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Items: 1 to 50 of 147


Production and characterisation of a marine Halomonas surface-active exopolymer.

Gutierrez T, Morris G, Ellis D, Mulloy B, Aitken MD.

Appl Microbiol Biotechnol. 2020 Feb;104(3):1063-1076. doi: 10.1007/s00253-019-10270-x. Epub 2019 Dec 7.


East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide.

Li H, Marceau M, Yang T, Liao T, Tang X, Hu R, Xie Y, Tang H, Tay A, Shi Y, Shen Y, Yang T, Pi X, Lamichhane B, Luo Y, Debowski AW, Nilsson HO, Haslam SM, Mulloy B, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

PLoS Genet. 2019 Nov 20;15(11):e1008497. doi: 10.1371/journal.pgen.1008497. eCollection 2019 Nov.


Galactosaminoglycans: Medical Applications and Drawbacks.

Pomin VH, Vignovich WP, Gonzales AV, Vasconcelos AA, Mulloy B.

Molecules. 2019 Aug 1;24(15). pii: E2803. doi: 10.3390/molecules24152803. Review.


Glycan Markers of Human Stem Cells Assigned with Beam Search Arrays.

Wu N, Silva LM, Liu Y, Zhang Y, Gao C, Zhang F, Fu L, Peng Y, Linhardt R, Kawasaki T, Mulloy B, Chai W, Feizi T.

Mol Cell Proteomics. 2019 Oct;18(10):1981-2002. doi: 10.1074/mcp.RA119.001309. Epub 2019 Jul 15.


The non-anticoagulant promise of heparin and its mimetics.

Mulloy B.

Curr Opin Pharmacol. 2019 Jun;46:50-54. doi: 10.1016/j.coph.2019.03.009. Epub 2019 Apr 19. Review.


Toward Automated Identification of Glycan Branching Patterns Using Multistage Mass Spectrometry with Intelligent Precursor Selection.

Sun S, Huang C, Wang Y, Liu Y, Zhang J, Zhou J, Gao F, Yang F, Chen R, Mulloy B, Chai W, Li Y, Bu D.

Anal Chem. 2018 Dec 18;90(24):14412-14422. doi: 10.1021/acs.analchem.8b03967. Epub 2018 Nov 30.


Hydrocarbon-degradation and MOS-formation capabilities of the dominant bacteria enriched in sea surface oil slicks during the Deepwater Horizon oil spill.

Gutierrez T, Morris G, Ellis D, Bowler B, Jones M, Salek K, Mulloy B, Teske A.

Mar Pollut Bull. 2018 Oct;135:205-215. doi: 10.1016/j.marpolbul.2018.07.027. Epub 2018 Jul 14.


The localisation of the heparin binding sites of human and murine interleukin-12 within the carboxyterminal domain of the P40 subunit.

Garnier P, Mummery R, Forster MJ, Mulloy B, Gibbs RV, Rider CC.

Cytokine. 2018 Oct;110:159-168. doi: 10.1016/j.cyto.2018.04.014. Epub 2018 May 10.


Assignment by Negative-Ion Electrospray Tandem Mass Spectrometry of the Tetrasaccharide Backbones of Monosialylated Glycans Released from Bovine Brain Gangliosides.

Chai W, Zhang Y, Mauri L, Ciampa MG, Mulloy B, Sonnino S, Feizi T.

J Am Soc Mass Spectrom. 2018 Jun;29(6):1308-1318. doi: 10.1007/s13361-018-1944-8. Epub 2018 May 11.


Glycosaminoglycans and Proteoglycans.

Pomin VH, Mulloy B.

Pharmaceuticals (Basel). 2018 Feb 27;11(1). pii: E27. doi: 10.3390/ph11010027.


The effect of increasing the sulfation level of chondroitin sulfate on anticoagulant specific activity and activation of the kinin system.

Hogwood J, Naggi A, Torri G, Page C, Rigsby P, Mulloy B, Gray E.

PLoS One. 2018 Mar 1;13(3):e0193482. doi: 10.1371/journal.pone.0193482. eCollection 2018.


Structural Analysis of Glycans.

Mulloy B, Dell A, Stanley P, H. Prestegard J.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 50.


Molecular Weights of Bovine and Porcine Heparin Samples: Comparison of Chromatographic Methods and Results of a Collaborative Survey.

Bertini S, Risi G, Guerrini M, Carrick K, Szajek AY, Mulloy B.

Molecules. 2017 Jul 19;22(7). pii: E1214. doi: 10.3390/molecules22071214.


Precipitation and Neutralization of Heparin from Different Sources by Protamine Sulfate.

Hogwood J, Mulloy B, Gray E.

Pharmaceuticals (Basel). 2017 Jul 2;10(3). pii: E59. doi: 10.3390/ph10030059.


Heparin, Heparan Sulphate and the TGF-β Cytokine Superfamily.

Rider CC, Mulloy B.

Molecules. 2017 Apr 29;22(5). pii: E713. doi: 10.3390/molecules22050713. Review.


The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains.

Li H, Yang T, Liao T, Debowski AW, Nilsson HO, Fulurija A, Haslam SM, Mulloy B, Dell A, Stubbs KA, Marshall BJ, Benghezal M.

PLoS Pathog. 2017 Mar 17;13(3):e1006280. doi: 10.1371/journal.ppat.1006280. eCollection 2017 Mar.


The binding of the bone morphogenetic protein antagonist gremlin to kidney heparan sulfate: Such binding is not essential for BMP antagonism.

Tatsinkam AJ, Rune N, Smith J, Norman JT, Mulloy B, Rider CC.

Int J Biochem Cell Biol. 2017 Feb;83:39-46. doi: 10.1016/j.biocel.2016.12.006. Epub 2016 Dec 12.


Mast cell glycosaminoglycans.

Mulloy B, Lever R, Page CP.

Glycoconj J. 2017 Jun;34(3):351-361. doi: 10.1007/s10719-016-9749-0. Epub 2016 Nov 30. Review.


Biochemical and functional characterization of glycosaminoglycans released from degranulating rat peritoneal mast cells: Insights into the physiological role of endogenous heparin.

Lever R, Smailbegovic A, Riffo-Vasquez Y, Gray E, Hogwood J, Francis SM, Richardson NV, Page CP, Mulloy B.

Pulm Pharmacol Ther. 2016 Dec;41:96-102. doi: 10.1016/j.pupt.2016.11.002. Epub 2016 Nov 3.


Abnormally High Content of Free Glucosamine Residues Identified in a Preparation of Commercially Available Porcine Intestinal Heparan Sulfate.

Mulloy B, Wu N, Gyapon-Quast F, Lin L, Zhang F, Pickering MC, Linhardt RJ, Feizi T, Chai W.

Anal Chem. 2016 Jul 5;88(13):6648-52. doi: 10.1021/acs.analchem.6b01662. Epub 2016 Jun 15.


The US regulatory and pharmacopeia response to the global heparin contamination crisis.

Szajek AY, Chess E, Johansen K, Gratzl G, Gray E, Keire D, Linhardt RJ, Liu J, Morris T, Mulloy B, Nasr M, Shriver Z, Torralba P, Viskov C, Williams R, Woodcock J, Workman W, Al-Hakim A.

Nat Biotechnol. 2016 Jun 9;34(6):625-30. doi: 10.1038/nbt.3606.


Structural characterization and anti-inflammatory activity of two novel polysaccharides from the sea squirt, Ascidiella aspersa.

Thomson D, Panagos CG, Venkatasamy R, Moss C, Robinson J, Bavington CD, Hogwood J, Mulloy B, Uhrín D, Spina D, Page CP.

Pulm Pharmacol Ther. 2016 Oct;40:69-79. doi: 10.1016/j.pupt.2016.05.001. Epub 2016 May 21.


Generation and characterization of β1,2-gluco-oligosaccharide probes from Brucella abortus cyclic β-glucan and their recognition by C-type lectins of the immune system.

Zhang H, Palma AS, Zhang Y, Childs RA, Liu Y, Mitchell DA, Guidolin LS, Weigel W, Mulloy B, Ciocchini AE, Feizi T, Chai W.

Glycobiology. 2016 Oct;26(10):1086-1096. doi: 10.1093/glycob/cww041. Epub 2016 Apr 6.


Pharmacology of Heparin and Related Drugs.

Mulloy B, Hogwood J, Gray E, Lever R, Page CP.

Pharmacol Rev. 2016 Jan;68(1):76-141. doi: 10.1124/pr.115.011247. Review.


The Bone Morphogenetic Proteins and Their Antagonists.

Mulloy B, Rider CC.

Vitam Horm. 2015;99:63-90. doi: 10.1016/bs.vh.2015.06.004. Epub 2015 Jul 15. Review.


Mapping the heparin-binding site of the BMP antagonist gremlin by site-directed mutagenesis based on predictive modelling.

Tatsinkam AJ, Mulloy B, Rider CC.

Biochem J. 2015 Aug 15;470(1):53-64. doi: 10.1042/BJ20150228. Epub 2015 Jun 11.


Current structural biology of the heparin interactome.

Pomin VH, Mulloy B.

Curr Opin Struct Biol. 2015 Oct;34:17-25. doi: 10.1016/ Epub 2015 May 30. Review.


Unravelling glucan recognition systems by glycome microarrays using the designer approach and mass spectrometry.

Palma AS, Liu Y, Zhang H, Zhang Y, McCleary BV, Yu G, Huang Q, Guidolin LS, Ciocchini AE, Torosantucci A, Wang D, Carvalho AL, Fontes CM, Mulloy B, Childs RA, Feizi T, Chai W.

Mol Cell Proteomics. 2015 Apr;14(4):974-88. doi: 10.1074/mcp.M115.048272. Epub 2015 Feb 10.


The importance of formulation in the successful lyophilization of influenza reference materials.

Duru C, Swann C, Dunleavy U, Mulloy B, Matejtschuk P.

Biologicals. 2015 Mar;43(2):110-6. doi: 10.1016/j.biologicals.2014.12.001. Epub 2015 Jan 20.


Chromatographic molecular weight measurements for heparin, its fragments and fractions, and other glycosaminoglycans.

Mulloy B, Hogwood J.

Methods Mol Biol. 2015;1229:105-18. doi: 10.1007/978-1-4939-1714-3_11.


Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity.

Panagos CG, Thomson DS, Moss C, Hughes AD, Kelly MS, Liu Y, Chai W, Venkatasamy R, Spina D, Page CP, Hogwood J, Woods RJ, Mulloy B, Bavington CD, Uhrín D.

J Biol Chem. 2014 Oct 10;289(41):28284-98. doi: 10.1074/jbc.M114.572297. Epub 2014 Aug 21.


USP compendial methods for analysis of heparin: chromatographic determination of molecular weight distributions for heparin sodium.

Mulloy B, Heath A, Shriver Z, Jameison F, Al Hakim A, Morris TS, Szajek AY.

Anal Bioanal Chem. 2014 Aug;406(20):4815-23. doi: 10.1007/s00216-014-7940-3. No abstract available.


The solution structure of heparan sulfate differs from that of heparin: implications for function.

Khan S, Fung KW, Rodriguez E, Patel R, Gor J, Mulloy B, Perkins SJ.

J Biol Chem. 2013 Sep 27;288(39):27737-51. doi: 10.1074/jbc.M113.492223. Epub 2013 Aug 6.


Typing of blood-group antigens on neutral oligosaccharides by negative-ion electrospray ionization tandem mass spectrometry.

Zhang H, Zhang S, Tao G, Zhang Y, Mulloy B, Zhan X, Chai W.

Anal Chem. 2013 Jun 18;85(12):5940-9. doi: 10.1021/ac400700e. Epub 2013 Jun 6.


Tissue-specific host recognition by complement factor H is mediated by differential activities of its glycosaminoglycan-binding regions.

Clark SJ, Ridge LA, Herbert AP, Hakobyan S, Mulloy B, Lennon R, Würzner R, Morgan BP, Uhrín D, Bishop PN, Day AJ.

J Immunol. 2013 Mar 1;190(5):2049-57. doi: 10.4049/jimmunol.1201751. Epub 2013 Jan 30.


Evaluation of a candidate International Standard for Meningococcal Group C polysaccharide.

Vipond C, Mulloy B, Rigsby P, Burkin K, Bolgiano B; MenC IS Working Group.

Biologicals. 2012 Sep;40(5):353-63. Epub 2012 May 22.


Structure and physicochemical characterisation of heparin.

Mulloy B.

Handb Exp Pharmacol. 2012;(207):77-98. doi: 10.1007/978-3-642-23056-1_5. Review.


The anticoagulant and antithrombotic mechanisms of heparin.

Gray E, Hogwood J, Mulloy B.

Handb Exp Pharmacol. 2012;(207):43-61. doi: 10.1007/978-3-642-23056-1_3. Review.


Bivalent and co-operative binding of complement factor H to heparan sulfate and heparin.

Khan S, Nan R, Gor J, Mulloy B, Perkins SJ.

Biochem J. 2012 Jun 15;444(3):417-28. doi: 10.1042/BJ20120183.


Pentosan polysulfate increases affinity between ADAMTS-5 and TIMP-3 through formation of an electrostatically driven trimolecular complex.

Troeberg L, Mulloy B, Ghosh P, Lee MH, Murphy G, Nagase H.

Biochem J. 2012 Apr 1;443(1):307-15. doi: 10.1042/BJ20112159.


Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions.

Chang SC, Mulloy B, Magee AI, Couchman JR.

J Biol Chem. 2011 Dec 30;286(52):44391-402. doi: 10.1074/jbc.M111.285361. Epub 2011 Nov 2.


An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro.

Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG.

J Nat Prod. 2011 Sep 23;74(9):1851-61. doi: 10.1021/np200124m. Epub 2011 Aug 29. Erratum in: J Nat Prod. 2012 Sep 28;75(9):1674. Szegezdi, Eva [added]; Samali, Afshin [added].


The solution structure of heparan sulfate differs from that of heparin: implications for function.

Khan S, Rodriguez E, Patel R, Gor J, Mulloy B, Perkins SJ.

J Biol Chem. 2011 Jul 15;286(28):24842-54. doi: 10.1074/jbc.M111.226027. Epub 2011 May 16. Retraction in: J Biol Chem. 2013 Jul 19;288(29):21209.


High-sensitivity visualisation of contaminants in heparin samples by spectral filtering of 1H NMR spectra.

Rudd TR, Gaudesi D, Lima MA, Skidmore MA, Mulloy B, Torri G, Nader HB, Guerrini M, Yates EA.

Analyst. 2011 Apr 7;136(7):1390-8. doi: 10.1039/c0an00835d. Epub 2011 Jan 31.


Construction and use of a library of bona fide heparins employing 1H NMR and multivariate analysis.

Rudd TR, Gaudesi D, Skidmore MA, Ferro M, Guerrini M, Mulloy B, Torri G, Yates EA.

Analyst. 2011 Apr 7;136(7):1380-9. doi: 10.1039/c0an00834f. Epub 2011 Jan 31.


Structural glycobiology: biosynthesis, recognition events, and new methods.

Boraston A, Mulloy B.

Curr Opin Struct Biol. 2010 Oct;20(5):533-5. doi: 10.1016/ Epub 2010 Oct 21. No abstract available.


Protamine neutralisation of low molecular weight heparins and their oligosaccharide components.

Schroeder M, Hogwood J, Gray E, Mulloy B, Hackett AM, Johansen KB.

Anal Bioanal Chem. 2011 Jan;399(2):763-71. doi: 10.1007/s00216-010-4220-8. Epub 2010 Oct 5.


Structural glycobiology and human health.

Mulloy B, Corfield AP.

Biochem Soc Trans. 2010 Oct;38(5):1329-32. doi: 10.1042/BST0381329.


Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists.

Rider CC, Mulloy B.

Biochem J. 2010 Jul 1;429(1):1-12. doi: 10.1042/BJ20100305. Review.


An assessment of polydispersed species in unfractionated and low molecular weight heparins by diffusion ordered nuclear magnetic resonance spectroscopy method.

Bednarek E, Sitkowski J, Bocian W, Mulloy B, Kozerski L.

J Pharm Biomed Anal. 2010 Nov 2;53(3):302-8. doi: 10.1016/j.jpba.2010.03.037. Epub 2010 Apr 2.


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