance for Cellular Signaling.

Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR; Participating investigators and scientists of the Alliance for Cellular Signaling.

Nature. 2002 Dec 12;420(6916):703-6.


A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function.

Ruvolo PP, Clark W, Mumby M, Gao F, May WS.

J Biol Chem. 2002 Jun 21;277(25):22847-52. Epub 2002 Apr 2.


Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits.

Silverstein AM, Barrow CA, Davis AJ, Mumby MC.

Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4221-6. Epub 2002 Mar 19.


A new role for protein methylation: switching partners at the phosphatase ball.

Mumby M.

Sci STKE. 2001 Apr 24;2001(79):pe1. Review.


An audit of clinical nurse practitioner led thrombolysis to improve the treatment of acute myocardial infarction.

Lloyd G, Roberts A, Bashir I, Mumby M, Kamalvand K, Cooke R.

J Public Health Med. 2000 Dec;22(4):462-5.


Effects of regulatory subunits on the kinetics of protein phosphatase 2A.

Price NE, Mumby MC.

Biochemistry. 2000 Sep 19;39(37):11312-8.


An anchoring factor targets protein phosphatase 2A to brain microtubules.

Price NE, Wadzinski B, Mumby MC.

Brain Res Mol Brain Res. 1999 Nov 10;73(1-2):68-77.


Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.

Hiesberger T, Trommsdorff M, Howell BW, Goffinet A, Mumby MC, Cooper JA, Herz J.

Neuron. 1999 Oct;24(2):481-9.


Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, White CL 3rd, Mumby MC, Bloom GS.

J Biol Chem. 1999 Sep 3;274(36):25490-8.


Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid.

Chalfant CE, Kishikawa K, Mumby MC, Kamibayashi C, Bielawska A, Hannun YA.

J Biol Chem. 1999 Jul 16;274(29):20313-7.


Brain protein serine/threonine phosphatases.

Price NE, Mumby MC.

Curr Opin Neurobiol. 1999 Jun;9(3):336-42. Review.


Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A.

Griswold-Prenner I, Kamibayashi C, Maruoka EM, Mumby MC, Derynck R.

Mol Cell Biol. 1998 Nov;18(11):6595-604.


Regulation of endosome sorting by a specific PP2A isoform.

Molloy SS, Thomas L, Kamibayashi C, Mumby MC, Thomas G.

J Cell Biol. 1998 Sep 21;142(6):1399-411.


Purification and characterization of ceramide-activated protein phosphatases.

Galadari S, Kishikawa K, Kamibayashi C, Mumby MC, Hannun YA.

Biochemistry. 1998 Aug 11;37(32):11232-8.


The interconversion of protein phosphatase 2A between PP2A1 and PP2A0 during retinoic acid-induced granulocytic differentiation and a modification on the catalytic subunit in S phase of HL-60 cells.

Zhu T, Matsuzawa S, Mizuno Y, Kamibayashi C, Mumby MC, Andjelkovic N, Hemmings BA, Onoé K, Kikuchi K.

Arch Biochem Biophys. 1997 Mar 1;339(1):210-7.


Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC.

Neuron. 1996 Dec;17(6):1201-7.


p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A.

Okamoto K, Kamibayashi C, Serrano M, Prives C, Mumby MC, Beach D.

Mol Cell Biol. 1996 Nov;16(11):6593-602.


Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.

Tehrani MA, Mumby MC, Kamibayashi C.

J Biol Chem. 1996 Mar 1;271(9):5164-70.


Regulation by tumour antigens defines a role for PP2A in signal transduction.

Mumby M.

Semin Cancer Biol. 1995 Aug;6(4):229-37. Review.


A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

Sontag E, Nunbhakdi-Craig V, Bloom GS, Mumby MC.

J Cell Biol. 1995 Mar;128(6):1131-44.


Translocation of protein phosphatase 1 catalytic subunits during 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL-60 cells.

Omay SB, Ogasawara H, Toyoda H, Nakai K, Shima H, Nagao M, Mumby MC, Shiku H, Nishikawa M.

Cancer Res. 1995 Feb 15;55(4):774-80.


Diversity in the regulatory B-subunits of protein phosphatase 2A: identification of a novel isoform highly expressed in brain.

Zolnierowicz S, Csortos C, Bondor J, Verin A, Mumby MC, DePaoli-Roach AA.

Biochemistry. 1994 Oct 4;33(39):11858-67.


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