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Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922.

Kühnel A, Schilling D, Combs SE, Haller B, Schwab M, Multhoff G.

Cells. 2019 Sep 28;8(10). pii: E1166. doi: 10.3390/cells8101166.


7Hsp70 serum levels in pet dogs-a potential diagnostic biomarker for spontaneous round cell tumors.

Salvermoser L, Dressel S, Schleißheimer S, Stangl S, Diederichs C, Wergin M, Bley CR, Haller B, Multhoff G.

Cell Stress Chaperones. 2019 Sep;24(5):969-978. doi: 10.1007/s12192-019-01024-9. Epub 2019 Aug 3.


Radiation-Induced Amplification of TGFB1-Induced Mesenchymal Stem Cell-Mediated Sodium Iodide Symporter (NIS) Gene 131I Therapy.

Schug C, Kitzberger C, Sievert W, Spellerberg R, Tutter M, Schmohl KA, Eberlein B, Biedermann T, Steiger K, Zach C, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C.

Clin Cancer Res. 2019 Oct 1;25(19):5997-6008. doi: 10.1158/1078-0432.CCR-18-4092. Epub 2019 Jun 13.


Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy - potential markers for predicting breast cancer recurrence?

Rothammer A, Sage EK, Werner C, Combs SE, Multhoff G.

Radiat Oncol. 2019 May 10;14(1):78. doi: 10.1186/s13014-019-1286-0.


Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer.

Shevtsov M, Pitkin E, Ischenko A, Stangl S, Khachatryan W, Galibin O, Edmond S, Lobinger D, Multhoff G.

Front Immunol. 2019 Mar 22;10:454. doi: 10.3389/fimmu.2019.00454. eCollection 2019.


Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy.

Shevtsov M, Sato H, Multhoff G, Shibata A.

Front Oncol. 2019 Mar 19;9:156. doi: 10.3389/fonc.2019.00156. eCollection 2019. Review.


Granzyme B Functionalized Nanoparticles Targeting Membrane Hsp70-Positive Tumors for Multimodal Cancer Theranostics.

Shevtsov M, Stangl S, Nikolaev B, Yakovleva L, Marchenko Y, Tagaeva R, Sievert W, Pitkin E, Mazur A, Tolstoy P, Galibin O, Ryzhov V, Steiger K, Smirnov O, Khachatryan W, Chester K, Multhoff G.

Small. 2019 Mar;15(13):e1900205. doi: 10.1002/smll.201900205. Epub 2019 Mar 4.


Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study.

Kokowski K, Stangl S, Seier S, Hildebrandt M, Vaupel P, Multhoff G.

Strahlenther Onkol. 2019 Apr;195(4):352-361. doi: 10.1007/s00066-019-01434-9. Epub 2019 Feb 11.


Hsp70 interactions with membrane lipids regulate cellular functions in health and disease.

Balogi Z, Multhoff G, Jensen TK, Lloyd-Evans E, Yamashima T, Jäättelä M, Harwood JL, Vígh L.

Prog Lipid Res. 2019 Apr;74:18-30. doi: 10.1016/j.plipres.2019.01.004. Epub 2019 Jan 30. Review.


Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy.

Reindl J, Shevtsov M, Dollinger G, Stangl S, Multhoff G.

Cell Stress Chaperones. 2019 Jan;24(1):213-221. doi: 10.1007/s12192-018-00958-w. Epub 2019 Jan 10.


Membrane Hsp70-A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition.

Breuninger S, Stangl S, Werner C, Sievert W, Lobinger D, Foulds GA, Wagner S, Pickhard A, Piontek G, Kokowski K, Pockley AG, Multhoff G.

Front Oncol. 2018 Nov 1;8:497. doi: 10.3389/fonc.2018.00497. eCollection 2018.


Preclinical Evaluation of the Hsp70 Peptide Tracer TPP-PEG24-DFO[89Zr] for Tumor-Specific PET/CT Imaging.

Stangl S, Tei L, De Rose F, Reder S, Martinelli J, Sievert W, Shevtsov M, Öllinger R, Rad R, Schwaiger M, D'Alessandria C, Multhoff G.

Cancer Res. 2018 Nov 1;78(21):6268-6281. doi: 10.1158/0008-5472.CAN-18-0707. Epub 2018 Sep 18.


Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression.

Vaupel P, Multhoff G.

Adv Exp Med Biol. 2018;1072:171-175. doi: 10.1007/978-3-319-91287-5_27. Review.


Recent Advances in Gold Nanoformulations for Cancer Therapy.

Shevtsov M, Zhou Y, Khachatryan W, Multhoff G, Gao H.

Curr Drug Metab. 2018;19(9):768-780. doi: 10.2174/1389200219666180611080736. Review.


Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis.

Lechner P, Buck D, Sick L, Hemmer B, Multhoff G.

Mult Scler J Exp Transl Clin. 2018 May 2;4(2):2055217318767192. doi: 10.1177/2055217318767192. eCollection 2018 Apr-Jun.


External Beam Radiation Therapy Enhances Mesenchymal Stem Cell-Mediated Sodium-Iodide Symporter Gene Delivery.

Schug C, Sievert W, Urnauer S, Müller AM, Schmohl KA, Wechselberger A, Schwenk N, Lauber K, Schwaiger M, Multhoff G, Wagner E, Nelson PJ, Spitzweg C.

Hum Gene Ther. 2018 Nov;29(11):1287-1300. doi: 10.1089/hum.2018.025. Epub 2018 May 3.


Improved Overall Survival of Mice by Reducing Lung Side Effects After High-Precision Heart Irradiation Using a Small Animal Radiation Research Platform.

Sievert W, Stangl S, Steiger K, Multhoff G.

Int J Radiat Oncol Biol Phys. 2018 Jul 1;101(3):671-679. doi: 10.1016/j.ijrobp.2018.02.017. Epub 2018 Feb 14.


PPARα Is Necessary for Radiation-Induced Activation of Noncanonical TGFβ Signaling in the Heart.

Subramanian V, Borchard S, Azimzadeh O, Sievert W, Merl-Pham J, Mancuso M, Pasquali E, Multhoff G, Popper B, Zischka H, Atkinson MJ, Tapio S.

J Proteome Res. 2018 Apr 6;17(4):1677-1689. doi: 10.1021/acs.jproteome.8b00001. Epub 2018 Mar 23.


Targeting experimental orthotopic glioblastoma with chitosan-based superparamagnetic iron oxide nanoparticles (CS-DX-SPIONs).

Shevtsov M, Nikolaev B, Marchenko Y, Yakovleva L, Skvortsov N, Mazur A, Tolstoy P, Ryzhov V, Multhoff G.

Int J Nanomedicine. 2018 Mar 12;13:1471-1482. doi: 10.2147/IJN.S152461. eCollection 2018.


Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol.

Lamprecht C, Gehrmann M, Madl J, Römer W, Multhoff G, Ebner A.

Cell Stress Chaperones. 2018 Jul;23(4):673-683. doi: 10.1007/s12192-018-0879-0. Epub 2018 Feb 5.


Heat shock protein 70 and tumor-infiltrating NK cells as prognostic indicators for patients with squamous cell carcinoma of the head and neck after radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Stangl S, Tontcheva N, Sievert W, Shevtsov M, Niu M, Schmid TE, Pigorsch S, Combs SE, Haller B, Balermpas P, Rödel F, Rödel C, Fokas E, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Stuschke M, Grosu AL, Abdollahi A, Debus J, Belka C, Maihöfer C, Mönnich D, Zips D, Multhoff G.

Int J Cancer. 2018 May 1;142(9):1911-1925. doi: 10.1002/ijc.31213. Epub 2017 Dec 23.


CXCR4 Is a Potential Target for Diagnostic PET/CT Imaging in Barrett's Dysplasia and Esophageal Adenocarcinoma.

Fang HY, Münch NS, Schottelius M, Ingermann J, Liu H, Schauer M, Stangl S, Multhoff G, Steiger K, Gerngroß C, Jesinghaus M, Weichert W, Kühl AA, Sepulveda AR, Wester HJ, Wang TC, Quante M.

Clin Cancer Res. 2018 Mar 1;24(5):1048-1061. doi: 10.1158/1078-0432.CCR-17-1756. Epub 2017 Dec 5.


Membrane heat shock protein 70: a theranostic target for cancer therapy.

Shevtsov M, Huile G, Multhoff G.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738). pii: 20160526. doi: 10.1098/rstb.2016.0526. Review.


Immunohistochemical and Flow Cytometric Analysis of Intracellular and Membrane-Bound Hsp70, as a Putative Biomarker of Glioblastoma Multiforme, Using the cmHsp70.1 Monoclonal Antibody.

Stangl S, Foulds GA, Fellinger H, Pilkington GJ, Pockley AG, Multhoff G.

Methods Mol Biol. 2018;1709:307-320. doi: 10.1007/978-1-4939-7477-1_22.


Selection of an Anticalin® against the membrane form of Hsp70 via bacterial surface display and its theranostic application in tumour models.

Friedrich L, Kornberger P, Mendler CT, Multhoff G, Schwaiger M, Skerra A.

Biol Chem. 2018 Feb 23;399(3):235-252. doi: 10.1515/hsz-2017-0207.


Dynamics of Heat Shock Protein 70 Serum Levels As a Predictor of Clinical Response in Non-Small-Cell Lung Cancer and Correlation with the Hypoxia-Related Marker Osteopontin.

Ostheimer C, Gunther S, Bache M, Vordermark D, Multhoff G.

Front Immunol. 2017 Oct 18;8:1305. doi: 10.3389/fimmu.2017.01305. eCollection 2017.


Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.


Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists.

Combs SE, Kessel C, Wilkens JJ, Multhoff G, Schmid TE, Vaupel P, Trott KR, Berberat P, Atkinson MJ.

Front Oncol. 2017 Sep 22;7:226. doi: 10.3389/fonc.2017.00226. eCollection 2017.


Overexpression of cytosolic, plasma membrane bound and extracellular heat shock protein 70 (Hsp70) in primary glioblastomas.

Thorsteinsdottir J, Stangl S, Fu P, Guo K, Albrecht V, Eigenbrod S, Erl J, Gehrmann M, Tonn JC, Multhoff G, Schichor C.

J Neurooncol. 2017 Dec;135(3):443-452. doi: 10.1007/s11060-017-2600-z. Epub 2017 Aug 28.


Effects of definitive and salvage radiotherapy on the distribution of lymphocyte subpopulations in prostate cancer patients.

Sage EK, Schmid TE, Geinitz H, Gehrmann M, Sedelmayr M, Duma MN, Combs SE, Multhoff G.

Strahlenther Onkol. 2017 Aug;193(8):648-655. doi: 10.1007/s00066-017-1144-7. Epub 2017 May 12.


The PD-1/PD-L1 axis and human papilloma virus in patients with head and neck cancer after adjuvant chemoradiotherapy: A multicentre study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG).

Balermpas P, Rödel F, Krause M, Linge A, Lohaus F, Baumann M, Tinhofer I, Budach V, Sak A, Stuschke M, Gkika E, Grosu AL, Abdollahi A, Debus J, Stangl S, Ganswindt U, Belka C, Pigorsch S, Multhoff G, Combs SE, Welz S, Zips D, Lim SY, Rödel C, Fokas E; DKTK-ROG.

Int J Cancer. 2017 Aug 1;141(3):594-603. doi: 10.1002/ijc.30770. Epub 2017 May 19.


Live cell imaging of mitochondria following targeted irradiation in situ reveals rapid and highly localized loss of membrane potential.

Walsh DWM, Siebenwirth C, Greubel C, Ilicic K, Reindl J, Girst S, Muggiolu G, Simon M, Barberet P, Seznec H, Zischka H, Multhoff G, Schmid TE, Dollinger G.

Sci Rep. 2017 Apr 25;7:46684. doi: 10.1038/srep46684.


B-Cell-Based and Soluble Biomarkers in Body Liquids for Predicting Acute/Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation.

Juric MK, Shevtsov M, Mozes P, Ogonek J, Crossland RE, Dickinson AM, Greinix HT, Holler E, Weissinger EM, Multhoff G.

Front Immunol. 2017 Jan 16;7:660. doi: 10.3389/fimmu.2016.00660. eCollection 2016. Review.


The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition.

Schilling D, Garrido C, Combs SE, Multhoff G.

Cancer Lett. 2017 Apr 1;390:146-152. doi: 10.1016/j.canlet.2017.01.015. Epub 2017 Jan 18.


Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies.

Shevtsov M, Multhoff G.

Front Immunol. 2016 Nov 11;7:492. eCollection 2016. Review.


Assisting the examination of large histopathological slides with adaptive forests.

Peter L, Mateus D, Chatelain P, Declara D, Schworm N, Stangl S, Multhoff G, Navab N.

Med Image Anal. 2017 Jan;35:655-668. doi: 10.1016/ Epub 2016 Oct 5.


HNSCC cells resistant to EGFR pathway inhibitors are hypermutated and sensitive to DNA damaging substances.

Schulz D, Wirth M, Piontek G, Buchberger AM, Schlegel J, Reiter R, Multhoff G, Pickhard A.

Am J Cancer Res. 2016 Sep 1;6(9):1963-1975. eCollection 2016.


Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment.

Vaupel P, Multhoff G.

Front Immunol. 2016 Aug 31;7:332. doi: 10.3389/fimmu.2016.00332. eCollection 2016. No abstract available.


Zero-valent Fe confined mesoporous silica nanocarriers (Fe(0) @ MCM-41) for targeting experimental orthotopic glioma in rats.

Shevtsov MA, Parr MA, Ryzhov VA, Zemtsova EG, Arbenin AY, Ponomareva AN, Smirnov VM, Multhoff G.

Sci Rep. 2016 Jul 8;6:29247. doi: 10.1038/srep29247.


Eigenspectra optoacoustic tomography achieves quantitative blood oxygenation imaging deep in tissues.

Tzoumas S, Nunes A, Olefir I, Stangl S, Symvoulidis P, Glasl S, Bayer C, Multhoff G, Ntziachristos V.

Nat Commun. 2016 Jun 30;7:12121. doi: 10.1038/ncomms12121.


Recent Developments of Magnetic Nanoparticles for Theranostics of Brain Tumor.

Shevtsov M, Multhoff G.

Curr Drug Metab. 2016;17(8):737-744. Review.


A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer.

Kinzel L, Ernst A, Orth M, Albrecht V, Hennel R, Brix N, Frey B, Gaipl US, Zuchtriegel G, Reichel CA, Blutke A, Schilling D, Multhoff G, Li M, Niyazi M, Friedl AA, Winssinger N, Belka C, Lauber K.

Oncotarget. 2016 Jul 12;7(28):43199-43219. doi: 10.18632/oncotarget.9774.


Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer.

Shevtsov M, Multhoff G.

Front Immunol. 2016 Apr 29;7:171. doi: 10.3389/fimmu.2016.00171. eCollection 2016. Review.


Adenosine can thwart antitumor immune responses elicited by radiotherapy : Therapeutic strategies alleviating protumor ADO activities.

Vaupel P, Multhoff G.

Strahlenther Onkol. 2016 May;192(5):279-87. doi: 10.1007/s00066-016-0948-1. Epub 2016 Mar 9. Review.


Stress Response Leading to Resistance in Glioblastoma-The Need for Innovative Radiotherapy (iRT) Concepts.

Combs SE, Schmid TE, Vaupel P, Multhoff G.

Cancers (Basel). 2016 Jan 13;8(1). pii: E15. doi: 10.3390/cancers8010015. Review.


Proton Minibeam Radiation Therapy Reduces Side Effects in an In Vivo Mouse Ear Model.

Girst S, Greubel C, Reindl J, Siebenwirth C, Zlobinskaya O, Walsh DW, Ilicic K, Aichler M, Walch A, Wilkens JJ, Multhoff G, Dollinger G, Schmid TE.

Int J Radiat Oncol Biol Phys. 2016 May 1;95(1):234-41. doi: 10.1016/j.ijrobp.2015.10.020. Epub 2015 Oct 22.


Comparative analysis of the effects of radiotherapy versus radiotherapy after adjuvant chemotherapy on the composition of lymphocyte subpopulations in breast cancer patients.

Sage EK, Schmid TE, Sedelmayr M, Gehrmann M, Geinitz H, Duma MN, Combs SE, Multhoff G.

Radiother Oncol. 2016 Jan;118(1):176-80. doi: 10.1016/j.radonc.2015.11.016. Epub 2015 Dec 9.


Detection of experimental myocardium infarction in rats by MRI using heat shock protein 70 conjugated superparamagnetic iron oxide nanoparticle.

Shevtsov MA, Nikolaev BP, Ryzhov VA, Yakovleva LY, Dobrodumov AV, Marchenko YY, Margulis BA, Pitkin E, Mikhrina AL, Guzhova IV, Multhoff G.

Nanomedicine. 2016 Apr;12(3):611-621. doi: 10.1016/j.nano.2015.10.017. Epub 2015 Dec 2.


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