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Items: 1 to 50 of 191

1.

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer's disease progression.

Liebsch F, Kulic L, Teunissen C, Shobo A, Ulku I, Engelschalt V, Hancock MA, van der Flier WM, Kunach P, Rosa-Neto P, Scheltens P, Poirier J, Saftig P, Bateman RJ, Breitner J, Hock C, Multhaup G.

Nat Commun. 2019 May 20;10(1):2240. doi: 10.1038/s41467-019-10152-w.

2.

Label-free distribution of anti-amyloid D-AIP in Drosophila melanogaster: prevention of Aβ42-induced toxicity without side effects in transgenic flies.

Zhong Y, Shobo A, Hancock MA, Multhaup G.

J Neurochem. 2019 Jul;150(1):74-87. doi: 10.1111/jnc.14720. Epub 2019 Jun 6.

PMID:
31077378
3.

Neurodegenerative Disease-Related Proteins within the Epidermal Layer of the Human Skin.

Akerman SC, Hossain S, Shobo A, Zhong Y, Jourdain R, Hancock MA, George K, Breton L, Multhaup G.

J Alzheimers Dis. 2019;69(2):463-478. doi: 10.3233/JAD-181191.

PMID:
31006686
4.

Hyperbranched Polyglycerol Derivatives as Prospective Copper Nanotransporter Candidates.

Quadir M, Fehse S, Multhaup G, Haag R.

Molecules. 2018 May 26;23(6). pii: E1281. doi: 10.3390/molecules23061281.

5.

Amyloid Precursor Protein Dimerisation Reduces Neurite Outgrowth.

Luu L, Ciccotosto GD, Vella LJ, Cheng L, Roisman LC, Multhaup G, Hill AF, Munter LM, Cappai R.

Mol Neurobiol. 2019 Jan;56(1):13-28. doi: 10.1007/s12035-018-1070-4. Epub 2018 Apr 19.

PMID:
29675574
6.

Dimerization of the cellular prion protein inhibits propagation of scrapie prions.

Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J.

J Biol Chem. 2018 May 25;293(21):8020-8031. doi: 10.1074/jbc.RA117.000990. Epub 2018 Apr 10.

7.

APLP1 is endoproteolytically cleaved by γ-secretase without previous ectodomain shedding.

Schauenburg L, Liebsch F, Eravci M, Mayer MC, Weise C, Multhaup G.

Sci Rep. 2018 Jan 30;8(1):1916. doi: 10.1038/s41598-018-19530-8.

8.

Dendritic Polyglycerol Sulfates in the Prevention of Synaptic Loss and Mechanism of Action on Glia.

Maysinger D, Ji J, Moquin A, Hossain S, Hancock MA, Zhang I, Chang PKY, Rigby M, Anthonisen M, Grütter P, Breitner J, McKinney RA, Reimann S, Haag R, Multhaup G.

ACS Chem Neurosci. 2018 Feb 21;9(2):260-271. doi: 10.1021/acschemneuro.7b00301. Epub 2017 Nov 10.

PMID:
29078046
9.

Direct evidence of amyloid precursor-like protein 1 trans interactions in cell-cell adhesion platforms investigated via fluorescence fluctuation spectroscopy.

Dunsing V, Mayer M, Liebsch F, Multhaup G, Chiantia S.

Mol Biol Cell. 2017 Dec 1;28(25):3609-3620. doi: 10.1091/mbc.E17-07-0459. Epub 2017 Oct 11.

10.

Distinct age and differentiation-state dependent metabolic profiles of oligodendrocytes under optimal and stress conditions.

Rao VTS, Khan D, Cui QL, Fuh SC, Hossain S, Almazan G, Multhaup G, Healy LM, Kennedy TE, Antel JP.

PLoS One. 2017 Aug 8;12(8):e0182372. doi: 10.1371/journal.pone.0182372. eCollection 2017.

11.

Full-length cellular β-secretase has a trimeric subunit stoichiometry, and its sulfur-rich transmembrane interaction site modulates cytosolic copper compartmentalization.

Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G.

J Biol Chem. 2017 Aug 11;292(32):13258-13270. doi: 10.1074/jbc.M117.779165. Epub 2017 Jun 21.

12.

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

Leonhardt J, Villela DC, Teichmann A, Münter LM, Mayer MC, Mardahl M, Kirsch S, Namsolleck P, Lucht K, Benz V, Alenina N, Daniell N, Horiuchi M, Iwai M, Multhaup G, Schülein R, Bader M, Santos RA, Unger T, Steckelings UM.

Hypertension. 2017 Jun;69(6):1128-1135. doi: 10.1161/HYPERTENSIONAHA.116.08814. Epub 2017 May 1.

PMID:
28461604
13.

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer's Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity.

Prade E, Barucker C, Sarkar R, Althoff-Ospelt G, Lopez del Amo JM, Hossain S, Zhong Y, Multhaup G, Reif B.

Biochemistry. 2016 Mar 29;55(12):1839-49. doi: 10.1021/acs.biochem.5b01272. Epub 2016 Mar 9.

PMID:
26900939
14.

Amyloid precursor-like protein 1 (APLP1) exhibits stronger zinc-dependent neuronal adhesion than amyloid precursor protein and APLP2.

Mayer MC, Schauenburg L, Thompson-Steckel G, Dunsing V, Kaden D, Voigt P, Schaefer M, Chiantia S, Kennedy TE, Multhaup G.

J Neurochem. 2016 Apr;137(2):266-76. doi: 10.1111/jnc.13540. Epub 2016 Mar 7.

15.

Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function.

Barucker C, Bittner HJ, Chang PK, Cameron S, Hancock MA, Liebsch F, Hossain S, Harmeier A, Shaw H, Charron FM, Gensler M, Dembny P, Zhuang W, Schmitz D, Rabe JP, Rao Y, Lurz R, Hildebrand PW, McKinney RA, Multhaup G.

Sci Rep. 2015 Oct 29;5:15410. doi: 10.1038/srep15410.

16.

Structural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide.

Prade E, Bittner HJ, Sarkar R, Lopez Del Amo JM, Althoff-Ospelt G, Multhaup G, Hildebrand PW, Reif B.

J Biol Chem. 2015 Nov 27;290(48):28737-45. doi: 10.1074/jbc.M115.675215. Epub 2015 Sep 28.

17.

Amyloid Precursor Protein (APP) Metabolites APP Intracellular Fragment (AICD), Aβ42, and Tau in Nuclear Roles.

Multhaup G, Huber O, Buée L, Galas MC.

J Biol Chem. 2015 Sep 25;290(39):23515-22. doi: 10.1074/jbc.R115.677211. Epub 2015 Aug 21. Review.

18.

Impact of amyloid precursor protein hydrophilic transmembrane residues on amyloid-beta generation.

Oestereich F, Bittner HJ, Weise C, Grohmann L, Janke LK, Hildebrand PW, Multhaup G, Munter LM.

Biochemistry. 2015 May 5;54(17):2777-84. doi: 10.1021/acs.biochem.5b00217. Epub 2015 Apr 23.

PMID:
25875527
19.

Polyglycerol based coatings to reduce non-specific protein adsorption in sample vials and on SPR sensors.

Becherer T, Grunewald C, Engelschalt V, Multhaup G, Risse T, Haag R.

Anal Chim Acta. 2015 Mar 31;867:47-55. doi: 10.1016/j.aca.2015.01.048. Epub 2015 Feb 10.

PMID:
25813027
20.

Interaction of the amyloid precursor protein-like protein 1 (APLP1) E2 domain with heparan sulfate involves two distinct binding modes.

Dahms SO, Mayer MC, Roeser D, Multhaup G, Than ME.

Acta Crystallogr D Biol Crystallogr. 2015 Mar;71(Pt 3):494-504. doi: 10.1107/S1399004714027114. Epub 2015 Feb 26.

21.

Alzheimer amyloid peptide aβ42 regulates gene expression of transcription and growth factors.

Barucker C, Sommer A, Beckmann G, Eravci M, Harmeier A, Schipke CG, Brockschnieder D, Dyrks T, Althoff V, Fraser PE, Hazrati LN, George-Hyslop PS, Breitner JC, Peters O, Multhaup G.

J Alzheimers Dis. 2015;44(2):613-24. doi: 10.3233/JAD-141902.

PMID:
25318543
22.

Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.

Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC.

Acta Neuropathol Commun. 2014 Jun 5;2:61. doi: 10.1186/2051-5960-2-61.

23.

Nuclear translocation uncovers the amyloid peptide Aβ42 as a regulator of gene transcription.

Barucker C, Harmeier A, Weiske J, Fauler B, Albring KF, Prokop S, Hildebrand P, Lurz R, Heppner FL, Huber O, Multhaup G.

J Biol Chem. 2014 Jul 18;289(29):20182-91. doi: 10.1074/jbc.M114.564690. Epub 2014 May 30.

24.

Novel zinc-binding site in the E2 domain regulates amyloid precursor-like protein 1 (APLP1) oligomerization.

Mayer MC, Kaden D, Schauenburg L, Hancock MA, Voigt P, Roeser D, Barucker C, Than ME, Schaefer M, Multhaup G.

J Biol Chem. 2014 Jul 4;289(27):19019-30. doi: 10.1074/jbc.M114.570382. Epub 2014 May 22.

25.

Copper transport mediated by nanocarrier systems in a blood-brain barrier in vitro model.

Fehse S, Nowag S, Quadir M, Kim KS, Haag R, Multhaup G.

Biomacromolecules. 2014 May 12;15(5):1910-9. doi: 10.1021/bm500400k. Epub 2014 Apr 29.

PMID:
24725062
26.

Model peptides uncover the role of the β-secretase transmembrane sequence in metal ion mediated oligomerization.

Munter LM, Sieg H, Bethge T, Liebsch F, Bierkandt FS, Schleeger M, Bittner HJ, Heberle J, Jakubowski N, Hildebrand PW, Multhaup G.

J Am Chem Soc. 2013 Dec 26;135(51):19354-61. doi: 10.1021/ja410812r. Epub 2013 Dec 13.

PMID:
24304299
27.

Characterization of intermediate steps in amyloid beta (Aβ) production under near-native conditions.

Olsson F, Schmidt S, Althoff V, Munter LM, Jin S, Rosqvist S, Lendahl U, Multhaup G, Lundkvist J.

J Biol Chem. 2014 Jan 17;289(3):1540-50. doi: 10.1074/jbc.M113.498246. Epub 2013 Nov 13.

28.

The cleavage domain of the amyloid precursor protein transmembrane helix does not exhibit above-average backbone dynamics.

Pester O, Götz A, Multhaup G, Scharnagl C, Langosch D.

Chembiochem. 2013 Oct 11;14(15):1943-8. doi: 10.1002/cbic.201300322. Epub 2013 Sep 17.

PMID:
24115334
29.

Discovery and characterization of protein-modifying natural products by MALDI mass spectrometry reveal potent SIRT1 and p300 inhibitors.

Holzhauser S, Freiwald A, Weise C, Multhaup G, Han CT, Sauer S.

Angew Chem Int Ed Engl. 2013 May 3;52(19):5171-4. doi: 10.1002/anie.201207325. Epub 2013 Apr 8. No abstract available.

PMID:
23568553
30.

The proton-pump inhibitor lansoprazole enhances amyloid beta production.

Badiola N, Alcalde V, Pujol A, Münter LM, Multhaup G, Lleó A, Coma M, Soler-López M, Aloy P.

PLoS One. 2013;8(3):e58837. doi: 10.1371/journal.pone.0058837. Epub 2013 Mar 8.

31.

Light-controlled toxicity of engineered amyloid β-peptides.

Hoppmann C, Barucker C, Lorenz D, Multhaup G, Beyermann M.

Chembiochem. 2012 Dec 21;13(18):2657-60. doi: 10.1002/cbic.201200605. Epub 2012 Nov 19.

PMID:
23161824
32.

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β.

Resenberger UK, Müller V, Munter LM, Baier M, Multhaup G, Wilson MR, Winklhofer KF, Tatzelt J.

J Biol Chem. 2012 Dec 21;287(52):43765-76. doi: 10.1074/jbc.M112.389007. Epub 2012 Oct 31.

33.

Meeting report: 7th Fabisch Symposium for Cancer Research and Molecular Cell Biology--regulated intramembrane proteolysis in cancer development and neurodegenerative diseases.

Kaden D, Multhaup G.

Neurodegener Dis. 2013;11(4):215-8. doi: 10.1159/000341594. Epub 2012 Aug 30. No abstract available.

34.

The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species.

Bien J, Jefferson T, Causević M, Jumpertz T, Munter L, Multhaup G, Weggen S, Becker-Pauly C, Pietrzik CU.

J Biol Chem. 2012 Sep 28;287(40):33304-13. Epub 2012 Aug 9.

35.

Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain.

Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W.

FASEB J. 2012 Sep;26(9):3765-78. doi: 10.1096/fj.11-201368. Epub 2012 Jun 1.

PMID:
22661005
36.

Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers.

Kaden D, Harmeier A, Weise C, Munter LM, Althoff V, Rost BR, Hildebrand PW, Schmitz D, Schaefer M, Lurz R, Skodda S, Yamamoto R, Arlt S, Finckh U, Multhaup G.

EMBO Mol Med. 2012 Jul;4(7):647-59. doi: 10.1002/emmm.201200239. Epub 2012 Apr 19.

37.

Metal binding dictates conformation and function of the amyloid precursor protein (APP) E2 domain.

Dahms SO, Könnig I, Roeser D, Gührs KH, Mayer MC, Kaden D, Multhaup G, Than ME.

J Mol Biol. 2012 Feb 24;416(3):438-52. doi: 10.1016/j.jmb.2011.12.057. Epub 2012 Jan 4.

38.

Disturbed copper bioavailability in Alzheimer's disease.

Kaden D, Bush AI, Danzeisen R, Bayer TA, Multhaup G.

Int J Alzheimers Dis. 2011;2011:345614. doi: 10.4061/2011/345614. Epub 2011 Nov 15.

39.

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms.

Isbert S, Wagner K, Eggert S, Schweitzer A, Multhaup G, Weggen S, Kins S, Pietrzik CU.

Cell Mol Life Sci. 2012 Apr;69(8):1353-75. doi: 10.1007/s00018-011-0882-4. Epub 2011 Nov 22.

40.

Structural and mechanistic implications of metal binding in the small heat-shock protein αB-crystallin.

Mainz A, Bardiaux B, Kuppler F, Multhaup G, Felli IC, Pierattelli R, Reif B.

J Biol Chem. 2012 Jan 6;287(2):1128-38. doi: 10.1074/jbc.M111.309047. Epub 2011 Nov 15.

41.

Is there a malignant progression associated with a linear change in protein expression levels from normal canine mammary gland to metastatic mammary tumors?

Klose P, Weise C, Bondzio A, Multhaup G, Einspanier R, Gruber AD, Klopfleisch R.

J Proteome Res. 2011 Oct 7;10(10):4405-15. doi: 10.1021/pr200112q. Epub 2011 Sep 27.

PMID:
21888431
42.

Toxicity of Alzheimer's disease-associated Aβ peptide is ameliorated in a Drosophila model by tight control of zinc and copper availability.

Hua H, Münter L, Harmeier A, Georgiev O, Multhaup G, Schaffner W.

Biol Chem. 2011 Oct;392(10):919-26. doi: 10.1515/BC.2011.084. Epub 2011 Jul 30.

43.

Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.

Cheng F, Cappai R, Ciccotosto GD, Svensson G, Multhaup G, Fransson LÅ, Mani K.

J Biol Chem. 2011 Aug 5;286(31):27559-72. doi: 10.1074/jbc.M111.243345. Epub 2011 Jun 3.

44.

The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.

Kaden D, Munter LM, Reif B, Multhaup G.

Eur J Cell Biol. 2012 Apr;91(4):234-9. doi: 10.1016/j.ejcb.2011.01.017. Epub 2011 Apr 2. Review.

PMID:
21459473
45.

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication.

Resenberger UK, Harmeier A, Woerner AC, Goodman JL, Müller V, Krishnan R, Vabulas RM, Kretzschmar HA, Lindquist S, Hartl FU, Multhaup G, Winklhofer KF, Tatzelt J.

EMBO J. 2011 May 18;30(10):2057-70. doi: 10.1038/emboj.2011.86. Epub 2011 Mar 25.

46.

Molecular mechanisms and therapeutic application of NSAIDs and derived compounds in Alzheimer's disease.

Heneka MT, Kummer MP, Weggen S, Bulic B, Multhaup G, Münter L, Hüll M, Pflanzner T, Pietrzik CU.

Curr Alzheimer Res. 2011 Mar;8(2):115-31. Review.

PMID:
21345168
47.

The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.

Botev A, Munter LM, Wenzel R, Richter L, Althoff V, Ismer J, Gerling U, Weise C, Koksch B, Hildebrand PW, Bittl R, Multhaup G.

Biochemistry. 2011 Feb 8;50(5):828-35. doi: 10.1021/bi1014002. Epub 2011 Jan 11.

PMID:
21186781
48.

Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis.

Wirths O, Erck C, Martens H, Harmeier A, Geumann C, Jawhar S, Kumar S, Multhaup G, Walter J, Ingelsson M, Degerman-Gunnarsson M, Kalimo H, Huitinga I, Lannfelt L, Bayer TA.

J Biol Chem. 2010 Dec 31;285(53):41517-24. doi: 10.1074/jbc.M110.178707. Epub 2010 Oct 22.

49.

Proteome of metastatic canine mammary carcinomas: similarities to and differences from human breast cancer.

Klopfleisch R, Klose P, Weise C, Bondzio A, Multhaup G, Einspanier R, Gruber AD.

J Proteome Res. 2010 Dec 3;9(12):6380-91. doi: 10.1021/pr100671c. Epub 2010 Nov 2.

PMID:
20932060
50.

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization.

Richter L, Munter LM, Ness J, Hildebrand PW, Dasari M, Unterreitmeier S, Bulic B, Beyermann M, Gust R, Reif B, Weggen S, Langosch D, Multhaup G.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14597-602. doi: 10.1073/pnas.1003026107. Epub 2010 Aug 2.

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