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Items: 46

1.

In Vitro and In Silico Analyses of the Inhibition of Human Aldehyde Oxidase by Bazedoxifene, Lasofoxifene, and Structural Analogues.

Chen S, Austin-Muttitt K, Zhang LH, Mullins JGL, Lau AJ.

J Pharmacol Exp Ther. 2019 Jul 9. pii: jpet.119.259267. doi: 10.1124/jpet.119.259267. [Epub ahead of print]

2.

Clinical and Functional Characterization of the Recurrent TUBA1A p.(Arg2His) Mutation.

Gardner JF, Cushion TD, Niotakis G, Olson HE, Grant PE, Scott RH, Stoodley N, Cohen JS, Naidu S, Attie-Bitach T, Bonnières M, Boutaud L, Encha-Razavi F, Palmer-Smith SM, Mugalaasi H, Mullins JGL, Pilz DT, Fry AE.

Brain Sci. 2018 Aug 7;8(8). pii: E145. doi: 10.3390/brainsci8080145.

3.

De novo mutations in GRIN1 cause extensive bilateral polymicrogyria.

Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, Giuliano F, Kerr MP, Banne E, Meiner V, Lerman-Sagie T, Helbig KL, Kofman LH, Knight KM, Chen W, Kannan V, Hu C, Kusumoto H, Zhang J, Swanger SA, Shaulsky GH, Mirzaa GM, Muir AM, Mefford HC, Dobyns WB, Mackenzie AB, Mullins JGL, Lemke JR, Bahi-Buisson N, Traynelis SF, Iago HF, Pilz DT.

Brain. 2018 Mar 1;141(3):698-712. doi: 10.1093/brain/awx358.

4.

Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System.

Skibinski DOF, Ghiselli F, Diz AP, Milani L, Mullins JGL.

Genome Biol Evol. 2017 Dec 1;9(12):3265-3281. doi: 10.1093/gbe/evx235.

5.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2017 Apr;42(5):1178. doi: 10.1038/npp.2016.263. No abstract available.

6.

Demethylase Inhibitor Fungicide Resistance in Pyrenophora teres f. sp. teres Associated with Target Site Modification and Inducible Overexpression of Cyp51.

Mair WJ, Deng W, Mullins JG, West S, Wang P, Besharat N, Ellwood SR, Oliver RP, Lopez-Ruiz FJ.

Front Microbiol. 2016 Aug 19;7:1279. doi: 10.3389/fmicb.2016.01279. eCollection 2016.

7.

Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

McGirr A, Lipina TV, Mun HS, Georgiou J, Al-Amri AH, Ng E, Zhai D, Elliott C, Cameron RT, Mullins JG, Liu F, Baillie GS, Clapcote SJ, Roder JC.

Neuropsychopharmacology. 2016 Mar;41(4):1080-92. doi: 10.1038/npp.2015.240. Epub 2015 Aug 14. Erratum in: Neuropsychopharmacology. 2017 Apr;42(5):1178.

8.

Recognizable cerebellar dysplasia associated with mutations in multiple tubulin genes.

Oegema R, Cushion TD, Phelps IG, Chung SK, Dempsey JC, Collins S, Mullins JG, Dudding T, Gill H, Green AJ, Dobyns WB, Ishak GE, Rees MI, Doherty D.

Hum Mol Genet. 2015 Sep 15;24(18):5313-25. doi: 10.1093/hmg/ddv250. Epub 2015 Jun 30.

9.

RfiA, a novel PAP2 domain-containing polytopic membrane protein that confers resistance to the FtsZ inhibitor PC190723.

Chen X, Zhang B, Xiao J, Ju F, Li S, Ren C, An L, Chen T, Liu G, Facey P, Mullins JG, Dyson P.

Future Microbiol. 2015;10(3):325-35. doi: 10.2217/fmb.14.131.

10.

Novel Substrate Specificity and Temperature-Sensitive Activity of Mycosphaerella graminicola CYP51 Supported by the Native NADPH Cytochrome P450 Reductase.

Price CL, Warrilow AG, Parker JE, Mullins JG, Nes WD, Kelly DE, Kelly SL.

Appl Environ Microbiol. 2015 May 15;81(10):3379-86. doi: 10.1128/AEM.03965-14. Epub 2015 Mar 6.

11.

Resistance to antifungals that target CYP51.

Parker JE, Warrilow AG, Price CL, Mullins JG, Kelly DE, Kelly SL.

J Chem Biol. 2014 Aug 27;7(4):143-61. doi: 10.1007/s12154-014-0121-1. eCollection 2014 Oct. Review.

12.

De novo mutations in the beta-tubulin gene TUBB2A cause simplified gyral patterning and infantile-onset epilepsy.

Cushion TD, Paciorkowski AR, Pilz DT, Mullins JG, Seltzer LE, Marion RW, Tuttle E, Ghoneim D, Christian SL, Chung SK, Rees MI, Dobyns WB.

Am J Hum Genet. 2014 Apr 3;94(4):634-41. doi: 10.1016/j.ajhg.2014.03.009.

13.

A novel GABRG2 mutation, p.R136*, in a family with GEFS+ and extended phenotypes.

Johnston AJ, Kang JQ, Shen W, Pickrell WO, Cushion TD, Davies JS, Baer K, Mullins JGL, Hammond CL, Chung SK, Thomas RH, White C, Smith PEM, Macdonald RL, Rees MI.

Neurobiol Dis. 2014 Apr;64:131-141. doi: 10.1016/j.nbd.2013.12.013. Epub 2014 Jan 7.

14.

New hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.

Bode A, Wood SE, Mullins JG, Keramidas A, Cushion TD, Thomas RH, Pickrell WO, Drew CJ, Masri A, Jones EA, Vassallo G, Born AP, Alehan F, Aharoni S, Bannasch G, Bartsch M, Kara B, Krause A, Karam EG, Matta S, Jain V, Mandel H, Freilinger M, Graham GE, Hobson E, Chatfield S, Vincent-Delorme C, Rahme JE, Afawi Z, Berkovic SF, Howell OW, Vanbellinghen JF, Rees MI, Chung SK, Lynch JW.

J Biol Chem. 2013 Nov 22;288(47):33745-59. doi: 10.1074/jbc.M113.509240. Epub 2013 Oct 9.

15.

Genotype-phenotype correlations in hyperekplexia: apnoeas, learning difficulties and speech delay.

Thomas RH, Chung SK, Wood SE, Cushion TD, Drew CJ, Hammond CL, Vanbellinghen JF, Mullins JG, Rees MI.

Brain. 2013 Oct;136(Pt 10):3085-95. doi: 10.1093/brain/awt207. Epub 2013 Sep 11.

PMID:
24030948
16.

Alternating hemiplegia of childhood-related neural and behavioural phenotypes in Na+,K+-ATPase α3 missense mutant mice.

Kirshenbaum GS, Dawson N, Mullins JG, Johnston TH, Drinkhill MJ, Edwards IJ, Fox SH, Pratt JA, Brotchie JM, Roder JC, Clapcote SJ.

PLoS One. 2013;8(3):e60141. doi: 10.1371/journal.pone.0060141. Epub 2013 Mar 20.

17.

Overlapping cortical malformations and mutations in TUBB2B and TUBA1A.

Cushion TD, Dobyns WB, Mullins JG, Stoodley N, Chung SK, Fry AE, Hehr U, Gunny R, Aylsworth AS, Prabhakar P, Uyanik G, Rankin J, Rees MI, Pilz DT.

Brain. 2013 Feb;136(Pt 2):536-48. doi: 10.1093/brain/aws338. Epub 2013 Jan 29.

PMID:
23361065
18.

GLRB is the third major gene of effect in hyperekplexia.

Chung SK, Bode A, Cushion TD, Thomas RH, Hunt C, Wood SE, Pickrell WO, Drew CJ, Yamashita S, Shiang R, Leiz S, Longardt AC, Raile V, Weschke B, Puri RD, Verma IC, Harvey RJ, Ratnasinghe DD, Parker M, Rittey C, Masri A, Lingappa L, Howell OW, Vanbellinghen JF, Mullins JG, Lynch JW, Rees MI.

Hum Mol Genet. 2013 Mar 1;22(5):927-40. doi: 10.1093/hmg/dds498. Epub 2012 Nov 25. Erratum in: Hum Mol Genet. 2013 Jun 15;22(12):2552. Longhardt, Ann-Carolyn [corrected to Longardt, Ann-Carolyn].

PMID:
23184146
19.

Structural modelling pipelines in next generation sequencing projects.

Mullins JG.

Adv Protein Chem Struct Biol. 2012;89:117-67. doi: 10.1016/B978-0-12-394287-6.00005-7. Review.

PMID:
23046884
20.

In silico directed mutagenesis identifies the CD81/claudin-1 hepatitis C virus receptor interface.

Davis C, Harris HJ, Hu K, Drummer HE, McKeating JA, Mullins JG, Balfe P.

Cell Microbiol. 2012 Dec;14(12):1892-903. doi: 10.1111/cmi.12008. Epub 2012 Sep 25.

21.

S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

Warrilow AG, Mullins JG, Hull CM, Parker JE, Lamb DC, Kelly DE, Kelly SL.

Antimicrob Agents Chemother. 2012 Apr;56(4):2099-107. doi: 10.1128/AAC.05389-11. Epub 2012 Jan 17.

22.

Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes.

Moody SC, Zhao B, Lei L, Nelson DR, Mullins JG, Waterman MR, Kelly SL, Lamb DC.

FEBS J. 2012 May;279(9):1640-9. doi: 10.1111/j.1742-4658.2011.08447.x. Epub 2012 Jan 27.

23.

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola.

Mullins JG, Parker JE, Cools HJ, Togawa RC, Lucas JA, Fraaije BA, Kelly DE, Kelly SL.

PLoS One. 2011;6(6):e20973. doi: 10.1371/journal.pone.0020973. Epub 2011 Jun 27.

24.

Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity.

Cools HJ, Mullins JG, Fraaije BA, Parker JE, Kelly DE, Lucas JA, Kelly SL.

Appl Environ Microbiol. 2011 Jun;77(11):3830-7. doi: 10.1128/AEM.00027-11. Epub 2011 Apr 8.

25.

Fine architecture and mutation mapping of human brain inhibitory system ligand gated ion channels by high-throughput homology modeling.

Mullins JG, Chung SK, Rees MI.

Adv Protein Chem Struct Biol. 2010;80:117-52. doi: 10.1016/B978-0-12-381264-3.00004-7. Review.

PMID:
21109219
26.

Pathophysiological mechanisms of dominant and recessive GLRA1 mutations in hyperekplexia.

Chung SK, Vanbellinghen JF, Mullins JG, Robinson A, Hantke J, Hammond CL, Gilbert DF, Freilinger M, Ryan M, Kruer MC, Masri A, Gurses C, Ferrie C, Harvey K, Shiang R, Christodoulou J, Andermann F, Andermann E, Thomas RH, Harvey RJ, Lynch JW, Rees MI.

J Neurosci. 2010 Jul 14;30(28):9612-20. doi: 10.1523/JNEUROSCI.1763-10.2010.

27.

The glycinergic system in human startle disease: a genetic screening approach.

Davies JS, Chung SK, Thomas RH, Robinson A, Hammond CL, Mullins JG, Carta E, Pearce BR, Harvey K, Harvey RJ, Rees MI.

Front Mol Neurosci. 2010 Mar 23;3:8. doi: 10.3389/fnmol.2010.00008. eCollection 2010.

28.

Claudin association with CD81 defines hepatitis C virus entry.

Harris HJ, Davis C, Mullins JG, Hu K, Goodall M, Farquhar MJ, Mee CJ, McCaffrey K, Young S, Drummer H, Balfe P, McKeating JA.

J Biol Chem. 2010 Jul 2;285(27):21092-102. doi: 10.1074/jbc.M110.104836. Epub 2010 Apr 7.

29.

Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans.

Martel CM, Warrilow AG, Jackson CJ, Mullins JG, Togawa RC, Parker JE, Morris MS, Donnison IS, Kelly DE, Kelly SL.

Bioresour Technol. 2010 Jun;101(12):4395-402. doi: 10.1016/j.biortech.2010.01.084. Epub 2010 Feb 12.

PMID:
20153640
30.

PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors.

Bowen AJ, Gonzalez D, Mullins JG, Bhatt AM, Martinez A, Conlan RS.

J Mol Biol. 2010 Feb 5;395(5):937-49. doi: 10.1016/j.jmb.2009.11.065. Epub 2009 Dec 4.

PMID:
19962994
31.

Biophysical properties of 9 KCNQ1 mutations associated with long-QT syndrome.

Yang T, Chung SK, Zhang W, Mullins JG, McCulley CH, Crawford J, MacCormick J, Eddy CA, Shelling AN, French JK, Yang P, Skinner JR, Roden DM, Rees MI.

Circ Arrhythm Electrophysiol. 2009 Aug;2(4):417-26. doi: 10.1161/CIRCEP.109.850149. Epub 2009 May 22.

32.

The first virally encoded cytochrome p450.

Lamb DC, Lei L, Warrilow AG, Lepesheva GI, Mullins JG, Waterman MR, Kelly SL.

J Virol. 2009 Aug;83(16):8266-9. doi: 10.1128/JVI.00289-09. Epub 2009 Jun 10.

33.

A combinatorial pattern discovery approach for the prediction of membrane dipping (re-entrant) loops.

Lasso G, Antoniw JF, Mullins JG.

Bioinformatics. 2006 Jul 15;22(14):e290-7.

PMID:
16873484
34.

Influence of CrgA on assembly of the cell division protein FtsZ during development of Streptomyces coelicolor.

Del Sol R, Mullins JG, Grantcharova N, Flärdh K, Dyson P.

J Bacteriol. 2006 Feb;188(4):1540-50.

35.

Identification of residues controlling transport through the yeast aquaglyceroporin Fps1 using a genetic screen.

Karlgren S, Filipsson C, Mullins JG, Bill RM, Tamás MJ, Hohmann S.

Eur J Biochem. 2004 Feb;271(4):771-9.

36.

A regulatory domain in the C-terminal extension of the yeast glycerol channel Fps1p.

Hedfalk K, Bill RM, Mullins JG, Karlgren S, Filipsson C, Bergstrom J, Tamás MJ, Rydström J, Hohmann S.

J Biol Chem. 2004 Apr 9;279(15):14954-60. Epub 2004 Jan 28.

37.

A short regulatory domain restricts glycerol transport through yeast Fps1p.

Tamás MJ, Karlgren S, Bill RM, Hedfalk K, Allegri L, Ferreira M, Thevelein JM, Rydström J, Mullins JG, Hohmann S.

J Biol Chem. 2003 Feb 21;278(8):6337-45. Epub 2002 Dec 16.

38.

TMCompare: transmembrane region sequence and structure.

Togawa RC, Antoniw JF, Mullins JG.

Bioinformatics. 2001 Dec;17(12):1238-9.

PMID:
11751238
39.
40.

Analysis of the pore of the unusual major intrinsic protein channel, yeast Fps1p.

Bill RM, Hedfalk K, Karlgren S, Mullins JG, Rydström J, Hohmann S.

J Biol Chem. 2001 Sep 28;276(39):36543-9. Epub 2001 Jul 9.

41.

Membrane topology of the Mep/Amt family of ammonium transporters.

Thomas GH, Mullins JG, Merrick M.

Mol Microbiol. 2000 Jul;37(2):331-44.

42.

Analysis of the intestinal absorption of essential fatty acids in vivo in the rat.

Punchard NA, Green AT, Mullins JG, Thompson RP.

Prostaglandins Leukot Essent Fatty Acids. 2000 Jan;62(1):27-33.

PMID:
10765976
43.

Functional expression of Na(+)-independent bile acid transport in Xenopus laevis oocytes following injection with pig intestinal mRNA.

Mullins JG, Knight GL, Gilani SS, Murphy GM, Wilkinson M.

Biochem Soc Trans. 1998 May;26(2):S179. No abstract available.

PMID:
9649854
44.

Effect of the bile acid: fatty acid ratio on in vivo essential fatty acid absorption in the rat.

Mullins JG, Green AT, Thompson RP, Punchard NA.

Biochem Soc Trans. 1998 May;26(2):S178. No abstract available.

PMID:
9649853
45.

Molecular modelling of the mechanism of bile acid transport by the hepatocyte canalicular ecto-ATPase (CAM-105).

Mullins JG, Antoniw J, Gilani SS, Murphy GM, Wilkinson ML.

Biochem Soc Trans. 1998 May;26(2):S123. No abstract available.

PMID:
9649798
46.

Characterization of the ileal Na+/bile salt co-transporter in brush border membrane vesicles and functional expression in Xenopus laevis oocytes.

Mullins JG, Beechey RB, Gould GW, Campbell FC, Shirazi-Beechey SP.

Biochem J. 1992 Aug 1;285 ( Pt 3):785-90.

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