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Items: 1 to 50 of 186

1.

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration.

Voigt AP, Mulfaul K, Mullin NK, Flamme-Wiese MJ, Giacalone JC, Stone EM, Tucker BA, Scheetz TE, Mullins RF.

Proc Natl Acad Sci U S A. 2019 Nov 11. pii: 201914143. doi: 10.1073/pnas.1914143116. [Epub ahead of print]

2.

Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

Genetics of Glaucoma in People of African Descent (GGLAD) Consortium, Hauser MA, Allingham RR, Aung T, Van Der Heide CJ, Taylor KD, Rotter JI, Wang SJ, Bonnemaijer PWM, Williams SE, Abdullahi SM, Abu-Amero KK, Anderson MG, Akafo S, Alhassan MB, Asimadu I, Ayyagari R, Bakayoko S, Nyamsi PB, Bowden DW, Bromley WC, Budenz DL, Carmichael TR, Challa P, Chen YI, Chuka-Okosa CM, Cooke Bailey JN, Costa VP, Cruz DA, DuBiner H, Ervin JF, Feldman RM, Flamme-Wiese M, Gaasterland DE, Garnai SJ, Girkin CA, Guirou N, Guo X, Haines JL, Hammond CJ, Herndon L, Hoffmann TJ, Hulette CM, Hydara A, Igo RP Jr, Jorgenson E, Kabwe J, Kilangalanga NJ, Kizor-Akaraiwe N, Kuchtey RW, Lamari H, Li Z, Liebmann JM, Liu Y, Loos RJF, Melo MB, Moroi SE, Msosa JM, Mullins RF, Nadkarni G, Napo A, Ng MCY, Nunes HF, Obeng-Nyarkoh E, Okeke A, Okeke S, Olaniyi O, Olawoye O, Oliveira MB, Pasquale LR, Perez-Grossmann RA, Pericak-Vance MA, Qin X, Ramsay M, Resnikoff S, Richards JE, Schimiti RB, Sim KS, Sponsel WE, Svidnicki PV, Thiadens AAHJ, Uche NJ, van Duijn CM, de Vasconcellos JPC, Wiggs JL, Zangwill LM, Risch N, Milea D, Ashaye A, Klaver CCW, Weinreb RN, Ashley Koch AE, Fingert JH, Khor CC.

JAMA. 2019 Nov 5;322(17):1682-1691. doi: 10.1001/jama.2019.16161.

PMID:
31688885
3.

Helper-Dependent Adenovirus Transduces the Human and Rat Retina but Elicits an Inflammatory Reaction When Delivered Subretinally in Rats.

Han IC, Burnight ER, Ulferts MJ, Worthington KS, Russell SR, Sohn EH, Mullins RF, Stone EM, Tucker BA, Wiley LA.

Hum Gene Ther. 2019 Nov;30(11):1371-1384. doi: 10.1089/hum.2019.159. Epub 2019 Sep 26.

PMID:
31456426
4.

Development of a Molecularly Stable Gene Therapy Vector for the Treatment of RPGR-Associated X-Linked Retinitis Pigmentosa.

Giacalone JC, Andorf JL, Zhang Q, Burnight ER, Ochoa D, Reutzel AJ, Collins MM, Sheffield VC, Mullins RF, Han IC, Stone EM, Tucker BA.

Hum Gene Ther. 2019 Aug;30(8):967-974. doi: 10.1089/hum.2018.244.

PMID:
31106594
5.

Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing.

Voigt AP, Whitmore SS, Flamme-Wiese MJ, Riker MJ, Wiley LA, Tucker BA, Stone EM, Mullins RF, Scheetz TE.

Exp Eye Res. 2019 Jul;184:234-242. doi: 10.1016/j.exer.2019.05.001. Epub 2019 May 8.

6.

Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.

Thompson JR, Worthington KS, Green BJ, Mullin NK, Jiao C, Kaalberg EE, Wiley LA, Han IC, Russell SR, Sohn EH, Guymon CA, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2019 Aug;94:204-218. doi: 10.1016/j.actbio.2019.04.057. Epub 2019 May 3.

PMID:
31055121
7.

Choriocapillaris Degeneration in Geographic Atrophy.

Sohn EH, Flamme-Wiese MJ, Whitmore SS, Workalemahu G, Marneros AG, Boese EA, Kwon YH, Wang K, Abramoff MD, Tucker BA, Stone EM, Mullins RF.

Am J Pathol. 2019 Jul;189(7):1473-1480. doi: 10.1016/j.ajpath.2019.04.005. Epub 2019 Apr 30.

PMID:
31051169
8.

Subretinal pseudocyst: A novel optical coherence tomography finding in age-related macular degeneration.

Sacconi R, Mullins RF, Lutty GA, Borrelli E, Bandello F, Querques G.

Eur J Ophthalmol. 2019 Apr 25:1120672119846437. doi: 10.1177/1120672119846437. [Epub ahead of print]

PMID:
31018677
9.

Wide-Field Swept-Source OCT and Angiography in X-Linked Retinoschisis.

Han IC, Whitmore SS, Critser DB, Lee SY, DeLuca AP, Daggett HT, Affatigato LM, Mullins RF, Tucker BA, Drack AV, Stone EM.

Ophthalmol Retina. 2019 Feb;3(2):178-185. doi: 10.1016/j.oret.2018.09.006. Epub 2018 Sep 19.

PMID:
31014769
10.

Optimizing Donor Cellular Dissociation and Subretinal Injection Parameters for Stem Cell-Based Treatments.

Scruggs BA, Jiao C, Cranston CM, Kaalberg E, Wang K, Russell SR, Wiley LA, Mullins RF, Stone EM, Tucker BA, Sohn EH.

Stem Cells Transl Med. 2019 Aug;8(8):797-809. doi: 10.1002/sctm.18-0210. Epub 2019 Apr 19.

11.

Correction of NR2E3 Associated Enhanced S-cone Syndrome Patient-specific iPSCs using CRISPR-Cas9.

Bohrer LR, Wiley LA, Burnight ER, Cooke JA, Giacalone JC, Anfinson KR, Andorf JL, Mullins RF, Stone EM, Tucker BA.

Genes (Basel). 2019 Apr 5;10(4). pii: E278. doi: 10.3390/genes10040278.

12.

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

van der Heide CJ, Alward WLM, Flamme-Wiese M, Riker M, Syed NA, Anderson MG, Carter K, Kuehn MH, Stone EM, Mullins RF, Fingert JH.

Ophthalmol Glaucoma. 2018 Sep-Oct;1(2):132-138. doi: 10.1016/j.ogla.2018.08.004. Epub 2018 Aug 17.

13.

POSTERIORLY INSERTED VITREOUS BASE: Preoperative Characteristics, Intraoperative Findings, and Outcomes After Vitrectomy.

Sohn EH, Strohbehn A, Stryjewski T, Brodowska K, Flamme-Wiese MJ, Mullins RF, Eliott D.

Retina. 2019 Feb 15. doi: 10.1097/IAE.0000000000002482. [Epub ahead of print]

PMID:
30883531
14.

How much green does it take to be orange? Determining the cost associated with trauma center readiness.

Ashley DW, Mullins RF, Dente CJ, Johns TJ, Garlow LE, Medeiros RS, Atkins EV, Solomon G, Abston D, Ferdinand CH; Georgia Research Institute for Trauma Study Group.

J Trauma Acute Care Surg. 2019 May;86(5):765-773. doi: 10.1097/TA.0000000000002213.

PMID:
30768564
15.

PyMINEr Finds Gene and Autocrine-Paracrine Networks from Human Islet scRNA-Seq.

Tyler SR, Rotti PG, Sun X, Yi Y, Xie W, Winter MC, Flamme-Wiese MJ, Tucker BA, Mullins RF, Norris AW, Engelhardt JF.

Cell Rep. 2019 Feb 12;26(7):1951-1964.e8. doi: 10.1016/j.celrep.2019.01.063.

16.

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter.

Giacalone JC, Miller MJ, Workalemahu G, Reutzel AJ, Ochoa D, Whitmore SS, Stone EM, Tucker BA, Mullins RF.

Microvasc Res. 2019 May;123:50-57. doi: 10.1016/j.mvr.2018.12.002. Epub 2018 Dec 18.

PMID:
30571950
17.

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Cheng J, Sohn EH, Jiao C, Adler KL, Kaalberg EE, Russell SR, Mullins RF, Stone EM, Tucker BA, Han IC.

Transl Vis Sci Technol. 2018 Nov 30;7(6):18. doi: 10.1167/tvst.7.6.18. eCollection 2018 Nov.

18.

The ARMS2 A69S Polymorphism Is Associated with Delayed Rod-Mediated Dark Adaptation in Eyes at Risk for Incident Age-Related Macular Degeneration.

Mullins RF, McGwin G Jr, Searcey K, Clark ME, Kennedy EL, Curcio CA, Stone EM, Owsley C.

Ophthalmology. 2019 Apr;126(4):591-600. doi: 10.1016/j.ophtha.2018.10.037. Epub 2018 Oct 31.

PMID:
30389424
19.

Autoimmune retinopathy and optic neuropathy associated with enolase-positive renal oncocytoma.

Cheng JL, Beebe JD, Nepple KG, Zakharia Y, Mullins RF, Flamme-Wiese MJ, Thurtell MJ, Han IC.

Am J Ophthalmol Case Rep. 2018 Sep 10;12:55-60. doi: 10.1016/j.ajoc.2018.09.005. eCollection 2018 Dec.

20.

Imidazole Compounds for Protecting Choroidal Endothelial Cells from Complement Injury.

Zeng S, Wen KK, Workalemahu G, Sohn EH, Wu M, Chirco KR, Flamme-Wiese MJ, Liu X, Stone EM, Tucker BA, Mullins RF.

Sci Rep. 2018 Sep 6;8(1):13387. doi: 10.1038/s41598-018-31846-z.

21.

Effect of Molecular Weight and Functionality on Acrylated Poly(caprolactone) for Stereolithography and Biomedical Applications.

Green BJ, Worthington KS, Thompson JR, Bunn SJ, Rethwisch M, Kaalberg EE, Jiao C, Wiley LA, Mullins RF, Stone EM, Sohn EH, Tucker BA, Guymon CA.

Biomacromolecules. 2018 Sep 10;19(9):3682-3692. doi: 10.1021/acs.biomac.8b00784. Epub 2018 Aug 9.

PMID:
30044915
22.

Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors.

Chirco KR, Flamme-Wiese MJ, Wiley JS, Potempa LA, Stone EM, Tucker BA, Mullins RF.

Eye (Lond). 2018 Nov;32(11):1740-1742. doi: 10.1038/s41433-018-0170-8. Epub 2018 Jul 16.

23.

Feeder-free differentiation of cells exhibiting characteristics of corneal endothelium from human induced pluripotent stem cells.

Wagoner MD, Bohrer LR, Aldrich BT, Greiner MA, Mullins RF, Worthington KS, Tucker BA, Wiley LA.

Biol Open. 2018 May 8;7(5). pii: bio032102. doi: 10.1242/bio.032102.

24.

CRISPR-Cas9 genome engineering: Treating inherited retinal degeneration.

Burnight ER, Giacalone JC, Cooke JA, Thompson JR, Bohrer LR, Chirco KR, Drack AV, Fingert JH, Worthington KS, Wiley LA, Mullins RF, Stone EM, Tucker BA.

Prog Retin Eye Res. 2018 Jul;65:28-49. doi: 10.1016/j.preteyeres.2018.03.003. Epub 2018 Mar 22. Review.

PMID:
29578069
25.

CRISPR-Cas9-Based Genome Editing of Human Induced Pluripotent Stem Cells.

Giacalone JC, Sharma TP, Burnight ER, Fingert JF, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2018 Feb 28;44:5B.7.1-5B.7.22. doi: 10.1002/cpsc.46.

26.

CRISPR-Cas9-Mediated Correction of the 1.02 kb Common Deletion in CLN3 in Induced Pluripotent Stem Cells from Patients with Batten Disease.

Burnight ER, Bohrer LR, Giacalone JC, Klaahsen DL, Daggett HT, East JS, Madumba RA, Worthington KS, Mullins RF, Stone EM, Tucker BA, Wiley LA.

CRISPR J. 2018 Feb;1:75-87. doi: 10.1089/crispr.2017.0015.

27.

APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2.

Jiao C, Eliott D, Spee C, He S, Wang K, Mullins RF, Hinton DR, Sohn EH.

Retina. 2019 Feb;39(2):265-273. doi: 10.1097/IAE.0000000000001952.

PMID:
29190236
28.

High-volume hemofiltration in adult burn patients with septic shock and acute kidney injury: a multicenter randomized controlled trial.

Chung KK, Coates EC, Smith DJ Jr, Karlnoski RA, Hickerson WL, Arnold-Ross AL, Mosier MJ, Halerz M, Sprague AM, Mullins RF, Caruso DM, Albrecht M, Arnoldo BD, Burris AM, Taylor SL, Wolf SE; Randomized controlled Evaluation of high-volume hemofiltration in adult burn patients with Septic shoCk and acUte kidnEy injury (RESCUE) Investigators.

Crit Care. 2017 Nov 25;21(1):289. doi: 10.1186/s13054-017-1878-8.

29.

Assessment of Adeno-Associated Virus Serotype Tropism in Human Retinal Explants.

Wiley LA, Burnight ER, Kaalberg EE, Jiao C, Riker MJ, Halder JA, Luse MA, Han IC, Russell SR, Sohn EH, Stone EM, Tucker BA, Mullins RF.

Hum Gene Ther. 2018 Apr;29(4):424-436. doi: 10.1089/hum.2017.179. Epub 2018 Feb 23.

30.

What Are the Costs of Trauma Center Readiness? Defining and Standardizing Readiness Costs for Trauma Centers Statewide.

Ashley DW, Mullins RF, Dente CJ, Garlow L, Medeiros RS, Atkins EV, Solomon G, Abston D, Ferdinand CH.

Am Surg. 2017 Sep 1;83(9):979-990.

PMID:
28958278
31.

Evaluation of sFLT1 protein levels in human eyes with the FLT1 rs9943922 polymorphism.

Chirco KR, Lewis CJ, Scheetz TE, Johnston RM, Tucker BA, Stone EM, Fingert JH, Mullins RF.

Ophthalmic Genet. 2018 Jan-Feb;39(1):68-72. doi: 10.1080/13816810.2017.1369550. Epub 2017 Sep 26.

32.

Generation of Xeno-Free, cGMP-Compliant Patient-Specific iPSCs from Skin Biopsy.

Wiley LA, Anfinson KR, Cranston CM, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Curr Protoc Stem Cell Biol. 2017 Aug 14;42:4A.12.1-4A.12.14. doi: 10.1002/cpsc.30.

33.

Choroidal γδ T cells in protection against retinal pigment epithelium and retinal injury.

Zhao Z, Liang Y, Liu Y, Xu P, Flamme-Wiese MJ, Sun D, Sun J, Mullins RF, Chen Y, Cai J.

FASEB J. 2017 Nov;31(11):4903-4916. doi: 10.1096/fj.201700533R. Epub 2017 Jul 20.

34.

Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Burnight ER, Gupta M, Wiley LA, Anfinson KR, Tran A, Triboulet R, Hoffmann JM, Klaahsen DL, Andorf JL, Jiao C, Sohn EH, Adur MK, Ross JW, Mullins RF, Daley GQ, Schlaeger TM, Stone EM, Tucker BA.

Mol Ther. 2017 Sep 6;25(9):1999-2013. doi: 10.1016/j.ymthe.2017.05.015. Epub 2017 Jun 12.

35.

Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease.

Stone EM, Andorf JL, Whitmore SS, DeLuca AP, Giacalone JC, Streb LM, Braun TA, Mullins RF, Scheetz TE, Sheffield VC, Tucker BA.

Ophthalmology. 2017 Sep;124(9):1314-1331. doi: 10.1016/j.ophtha.2017.04.008. Epub 2017 May 27.

36.

Rapid Communication: Solution for the MEEK Glue Transfer Problem.

Culnan DM, Craft-Coffman B, Bitz G, Mullins RF.

J Burn Care Res. 2018 Feb 20;39(2):274-277. doi: 10.1097/BCR.0000000000000587.

PMID:
28557867
37.

Preparation and evaluation of human choroid extracellular matrix scaffolds for the study of cell replacement strategies.

Chirco KR, Worthington KS, Flamme-Wiese MJ, Riker MJ, Andrade JD, Ueberheide BM, Stone EM, Tucker BA, Mullins RF.

Acta Biomater. 2017 Jul 15;57:293-303. doi: 10.1016/j.actbio.2017.05.011. Epub 2017 May 5.

38.

From compliment to insult: genetics of the complement system in physiology and disease in the human retina.

Mullins RF, Warwick AN, Sohn EH, Lotery AJ.

Hum Mol Genet. 2017 Aug 1;26(R1):R51-R57. doi: 10.1093/hmg/ddx181. Review.

39.

Connective Tissue Growth Factor Promotes Efficient Generation of Human Induced Pluripotent Stem Cell-Derived Choroidal Endothelium.

Songstad AE, Worthington KS, Chirco KR, Giacalone JC, Whitmore SS, Anfinson KR, Ochoa D, Cranston CM, Riker MJ, Neiman M, Stone EM, Mullins RF, Tucker BA.

Stem Cells Transl Med. 2017 Jun;6(6):1533-1546. doi: 10.1002/sctm.16-0399. Epub 2017 May 5.

40.

Patient-specific induced pluripotent stem cells to evaluate the pathophysiology of TRNT1-associated Retinitis pigmentosa.

Sharma TP, Wiley LA, Whitmore SS, Anfinson KR, Cranston CM, Oppedal DJ, Daggett HT, Mullins RF, Tucker BA, Stone EM.

Stem Cell Res. 2017 May;21:58-70. doi: 10.1016/j.scr.2017.03.005. Epub 2017 Mar 18.

41.

Two-photon polymerization for production of human iPSC-derived retinal cell grafts.

Worthington KS, Wiley LA, Kaalberg EE, Collins MM, Mullins RF, Stone EM, Tucker BA.

Acta Biomater. 2017 Jun;55:385-395. doi: 10.1016/j.actbio.2017.03.039. Epub 2017 Mar 27.

42.

Drusen on Demand? Authors Describe a Novel Culture System for Generating subRPE Deposits.

Mullins RF.

Invest Ophthalmol Vis Sci. 2017 Feb 1;58(2):720. doi: 10.1167/iovs.17-21419. No abstract available.

43.

Bestrophinopathy: An RPE-photoreceptor interface disease.

Guziewicz KE, Sinha D, Gómez NM, Zorych K, Dutrow EV, Dhingra A, Mullins RF, Stone EM, Gamm DM, Boesze-Battaglia K, Aguirre GD.

Prog Retin Eye Res. 2017 May;58:70-88. doi: 10.1016/j.preteyeres.2017.01.005. Epub 2017 Jan 19. Review.

44.

Transgenic TBK1 mice have features of normal tension glaucoma.

Fingert JH, Miller K, Hedberg-Buenz A, Roos BR, Lewis CJ, Mullins RF, Anderson MG.

Hum Mol Genet. 2017 Jan 1;26(1):124-132. doi: 10.1093/hmg/ddw372.

45.

MMP19 expression in the human optic nerve.

Chirco KR, Hazlewood RJ, Miller K, Workalemahu G, Jampol LM, Lesser GR, Mullins RF, Kuehn MH, Fingert JH.

Mol Vis. 2016 Dec 14;22:1429-1436. eCollection 2016.

46.

Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.

Lee WH, Higuchi H, Ikeda S, Macke EL, Takimoto T, Pattnaik BR, Liu C, Chu LF, Siepka SM, Krentz KJ, Rubinstein CD, Kalejta RF, Thomson JA, Mullins RF, Takahashi JS, Pinto LH, Ikeda A.

Elife. 2016 Nov 15;5. pii: e19264. doi: 10.7554/eLife.19264.

47.

West Nile Virus Infection in Human and Mouse Cornea Tissue.

Blitvich BJ, Wang T, Saxena V, Zeng S, Harmon KM, Raymond MD, Goins KM, Reed CR, Mullins RF, Greiner MA.

Am J Trop Med Hyg. 2016 Nov 2;95(5):1185-1191. Epub 2016 Sep 26.

48.

Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.

Worthington KS, Wiley LA, Mullins RF, Tucker BA, Nuxoll E.

J Biomed Mater Res B Appl Biomater. 2016 Nov;104(8):1602-1609. doi: 10.1002/jbm.b.33506. Epub 2015 Aug 28.

49.

Structural and molecular changes in the aging choroid: implications for age-related macular degeneration.

Chirco KR, Sohn EH, Stone EM, Tucker BA, Mullins RF.

Eye (Lond). 2017 Jan;31(1):10-25. doi: 10.1038/eye.2016.216. Epub 2016 Oct 7. Review.

50.

cGMP production of patient-specific iPSCs and photoreceptor precursor cells to treat retinal degenerative blindness.

Wiley LA, Burnight ER, DeLuca AP, Anfinson KR, Cranston CM, Kaalberg EE, Penticoff JA, Affatigato LM, Mullins RF, Stone EM, Tucker BA.

Sci Rep. 2016 Jul 29;6:30742. doi: 10.1038/srep30742.

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